Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies
Open accessAbstract
In liver tissue matrix metalloproteinases (MMPs) and their specific inhibitors (tissue inhibitors of metalloproteinases, TIMPs) play a pivotal role in both, fibrogenesis and fibrolysis. The current knowledge of the pathophysiology of liver fibrogenesis with special emphasis on MMPs and TIMPs is presented. A systematic literature search was conducted. All experimental models of liver fibrosis that evaluated a defined anti-fibrotic intervention in vivo or in vitro considering MMPs and TIMPs were selected. The methodological quality of all these publications has been critically appraised using an objective scoring system and the content has been summarized in a table.
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Both TIMPs and MMPs can be secreted by macrophages and aHSCs.
“Both TIMPs and MMPs can be secreted by macrophages and aHSCs (80, 81).”
From Targeting macrophages in liver fibrosis (2026) · cites this paper as [81]
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- Authors
- Hemmann, S., Graf, J., Roderfeld, M., & Roeb, E.
- Affiliations
- Universitätsklinikum Gießen und Marburg (DE)
- Corresponding author
- Roeb, Elke
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 46
- Issue
- 5
- Pages
- 955-975
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W1971094896
- Cited by
- 509
- References
- 6
- Citations by year
- 2026: 17 · 2025: 19 · 2024: 17 · 2023: 23 · 2022: 34 · 2021: 33 · 2020: 28 · 2019: 34 · 2018: 45 · 2017: 33 · 2016: 30 · 2015: 32 · 2014: 23 · 2013: 30 · 2012: 26
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 542, TP C3)
- Bundesministerium für Bildung und Forschung
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- liver fibrosis, matrix metalloproteinases, tissue inhibitors of metalloproteinases, fibrogenesis, fibrolysis, matrix metalloproteinase inhibitors
- MeSH terms
- Animals, Extracellular Matrix, Humans, Liver Cirrhosis, Molecular Conformation, Gene Expression Regulation, Enzymologic, Tissue Inhibitor of Metalloproteinases, Matrix Metalloproteinases, Mice
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