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Cited by 38Reproductive Biology and FertilitySperm and Testicular FunctionGenetics, Aging, and Longevity in Model Organisms

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Reproductive aging: biological pathways and potential interventive strategies

Liu, Yuanyuan, Gao, Jinmin·2023·Journal of Genetics and Genomics
DOI 10.1016/j.jgg.2022.07.002
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Abstract

Reproductive aging is a natural process conserved across species and is well-known in females. It shows age-related follicle depletion and reduction of oocyte quality, eventually causing reproductive senescence and menopause. Although reproductive aging in males is not well noticed as in females, it also causes infertility and has deleterious consequences on the offspring. Various factors have been suggested to contribute to reproductive aging, including oxidative stress, mitochondrial defects, telomere shortening, meiotic chromosome segregation errors and genetic alterations. With the increasing trend of pregnancy age, it is particularly crucial to find interventions to preserve or extend human fertility. Studies in humans and model organisms have provided insights into the biological pathways associated with reproductive aging, and a series of potential interventive strategies have been tested. Here, we review factors affecting reproductive aging in females and males and summarize interventive strategies that may help delay or rescue the aging phenotypes of reproduction.

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Metadata

Authors
Liu, Y., & Gao, J.
Affiliations
Shandong Normal University (CN)
Corresponding author
Gao, Jinmin
ORCID
Venue
Journal of Genetics and Genomics
Publisher
Elsevier BV
Published
2023-03
Volume
50
Issue
3
Pages
141-150
ISSN
  • 1873-5533 (ISSN-L)
  • 1673-8527
DOI
10.1016/j.jgg.2022.07.002
OpenAlex
W4285405294
Cited by
38
References
4
Citations by year
2026: 14 · 2025: 12 · 2024: 7 · 2023: 4
FWCI
1.15
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of genetics and genomics/Journal of Genetics and Genomics (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (31871360, 32022018)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
reproductive aging, male reproductive aging, follicle depletion, oocyte quality, menopause, male infertility, oxidative stress, mitochondrial dysfunction, telomere shortening, advanced maternal age, fertility preservation
MeSH terms
Aging, Female, Humans, Infertility, Male, Maternal Age, Oocytes, Pregnancy, Reproduction

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Liu, Y., & Gao, J. (2023). Reproductive aging: biological pathways and potential interventive strategies. Journal of Genetics and Genomics. https://doi.org/10.1016/j.jgg.2022.07.002