The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Evolution in the understanding of the pathophysiological basis of portal hypertension: How changes in paradigm are leading to successful new treatments
Open accessAbstract
Among the common complication of cirrhosis portal hypertension witnessed a major improvement of prognosis during the past decades. Principally due to the introduction of rational treatments based on new pathophysiological paradigms (concepts of thought) developed in the 1980s. The best example being the use of non-selective beta-blockers and of vasopressin analogs, somatostatin, and its analogs. Further refinement in the knowledge of the molecular mechanisms involved in the regulation of both the splanchnic and hepatic circulation has led to the emergence of new treatments, which are based on evidence that show not only structural but also vasoactive components increase the hepatic vascular resistance, as well as of angiogenesis. This knowledge and future improvements will most likely result in more effective treatment of portal hypertension and effective prevention of its complications in early stages.
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Cites
Mechanisms of hepatic fibrogenesis
Lee, U. E., & Friedman, S. L. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2011.02.005 · Cited by 923
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis
Ding, B.-S., Cao, Z., Lis, R., Nolan, D. J., Guo, P., Simons, M., Penfold, M. E., Shido, K., Rabbany, S. Y., & Rafii, S. (2014) · Nature · doi:10.1038/nature12681 · Cited by 626
Liver sinusoidal endothelial cells in hepatic fibrosis
DeLeve, L. D. (2015) · Hepatology · doi:10.1002/hep.27376 · Cited by 482 · cited 1×
“Recent work suggests that these changes may play a very important pathogenic role in the subsequent steps of liver fibrosis and highlight the potential role of the sinusoidal endothelial cell as a very early player, not only in increased intrahepatic resistance, but in liver injury and fibrosis itself [28,46].”
DeLeve, L. D., Wang, X., & Guo, Y. (2008) · Hepatology · doi:10.1002/hep.22351 · Cited by 408
Cited by
Garcia‐Tsao, G., Abraldes, J. G., Berzigotti, A., & Bosch, J. (2017) · Hepatology · doi:10.1002/hep.28906 · Cited by 2,154
Self-citationBerzigotti, A., Albillos, A., Villanueva, C., Genescá, J., Ardevol, A., Augustín, S., Calleja, J. L., Bañares, R., García‐Pagán, J. C., Mesonero, F., et al. (2017) · Hepatology · doi:10.1002/hep.28992 · Cited by 334
Hilscher, M. B., Sehrawat, T., Arab, J. P., Zeng, Z., Gao, J., Liu, M., Kostallari, E., Gao, Y., Simonetto, D. A., Yaqoob, U., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.03.013 · Cited by 240
Self-citationBoyer-Diaz, Z., Aristu-Zabalza, P., Andrés-Rozas, M., Robert, C., Ortega-Ribera, M., Fernández-Iglesias, A., Broqua, P., Junien, J.-L., Wettstein, G., Bosch, J., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2020.11.045 · Cited by 168
Self-citationAngiocrine signaling in sinusoidal homeostasis and liver diseases
Gao, J., Lan, T., Kostallari, E., Guo, Y., Lai, E., Guillot, A., Ding, B., Tacke, F., Tang, C., & Shah, V. H. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.05.014 · Cited by 90
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Metadata
- Authors
- Bosch, J., Groszmann, R. J., & Shah, V. H.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 62
- Issue
- 1
- Pages
- S121-S130
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2066867615
- Cited by
- 252
- References
- 4
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Bosch, J., Groszmann, R. J., & Shah, V. H. (2015). Evolution in the understanding of the pathophysiological basis of portal hypertension: How changes in paradigm are leading to successful new treatments. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2015.01.003
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
