CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease
Open accessAbstract
Alcoholic (ALD) and non-alcoholic fatty liver diseases (NAFLD) are clinical conditions leading to hepatocellular injury and inflammation resulting from alcohol consumption, high fat diet, obesity and diabetes, among others. Oxidant stress is a major contributing factor to the pathogenesis of ALD and NAFLD. Multiple studies have shown that generation of reactive oxygen species (ROS) is key for the progression of fatty liver to steatohepatitis. Cytochrome P450 2E1 (CYP2E1) plays a critical role in ROS generation and CYP2E1 is also induced by alcohol itself. This review summarizes the role of CYP2E1 in ALD and NAFLD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Activated CYP2E1 promotes the production of acetaldehyde through the formation of ROS.
“Activated CYP2E1 promotes the production of acetaldehyde through the formation of reactive oxygen species (ROS) [29,30].”
From Pathophysiological Aspects of Alcohol Metabolism in the Liver (2021) · cites this paper as [30]
Excess alcohol consumption increases the expression and activity of CYP2E1, not ADH.
“Excess alcohol consumption increases the expression and activity of cytochrome P450 2E1 (CYP2E1), not ADH.”
From Pathophysiological Aspects of Alcohol Metabolism in the Liver (2021) · cites this paper as [30]
Cites
Mitochondrial dysfunction in Nash: causes, consequences and possible means to prevent it
Begriche, K., Igoudjil, A., Pessayre, D., & Fromenty, B. (2006) · Mitochondrion · doi:10.1016/j.mito.2005.10.004 · Cited by 753 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Seitz, H. K., Bataller, R., Cortez-Pinto, H., Gao, B., Gual, A., Lackner, C., Mathurin, P., Mueller, S., Szabo, G., & Tsukamoto, H. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0014-7 · Cited by 1,271 · see citing works
Gut–Liver Axis in Alcoholic Liver Disease
Szabo, G. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.10.042 · Cited by 754 · see citing works
Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411 · see citing works
Taru, V., Szabo, G., Mehal, W., & Reiberger, T. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.06.016 · Cited by 344 · see citing works
Pathophysiological Aspects of Alcohol Metabolism in the Liver
Hyun, J., Han, J., Lee, C., Yoon, M., & Jung, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115717 · Cited by 324 · see citing works
Danger signals in liver injury and restoration of homeostasis
Han, H., Desert, R., Das, S., Song, Z., Athavale, D., Ge, X., & Nieto, N. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.04.033 · Cited by 127 · see citing works
Self-citationCho, Y.-E., Yu, L.-R., Abdelmegeed, M. A., Yoo, S.-H., & Song, B.-J. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.02.005 · Cited by 99 · see citing works
A dual inhibition: microRNA-552 suppresses both transcription and translation of cytochrome P450 2E1
Miao, L., Yao, H., Li, C., Pu, M., Yao, X., Yang, H., Qi, X., Ren, J., & Wang, Y. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.02.016 · Cited by 98 · see citing works
Liu, Y., Zhao, C., Xiao, J., Liu, L., Zhang, M., Wang, C., Wu, G., Zheng, M.-H., Xu, L.-M., Chen, Y.-P., et al. (2016) · Scientific Reports · doi:10.1038/srep31026 · Cited by 78 · see citing works
Zhao, X., Wang, C., Dai, S., Liu, Y., Zhang, F., Peng, C., & Li, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4591134 · Cited by 75 · see citing works
Han, X., Ding, C., Zhang, G., Pan, R., Liu, Y., Huang, N., Hou, N., Han, F., Xu, W., & Sun, X. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.03.032 · Cited by 63 · see citing works
Lee, S., Koh, H., Joo, D. J., Nedumaran, B., Jeon, H., Park, C., Harris, R. A., & Kim, Y. D. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12638 · Cited by 48 · see citing works
Xia, T., Zhang, J., Yao, J., Zhang, B., Duan, W., Zhao, C., Du, P., Song, J., Zheng, Y., & Wang, M. (2018) · Nutrients · doi:10.3390/nu10070805 · Cited by 45 · see citing works
The role of <scp>IL</scp>‐22 in the resolution of sterile and nonsterile inflammation
Alabbas, S. Y., Begun, J., Florin, T. H., & Oancea, I. (2018) · Clinical & Translational Immunology · doi:10.1002/cti2.1017 · Cited by 37 · see citing works
- Authors
- Leung, T.-M., & Nieto, N.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Mount Sinai Hospital (US)
- Corresponding author
- Nieto, Natalia
- ORCID
- Nieto, Natalia
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 58
- Issue
- 2
- Pages
- 395-398
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2003272885
- Cited by
- 514
- References
- 1
- Citations by year
- 2026: 28 · 2025: 41 · 2024: 45 · 2023: 41 · 2022: 45 · 2021: 55 · 2020: 49 · 2019: 37 · 2018: 39 · 2017: 36 · 2016: 23 · 2015: 29 · 2014: 29 · 2013: 14 · 2012: 2
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Hepatology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (5P20 AA017067-01S1)
- National Institute on Alcohol Abuse and Alcoholism
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- CYP2E1, oxidative stress, alcoholic liver disease, non-alcoholic fatty liver disease, reactive oxygen species, steatohepatitis, hepatocyte injury, alcohol consumption
- MeSH terms
- Fatty Liver, Humans, Insulin Resistance, Liver, Liver Diseases, Alcoholic, Reactive Oxygen Species, Oxidative Stress, Disease Progression, Cytochrome P-450 CYP2E1, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
