The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Overview of hepatitis B viral replication and genetic variability
Open accessAbstract
Summary Chronic infection with hepatitis B virus (HBV) greatly increases the risk for liver cirrhosis and hepatocellular carcinoma (HCC). HBV isolates worldwide can be divided into 10 genotypes. Moreover, the immune clearance phase selects for mutations in different parts of the viral genome. The outcome of HBV infection is shaped by the complex interplay of the mode of transmission, host genetic factors, viral genotype and adaptive mutations, as well as environmental factors. Core promoter mutations and mutations abolishing HBeAg expression have been implicated in acute liver failure, while genotypes B, C, subgenotype A1, core promoter mutations, preS deletions, C-terminal truncation of envelope proteins, and spliced pregenomic RNA are associated with HCC development. Our efforts to treat and prevent HBV infection are hampered by the emergence of drug resistant mutants and vaccine escape mutants. This paper provides an overview of the HBV life cycle, followed by review of HBV genotypes and mutants in terms of their biological properties and clinical significance.
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Cites
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Tenofovir Disoproxil Fumarate versus Adefovir Dipivoxil for Chronic Hepatitis B
Marcellin, P., Heathcote, E. J., Buti, M., Gane, E., de Man, R. A., Krastev, Z., Germanidis, G., Lee, S. S., Flisiak, R., Kaita, K., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802878 · Cited by 1,181
Vaccine-induced escape mutant of hepatitis B virus
Carman, W. F., Karayiannis, P., Waters, J., Thomas, H. C., Zanetti, A. R., Manzillo, G., & Zuckerman, A. J. (1990) · The Lancet · doi:10.1016/0140-6736(90)91874-a · Cited by 1,074
Mechanisms of HBV-induced hepatocellular carcinoma
Levrero, M., & Zucman-Rossi, J. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.02.021 · Cited by 1,052
HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B
Nassal, M. (2015) · Gut · doi:10.1136/gutjnl-2015-309809 · Cited by 899
Norder, H., Couroucé, A.-M., Coursaget, P., Echevarria, J. M., Lee, S.-D., Mushahwar, I. K., Robertson, B. H., Locarnini, S., & Magnius, L. O. (2004) · Intervirology · doi:10.1159/000080872 · Cited by 868
Molecular biology of hepatitis B virus infection
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Hepatitis B Virus Resistance to Nucleos(t)ide Analogues
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Cited by
Global burden of hepatitis B virus: current status, missed opportunities and a call for action
Hsu, Y.-C., Huang, D. Q., & Nguyen, M. H. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00760-9 · Cited by 632
Chronic hepatitis B virus infection
Seto, W.-K., Lo, Y.-R., Pawlotsky, J.-M., & Yuen, M.-F. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31865-8 · Cited by 555
Zeng, Y., Chen, S., Fu, Y., Wu, W., Chen, T., Chen, J., Yang, B., & Ou, Q. (2020) · Journal of Viral Hepatitis · doi:10.1111/jvh.13216 · Cited by 148
Metadata
- Authors
- Tong, S., & Revill, P.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 64
- Issue
- 1
- Pages
- S4-S16
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2336184200
- Cited by
- 417
- References
- 78
- FWCI
- 34.07
- Type
- journal article
- Language
- en
- Open access
- green
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
