The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Acute-on-chronic liver failure: A new syndrome that will re-classify cirrhosis
Open accessAbstract
Acute-on-chronic liver failure (ACLF) is a recently recognized syndrome characterized by acute decompensation (AD) of cirrhosis and organ/system failure(s) (organ failure: liver, kidney, brain, coagulation, circulation and/or respiration) and extremely poor survival (28-day mortality rate 30-40%). ACLF occurs in relatively young patients. It is especially frequent in alcoholic- and untreated hepatitis B associated-cirrhosis, in addition it is related to bacterial infections and active alcoholism, although in 40% of cases no precipitating event can be identified. It may develop at any time during the course of the disease in the patient (from compensated to long-standing cirrhosis). The development of ACLF occurs in the setting of a systemic inflammation, the severity of which correlates with the number of organ failures and mortality. Systemic inflammation may cause ACLF through complex mechanisms including an exaggerated inflammatory response and systemic oxidative stress to pathogen- or danger/damage-associated molecular patterns (immunopathology) and/or alteration of tissue homeostasis to inflammation caused either by the pathogen itself or through a dysfunction of tissue tolerance. A scoring system composed of three scores (CLIF-C OFs, CLIF-C AD, and CLIF-C ACLFs) specifically designed for patients with AD, with and without ACLF, allows a step-wise algorithm for a rational indication of therapy. The management of ACLF should be carried out in enhanced or intensive care units. Current therapeutic measures comprise the treatment for associated complications, organ failures support and liver transplantation.
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1 retracted
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Research works printed but not linked: 4
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Cited by
Liver Macrophages in Tissue Homeostasis and Disease
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Self-citationToll-like receptor 4 is a therapeutic target for prevention and treatment of liver failure
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Metadata
- Authors
- Arroyo, V., Moreau, R., Jalan, R., & Ginès, P.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 62
- Issue
- 1
- Pages
- S131-S143
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2162940124
- Cited by
- 451
- References
- 66
- FWCI
- 26.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
- Funders
- European Regional Development Fund (FIS PI12/00330)
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- Arroyo, V., Moreau, R., Jalan, R., & Ginès, P. (2015). Acute-on-chronic liver failure: A new syndrome that will re-classify cirrhosis. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2014.11.045
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
