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Cited by 923Liver physiology and pathologyLiver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Mechanisms of hepatic fibrogenesis

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Lee, Ursula E., Friedman, Scott L.·2011·Best Practice & Research Clinical Gastroenterology
DOI 10.1016/j.bpg.2011.02.005PMC PMC3079877
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Abstract

Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks that regulate the deposition of extracellular matrix. This cascade of responses drives the activation of hepatic stellate cells (HSCs) into a myofibroblast-like phenotype that is contractile, proliferative and fibrogenic. Collagen and other extracellular matrix (ECM) components are deposited as the liver generates a wound-healing response to encapsulate injury. Sustained fibrogenesis leads to cirrhosis, characterized by a distortion of the liver parenchyma and vascular architecture. Uncovering the intricate mechanisms that underlie liver fibrogenesis forms the basis for efforts to develop targeted therapies to reverse the fibrotic response and improve the outcomes of patients with chronic liver disease.

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Crossref · 10.1016/j.bpg.2011.02.005

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  • SOX9 is involved in promoting liver and cardiac fibrosis by stimulating ECM deposition.

    “and is involved in promoting liver and cardiac fibrosis by stimulating ECM deposition (14,15).”

    From SOX9 reprograms endothelial cells by altering the chromatin landscape (2022) · cites this paper as [14]

    The Introduction and Fibrogenic Signaling Pathways section describe extracellular-matrix deposition as a mechanism of liver fibrosis. But the Transcription Factors section does not identify SOX9, and the searched passages do not address cardiac fibrosis. The source therefore supports the general liver-fibrosis mechanism, not the claim that SOX9 promotes liver and cardiac fibrosis through it. (LLM, conf=0.84)

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Authors
Lee, U. E., & Friedman, S. L.
Affiliations
Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Friedman, Scott L.
ORCID
Friedman, Scott L.
Venue
Best Practice & Research Clinical Gastroenterology
Publisher
Elsevier BV
Published
2011-04
Volume
25
Issue
2
Pages
195-206
ISSN
1521-6918 (ISSN-L)
DOI
10.1016/j.bpg.2011.02.005
PMC
PMC3079877
OpenAlex
W2089149502
Cited by
923
References
11
Citations by year
2026: 21 · 2025: 35 · 2024: 55 · 2023: 68 · 2022: 74 · 2021: 83 · 2020: 79 · 2019: 77 · 2018: 75 · 2017: 74 · 2016: 56 · 2015: 81 · 2014: 65 · 2013: 46 · 2012: 31
FWCI
29.48
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Best Practice & Research Clinical Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
Cell and Developmental Biology Training
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Keywords
liver fibrosis, hepatic fibrogenesis, hepatic stellate cells, stellate cell activation, myofibroblast phenotype, extracellular matrix deposition, collagen, liver cirrhosis, chronic liver disease, wound healing, signaling networks, fibrosis reversal
MeSH terms
Animals, Humans, Liver Cirrhosis, Signal Transduction, Hepatic Stellate Cells

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