Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1α/Sirt3

Mitochondrial free radical generation, oxidative stress, and aging

Cadenas, E., & Davies, K. J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00317-8 · Cited by 3,010

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

Fukai, T., & Ushio‐Fukai, M. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3999 · Cited by 2,074

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

Ahn, B.-H., Kim, H.-S., Song, S., Lee, I. H., Liu, J., Vassilopoulos, A., Deng, C.-X., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803790105 · Cited by 1,291

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

Brand, M. D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.001 · Cited by 1,063

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

Sundaresan, N. R., Gupta, M., Gene, K., Rajamohan, S. B., Isbatan, A., & Gupta, M. P. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39162 · Cited by 1,006

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

Sheng, Z., & Cai, Q. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3156 · Cited by 940

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress

Tao, R., Coleman, M. C., Pennington, J. D., Ozden, O., Park, S.-H., Jiang, H., Kim, H.-S., Flynn, C. R., Hill, S., Hayes McDonald, W., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.12.013 · Cited by 899

Redox Homeostasis and Mitochondrial Dynamics

Willems, P. H. G. M., Rossignol, R., Dieteren, C. E. J., Murphy, M. P., & Koopman, W. J. H. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.006 · Cited by 876

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

Chen, M., Zhu, X., Ran, L., Lang, H., Yi, L., & Mi, M. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006347 · Cited by 600

Mitochondrial quality control disorder in neurodegenerative disorders: Potential and advantages of traditional Chinese medicines

Xu, L., Zhang, T., Zhu, B., Tao, H., Liu, Y., Liu, X., Zhang, Y., & Meng, X. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.101146 · Cited by 4

The mechanism and therapeutic potential of SIRT3 in central nervous system diseases: a review

Hong, C. S., Wei, Y., Wang, Y., Lv, G., Dong, X., & Huang, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1652296 · Cited by 4

New insight into molecular mechanisms of different polyphenols affecting Sirtuin 3 deacetylation activity

Wei, Y., Zhang, Y., Wang, Z., Yang, Z., Wang, Z., Hao, Y., Li, G., Gao, F., Ye, G., Wang, J., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132026 · Cited by 4

Honokiol alleviates monosodium urate-induced gouty pain by inhibiting voltage-gated proton channels in mice

Miao, L., Yuan, Z., Zhang, S., & Zhang, G. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01498-9 · Cited by 4

Protective effect of astragaloside IV against zinc oxide nanoparticles induced human neuroblastoma SH-SY5Y cell death: a focus on mitochondrial quality control

Wang, L., Zhang, L., Yun, Y., Liang, T., Yan, C., Mao, Z., Zhang, J., Liu, B., Zhang, J., & Liang, T. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05172-0 · Cited by 4

THRA1/PGC-1α/SIRT3 pathway regulates oxidative stress and is implicated in hypertension of maternal hypothyroid rat offspring

Guo, J. X., Shi, Y., Yu, X., Zhao, Y., Wei, B., Huo, M., Lu, L., Li, L., Gao, Q., & Sun, M. (2024) · Hypertension Research · doi:10.1038/s41440-024-02023-9 · Cited by 4

Serum SIRT3 levels in epilepsy patients and its association with clinical outcomes and severity: A prospective observational study

Hu, Y., Zhou, T., & Li, Q. (2024) · Open Medicine · doi:10.1515/med-2024-1011 · Cited by 3

Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's

Goyal, A., Kumari, A., Verma, A., Chaudhary, V., Pathak, P., & Yadav, H. N. (2025) · Brain Disorders · doi:10.1016/j.dscb.2025.100208 · Cited by 3

Honokiol ameliorates hepatic fibrosis by inducing lysosomal membrane permeabilization and impairing lipophagy in hepatic stellate cells

Wang, Z., Li, Z., Yang, W., Li, Y., Huang, Z., Guo, Z., Xu, E., Bai, M., & Li, Y. (2025) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2025.117632 · Cited by 2

Cyclovirobuxine D ameliorates cardiomyocyte senescence in diabetic cardiomyopathy mice by enhancing mitochondrial function via sirtuin 3–ATP5O signal axis

An, J., Su, H., Wang, X., Zhang, G., Xiao, C.-D., Wollenberga, B., Chen, Y.-X., Yang, H., Luo, H., Yang, L., et al. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01254-3 · Cited by 2

Nicotine Improves Memory Impairment in Aged Rats Through Enhanced Mitochondrial Homeostasis

Ni, Z., Li, Y., Wang, G., Wang, S., Chen, H., Hou, H., & Hu, Q. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05342-1 · Cited by 2

ER stress promoted MAMs formation and ER-Mito Ca2+ transfer: implication for fluoride-induced hippocampal neuronal injury and cognitive deficits in mice

Lin, S., Cao, L., Zhou, Y., Liu, S., Yan, Y., Zhang, Q., Yuan, Q., Gao, Y.-F., Du, G., Hu, J., et al. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.112252 · Cited by 2

Effects of Selenium Deficiency and the Environmental Pollutant Trimethylstannyl Chloride on Aging in Broiler Chickens Based on Adverse Outcome Pathways

Xie, R., Liu, M., Xu, T., Li, S., & Xu, S. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c12255 · Cited by 3

T7 peptide-engineered liposomal Irisin mitigates PND progression through AMPK/PGC-1α signaling: multi-omic evidence of metabolic and epigenetic modulation

Wu, H., Dai, W., Cheng, J., Li, A., Peng, Y., Guo, P., & Kong, Z. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04109-7 · Cited by 2

Resveratrol‒loaded self‒assembled tetrahedral framework nucleic acids reshape the epileptic microenvironment by regulating oxidative stress and neuroinflammation via the SIRT3/SOD2 pathway

Cui, J., Zhai, Q., Tan, Z., Zou, Z., Zhang, M., Gao, N., & Sun, J. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04145-3 · Cited by 2

An Update on the Role of Sirtuins in the Prevention of the Aging Process: A Narrative Review

Lucà, F., Fioravanti, L., Scevola, S., Arpino, A., Saler, M., & Nicoletti, G. J. (2026) · Journal of Gerontology and Geriatrics · doi:10.3390/jgg74010006 · Cited by 2

Hippocampal HDAC7 induces perioperative neurocognitive disorders via an NF-κB-MFN2-ACSL4 ferroptosis pathway

Guo, J., Chi, W., Zhang, K., Huang, Y., Zhang, B., Guo, X., & Meng, F. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112531 · Cited by 2

Unlocking the Power of Plant-Derived Natural Products: Therapeutic Benefits for Cognitive Health and Neuropsychiatric Symptoms in Dementia-Related Diseases

小山, 幸., Pham, L., Murakawa, Y., Ogawa, Y., 寺内加奈子, & Davis, K. (2026) · Plants · doi:10.3390/plants15111619 · Cited by 2

Physical exercise therapy as an anti-aging strategy for osteosarcopenia: a narrative review

Liu, T. T., Zhang, P., Dong, W. T., Gong, Y. L., Fang, Z. J., Li, N., & Ma, X. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1791384 · Cited by 2

Honokiol prevents central kainic acid-induced neurodegeneration by suppressing oxidative stress, inflammation, and TGF-β1 expression

Demir, M. T., Çetinavcı, D., Dogan, K., Elbe, H., & Saruhan, E. (2025) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2025.2535723 · Cited by 2

Deficient Mitochondrial Respiration Impairs Sirtuin Activity in Dorsal Root Ganglia in Friedreich Ataxia Mouse and Cell ModelsPreprint

Sanz‐Alcázar, A., Britti, E., Delaspre, F., Medina‐Carbonero, M., Pazos-Gil, M., Tamarit, J., Ros, J., & Cabiscol, E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.01.526688 · Cited by 2

Mitochondrial DNA (mtDNA) accelerates oxygen-glucose deprivation-induced injury of proximal tubule epithelia cell via inhibiting NLRC5

Ge, G., Zhu, B., Zhu, X., Yu, Z., Zhu, K., & Cheng, M. (2024) · Mitochondrion · doi:10.1016/j.mito.2024.101989 · Cited by 1

Poricoic acid a inhibits mitochondrial dysfunction in myocardial infarction by activating SIRT3

Yin, J., Jin, Q., & Liu, Z. (2025) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.24-208 · Cited by 1

Exploring the potential of honokiol as a treatment for cardiovascular disease (Review)

Zeng, Y. Y., Li, Z., & Lin, X. (2025) · Biomedical Reports · doi:10.3892/br.2025.2012 · Cited by 1

Hesperidin attenuates lipopolysaccharide-induced endometritis by inhibiting mitochondrial oxidative stress via activating the AMPK/PGC-1α signalling pathway

Wu, L., Wang, J., Yan, Y., Wang, L., Huang, Q., Peng, J., & Li, L. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178100 · Cited by 1

Gestational exposure to PM2.5 impaired cardiac development through ANGPTL4-mediated mitochondrial metabolic dysfunction

Lv, J., Ding, R., Chen, L., Tian, L., Liu, Z., Liu, S., Xiong, Z., Liu, R., Sun, Z., Yin, C., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.11.022 · Cited by 2

Honokiol-loaded nanoparticles for targeted bacterial eradication and treatment of MRSA infection

Yi, S., Zhang, H., Yang, Z., Wu, D., Shao, D., He, J., Liu, Y., Hao, B., & Wang, S. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102562 · Cited by 2

T-cell apoptosis is more susceptible to overactivated neutrophils delivered-NETs-MPO/NE complex

Lu, C., Shao, L., Li, H., Gao, X., Mei, Y., & Sun, B. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.116100 · Cited by 1

Anti-tumor effects of Guggulsterone in osteosarcoma: Role of SIRT3-mediated PINK1-Parkin mitophagy activation

Zeng, L., Li, S., Wu, K., Bai, X., & Zhang, L. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.157860 · Cited by 1

Combining Network Pharmacology and Experimental Verification to Investigate the Protective Effect of Melatonin on Fluoride-Induced Brain Injury

Ma, R., Wang, C., Qin, W., Li, Y., Zhang, M., Liang, Y., Wang, L., Wang, S., Xie, G., & Niu, Q. (2026) · Toxics · doi:10.3390/toxics14020128 · Cited by 1

Honokiol attenuates renal fibrosis via SIRT3-Mediated regulation of Wnt/β-Catenin signaling

Guo, Z. Q., Wang, J., Li, X. U., Ren, X., Yin, Y., Tian, Y., Qin, Z., Yuan, K., & Zeng, X. (2026) · Functional & Integrative Genomics · doi:10.1007/s10142-025-01816-6 · Cited by 1

Synergistic redox and metabolic reprogramming by functionalized Prussian blue nanozymes for spinal cord injury repair

Deng, Y., Guo, Y., Zhao, B., Wang, Y.-S., Jin, F., Fang, S., Yang, H.-K., Li, D.-Y., Mei, X., Lin, S., et al. (2026) · Materials & Design · doi:10.1016/j.matdes.2026.115680 · Cited by 1

ROS-Mediated Cardiomyocyte Proliferation and Myocardial Regeneration: Mechanisms and Targeted Strategies for Ischemic Heart Disease

Chen, M., Liu, T., Sun, F., Tian, X., Zheng, W., Zhu, Z., & Wang, W. (2026) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd13030105 · Cited by 1

Bazi Bushen Capsule Rescues Menopausal Obesity–Induced Cognitive Impairment by Restoring AhR–miR-23a-Dependent Mitochondrial Bioenergetics

An, X., Xu, W., Chen, H., Zhang, M., Zhong, X., Liu, J., Chen, H., Zhao, X., Wu, Y., Li, J. L., et al. (2026) · Engineering · doi:10.1016/j.eng.2026.05.005 · Cited by 1

Melatonin alleviates fluoride-induced developmental neurotoxicity by restoring SIRT3/HIF-1α axis-mediated mitochondrial dysfunction and reversing energy metabolism reprogramming

Ma, R., Wang, C., Qin, W., Yan, C., Zhang, M., Li, Y., Liang, Y., Zhang, J., & Niu, Q. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120301 · Cited by 2

San Wei Tan Xiang (SWTX) ameliorates depressive-like behaviors by modulating 6-phosphogluconate dehydrogenase (6PGD) activity in mice

Ling, Y., Gu, L., 馮樹勳, Dong, M., Li, L., Zhang, X., Zhang, X., Ma, R., Chen, M., & Tong, L. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.122021 · Cited by 1

Time-dependent effects of hypoxia on mitochondrial dynamics, dysfunction and apoptosis in C8-D1A astrocytes

Chen, Y., Hou, J., Tian, M., Hao, E., Zhang, Y., Huang, D., Zhang, T., & Ma, Y. (2026) · Open Life Sciences · doi:10.1515/biol-2025-1353 · Cited by 1

Astaxanthin activates PI3K/AKT and AMPK signaling to alleviate oxidative stress and improve mouse oocyte In vitro maturation

Zhou, M., Luo, M., Yuan, Y., Han, L., Chen, L., & Gan, S. (2026) · Theriogenology · doi:10.1016/j.theriogenology.2026.118121 · Cited by 1

Protective mechanisms of Sirtuin Family in myocardial ischemia-reperfusion injury and translational therapeutic perspectives

Xue, T., Wang, S., Zhu, X., Luo, J., Zhu, R., Li, H., Ju, R., Zhang, P., Cui, X., & Jing, X. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12521-3 · Cited by 1

Mitochondrial quality control as a unifying regulatory platform in inflammatory bone diseases

Dong, Z., Liu, C., Li, Y., Yang, T., Xiang, T., Wang, J., Chen, L., & Kou, X. (2026) · The Innovation Medicine · doi:10.59717/j.xinn-med.2026.100255 · Cited by 1

TEX264-mediated ER-phagy dysfunction contributes to Cadmium-induced ER stress: Implication of hippocampal neuronal apoptosis and cognitive deficits

Gao, Y., Cao, L., Hong, Y., Ke, H., Yuan, Q., Hu, J., Xu, Q., Liu, Z., Wang, D., & Fan, H. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.112322 · Cited by 1

SIRT3-Mediated Mitophagy Ameliorates Atherosclerosis by Attenuating Endothelial LDL Transcytosis in DiabetesPreprint

Jia, X., Yin, Z., Liu, Z., Chen, Y., Wang, Y., Zhu, X., Zhang, Y., Bai, X., Zhao, P., Jin, S., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4903215

Positive Effects of Seabuckthorn oil on Scopolamine Induced PC12 Cell Damage and APP/PS1 Mice

Yang, D., Zhang, S., Wang, D., Yue, Q., Zhao, C., Sun, X., Li, K., Li, B., Su, L., Zhang, Y., et al. (2025) · Natural Product Communications · doi:10.1177/1934578x251329127

Fluoride-induced vascular endothelial injury and the protective mechanism of blueberry anthocyanins

Zhang, C., Wang, Y., Huang, F., Zhang, Y., Huang, M., Liu, Y., Angwa, L. M., Gao, Y., Sun, D., & Jiang, Y. (2025) · Food and Chemical Toxicology · doi:10.1016/j.fct.2025.115665

Effects of occupational exposure factors interacting with NLRP3 gene polymorphisms on mild cognitive impairment: A cross-sectional study of workers in an aluminum electrolysis production environment

Li, Y., Pang, Y., Li, W., Chen, D., Zhang, C., Cen, Y., Wei, J., Xiao, R., Rao, W., Lin, Y., et al. (2025) · Hygiene and Environmental Health Advances · doi:10.1016/j.heha.2025.100144

Pharmacological correction of cognitive dysfunctions in animals

Shahanenko, R., Lukyanenko, K., Yeroshenko, O., Koziі, N., Shahanenko, V., Antipov, A., Goncharenko, V., & Kozіy, V. (2025) · Regulatory Mechanisms in Biosystems · doi:10.15421/0225119

Honokiol (HNK) accelerates corneal epithelial wound healing by promoting HMGCS2-mediated mitochondrial metabolic homeostasis

Wang, X., Chen, J., Chen, X., Huang, Y., Li, Y., Qiu, J., Chen, H., Mu, Q., Zhuang, J., Luo, Y., et al. (2025) · Experimental Eye Research · doi:10.1016/j.exer.2025.110805

Additional file 1 of Microglia-derived TNF-α contributes to RVLM neuronal mitochondrial dysfunction via blocking the AMPK–Sirt3 pathway in stress-induced hypertension

Wang, L., Liu, T., Wang, X., Tong, L., Chen, G., Zhou, S., Zhang, H., Liu, H., Lu, W., Wang, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593412

Additional file 2 of Microglia-derived TNF-α contributes to RVLM neuronal mitochondrial dysfunction via blocking the AMPK–Sirt3 pathway in stress-induced hypertension

Wang, L., Liu, T., Wang, X., Tong, L., Chen, G., Zhou, S., Zhang, H., Liu, H., Lu, W., Wang, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593415

Injectable Magnolol-Peptide Hydrogel as a Minimally Invasive Treatment for Doxorubicin-Induced Cardiomyopathy via Inhibition of Aberrant Mitochondrial Fission

Hua, Y., Chen, H., Wu, Y., Wu, Y., Hu, C., Zeng, Y., Shen, M., Zhan, J. P., Meng, R., & Cai, Y. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c20219

Honokiol Inhibits Stemness in Pancreatic Cancer via Downregulating c‐Met Expression

Song, Y., Zeng, J., Wu, J., Chen, X., Feng, Z., Qian, W., Wang, Z., & Qin, T. (2026) · Phytotherapy Research · doi:10.1002/ptr.70176

Honokiol protects against acute pancreatitis by activating SIRT3 to restore mitochondrial oxidative phosphorylation and alleviate hyperacetylation

Miao, Y.-F., Yao, J., Peng, Y., Bai, D., Fan, S.-H., Li, H.-Y., Jin, W., & Lu, Y. (2026) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2026.01.007

The Emerging Role of AMPK in Salivary Gland: From Disorder to Recovery

Guo, X., Peng, B., Li, B., & Cheng, Y. (2026) · Oral Diseases · doi:10.1111/odi.70242

Neuroprotective potential of Entada africana stem bark hydroalcoholic extract in sodium fluoride-induced neurobehavioral and biochemical alterations in animals

TOGBOSSI, L. A., Kantati, Y. T., Lawson-Evi, P., & Kwashie, E.-G. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150230

miR-7480-5p/SIRT3/GSH axis mediates selenium Deficiency-Exacerbated trimethyltin chloride-induced ferroptosis in chicken thymus

Gao, H., Gao, M., Liu, Y., Nie, T., Wang, J., Xu, T., & Lin, H. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.03.043

Lutein attenuates sodium fluoride (NaF) and gamma-irradiation induced hepatotoxicity via AMPK-PGC1α mitochondrial biogenesis induction

Abd-ElRaouf, A., Abdou, F. Y., Ali, M., & Habieb, M. E. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11634-z

Targeting sirtuins in diabetic retinopathy: Differential roles in inflammation and mitochondrial dysfunction

Pan, C.-C., Xie, Q.-Q., Lu, P.-Y., Shi, Z., Li, H., Ma, Y.-J., Ding, T.-Y., Zeng, M.-Q., Luo, C., & Zhuge, F. (2026) · World Journal of Diabetes · doi:10.4239/wjd.v17.i4.116208

Extracellular vesicles from honokiol-enhanced human induced pluripotent stem cell-derived cardiomyocytes promote cardiac repair through macrophage metabolic reprogramming

Wang, R., Wang, Y., Zhang, H., Xu, H., Tan, B., Tang, S., huang, S., Gu, W., Yi, Q., & Zhu, J. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102188

Role of AMP-activated protein kinase in oxidative damage of the gubernaculum testis induced by diethylstilbestrol

Tang, S., Xie, Y., Ding, H., Huang, A., Weng, L., Fu, M., Li, Z., Ren, L., Wu, W., Huang, K., et al. (2026) · European journal of medical research · doi:10.1186/s40001-026-04542-2

Deficiency of TEX264-mediated reticulophagy is linked to ER stress-induced neuronal necroptosis: Implication of fluoride-associated hippocampal injury and cognitive dysfunction

Du, G., Yuan, Q., Liu, R., Liang, J., Yang, M., Gao, Y., Liu, X., Lin, S., Zhang, R., Wang, B., et al. (2026) · Journal of Environmental Sciences · doi:10.1016/j.jes.2026.05.025

Epicardial Adipose Tissue Metabolic Changes Associated with Different Intensities Interval Exercise Preconditioning in Myocardial I/R Injury

Shi, N., Yu, Z., Lin, C., Jiang, N., Li, H., Peng, F., & Wu, Z. (2026) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-026-05723-9

Bibliometric analysis of nanomaterials in the diagnosis and treatment of neurological and psychiatric disorders (1997–2025): trends and future directions

Luo, M. H., Zhao, F., Wang, Y.-M., Bian, J., & Luo, Y. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04529-5

Distinct Pathogenic Mechanisms of Two Novel NHS Mutations Identified in Chinese Han Families With Nance–Horan Syndrome

Li, L., Song, J., Qin, M., Zhou, S., Liu, J., & Zheng, G. (2026) · Human Mutation · doi:10.1155/humu/3739907

Comprehensive profiling of chemical composition, plasma-absorbed prototypes, metabolites, and pharmacokinetics of Jiannao Bushen Pill in rats using UHPLC-MS and microdialysis

Yu, X., Kong, L., Wang, B., Liu, J., Lv, X., Sun, Q., Liu, R., Zhao, B., Lv, J., & Gao, Y. N. (2026) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2026.117607

Identification of A Novel Antioxidant Tripeptide Ameliorating Skin Photoaging

Lu, J., Li, J., wang, L., Xia, L., Wan, Y., & Li, Q. (2026) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.70977

A nose-to-brain drug delivery system targeting mitochondrial dysfunction: application potential and future prospects of chitosan nanogels in Alzheimer's disease

Huang, Q., Zuo, Y., Xie, Y., Liu, Z., Wang, L., Xu, H., Yu, M., & Liu, C. (2026) · Biomaterials Science · doi:10.1039/d6bm00624h

CAPNS1 restoration partially alleviates mitochondrial dysfunction and synaptic deficits in Alzheimer’s disease through the Ca2+-CaMKIIβ-MAPK-PGC-1α axis

Han, J., Wu, S., Cui, X., Zhou, X., Yu, Q., Cheng, Q., Lu, Z., & Zong, S. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.07.021

Honokiol attenuates neuroinflammation and enhances remyelination in mouse models of multiple sclerosis through PPARγ-mediated ERK/AKT signalling

Yu, X., Wei, L., Zheng, Y., Qi, X., Mu, X., Wang, Q., Hua, Y., Chen, Q., Zhang, Y., Jiang, H., et al. (2026) · Neurotherapeutics · doi:10.1016/j.neurot.2026.e00965

Inhibition of AMPK Signaling Pathway Mediates Cardiotoxicity Induced by Co-Exposure to Polylactic Acid Nanoplastics and Silica Nanoparticles

Dai, Y., Wang, Y., Wang, X., Zhou, Y., & Xu, H. (2026) · Food and Chemical Toxicology · doi:10.1016/j.fct.2026.116287

Liraglutide affects mitochondrial function and histone acetylation through the NQO1/SIRT3 pathway in diabetic kidney disease

Gao, J., Lv, X., Zhao, P., Pan, B., & Liu, J. (2026) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-026-05670-3

Honokiol targets cyclophilin D and blocks mitochondrial DNA release to inhibit microglial NLRP3 inflammasome activation and alleviate neurodegeneration in Parkinson's disease models

Gan, Q., Xian, Y., Zhou, T., Fu, X., Gou, S., & Zhou, S. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.112305

Liposomal Honokiol Nanoparticles Attenuate Manganese-Induced Hippocampal Neurotoxicity via NRF2/HO-1 and SIRT1/PGC-1α Pathways: Association with Oxidative Stress, Neuroinflammation, Mitochondrial Dysfunction, and Apoptosis

AlRuwaili, R., Elmorsy, E. M., Abdel‐Daim, M. M., Alshammari, E. M., Shaalan, A. A. M., Habotta, O. A., Fawzy, M. S., & Salem, M. (2026) · Brain Sciences · doi:10.3390/brainsci16090900

The regulatory role of lncRNA-LOC680225 in fluoride-induced neurotoxicity: Insights into the miR-194–5p/Slc5a7 signaling axis

Wang, S., Niu, Q., Chen, J., Zhou, G., Xie, L., Xia, T., & Wang, A. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120724

Tuina ameliorates age-related cognitive impairment in SAMP8 mice via the PGC-1α/SIRT3/FOXO3a pathway by restoring mitochondrial ROS homeostasis

Xu, Z., Sun, X., Wang, R., Wang, H., Wang, M., Wang, P., & Song, J. (2026) · Clinical Traditional Medicine and Pharmacology · doi:10.1016/j.ctmp.2026.200304

Core regulatory pathways of natural products in anti-aging: Research progress at molecular, cellular, and systemic levels

Yang, G., Wang, J., Zhang, S., Cheng, Y., Li, Y., 杨旭, Qu, L., Wang, J., Liu, Y., Li, Y., et al. (2026) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2026.101794

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Chrysin Pretreatment Ameliorates Ischemia-Induced Hippocampal LFP Disruption via AMPK Dependent Modulation of SIRT3, FNDC5, and (Pro)BDNF Axis in Rats

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α7-nAChR Activation is Associated with Attenuation of Cardiac Fibrosis in Ischemic Cardiomyopathy via SIRT3-Dependent Modulation of EndMT

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Electroacupuncture Improves Rat Traumatic Brain Injury by Affecting Mitochondrial Function through the AMPK-PGC1α/SIRT1 Pathway

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Magnolia officinalis: propiedades, suplementación, patologías tratadas y sistema nervioso

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Gastrodin combined with donepezil alleviates cognitive dysfunction in Alzheimer’s disease mice by improving mitochondrial function through AMPK/PGC-1α/SIRT3 axis

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Sirtuin 3-mediated deacetylation of superoxide dismutase 2 ameliorates sodium fluoride-induced mitochondrial dysfunction in porcine oocytes

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Honokiol improves cognitive impairment in APP/PS1 mice through activating mitophagy and mitochondrial unfolded protein response

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Sirt3-mediated mitochondrial dysfunction is involved in fluoride-induced cognitive deficits

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SIRT3 activator honokiol ameliorates surgery/anesthesia‐induced cognitive decline in mice through anti‐oxidative stress and anti‐inflammatory in hippocampus

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Mangiferin prevents the impairment of mitochondrial dynamics and an increase in oxidative stress caused by excessive fluoride in SH‐SY5Y cells

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