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Non-alcoholic fatty liver disease in patients with chronic plaque psoriasis

Gisondi, Paolo, Targher, Giovanni, Zoppini, Giacomo, Girolomoni, Giampiero·2009·Journal of Hepatology

Abstract

Background/aims Non-alcoholic fatty liver disease (NAFLD) and chronic plaque psoriasis are both associated with metabolic syndrome and increased risk of incident cardiovascular disease. We assessed the frequency and characteristics of NAFLD in patients with chronic plaque psoriasis. Methods One hundred and thirty consecutive patients with chronic plaque psoriasis and 260 apparently healthy controls matched for age, sex and body mass index were enrolled. NAFLD was diagnosed by abdominal ultrasound after excluding other secondary causes of chronic liver disease. Results The frequency of NAFLD was remarkably greater in psoriasis patients than in controls (47% vs. 28%; p Conclusions NAFLD is frequent in patients with chronic plaque psoriasis - affecting up to nearly half of these patients - and is strongly associated with psoriasis severity. Early recognition of NAFLD by radiological imaging tests in this group of patients is warranted.

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Metadata

Authors
Gisondi, P., Targher, G., Zoppini, G., & Girolomoni, G.
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2009-10
Volume
51
Issue
4
Pages
758-764
ISSN
0168-8278
Cited by
225
References
3
Language
en

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Gisondi, P., Targher, G., Zoppini, G., & Girolomoni, G. (2009). Non-alcoholic fatty liver disease in patients with chronic plaque psoriasis. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2009.04.020