A dual inhibition: microRNA-552 suppresses both transcription and translation of cytochrome P450 2E1

Miao, Lingling; Yao, Hailan; Li, Chenggang; Pu, Mengfan; Yao, Xuan; Yang, Hui; Qi, Xinming; Ren, Jin; Wang, Yizheng

doi:10.1016/j.bbagrm.2016.02.016

Cited by 98MicroRNA in disease regulationPlant Molecular Biology ResearchCancer-related molecular mechanisms research

A dual inhibition: microRNA-552 suppresses both transcription and translation of cytochrome P450 2E1

Miao, Lingling, Yao, Hailan, Li, Chenggang, Pu, Mengfan, Yao, Xuan, Yang, Hui, Qi, Xinming, Ren, Jin +1 more·2016·Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

DOI 10.1016/j.bbagrm.2016.02.016

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Abstract

MicroRNAs (miRNAs) can direct post-transcriptional or transcriptional gene silencing. Here, we report that miR-552 is in the nucleus and cytosol and inhibits human cytochrome P450 (CYP) 2E1 expression at both transcriptional and post-transcriptional levels. MiR-552 via its non-seed sequence forms hybrids with a loop hairpin of the cruciform structure in CYP2E1 promoter region to inhibit SMARCE1 and RNA polymerase II binding to the promoter and CYP2E1 transcription. Expressing SMARCE1 reverses the inhibitory effects of miR-552 on CYP2E1 mRNA expression. MiR-552 with mutations in non-seed region losses its transcriptional, but retains its post-transcriptional repression to CYP2E1. In contrast, mutation in miR-552 seed sequence suppresses its inhibitory effects on CYP2E1 expression at protein, but not at mRNA, levels. Our results suggest that miR-552 is a miRNA with a dual inhibitory ability at transcriptional and post-transcriptional levels leading to an effective inhibition.

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Nuclear miR-522 interacts with a DNA cruciform structure within the promoter of CYP2E1 and suppresses its transcription.
“A more recent study by Miao et al. (66) found nuclear miR-522 interacting with a DNA cruciform structure (a stem-loop on sense and antisense DNA strands) within the promoter of CYP2E1 and suppressing its transcription (66).”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [66]

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Authors: Miao, L., Yao, H., Li, C., Pu, M., Yao, X., Yang, H., Qi, X., Ren, J., & Wang, Y.
Affiliations: Chinese Academy of Sciences (CN)
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences (CN)
Corresponding author: Ren, Jin
Wang, Yizheng
ORCID: Miao, Lingling
Yao, Hailan
Li, Chenggang
Pu, Mengfan
Yao, Xuan
Yang, Hui
Qi, Xinming
Ren, Jin
Wang, Yizheng
Venue: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Publisher: Elsevier BV
Published: 2016-04
Volume: 1859
Issue: 4
Pages: 650-662
ISSN: 1874-9399 (ISSN-L)
DOI: 10.1016/j.bbagrm.2016.02.016
OpenAlex: W2291743740
Cited by: 98
References: 61
Citations by year: 2026: 1 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 16 · 2021: 16 · 2020: 13 · 2019: 12 · 2018: 10 · 2017: 9 · 2016: 6
FWCI: 5.15
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (81,130,081)
National Science and Technology Major Project (2012ZX09302-003, 2015ZX09102005)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: CYP2E1, transcriptional repression, post-transcriptional gene silencing, SMARCE1, RNA polymerase II, cruciform structure, promoter binding
MeSH terms: Chromosomal Proteins, Non-Histone, DNA-Binding Proteins, Gene Expression Regulation, Humans, Mutation, Promoter Regions, Genetic, RNA Polymerase II, RNA, Messenger, Transcription, Genetic, Protein Biosynthesis, Cytochrome P-450 CYP2E1, Gene Silencing, MicroRNAs

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A dual inhibition: microRNA-552 suppresses both transcription and translation of cytochrome P450 2E1

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