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Cited by 908Liver Disease and TransplantationSepsis Diagnosis and TreatmentGut microbiota and health

The DOI matches its Crossref record; 164 of the 165 references it cites were found in a registry or an index.

Bacterial infections in cirrhosis: A position statement based on the EASL Special Conference 2013

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Jalan, Rajiv, Fernandez, Javier, Wiest, Reiner, Schnabl, Bernd, Moreau, Richard, Angeli, Paolo, Stadlbauer, Vanessa, Gustot, Thierry, Bernardi, Mauro, Canton, Rafael, Albillos, Agustin, Lammert, Frank, Wilmer, Alexander, Mookerjee, Rajeshwar, Vila, Jordi, Garcia-Martinez, Rita, Wendon, Julia, Such, José, Cordoba, Juan, Sanyal, Arun, Garcia-Tsao, Guadalupe, Arroyo, Vicente, Burroughs, Andrew, Ginès, Pere·2014·Journal of Hepatology
DOI 10.1016/j.jhep.2014.01.024
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Abstract

Bacterial infections are very common and represent one of the most important reasons of progression of liver failure, development of liver-related complications, and mortality in patients with cirrhosis. In fact, bacterial infections may be a triggering factor for the occurrence of gastrointestinal bleeding, hypervolemic hyponatremia, hepatic encephalopathy, kidney failure, and development of acute-on-chronic liver failure. Moreover, infections are a very common cause of repeated hospitalizations, impaired health-related quality of life, and increased healthcare costs in cirrhosis. Bacterial infections develop as a consequence of immune dysfunction that occurs progressively during the course of cirrhosis. In a significant proportion of patients, infections are caused by gram-negative bacteria from intestinal origin, yet gram-positive bacteria are a frequent cause of infection, particularly in hospitalized patients. In recent years, infections caused by multidrug-resistant bacteria are becoming an important clinical problem in many countries. The reduction of the negative clinical impact of infections in patients with cirrhosis may be achieved by a combination of prophylactic measures, such as administration of antibiotics, to reduce the occurrence of infections in high-risk groups together with early identification and management of infection once it has developed. Investigation on the mechanisms of altered gut microflora, translocation of bacteria, and immune dysfunction may help develop more effective and safe methods of prevention compared to those that are currently available. Moreover, research on biomarkers of early infection may be useful in early diagnosis and treatment of infections. The current manuscript reports an in-depth review and a position statement on bacterial infections in cirrhosis.

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Crossref · 10.1016/j.jhep.2014.01.024

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Research works printed but not linked: 2

  1. Bone, 2009, Chest, 136, 864
  2. Zapater, 2007, Presence of bacterial DNA is a new survival indicator in patients with cirrhosis and non-infected ascitic fluid, Hepatology, 46, A40

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Metadata

Authors
Jalan, R., Fernandez, J., Wiest, R., Schnabl, B., Moreau, R., Angeli, P., Stadlbauer, V., Gustot, T., Bernardi, M., Canton, R., Albillos, A., Lammert, F., Wilmer, A., Mookerjee, R., Vila, J., Garcia-Martinez, R., Wendon, J., Such, J., Cordoba, J., Sanyal, A., Garcia-Tsao, G., Arroyo, V., Burroughs, A., & Ginès, P.
Affiliations
  • The Royal Free Hospital (GB)
  • University Hospital of Bern (CH)
  • University of California San Diego (US)
  • Inserm (FR)
  • University of Padua (IT)
  • Medical University of Graz (AT)
  • Université Libre de Bruxelles (BE)
  • University of Bologna (IT)
  • Universitätsklinikum des Saarlandes (DE)
  • Universitair Ziekenhuis Leuven (BE)
  • King's College London (GB)
  • Instituto de Salud Carlos III (ES)
  • Virginia Commonwealth University (US)
Corresponding author
Ginès, Pere
ORCID
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2014-06
Volume
60
Issue
6
Pages
1310-1324
ISSN
0168-8278 (ISSN-L)
DOI
10.1016/j.jhep.2014.01.024
OpenAlex
W2136919496
Cited by
906
References
165
Citations by year
2026: 35 · 2025: 52 · 2024: 63 · 2023: 56 · 2022: 88 · 2021: 105 · 2020: 83 · 2019: 79 · 2018: 102 · 2017: 84 · 2016: 72 · 2015: 65 · 2014: 22
FWCI
45.19
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Hepatology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • BORIS (University Library Bern) (submittedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
  • UCL Discovery (University College London) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion, other-oa)
  • Lirias (KU Leuven) (submittedVersion, cc-by-nc-nd)
  • Padua Research Archive (University of Padova) (submittedVersion)
  • INFM-OAR (INFN Catania) (submittedVersion, cc-by-nc-nd)
Funders
Fondo de Investigación Sanitaria (FIS PI08/0126, FIS PI12/00330)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
bacterial infection, liver cirrhosis, immune dysfunction, Gram-negative bacteria, Gram-positive bacteria, multidrug-resistant bacteria, infection control, antibiotic prophylaxis, gut microbiota, bacterial translocation, acute-on-chronic liver failure, infection biomarkers, early infection detection, hospitalization
MeSH terms
Anti-Bacterial Agents, Bacterial Infections, Gastroenterology, Humans, Liver Cirrhosis, Practice Guidelines as Topic, Drug Resistance, Bacterial

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