Irisin in patients with nonalcoholic fatty liver disease
Abstract
Objective Irisin is a recently discovered myokine proposed to increase thermogenesis-related energy expenditure and improve metabolism. We aimed to comparatively evaluate serum irisin levels in patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD) vs. controls and study their association with disease severity.Methods Fifteen and 16 consecutively enrolled patients with biopsy-proven nonalcoholic simple steatosis (NAFL) and steatohepatitis (NASH), respectively, and 24 lean and 28 obese controls without NAFLD were recruited. Irisin, established adipokines and biochemical tests were measured.Results Serum irisin levels were statistically different in obese controls (33.7±2.7 ng/mL; p<0.001) and patients with NAFL (30.5±1.5 ng/mL; p<0.001) and NASH (35.8±1.9 ng/mL; p=0.001) compared with lean controls (47.7±2.0 ng/mL), but were similar among patients with NAFL, NASH and obese controls. This difference remained significant after adjustment for body mass index (or waist circumference), gender, age, insulin resistance (assessed by HOMA-IR or QUICKI), exercise and time since blood collection. Serum leptin and adiponectin, but not irisin, levels were independently from BMI correlated with insulin resistance and cardiometabolic factors. Serum irisin tended to be higher in patients with (36.7±2.4 ng/mL) than without (30.8±1.2 ng/mL; p=0.02) portal inflammation and independently associated with the latter; these data need to be confirmed by future studies.Conclusions Serum irisin levels differ between lean controls and obese controls or NAFLD patients. Despite similar circulating irisin levels between NAFL and NASH groups, irisin may be independently and positively associated with the presence of portal inflammation. Future clinical and mechanistic studies are needed to confirm and extend these data.
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Individuals with MASLD have lower serum irisin levels compared to healthy individuals.
“Interestingly, individuals with MASLD have been reported to have lower serum irisin levels compared to healthy individuals (91).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [91]
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- Authors
- Polyzos, S. A., Kountouras, J., Anastasilakis, A. D., Geladari, E. V., & Mantzoros, C. S.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- 424 General Military Hospital (GR)
- Beth Israel Deaconess Medical Center (US)
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 63
- Issue
- 2
- Pages
- 207-217
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2020381773
- Cited by
- 215
- References
- 50
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 12 · 2023: 15 · 2022: 19 · 2021: 12 · 2020: 24 · 2019: 18 · 2018: 13 · 2017: 17 · 2016: 27 · 2015: 23 · 2014: 24 · 2013: 2
- FWCI
- 18.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (NIDDK 81913)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- irisin, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, myokines, serum biomarkers, disease severity, portal inflammation, obesity, insulin resistance, leptin, adiponectin, adipokines
- MeSH terms
- Adult, Aged, Fatty Liver, Female, Fibronectins, Humans, Inflammation, Insulin Resistance, Male, Middle Aged, Obesity, Portal Vein, Risk Factors, Severity of Illness Index, Thinness, Biomarkers, Body Mass Index, Case-Control Studies, Chemokines, Leptin, Intercellular Signaling Peptides and Proteins, Adiponectin, Adipokines, Retinol-Binding Proteins, Plasma, Non-alcoholic Fatty Liver Disease
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