Cited by 234Liver Disease Diagnosis and TreatmentAdipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

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Irisin is inversely associated with intrahepatic triglyceride contents in obese adults

Zhang, Hui-Jie, Zhang, Xian-Feng, Ma, Zhi-Min, Pan, Ling-Ling, Chen, Zheng, Han, Hai-Wei, Han, Cheng-Kun, Zhuang, Xiong-Jie, Lu, Yan, Li, Xue-Jun, Yang, Shu-Yu, Li, Xiao-Ying·2013·Journal of Hepatology

DOI 10.1016/j.jhep.2013.04.030

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Abstract

Background & aims Obesity is closely related to non-alcoholic fatty liver disease (NAFLD), which has become an important public health problem because of its high prevalence and association with metabolic syndromes. Irisin was recently identified as a novel peptide to improve obesity and glucose homeostasis, and considered to be therapeutic for human metabolic diseases. The aim of this study was to examine the association of serum irisin concentration and liver triglyceride contents in obese Chinese adults.Methods Serum irisin levels were measured and liver fat contents determined by (1)H MRS in 296 obese adults. Anthropometric parameters and blood biochemical indexes including liver enzymes, glucose, and lipid profiles were detected. The liver triglyceride contents of subjects were measured by (1)H MRS. The protein levels of irisin were determined by quantitative ELISA.Results We found that serum irisin levels were reduced in obese adults with NAFLD. By dividing the distribution of intrahepatic triglyceride (IHTG) contents into quartiles, serum irisin levels were reduced gradually with the increase of IHTG contents (p<0.01). Higher serum irisin levels were associated with preferable TG levels. Serum ALT and AST concentrations were inversely correlated with serum irisin levels. Multivariate linear regression analysis demonstrated that serum irisin levels were independently associated with liver fat (p<0.01). By logistic regression analysis, the odds ratio for higher IHTG contents was reduced by 12.4% per 1 SD increase in serum irisin concentrations after adjustment for multivariate metabolic factors [OR (95% CI); 0.876 (0.777-0.987)].Conclusions These results demonstrated that serum irisin concentrations were inversely associated with the triglyceride contents in the liver and liver enzymes in obese Chinese adults.

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See all 234

Authors: Zhang, H.-J., Zhang, X.-F., Ma, Z.-M., Pan, L.-L., Chen, Z., Han, H.-W., Han, C.-K., Zhuang, X.-J., Lu, Y., Li, X.-J., Yang, S.-Y., & Li, X.-Y.
Affiliations: Xiamen University (CN)
Shanghai Jiao Tong University (CN)
Corresponding author: Li, Xiao-Ying
ORCID: Chen, Zheng
Venue: Journal of Hepatology
Publisher: Elsevier BV
Published: 2013-09
Volume: 59
Issue: 3
Pages: 557-562
ISSN: 0168-8278 (ISSN-L)
DOI: 10.1016/j.jhep.2013.04.030
OpenAlex: W2101439943
Cited by: 234
References: 34
Citations by year: 2026: 7 · 2025: 11 · 2024: 15 · 2023: 7 · 2022: 29 · 2021: 13 · 2020: 22 · 2019: 11 · 2018: 21 · 2017: 21 · 2016: 22 · 2015: 26 · 2014: 18 · 2013: 11
FWCI: 18.70
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Hepatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: irisin, intrahepatic triglyceride, non-alcoholic fatty liver disease, obesity, hepatic steatosis, liver fat, alanine aminotransferase, aspartate aminotransferase, serum biomarkers, Chinese adults
MeSH terms: Adult, Aged, Alanine Transaminase, Aspartate Aminotransferases, China, Cross-Sectional Studies, Fatty Liver, Female, Fibronectins, Humans, Liver, Male, Middle Aged, Magnetic Resonance Spectroscopy, Obesity, Triglycerides, Asian People, Non-alcoholic Fatty Liver Disease

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Irisin is inversely associated with intrahepatic triglyceride contents in obese adults

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