The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Monitoring Hg2+ and MeHg+ poisoning in living body with an activatable near-infrared II fluorescence probe
Abstract
Noninvasively imaging mercury poisoning in living organisms is critical to understanding its toxicity and treatments. Especially, simultaneous fluorescence imaging of Hg 2+ and MeHg+in vivo is helpful to disclose the mysteries of mercury poisoning. The key limitation for mercury imaging in vivo is the low imaging signal-to-background ratio (SBR) and limited imaging depth, which may result in unreliable detection results. Here, we designed and prepared a near-infrared II (NIR II) emissive probe, NIR-Rh-MS, leveraging the "spirolactam ring-open" tactic of xanthene dyes for in situ visualization of mercury toxicity in mice. The probe produces a marked fluorescence signal at 1015 nm and displays good linear responses to Hg 2+ and MeHg+ with excellent sensitivity, respectively. The penetration experiments elucidate that the activated NIR-II fluorescence signal of the probe penetrates to a depth of up to 7 mm in simulated tissues. Impressively, the probe can monitor the toxicity of Hg 2+ in mouse livers and the accumulation of MeHg+ in mouse brains via intravital NIR-II imaging for the first time. Thus, we believe that detecting Hg 2+ and MeHg+ in different organs with a single NIR-II fluorescence probe in mice would assuredly advance the toxicologic study of mercury poisoning in vivo.
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In the citing paper
“Notably, NIR-Rh-MS successfully traversed the BBB, achieving for the first time the tracking of MeHg+ accumulation in the mouse brain.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [174]
In the citing paper
“Xanthene dyes, particularly rhodamines and fluoresceins, have attracted considerable attention in biomedical imaging owing to their outstanding photophysical properties, including high molar absorptivity, excellent photostability, facile functionalization, and tunable emission”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [174]
In the citing paper
“Liu et al. designed and synthesized a novel activatable NIR-II probe, NIR-Rh-MS, based on the xanthene “spirolactam close/open-switched fluorescence” strategy (Fig. 18b)174.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [174]
In the citing paper
“This probe specifically responded to both Hg2+ and MeHg+, exhibiting concentration-dependent fluorescence enhancement at 1015 nm with detection limits of 40 nM and 1.14 μM, respectively.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [174]
Citations
Cites
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Self-citationIn Vivo Monitoring of Mercury Ions Using a Rhodamine-Based Molecular Probe
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Ariya, P. A., Amyot, M., Dastoor, A. P., Deeds, D. A., Feinberg, A. I., Kos, G., Poulain, A. J., Ryjkov, A., Semeniuk, K., Subir, M., et al. (2015) · Chemical Reviews · doi:10.1021/cr500667e · Cited by 455
Activatable fluorescent probes for in situ imaging of enzymes
Wu, X., Wang, R., Kwon, N., Ma, H., & Yoon, J. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00543j · Cited by 424
Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging
Li, B., Zhao, M., Feng, L., Dou, C., Ding, S., Zhou, G., Lu, L., Zhang, H., Chen, F., Li, X., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16924-z · Cited by 374
Small-molecule fluorescence-based probes for interrogating major organ diseases
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Hybrid Rhodamine Fluorophores in the Visible/NIR Region for Biological Imaging
Wang, L., Du, W., Hu, Z., Uvdal, K., Li, L., & Huang, W. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201901061 · Cited by 349
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Research works printed but not linked: 1
- Wang, 2022, An activity-based fluorescent probe for imaging fluctuations of peroxynitrite (ONOO−) in the Alzheimer's disease brain, Angew Chem Int Ed, 61
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Singh, A., Shah, S. S., Sharma, C., Gupta, V., Sundramoorthy, A. K., Kumar, P., & Arya, S. K. (2024) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2024.113032 · Cited by 131
THQ–Xanthene: An Emerging Strategy to Create Next‐Generation NIR‐I/II Fluorophores
Mao, Z., Rha, H., Kim, J., You, X., Zhang, F., Tao, W., & Kim, J. S. (2023) · Advanced Science · doi:10.1002/advs.202301177 · Cited by 67
Self-citationErdemir, S., Oğuz, M., & Malkondu, S. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131278 · Cited by 51
Stimuli-responsive organic small-molecule NIR-II fluorescent probes
Zhang, Z., Mei, A., Wang, W., Xu, K., Wang, M., Chen, P., Shao, J., & Dong, X. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.217026 · Cited by 40
Zhou, J., Li, J., Xiao-tong, X., Long, S., Cui, N., Zhang, Y., Shi, L., & Zhou, J. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.134269 · Cited by 31
Metadata
- Authors
- Ye, M., Xiang, Y., Gong, J., Wang, X., Mao, Z., & Liu, Z.
- Affiliations
- Wuhan University (CN)
- Hubei University (CN)
- Corresponding author
- Mao, Zhiqiang
- Liu, Zhihong
- Venue
- Journal of Hazardous Materials
- Publisher
- Elsevier BV
- Published
- 2023-03
- Volume
- 445
- Pages
- 130612
- ISSN
- 0304-3894 (ISSN-L)
- OpenAlex
- W4311752065
- Cited by
- 37
- References
- 56
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 11 · 2023: 7
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Hazardous Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21625503, 22174034)
- Natural Science Foundation of Hubei Province (2021CFB305)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Mercury impact and mitigation studies
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Keywords
- mercury toxicity, mercury(II) detection, methylmercury, spirolactam ring opening, xanthene dyes, intravital imaging, noninvasive in vivo imaging, imaging depth
- MeSH terms
- Animals, Benzopyrans, Coloring Agents, Fluorescent Dyes, Mercury, Mercury Poisoning, Spectroscopy, Near-Infrared, Mice
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