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Cited by 609Hepatocellular Carcinoma Treatment and PrognosisLiver Disease Diagnosis and TreatmentHead and Neck Cancer Studies

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Hepatocellular cancer: The impact of obesity, type 2 diabetes and a multidisciplinary team

Open access
Dyson, Jessica, Jaques, Bryan, Chattopadyhay, Dipankar, Lochan, Rajiv, Graham, Janine, Das, Debasish, Aslam, Tahira, Patanwala, Imran, Gaggar, Sameer, Cole, Michael, Sumpter, Kate, Stewart, Stephen, Rose, John, Hudson, Mark, Manas, Derek, Reeves, Helen L.·2014·Journal of Hepatology
DOI 10.1016/j.jhep.2013.08.011
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Abstract

Background & aims Hepatocellular cancer (HCC) commonly complicates chronic liver disease and increases in incidence have been reported despite falling prevalences of viral hepatitis.Methods Following the introduction of centralised specialist teams to manage patients with cancer in England, we characterised the demographics of patients with HCC referred to the Newcastle-upon-Tyne Hospitals NHS Foundation Trust between 2000 and 2010. Regional HCC mortality data was from Public Health England.Results HCC related mortality in the region rose 1.8 fold in 10 years, from 2.0 to 3.7 per 100,000. 632 cases were reviewed centrally, with 2-3 fold increases in referrals of patients with associated hepatitis C, alcoholic liver disease or no chronic liver disease and a >10 fold increase in HCC associated with non-alcoholic fatty liver disease (NAFLD). By 2010 NAFLD accounted for 41/118 (34.8%) cases. Irrespective of associated etiologies, metabolic risk factors were present in 78/118 (66.1%) cases in 2010, associated with regional increases in obesity and diabetes. Median overall survival was just 10.7 months. Although patients with NAFLD associated HCC were older (71.3 yr vs. 67.1 yr; p<0.001) and their cancers less often detected by surveillance, their survival was similar to other etiologies. This was attributed to significantly higher incidental presentation (38.2%) and lower prevalence of cirrhosis (77.2%).Conclusions HCC related mortality is increasing, with typical patients being elderly with metabolic risk factors. The prognosis for most of the cases is poor, but older patients with co-morbidities can do well, managed, within a specialist multidisciplinary team if their cancer is detected pre-symptomatically.

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Crossref · 10.1016/j.jhep.2013.08.011

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Metadata

Authors
Dyson, J., Jaques, B., Chattopadyhay, D., Lochan, R., Graham, J., Das, D., Aslam, T., Patanwala, I., Gaggar, S., Cole, M., Sumpter, K., Stewart, S., Rose, J., Hudson, M., Manas, D., & Reeves, H. L.
Affiliations
  • Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
  • Newcastle University (GB)
Corresponding author
Reeves, Helen L.
ORCID
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2014-01
Volume
60
Issue
1
Pages
110-117
ISSN
0168-8278 (ISSN-L)
DOI
10.1016/j.jhep.2013.08.011
OpenAlex
W2076341209
Cited by
603
References
25
Citations by year
2026: 23 · 2025: 32 · 2024: 45 · 2023: 43 · 2022: 72 · 2021: 65 · 2020: 63 · 2019: 60 · 2018: 57 · 2017: 48 · 2016: 38 · 2015: 33 · 2014: 18
FWCI
19.26
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Hepatology (publishedVersion)
  • PubMed (publishedVersion)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
  • Newcastle University ePrints (Newcastle Univesity)
Topics
  • Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
Keywords
hepatocellular carcinoma, obesity, type 2 diabetes, non-alcoholic fatty liver disease, HCC mortality, chronic liver disease, hepatitis C, alcoholic liver disease, metabolic risk factors, multidisciplinary cancer care, cancer surveillance, liver cirrhosis, overall survival, cancer incidence trends
MeSH terms
Age Factors, Aged, Diabetes Mellitus, Type 2, Fatty Liver, Humans, Liver Neoplasms, Middle Aged, Obesity, Risk Factors, Non-alcoholic Fatty Liver Disease

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