The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
miR-122, a paradigm for the role of microRNAs in the liver
Open accessAbstract
Recent studies have uncovered profound and unexpected roles for a family of tiny regulatory RNAs, known as microRNAs (miRNAs), in the control of diverse aspects of hepatic function and dysfunction, including hepatocyte growth, stress response, metabolism, viral infection and proliferation, gene expression, and maintenance of hepatic phenotype. In liver cancer, misexpression of specific miRNAs suggests diagnostic and prognostic significance. Here, we review the biology of the most abundant miRNA in human liver, miR-122, and consider the diversity of its roles in the liver. We provide a compilation of all miRNAs expressed in the liver, and consider some possible therapeutic opportunities for exploiting miRNAs in the different settings of liver diseases.
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Cites
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Cited by
Xu, J., Wu, C., Che, X., Wang, L., Yu, D., Zhang, T., Huang, L., Li, H., Tan, W., Wang, C., et al. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20712 · Cited by 567
Silencing disease genes in the laboratory and the clinic
Watts, J. K., & Corey, D. R. (2012) · The Journal of Pathology · doi:10.1002/path.2993 · Cited by 470
Plasma MicroRNA-122 as a Biomarker for Viral-, Alcohol-, and Chemical-Related Hepatic Diseases
Zhang, Y., Jia, Y., Zheng, R., Guo, Y., Wang, Y., Guo, H., Fei, M., & Sun, S. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.147850 · Cited by 415
Trials and Tribulations of MicroRNA Therapeutics
Seyhan, A. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031469 · Cited by 381
Reexamining assumptions about miRNA-guided gene silencing
Kilikevicius, A., Meister, G., & Corey, D. R. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab1256 · Cited by 194
“miR-122 is a case study for targeting miRNAs for therapeutic development (89).”
Metadata
- Authors
- Girard, M., Jacquemin, E., Munnich, A., Lyonnet, S., & Henrion-Caude, A.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 48
- Issue
- 4
- Pages
- 648-656
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W1976628534
- Cited by
- 375
- References
- 9
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Girard, M., Jacquemin, E., Munnich, A., Lyonnet, S., & Henrion-Caude, A. (2008). miR-122, a paradigm for the role of microRNAs in the liver. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2008.01.019
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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