The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Hepatitis B virus PreS/S gene variants: Pathobiology and clinical implications
Open accessAbstract
The emergence and takeover of hepatitis B virus (HBV) variants carrying mutation(s) in the preS/S genomic region is a fairly frequent event that may occur spontaneously or may be the consequence of immunoprophylaxis or antiviral treatments. Selection of preS/S mutants may have relevant pathobiological and clinical implications. Both experimental data and studies in humans show that several specific mutations in the preS/S gene may induce an imbalance in the synthesis of the surface proteins and their consequent retention within the endoplasmic reticulum (ER) of the hepatocytes. The accumulation of mutated surface proteins may cause ER stress with the consequent induction of oxidative DNA damage and genomic instability. Viral mutants with antigenically modified surface antigen may be potentially infectious to immune-prophylaxed patients and may account for cases of occult HBV infection. In addition, preS/S variants were reported to be associated with cases of fulminant hepatitis as well as of fibrosing cholestatic hepatitis, and they are associated with cirrhosis and hepatocellular carcinoma development.
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Cites
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Lamivudine for Patients with Chronic Hepatitis B and Advanced Liver Disease
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Hepatitis B Virus Immunopathogenesis
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Vaccine-induced escape mutant of hepatitis B virus
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Long-term Therapy With Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B for up to 5 Years
Hadziyannis, S. J., Tassopoulos, N. C., Heathcote, E. J., Chang, T., Kitis, G., Rizzetto, M., Marcellin, P., Lim, S. G., Goodman, Z., Ma, J., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.09.020 · Cited by 881
Large surface proteins of hepatitis B virus containing the pre-s sequence
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Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice
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Cited by
Mechanisms of HBV-induced hepatocellular carcinoma
Levrero, M., & Zucman-Rossi, J. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.02.021 · Cited by 1,052
Mak, L.-Y., Wong, D. K.-H., Pollicino, T., Raimondo, G., Hollinger, F. B., & Yuen, M.-F. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.05.042 · Cited by 223
Self-citationNAFLD and HBV interplay - related mechanisms underlying liver disease progression
Tourkochristou, E., Assimakopoulos, S. F., Thomopoulos, K., Marangos, M., & Triantos, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.965548 · Cited by 70
Metadata
- Authors
- Pollicino, T., Cacciola, I., Saffioti, F., & Raimondo, G.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 61
- Issue
- 2
- Pages
- 408-417
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2012333875
- Cited by
- 277
- References
- 92
- FWCI
- 18.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pollicino, T., Cacciola, I., Saffioti, F., & Raimondo, G. (2014). Hepatitis B virus PreS/S gene variants: Pathobiology and clinical implications. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2014.04.041
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
