The DOI matches its Crossref record; 122 of the 125 references it cites were found in a registry or an index.
IL-6 pathway in the liver: From physiopathology to therapy
Open accessAbstract
Interleukin 6 (IL-6) is a pleiotropic four-helix-bundle cytokine that exerts multiple functions in the body. In the liver, IL-6 is an important inducer of the acute phase response and infection defense. IL-6 is furthermore crucial for hepatocyte homeostasis and is a potent hepatocyte mitogen. It is not only implicated in liver regeneration, but also in metabolic function of the liver. However, persistent activation of the IL-6 signaling pathway is detrimental to the liver and might ultimately result in the development of liver tumors. On target cells IL-6 can bind to the signal transducing subunit gp130 either in complex with the membrane-bound or with the soluble IL-6 receptor to induce intracellular signaling. In this review we describe how these different pathways are involved in the physiology and pathophyiology of the liver. We furthermore discuss how IL-6 pathways can be selectively inhibited and therapeutically exploited for the treatment of liver pathologies.
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“Interleukin-6 (IL-6) plays an important role in both the acute-phase response against infections as well as liver regeneration (Figure 1).”
From The Role of Perioperative Interleukin-6 Serum Levels on Liver Dysfunction and Infectious Complications After Hepatectomy—A Systematic Review (2025) · cites this paper as [2]
In the citing paper
“As a pro-inflammatory cytokine IL-6 is produced at local tissue sites by various cells [1,2].”
From The Role of Perioperative Interleukin-6 Serum Levels on Liver Dysfunction and Infectious Complications After Hepatectomy—A Systematic Review (2025) · cites this paper as [2]
In the citing paper
“Moreover, IL-6 is a major factor in hepatic regeneration [2].”
From The Role of Perioperative Interleukin-6 Serum Levels on Liver Dysfunction and Infectious Complications After Hepatectomy—A Systematic Review (2025) · cites this paper as [2]
In the citing paper
“The acute phase response in the liver usually does not exceed 48 h, after which the organism returns to normal hepatic function, except in chronic states of inflammation [2].”
From The Role of Perioperative Interleukin-6 Serum Levels on Liver Dysfunction and Infectious Complications After Hepatectomy—A Systematic Review (2025) · cites this paper as [2]
In the citing paper
“However, the deletion of il6 gene also impairs the hepatocyte homeostasis and liver regeneration [3–5].”
From The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases (2024) · cites this paper as [5]
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Potential Beneficial Effects of Vitamin K in SARS-CoV-2 Induced Vascular Disease?
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Paternal high‐fat diet transgenerationally impacts hepatic immunometabolism
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“With liver damage, hepatic Kupffer cell-dependent TNF-a signaling leads to the production of the growth promoting cytokine IL-6, and subsequent liver regeneration (35).”
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Zhang, J., Liu, W., Bi, M., Xu, J.-W., Yang, H., & Zhang, Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.802783 · Cited by 24
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Niu, Y., Fan, S., Luo, Q., Chen, L., Huang, D., Chang, W., Qin, W., & Shi, G. (2021) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2021.00036 · Cited by 21
Alcohol and HIV-Derived Hepatocyte Apoptotic Bodies Induce Hepatic Stellate Cell Activation
New‐Aaron, M., Dagur, R. S., Koganti, S. S., Ganesan, M., Wang, W., Makarov, E., Ogunnaike, M., Kharbanda, K. K., Poluektova, L. Y., & Osna, N. A. (2022) · Biology · doi:10.3390/biology11071059 · Cited by 21
“Moreover, the upregulation of IL6 mRNA in HSC after ABAGS+HIV engulfment and the expression of IL6 receptors on HSC [83] confirms that ABAGS+HIV-induced JAK-STAT3 activation in HSC may be induced by IL6, a canonic ligand for STAT3 activation [84].”
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Cabrera, J. J., Araujo, E., de Mirecki-Garrido, M., Pérez-Rodríguez, D., Guerra, B., Aranda-Tavío, H., Guerra-Rodríguez, M., Brito‐Casillas, Y., Melián, C., Martínez-Martin, M. S., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114060 · Cited by 21
iRhom2 inhibits bile duct obstruction–induced liver fibrosis
Sundaram, B., Behnke, K., Belancic, A., Al-Salihi, M. A., Thabet, Y., Polz, R., Pellegrino, R., Zhuang, Y., Shinde, P. V., Xu, H. C., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aax1194 · Cited by 20
“IL-6 trans-signaling can be activated by binding of IL-6 to soluble IL-6R, and earlier studies have described the importance of IL-6 trans-signaling for the protection of the liver during acute damage to the organ (45, 46).”
BackgroundUeno, K., Aiba, Y., Hitomi, Y., Shimoda, S., Nakamura, H., Gervais, O., Kawai, Y., Kawashima, M., Nishida, N., Kohn, S.-S., et al. (2020) · Hepatology Communications · doi:10.1002/hep4.1497 · Cited by 21
“Because the IL-6–STAT3 signaling pathway is markedly activated in the resected liver,(32) it was considered that significant alteration in the levels of these mRNA was due to the effect of the procedure of sample collection.”
BackgroundDanoy, M., Poulain, S., Lereau, M., Kato, S., Scheidecker, B., Kido, T., Miyajima, A., Sakai, Y., Plessy, C., & Leclerc, É. (2020) · Biotechnology Progress · doi:10.1002/btpr.3013 · Cited by 20
“Interestingly, interleukin-6 was found as a potential upstream regulator based on IPA (Data S3), which is consistent with processes such as liver regeneration, hepatocyte mitogen regulation, and hepatocyte homeostasis.(39) While cells near the inlet were characterized by their regenerative function based on interactio…”
BackgroundTargeting Certain Interleukins as Novel Treatment Options for Liver Fibrosis
An, S. Y., Petrescu, A. D., & DeMorrow, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.645703 · Cited by 21
“In the case of IL-6 or IL-22, it prevents fibrogenesis but promotes hepatocellular carcinoma, so the risk of tumor occurrence should be considered in the treatment of patients with hepatic fibrosis (Schmidt-Arras and Rose-John, 2016; Wu et al., 2020).”
BackgroundInfection: a Cause of and Cure for Cancer
Newman, J. H., & Zloza, A. (2017) · Current Pharmacology Reports · doi:10.1007/s40495-017-0109-y · Cited by 21
“Research has shown that cytokines that are present at constitutively high levels as a product of chronic inflammation, such as TNF-α and IL-6, may promote tumor cell proliferation [18].”
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Park, J. B., Peters, R., Pham, Q., & Wang, T. T. Y. (2020) · Biomedicines · doi:10.3390/biomedicines8060138 · Cited by 22
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“Long-term increased IL6 levels lead to increased proliferation, resistance to apoptosis, chemoresistance, and metastatic potential in HCC [14].”
BackgroundWang, H., Wang, Y., Luo, W., Zhang, X., Cao, R., Yang, Z. H., Duan, J., & Wang, K. (2022) · BMC Pulmonary Medicine · doi:10.1186/s12890-022-02184-8 · Cited by 20
“IL-6 is a pleiotropic four-helix bundle cytokine that plays various functions in the body [29].”
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Post-hepatectomy liver failure: A timeline centered review
Bekheit, M., Grundy, L., Salih, A. K. A., Bucur, P. O., Vibert, É., & Ghazanfar, M. A. (2023) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2023.03.001 · Cited by 22
Interleukins in liver disease treatment
Yang, M. J., & Zhang, C. (2024) · World Journal of Hepatology · doi:10.4254/wjh.v16.i2.140 · Cited by 22
Raghu, C., Ekena, J. L., Cullen, J. M., Webb, C. B., & Trepanier, L. A. (2018) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.15064 · Cited by 20
“Interleukin 6 is part of the acute phase inflammatory response and is produced by activated monocytes, macrophages, antigen-presenting cells, and Kupffer cells, as well as by fibroblasts and endothelial cells.(33,34) However, IL-6 can have either both proinflammatory or anti-inflammatory properties depending on the si…”
BackgroundAzam, F., Sheikh, N., Ali, G., & Tayyeb, A. (2018) · Journal of Immunology Research · doi:10.1155/2018/7967135 · Cited by 20
“Under pathological conditions, IL-6 synthesis and secretion are induced during inflammation such as upon stimulation of cells by interleukin-1 (IL-1) or TNF-α [70].”
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The potential diagnostic and therapeutic applications of exosomes in drug-induced liver injury
Zhao, L., Wang, Y., & Zhang, Y. (2020) · Toxicology Letters · doi:10.1016/j.toxlet.2020.11.021 · Cited by 20
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Velusamy, P., Buckley, D. J., Greaney, J. L., Case, A. J., Fadel, P. J., & Trott, D. W. (2025) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00289.2024 · Cited by 20
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Meurer, S. K., Tezcan, O., Lammers, T., & Weiskirchen, R. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109731 · Cited by 19
Liu, D., Zhang, T., Wang, Y., & Xia, L. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.571597 · Cited by 21
Ishida, N., Yamada, H., & Hirose, M. (2021) · Nutrients · doi:10.3390/nu13113765 · Cited by 15
“IL-6 signaling leads to a STAT3dependent upregulation of SOCS3, which in turn induces insulin resistance in the liver [53].”
BackgroundHepatoprotective Effects of Rosmarinic Acid on Ovalbumin-Induced Intestinal Food Allergy Mouse Model
Jia, B., Shang, J., Zeng, H., Wang, X., Fang, M., Xu, L., Liu, X., Wu, K., Gong, Z., & Yang, Q. (2023) · Molecules · doi:10.3390/molecules28020788 · Cited by 19
“IL-6 and IL4, which play active roles in host immune response, are critical inducers of cytokine storm in liver injury [43,44].”
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Ranjpour, M., Wajid, S., & Jain, S. K. (2018) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520618666181015142810 · Cited by 19
Fucoxanthin alters the apelin-13/APJ pathway in certain organs of γ-irradiated mice
Bakary, N. M. E., Thabet, N. M., Fatih, N. M. E., Abdel-Rafei, M. K., Tawill, G. E., & Azab, K. S. (2021) · Journal of Radiation Research · doi:10.1093/jrr/rraa141 · Cited by 19
The synergistic antitumor effect of IL-6 neutralization with NVP-BEZ235 in hepatocellular carcinoma
Wang, Y., Miao, X., Jiang, Y., Wu, Z., Zhu, X., Liu, H., Wu, X., Cai, J., Ding, X., & Gong, W. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04583-5 · Cited by 21
“As we all know, a large number of clinical samples have shown that the serum IL-6 levels in patients with HCC are significantly higher than that of healthy people, and high serum IL-6 levels are associated with poor prognosis [30].”
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“For this reason, IL-6 has been causally related to metabolic disease [50].”
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“The synthesis and secretion of IL-6 is induced by inflammatory responses [24].”
BackgroundInflammatory networks cultivate cancer cell metastasis to the liver
Lee, J. W., & Beatty, G. L. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1728013 · Cited by 18
“While this signaling is critical for the formation of a pro-metastatic niche in the liver, IL6 – STAT3 signaling is also important for coordinating liver repair and regeneration after injury [52].”
BackgroundInsights into the role of STAT3 in intrahepatic cholangiocarcinoma (Review)
Yang, R., Song, Y., Shakoor, K., Yi, W., Peng, C., & Liu, S. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12687 · Cited by 18
Lazcanoiturburu, N., García‐Sáez, J., González‐Corralejo, C., Roncero, C., Sanz‐Ortega, J., Rodríguez, C. M., Valdecantos, M. P., Martínez‐Palacián, A., Almalé, L., Bragado, P., et al. (2022) · The Journal of Pathology · doi:10.1002/path.6002 · Cited by 18
“Although the source of this enhanced signaling is not revealed, it could also be associated with the inflammatory signals that are being secreted in ΔEGFR livers, as cytokines (IL6, IL10) can trigger their activation [57,58].”
BackgroundWang, C., Bai, Y., Li, T., Liu, J., Wang, Y., Ju, S., Yao, W., & Xiong, B. (2024) · Phytotherapy Research · doi:10.1002/ptr.8106 · Cited by 21
“As the dominant cellular sources of IL-6 in the liver are hepatocytes and macrophages (Li et al., 2023; Schmidt-Arras & Rose-John, 2016), we further investigated the effects of ginkgetin on primary hepatocytes and macrophages isolated from mice of TAA + Veh or TAA + Gink groups.”
BackgroundAnticancer effect of propranolol on diethylnitrosamine‐induced hepatocellular carcinoma rat model
Tamim, Y. M., Nagy, A. A., Abdellah, A. M., Osman, A. H., & Ismail, A. F. M. (2024) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12990 · Cited by 18
Increase of circulating inflammatory molecules in preeclampsia, an update
Güney, G., Taşkın, M. İ., & Tokmak, A. (2020) · European Cytokine Network · doi:10.1684/ecn.2020.0443 · Cited by 18
“IL 6 is the major stimulator of most acute phase reactants [24].”
BackgroundSignal Transduction and Molecular Regulation in Fatty Liver Disease
Dong, X. C., Chowdhury, K., Huang, M., & Kim, H.-G. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0076 · Cited by 18
“Numerous miR-21 target genes have been identified, including SMAD7, forkhead box O1 (FOXO1), HMGCR, and STAT3 (20, 214).”
InfluentialPharmacologic IL-6Rα inhibition in cholangiocarcinoma promotes cancer cell growth and survival
Kleinegger, F., Hofer, E. M., Wodlej, C., Golob‐Schwarzl, N., Birkl-Toeglhofer, A. M., Stallinger, A., Petzold, J., Orlova, A., Krassnig, S., Reihs, R., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.11.006 · Cited by 18
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“Persistently high levels of CRP are a sign of ongoing chronic inflammation and it is a key inflammatory indicator linked to increased risks of death and organ damage (Clyne & Olshaker, 1999; Schmidt-Arras & Rose-John, 2016; Sharifpour et al., 2020).”
BackgroundGastrodin ameliorates Concanavalin A-induced acute hepatitis via the IL6/JAK2/STAT3 pathway
Zhou, Y., Chen, J., Yao, Z., et al. (2022) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2022.2093741 · Cited by 17
“IL-6 is an inflammatory cytokine with pleiotropic functions in the body [42].”
BackgroundSignificance of CCNs in liver regeneration
Barkin, J., Jin-Smith, B., Torok, K., & Pi, L. (2023) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-023-00762-x · Cited by 18
“1 3 IL6 and C-X-C Motif Chemokine Ligand 2 (Cxcl2), two ligands crucial for hepatocyte proliferation (Ren et al. 2003; Schmidt-Arras and Rose-John 2016; Pullamsetti et al. 2018).”
BackgroundMagnesium and Liver Metabolism Through the Lifespan
Bravo, M., Simón, J., González‐Recio, I., Martínez‐Cruz, L. A., Goikoetxea‐Usandizaga, N., & Martínez‐Chantar, M. L. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.05.009 · Cited by 20
“Its deficiency maintains an activated state of immune cells with increased plasma levels of IL-6 and TNFα [58,59], which is detrimental to the liver and might ultimately lead to the development of liver tumors [60].”
BackgroundDiagnostic accuracy of interleukin-6 in multiple diseases: An umbrella review of meta-analyses
Han, Z., Li, J., Yi, X., Zhang, T., Liao, D., You, J. E., & Ai, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27769 · Cited by 21
“When exposed to various stimuli, including toxins, cytokines, pathogens, and inflammatory stimuli, IL-6 is secreted by different types of cells during the disease process [1].”
BackgroundGeorge, J. (2018) · Biological Chemistry · doi:10.1515/hsz-2017-0260 · Cited by 17
Tmub1 negatively regulates liver regeneration via inhibiting STAT3 phosphorylation
Fu, H., Dong, R., Zhang, Y., Xu, J., Liu, M., & Chen, P. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2018.12.013 · Cited by 17
Effect of CT manifestations of cholesteatoma on MMP‑2, MMP‑9 and IL‑6 in the serum of patients
Wu, Y., Tang, X., Shao, W., et al. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7484 · Cited by 17
“Interleukin-6 (IL-6) is involved in the proliferation and differentiation of cells in anti-infective reactions and improves their functions (11).”
BackgroundWu, Y., Fan, W., Xue, M., et al. (2019) · The Oncologist · doi:10.1634/theoncologist.2018-0669 · Cited by 17
“to the liver, which may lead to cell proliferation, protection from apoptosis, chemoresistance, and increased metastatic potential in HCC [20, 21].”
BackgroundBalaphas, A., Meyer, J., Perozzo, R., Labouebe, M. Z., Berndt, S., Turzi, A., Fontana, P., Scapozza, L., Gonelle‐Gispert, C., & Bühler, L. H. (2020) · Cells · doi:10.3390/cells9051311 · Cited by 18
“IL-6 is a key cytokine at the center of inflammatory processes and connects acute liver inflammation to liver regeneration [2,16].”
BackgroundKim, E.-A. L., Lee, J., Heo, S., & Jeon, Y. (2020) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2020.109362 · Cited by 18
Metabolomics profiling predicts outcome of tocilizumab in rheumatoid arthritis: an exploratory study
Murillo‐Saich, J., Díaz‐Torné, C., Ortiz, M. A., Coras, R., Alabarse, P. V. G., Pedersen, A., Corominas, H., Vidal, S., & Gumá, M. (2021) · Metabolomics · doi:10.1007/s11306-021-01822-2 · Cited by 17
Hashim, A., Bremner, S. A., Grove, J. I., Astbury, S., Mengozzi, M., O'Sullivan, M., Macken, L., Worthley, T., Katarey, D. R., Aithal, G. P., et al. (2021) · Liver International · doi:10.1111/liv.15122 · Cited by 17
“7 1a EBR/GZR + RBV 16 wk Yes Yes No (ex IDU) Yes (27)”
BackgroundGao, J. Q., Chen, S., Qiu, Z., Fang, L., Zhang, L., Guo, C., Chen, T., & Qiu, L. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8740 · Cited by 17
“Persistent activation of IL-6 signaling may be detrimental to the liver and may cause liver tumors (31).”
Lmo4‐resistin signaling contributes to adipose tissue‐liver crosstalk upon weight cycling
Sun, Y., Geng, M., Yuan, Y., Guo, P., Chen, Y., Yang, D. L., Petersen, R. B., Huang, K., & Zheng, L. (2020) · The FASEB Journal · doi:10.1096/fj.201902708r · Cited by 17
Eder, K., Ringseis, R., & Geßner, D. K. (2025) · Animals · doi:10.3390/ani15111536 · Cited by 19
“…and additively acting endotoxins such as lipopolysaccharides and lipoteichoic acid—classified as pathogen-associated molecular patterns—and various pro-inflammatory cytokines, such as IL-6, IL1 β , tumor necrosis factor (TNF)- α , transforming growth factor (TGF)- β , IL8, and IL-22 [62,63].”
Vitamin D deficiency aggravates the liver metabolism and inflammation in ovariectomized mice
Borges, C. C., Bringhenti, I., Mandarim‐de‐Lacerda, C. A., & Águila, M. B. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.075 · Cited by 16
A new insight into cell biological and biochemical changes through aging
Sahabi, S., Jafari-Gharabaghlou, D., & Zarghami, N. (2022) · Acta Histochemica · doi:10.1016/j.acthis.2021.151841 · Cited by 16
Stoffers, P., Guckenbiehl, S., Welker, M. W., Zeuzem, S., Lange, C. M., Trebicka, J., Herrmann, E. M., & Welsch, C. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263989 · Cited by 16
Brown, A. R., Alhallak, I., Simmen, R. C. M., et al. (2022) · Cancers · doi:10.3390/cancers14071737 · Cited by 16
“Our observation of a potential linkage between KLF9 and IL-6 is also noteworthy since IL-6 is a known liver mitogen implicated in liver carcinogenesis [63,64].”
BackgroundRoy, N., Nadda, N., Kumar, H., Prasad, C., Jha, J. K., Pandey, H. C., Vanamail, P., Saraya, A., Balhara, Y. P. S., Shalimar, S., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.975027 · Cited by 16
The Crosstalk between Mesenchymal Stromal/Stem Cells and Hepatocytes in Homeostasis and under Stress
Kholodenko, I. V., Kholodenko, R. V., & Yarygin, K. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015212 · Cited by 16
Discovery of bazedoxifene analogues targeting glycoprotein 130
Song, D., Yu, W., Ren, Y., Zhu, J., Wan, C., Cai, G., Guo, J., Zhang, W., & Kong, L. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112375 · Cited by 16
Altered microRNA Transcriptome in Cultured Human Liver Cells upon Infection with Ebola Virus
Diallo, I., Ho, J., Laffont, B., Laugier, J., Benmoussa, A., Lambert, M., Husseini, Z., Soule, G., Kozak, R. A., Kobinger, G., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073792 · Cited by 16
“Even though the liver is an organ taking part in the systemic defense mechanisms initiated by the host after infection [71,72], the study of cytokines remains illustrative in an HCC cell model.”
BackgroundGrujić-Milanović, J. D., Miloradović, Z., Mihailovic‐Stanojevic, N., Banjac, V. V., Vidosavljević, S., Ivanov, M., Karanović, D., Vajić, U.-J., & Jovović, D. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111691 · Cited by 16
Li, S., Chen, L., & Lv, G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.905936 · Cited by 17
Liver Regeneration in the Acute Liver Failure Patient
Wirth, K. M., Kizy, S., & Steer, C. J. (2018) · Clinics in Liver Disease · doi:10.1016/j.cld.2018.01.004 · Cited by 16
Chronic Inflammatory and Immune Microenvironment Promote Hepatocellular Carcinoma Evolution
Chen, S., Zhang, L., Chen, Y., Zhang, X., & Ma, Y. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s435316 · Cited by 14
“22 However, persistently increased IL-6 in chronic inflammation contributes to the development of HCC.”
The Impact of Immunomodulatory Components Used in Clinical Nutrition—A Narrative Review
Raczyńska, A., Koronowicz, A., Skotnicki, P., & Leszczyńska, T. (2025) · Nutrients · doi:10.3390/nu17050752 · Cited by 20
Saydmohammed, M., Jha, A., Mahajan, V., Gavlock, D. C., Shun, T. Y., DeBiasio, R., Lefever, D. E., Li, X., Reese, C. E., Kershaw, E. E., et al. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211009228 · Cited by 16
The two facets of gp130 signalling in liver tumorigenesis
Schmidt‐Arras, D., Galun, E., & Rose‐John, S. (2021) · Seminars in Immunopathology · doi:10.1007/s00281-021-00861-0 · Cited by 15
Self-citationPulmonary Arterial Hypertension and Consecutive Right Heart Failure Lead to Liver Fibrosis
Hamberger, F., Legchenko, E., Chouvarine, P., Mederacke, Y., Taubert, R., Meier, M., Jonigk, D. D., Hansmann, G., & Mederacke, I. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.862330 · Cited by 14
Cardiovascular Toxicities with Chimeric Antigen Receptor T-cell Therapy
Gill, J. (2022) · Current Cardiology Reviews · doi:10.2174/1573403x18666220623152350 · Cited by 16
“Furthermore, serum CRP levels should be monitored since its production by hepatocytes is mediated by IL-6 [46].”
BackgroundWuestefeld, A., Iakovleva, V., Yap, S. X. L., Ong, A. B. L., Huang, D. Q., Shuen, T. W. H., Toh, H. C., Dan, Y. Y., Zender, L., & Wüestefeld, T. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-1477 · Cited by 17
Tokuchi, Y., Suda, G., Kawagishi, N., Ohara, M., Kohya, R., Sasaki, T., Yoda, T., Maehara, O., Ohnishi, S., Kubo, A., et al. (2023) · Hepatology Research · doi:10.1111/hepr.13899 · Cited by 15
“Interleukin‐6 signaling leads to liver steatosis.(37) We previously reported that the HCV core protein induced SOCS3, which could block IL‐6‐mediated signaling(38); thus, HCV eradication with DAAs might decrease SOCS3 expression, causing increased liver steatosis.”
BackgroundHCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article
Milošević, I., Todorović, N., Filipović, A., Simić, J., Marković, M., Stevanović, O., Malinić, J., Katanić, N., Mitrović, N., & Nikolic, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216048 · Cited by 16
Du, J., Huang, Z., & Zhang, E. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1329634 · Cited by 15
“Experimental studies using a diethylnitrosamine-induced hepatocellular carcinoma model have demonstrated that IL-6 promotes compensatory proliferation of hepatocytes, and its absence or inhibition of IL-6 receptor-related proteins impedes liver tumor development (23).”
BackgroundInflammatory liver diseases and susceptibility to sepsis
Lü, H. (2024) · Clinical Science · doi:10.1042/cs20230522 · Cited by 18
González-Aldaco, K., Torres-Reyes, L. A., Ojeda‐Granados, C., Leal-Mercado, L., Román, S., & Panduro, A. (2024) · Clinics and Practice · doi:10.3390/clinpract14060200 · Cited by 15
Price, J. C., Wang, R., Seaberg, E. C., Budoff, M. J., Kingsley, L., Palella, F. J., Witt, M. D., Post, W. S., & Thio, C. L. (2017) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofx153 · Cited by 15
“More importantly, sCD163, microbial translocation, and Tolllike receptor 4 signaling have been associated with fatty liver progression to NASH and fibrosis [42, 43].”
BackgroundSiramolpiwat, S., Punjachaipornpon, T., Pornthisarn, B., et al. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05652-0 · Cited by 15
Nopparat, J., Nualla‐ong, A., & Phongdara, A. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.8877 · Cited by 15
“Similarly, levels of hepatic TNF-α were also found to be significantly increased (P 0.01 and P 0.0001, 4 and 8 weeks, respectively) in the diabetic liver compared with those in the control mice (Fig.”
InfluentialLipidomic Signatures Align with Inflammatory Patterns and Outcomes in Critical IllnessPreprint
Wu, J., Cyr, A. R., Gruen, D. S., Lovelace, T. C., Benos, P. V., Chen, T., Guyette, F. X., Yazer, M. H., Daley, B. J., Miller, R., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-106579/v1 · Cited by 15
Advances in the Pathogenesis of Metabolic Liver Disease-Related Hepatocellular Carcinoma
Chen, P., Li, Y., Dai, Y., Wang, Z., Zhou, Y., Wang, Y., & Li, G. (2024) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s450460 · Cited by 14
Zekić, T., Benić, M. S., & Radić, M. (2022) · Rheumatology International · doi:10.1007/s00296-022-05143-y · Cited by 14
“IL-6 values correlate with the degree of obesity and the development of diabetes which are associated with NAFLD and maybe a patient predisposition to DILI in RA [52].”
Background
Metadata
- Authors
- Schmidt-Arras, D., & Rose-John, S.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 64
- Issue
- 6
- Pages
- 1403-1415
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2253819322
- Semantic Scholar
- 475d5a2af141aef15b1a1a8fb6b45473f2ce0e4b
- Cited by
- 881
- References
- 125
- Citations by year
- 2026: 59 · 2025: 106 · 2024: 97 · 2023: 106 · 2022: 121 · 2021: 114 · 2020: 98 · 2019: 72 · 2018: 54 · 2017: 37 · 2016: 17
- FWCI
- 27.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Hepatology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Keywords
- interleukin-6, IL-6 signaling, liver, acute phase response, liver regeneration, hepatic metabolism, gp130, soluble IL-6 receptor, IL-6 inhibition, liver disease treatment, liver tumors
- MeSH terms
- Interleukin-6 Inhibitors, Acute-Phase Reaction, Animals, Humans, Insulin Resistance, Liver, Liver Neoplasms, Liver Regeneration, Signal Transduction, Interleukin-6, Receptors, Interleukin-6, STAT3 Transcription Factor
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