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Cited by 408

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice

Open access
Lin, Chih-Wen, Zhang, Hao, Li, Min, Xiong, Xiwen, Chen, Xi, Chen, Xiaoyun, Dong, Xiaocheng C., Yin, Xiao-Ming·2013·Journal of Hepatology
DOI 10.1016/j.jhep.2013.01.011
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Abstract

Background & Aims Pharmacological approaches can potentially improve fatty liver condition in alcoholic and non-alcoholic fatty liver diseases. The salutary effects of reducing lipid synthesis or promoting lipid oxidation have been well reported, but the benefits of increasing lipid degradation have yet to be well explored. Macroautophagy is a cellular degradation process that can remove subcellular organelles including lipid droplets. We thus investigated whether pharmacological modulation of macroautophagy could be an effective approach to alleviate fatty liver condition and liver injury. Methods C57BL/6 mice were given ethanol via intraperitoneal injection (acute) or by a 4-week oral feeding regime (chronic), or given high fat diet for 12 weeks. An autophagy enhancer, carbamazepine or rapamycin, or an autophagy inhibitor, chloroquine, was given before sacrifice. Activation of autophagy, level of hepatic steatosis, and blood levels of triglycerides, liver enzyme, glucose and insulin were measured. Results In both acute and chronic ethanol condition macroautophagy were activated. Carbamazepine, as well as rapamycin, enhanced ethanol-induced macroautophagy in hepatocytes in vitro and in vivo. Hepatic steatosis and liver injury were exacerbated by chloroquine, but alleviated by carbamazepine. The protective effects of carbamazepine and rapamycin in reducing steatosis and in improving insulin sensitivity were also demonstrated in high fat diet-induced non-alcoholic fatty liver condition. Conclusions These findings indicate that pharmacological modulation of macroautophagy in the liver can be an effective strategy for reducing fatty liver condition and liver injury.

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Metadata

Authors
Lin, C.-W., Zhang, H., Li, M., Xiong, X., Chen, X., Chen, X., Dong, X. C., & Yin, X.-M.
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2013-05
Volume
58
Issue
5
Pages
993-999
ISSN
0168-8278 (ISSN-L)
DOI
10.1016/j.jhep.2013.01.011
OpenAlex
W2033212418
Cited by
408
References
10
FWCI
20.32
Type
journal article
Language
en
Open access
green

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