Alcoholic liver disease

Diagnostic and Statistical Manual of Mental Disorders

American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works

EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

Galle, P. R., Forner, A., Llovet, J. M., Mazzaferro, V., Piscaglia, F., Raoul, J.-L., Schirmacher, P., & Vilgrain, V. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.019 · Cited by 11,406 · see citing works

Changes of Intestinal Functions in Liver Cirrhosis

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The AUDIT Alcohol Consumption Questions (AUDIT-C)<subtitle>An Effective Brief Screening Test for Problem Drinking</subtitle>

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Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

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AASLD guidelines for the treatment of hepatocellular carcinoma

Heimbach, J. K., Kulik, L., Finn, R. S., Sirlin, C. B., Abecassis, M. M., Roberts, L. R., Zhu, A. X., Murad, M. H., & Marrero, J. A. (2017) · Hepatology · doi:10.1002/hep.29086 · Cited by 4,072 · see citing works

Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders

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Mechanisms of hepatic stellate cell activation

Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909 · see citing works

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

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The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level

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TLR4 enhances TGF-β signaling and hepatic fibrosis

Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine · doi:10.1038/nm1663 · Cited by 1,942 · see citing works

Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence: The COMBINE Study: A Randomized Controlled Trial

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The Alcohol Use Disorders Identification Test (AUDIT): validation of a screening instrument for use in medical settings

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The burden of liver disease in Europe: A review of available epidemiological data

Blachier, M., Leleu, H., Peck‐Radosavljevic, M., Valla, D. C., & Roudot‐Thoraval, F. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2012.12.005 · Cited by 1,340 · see citing works

The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis

Ascha, M. S., Hanouneh, I. A., Lopez, R., Tamimi, T. A.-R., Feldstein, A. F., & Zein, N. N. (2010) · Hepatology · doi:10.1002/hep.23527 · Cited by 1,296 · see citing works

Alcohol, oxidative stress and free radical damage

Albano, E. (2006) · Proceedings of The Nutrition Society · doi:10.1079/pns2006496 · Cited by 1,215 · see citing works

Molecular mechanisms of alcohol-mediated carcinogenesis

Seitz, H. K., & Stickel, F. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2191 · Cited by 1,144 · see citing works

Serum markers detect the presence of liver fibrosis: A cohort study

Rosenberg, W. M., Voelker, M., Thiel, R. P., Becka, M., Burt, A. D., Schuppan, D., Hübscher, S. G., Roskams, T., Pinzani, M., & Arthur, M. J. P. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.08.052 · Cited by 1,103 · see citing works

Effectiveness and cost-effectiveness of policies and programmes to reduce the harm caused by alcohol

Anderson, P., Chisholm, D., & Fuhr, D. C. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60744-3 · Cited by 1,102 · see citing works

Alcoholic Liver Disease

O’Shea, R. S., Dasarathy, S., & McCullough, A. J. (2009) · Hepatology · doi:10.1002/hep.23258 · Cited by 1,085 · see citing works

EASL Clinical Practice Guidelines: Management of alcohol-related liver disease

Thursz, M. R., Gual, A., Lackner, C., Mathurin, P., Moreno, C., Spahr, L., Sterneck, M. R., & Cortez‐Pinto, H. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.018 · Cited by 953 · see citing works

Early Liver Transplantation for Severe Alcoholic Hepatitis

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Corticosteroid therapy of alcoholic hepatitis

Maddrey, W. C., Boitnott, J. K., Bedine, M. S., Weber, F. L., Mezey, E., & White, R. I. (1978) · Gastroenterology · doi:10.1016/0016-5085(78)90401-8 · Cited by 922 · see citing works

Alcoholic Hepatitis

Lucey, M. R., Mathurin, P., & Morgan, T. R. M. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0805786 · Cited by 882 · see citing works

Carcinogenicity of alcoholic beverages

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Prediction of risk of liver disease by alcohol intake, sex, and age: A prospective population study

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Prednisolone or Pentoxifylline for Alcoholic Hepatitis

Thursz, M. R., Richardson, P., Allison, M., Austin, A., Bowers, M., Day, C. P., Downs, N., Gleeson, D., MacGilchrist, A., Grant, A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1412278 · Cited by 827 · see citing works

Alcoholic liver disease: mechanisms of injury and targeted treatment

Louvet, A., & Mathurin, P. (2015) · Nature Reviews Gastroenterology &Hepatology · doi:10.1038/nrgastro.2015.35 · Cited by 820 · see citing works

Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Than Transient Elastography

Imajo, K., Kessoku, T., Honda, Y., Tomeno, W., Ogawa, Y., Mawatari, H., Fujita, K., Yoneda, M., Taguri, M., Hyogo, H., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.11.048 · Cited by 815 · see citing works

The reliability of the Alcohol Timeline Followback when administered by telephone and by computer

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Global burden of alcoholic liver diseases

Rehm, J., Samokhvalov, A. V., & Shield, K. D. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.03.007 · Cited by 740 · see citing works

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

Petrasek, J., Bala, S., Csak, T., Lippai, D., Kodys, K., Menashy, V., Barrieau, M., Min, S.-Y., Kurt-Jones, E. A., & Szabo, G. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60777 · Cited by 735 · see citing works

The Lille model: A new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids

Louvet, A., Naveau, S., Abdelnour, M., Ramond, M.-J., Diaz, E., Fartoux, L., Dharancy, S., Texier, F., Hollebecque, A., Serfaty, L., et al. (2007) · Hepatology · doi:10.1002/hep.21607 · Cited by 728 · see citing works

EASL Clinical Practical Guidelines: Management of Alcoholic Liver Disease

European Association for the Study of the Liver (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.04.004 · Cited by 720 · see citing works

Burden of liver disease in Europe: Epidemiology and analysis of risk factors to identify prevention policies

Pimpin, L., Cortez‐Pinto, H., Negro, F., Corbould, E., Lazarus, J. V., Webber, L., & Sheron, N. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.05.011 · Cited by 713 · see citing works

Antibiotics prevent liver injury in rats following long-term exposure to ethanol

Adachi, Y., Moore, L. E., Bradford, B. U., Gao, W., & Thurman, R. G. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90027-6 · Cited by 692 · see citing works

Alcohol as a risk factor for liver cirrhosis: A systematic review and meta‐analysis

REHM, J., TAYLOR, B., MOHAPATRA, S., IRVING, H., BALIUNAS, D., PATRA, J., & ROERECKE, M. (2010) · Drug and Alcohol Review · doi:10.1111/j.1465-3362.2009.00153.x · Cited by 668 · see citing works

Excess weight risk factor for alcoholic liver disease

Naveau, S., Giraud, V., Borotto, E., Aubert, A., Capron, F., & Chaput, J. (1997) · Hepatology · doi:10.1002/hep.510250120 · Cited by 666 · see citing works

Toll-Like Receptor 4 Mediates Inflammatory Signaling by Bacterial Lipopolysaccharide in Human Hepatic Stellate Cells

Paik, Y.-H., Schwabe, R. F., Bataller, R., Russo, M. P., Jobin, C., & Brenner, D. A. (2003) · Hepatology · doi:10.1053/jhep.2003.50182 · Cited by 651 · see citing works

Alcohol and hepatocellular carcinoma

Morgan, T. R. M., Mandayam, S., & Jamal, M. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.020 · Cited by 631 · see citing works

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases

Bala, S., Petrášek, J., Mundkur, S., Catalano, D., Levin, I., Ward, J. A., Alao, H., Kodys, K., & Szabó, G. (2012) · Hepatology · doi:10.1002/hep.25873 · Cited by 631 · see citing works

Natural Killer Cells Ameliorate Liver Fibrosis by Killing Activated Stellate Cells in NKG2D-Dependent and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Dependent Manners

Radaeva, S., Sun, R., Jaruga, B., Nguyen, V. T., Tian, Z., & Gao, B. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.10.055 · Cited by 610 · see citing works

Changes in the Prevalence of Hepatitis C Virus Infection, Nonalcoholic Steatohepatitis, and Alcoholic Liver Disease Among Patients With Cirrhosis or Liver Failure on the Waitlist for Liver Transplantation

Goldberg, D. S., Ditah, I. C., Saeian, K., Lalehzari, M., Aronsohn, A. I., Gorospe, E. C., & Charlton, M. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.003 · Cited by 601 · see citing works

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis

Buch, S., Stickel, F., Trépo, E., Way, M., Herrmann, A., Nischalke, H. D., Brosch, M., Rosendahl, J., Berg, T., Ridinger, M., et al. (2015) · Nature Genetics · doi:10.1038/ng.3417 · Cited by 565 · see citing works

Inactivation of Kupffer cells prevents early alcohol-induced liver injury

Adachi, Y., Bradford, B. U., Gao, W., Bojes, H. K., & Thurman, R. G. (1994) · Hepatology · doi:10.1002/hep.1840200227 · Cited by 555 · see citing works

Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia

Crabb, D. W., Bataller, R. A., Chalasani, N., Kamath, P. S., Lucey, M. R., Mathurin, P., McClain, C. J., McCullough, A. J., Mitchell, M. C., Morgan, T. R. M., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.042 · Cited by 554 · see citing works

Ethanol Induces Fatty Acid Synthesis Pathways by Activation of Sterol Regulatory Element-binding Protein (SREBP)

You, M., Fischer, M., Deeg, M. A., & Crabb, D. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202411200 · Cited by 543 · see citing works

Clinical Course of Alcoholic Liver Cirrhosis: A Danish Population-Based Cohort Study

Jepsen, P., Ott, P., Andersen, P. K., Sørensen, H. T., & Vilstrup, H. (2009) · Hepatology · doi:10.1002/hep.23500 · Cited by 536 · see citing works

MELD accurately predicts mortality in patients with alcoholic hepatitis†

Dunn, W., Jamil, L. H., Brown, L. S., Wiesner, R. H., Kim, W. R., Menon, K. V., Malinchoc, M., Kamath, P. S., & Shah, V. H. (2005) · Hepatology · doi:10.1002/hep.20503 · Cited by 525 · see citing works

Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice

Ding, W., Li, M., Chen, X., Ni, H., Lin, C., Gao, W., Lu, B., Stolz, D. B., Clemens, D. L., & Yin, X. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.07.041 · Cited by 515 · see citing works

CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease

Leung, T.-M., & Nieto, N. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2012.08.018 · Cited by 514 · see citing works

Methylprednisolone Therapy in Patients with Severe Alcoholic Hepatitis

Carithers, R. L., Herlong, H. F., Diehl, A. M., Shaw, E. W., Combes, B., Fallon, H. J., & Maddrey, W. C. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-110-9-685 · Cited by 500 · see citing works

Inflammasomes in liver diseases

Szabó, G., & Csák, T. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.03.035 · Cited by 498 · see citing works

The role of AMP-activated protein kinase in the action of ethanol in the liver

You, M., Matsumoto, M., Pacold, C. M., Cho, W. K., & Crabb, D. W. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.049 · Cited by 469 · see citing works

Evidence of Genetic Predisposition to Alcoholic Cirrhosis and Psychosis: Twin Concordances for Alcoholism and Its Biological End Points by Zygosity among Male Veterans

Hrubec, Z., & Omenn, G. S. (1981) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1981.tb04890.x · Cited by 464 · see citing works

Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data

Mathurin, P., O’Grady, J., Carithers, R. L., Phillips, M., Louvet, A., Mendenhall, C. L., Ramond, M.-J., Naveau, S., Maddrey, W. C., & Morgan, T. R. M. (2010) · Gut · doi:10.1136/gut.2010.224097 · Cited by 451 · see citing works

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

Petrasek, J., Iracheta‐Vellve, A., Csák, T., Satishchandran, A., Kodys, K., Kurt‐Jones, E. A., Fitzgerald, K. A., & Szabó, G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308331110 · Cited by 449 · see citing works

A Histologic Scoring System for Prognosis of Patients With Alcoholic Hepatitis

Altamirano, J., Miquel, R., Katoonizadeh, A., Abraldeṣ, J. G., Duarte‐Rojo, A., Louvet, A., Augustín, S., Mookerjee, R. P., Michelena, J., Smyrk, T. C., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.018 · Cited by 421 · see citing works

Glucocorticoids plusN-Acetylcysteine in Severe Alcoholic Hepatitis

Nguyen-Khac, É., Thévenot, T., Piquet, M., Benferhat, S., Goria, O., Chatelain, D., Tramier, B., Dewaele, F., Ghrib, S., Rudler, M., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1101214 · Cited by 409 · see citing works

Effects of ethanol on lipid metabolism.

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Analysis of factors predictive of mortality in alcoholic hepatitis and derivation and validation of the Glasgow alcoholic hepatitis score

Forrest, E. H., Evans, C. D. J., Stewart, S., Phillips, M., Oo, Y. H., McAvoy, N. C., Fisher, N. C., Singhal, S., Brind, A., Haydon, G., et al. (2005) · Gut · doi:10.1136/gut.2004.050781 · Cited by 388 · see citing works

Risk factors of fibrosis in alcohol-induced liver disease

Raynard, B., Balian, A., Fallik, D., Capron, F., Bédossa, P., Chaput, J., & Naveau, S. (2002) · Hepatology · doi:10.1053/jhep.2002.31782 · Cited by 387 · see citing works

Noninvasive diagnosis of hepatic fibrosis or cirrhosis

Oberti, F., Valsesia, E., Pilette, C., Rousselet, M., Bédossa, P., Aubé, C., Gallois, Y., Rifflet, H., Maïga, M., Penneau-Fontbonne, D., et al. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.pm9352863 · Cited by 368 · see citing works

Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics

Yokoyama, A. (1998) · Carcinogenesis · doi:10.1093/carcin/19.8.1383 · Cited by 368 · see citing works

Infection in Patients With Severe Alcoholic Hepatitis Treated With Steroids: Early Response to Therapy Is the Key Factor

Louvet, A., Wartel, F., Castel, H., Dharancy, S., Hollebecque, A., Canva-Delcambre, V., Deltenre, P., & Mathurin, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.062 · Cited by 365 · see citing works

Treatment of Patients with Cirrhosis

Ge, P. S., & Runyon, B. A. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1504367 · Cited by 358 · see citing works

MRI and MRE for non-invasive quantitative assessment of hepatic steatosis and fibrosis in NAFLD and NASH: Clinical trials to clinical practice

Dulai, P. S., Sirlin, C. B., & Loomba, R. S. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.06.005 · Cited by 357 · see citing works

Genetic Polymorphisms and the Progression of Liver Fibrosis: A Critical Appraisal

Bataller, R. A., North, K. E., & Brenner, D. A. (2003) · Hepatology · doi:10.1053/jhep.2003.50127 · Cited by 354 · see citing works

Enhanced liver fibrosis test can predict clinical outcomes in patients with chronic liver disease

Parkes, J., Roderick, P. J., Harris, S., Day, C. P., Mutimer, D., Collier, J. D., Lombard, M., Alexander, G., Ramage, J. K., Dusheiko, G. M., et al. (2010) · Gut · doi:10.1136/gut.2009.203166 · Cited by 349 · see citing works

CIRRHOSIS IN THE ALCOHOLIC AND ITS RELATION TO THE VOLUME OF ALCOHOL ABUSE

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Liver Transplantation for Alcoholic Liver Disease in Europe: A Study from the ELTR (European Liver Transplant Registry)

Burra, P., Senzolo, M., Adam, R. A., Delvart, V., Karam, V. H., Germani, G., & Neuberger, J. (2009) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2009.02869.x · Cited by 332 · see citing works

Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome

Mookerjee, R. P., Stadlbauer, V., Lidder, S., Wright, G. A. K., Hodges, S. J., Davies, N. A., & Jalan, R. (2007) · Hepatology · doi:10.1002/hep.21737 · Cited by 332 · see citing works

Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress

Seitz, H. K., & Stickel, F. (2006) · Biological Chemistry · doi:10.1515/bc.2006.047 · Cited by 326 · see citing works

A New Scoring System for Prognostic Stratification of Patients With Alcoholic Hepatitis

Domínguez, M., Rincón, D., Abraldeṣ, J. G., Miquel, R., Colmenero, J., Bellot, P., García‐Pagán, J. C., Fernández, R. A., Moreno, M., Bañares, R., et al. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.02104.x · Cited by 325 · see citing works

Molecular Mechanisms of Alcoholic Fatty Liver

Purohit, V., Gao, B., & Song, B. (2009) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00827.x · Cited by 312 · see citing works

Alcohol Metabolism-mediated Oxidative Stress Down-regulates Hepcidin Transcription and Leads to Increased Duodenal Iron Transporter Expression

Harrison-Findik, D. D., Schafer, D., Klein, E., Timchenko, N. A., Kulaksiz, H., Clemens, D. L., Fein, E., Andriopoulos, B., Pantopoulos, K., & Gollan, J. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602098200 · Cited by 308 · see citing works

The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis

Bala, S., Csák, T., Saha, B., Zatsiorsky, J., Kodys, K., Catalano, D. E., Satishchandran, A., & Szabó, G. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.01.035 · Cited by 305 · see citing works

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

BasuRay, S., Smagris, E., Cohen, J. C., & Hobbs, H. H. (2017) · Hepatology · doi:10.1002/hep.29273 · Cited by 302 · see citing works

Contribution of mitochondria to oxidative stress associated with alcoholic liver disease1 1This article is part of a series of reviews on “Alcohol, Oxidative Stress and Cell Injury”. The full list of papers may be found on the homepage of the journal.

Bailey, S. M., & CUNNINGHAM, C. C. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00769-9 · Cited by 301 · see citing works

Reducing harm from alcohol: call to action

Casswell, S., & Thamarangsi, T. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60745-5 · Cited by 294 · see citing works

Histological parameters and alcohol abstinence determine long-term prognosis in patients with alcoholic liver disease

Lackner, C., Spindelboeck, W., Haybaeck, J., Douschan, P., Rainer, F., Terracciano, L., Haas, J. G., Berghold, A., Bataller, R. A., & Stauber, R. E. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.11.011 · Cited by 294 · see citing works

Histological course of alcoholic hepatitis

Parés, A. R., Caballería, J., Bruguera, M., Torres, M., & Rodés, J. (1986) · Journal of Hepatology · doi:10.1016/s0168-8278(86)80006-x · Cited by 293 · see citing works

Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease†

Naveau, S., Gaudé, G., Asnacios, A., Agostini, H., Abella, A., Barri‐Ova, N., Dauvois, B., Prevot, S., Ngo, Y., Munteanu, M., et al. (2008) · Hepatology · doi:10.1002/hep.22576 · Cited by 292 · see citing works

Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians

Stickel, F., Buch, S., Lau, K., zu Schwabedissen, H. E. M., Berg, T., Ridinger, M., Rietschel, M., Schafmayer, C., Braun, F., Hinrichsen, H. M., et al. (2010) · Hepatology · doi:10.1002/hep.24017 · Cited by 291 · see citing works

Trends in the management and burden of alcoholic liver disease

Mathurin, P., & Bataller, R. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.03.006 · Cited by 288 · see citing works

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