The DOI matches its Crossref record; 145 of the 147 references it cites were found in a registry or an index.
Sarcopenia from mechanism to diagnosis and treatment in liver disease
Open accessAbstract
Sarcopenia or loss of skeletal muscle mass is the major component of malnutrition and is a frequent complication in cirrhosis that adversely affects clinical outcomes. These include survival, quality of life, development of other complications and post liver transplantation survival. Radiological image analysis is currently utilized to diagnose sarcopenia in cirrhosis. Nutrient supplementation and physical activity are used to counter sarcopenia but have not been consistently effective because the underlying molecular and metabolic abnormalities persist or are not influenced by these treatments. Even though alterations in food intake, hypermetabolism, alterations in amino acid profiles, endotoxemia, accelerated starvation and decreased mobility may all contribute to sarcopenia in cirrhosis, hyperammonemia has recently gained attention as a possible mediator of the liver-muscle axis. Increased muscle ammonia causes: cataplerosis of α-ketoglutarate, increased transport of leucine in exchange for glutamine, impaired signaling by leucine, increased expression of myostatin (a transforming growth factor beta superfamily member) and an increased phosphorylation of eukaryotic initiation factor 2α. In addition, mitochondrial dysfunction, increased reactive oxygen species that decrease protein synthesis and increased autophagy mediated proteolysis, also play a role. These molecular and metabolic alterations may contribute to the anabolic resistance and inadequate response to nutrient supplementation in cirrhosis. Central and skeletal muscle fatigue contributes to impaired exercise capacity and responses. Use of proteins with low ammoniagenic potential, leucine enriched amino acid supplementation, long-term ammonia lowering strategies and a combination of resistance and endurance exercise to increase muscle mass and function may target the molecular abnormalities in the muscle. Strategies targeting endotoxemia and the gut microbiome need further evaluation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Finally, malnutrition [105], frailty [106, 107] and especially sarcopenia [108, 109, 110, 111] have become increasingly important in patients with advanced chronic liver disease and should be evaluated and treated in each patient.”
From Current treatment of non‐alcoholic fatty liver disease (2022) · cites this paper as [108]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Calcium's Role in Mechanotransduction during Muscle Development
Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,552
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601
Fiber Types in Mammalian Skeletal Muscles
Schiaffino, S., & Reggiani, C. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2010 · Cited by 3,022
Shen, W., Punyanitya, M., Wang, Z., Gallagher, D., St.-Onge, M.-P., Albu, J., Heymsfield, S. B., & Heshka, S. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00744.2004 · Cited by 1,692
The key role of anaplerosis and cataplerosis for citric acid cycle function
Owen, O. E., Kalhan, S. C., & Hanson, R. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r200006200 · Cited by 1,172 · cited 1×
“substrates to generate a ketoglutarate (aKG) and ammonia in most tissues to maintain sufficient concentrations of the tricarboxylic acid (TCA) cycle intermediates [94].”
Altered profile of human gut microbiome is associated with cirrhosis and its complications
Bajaj, J. S., Heuman, D. M., Hylemon, P. B., Sanyal, A. J., White, M. B., Monteith, P., Noble, N. A., Unser, A. B., Daita, K., Fisher, A. R., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.12.019 · Cited by 1,099
Muscle Wasting Is Associated With Mortality in Patients With Cirrhosis
Montaño‐Loza, A. J., Meza–Junco, J., Prado, C. M. M., Lieffers, J. R. L., Baracos, V. E., Bain, V. G., & Sawyer, M. B. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.08.028 · Cited by 827
Sarcopenia and Mortality after Liver Transplantation
Englesbe, M. J., Patel, S. P., He, K., Lynch, R., Schaubel, D. E., Harbaugh, C. M., Holcombe, S. A., Wang, S. C., Segev, D. L., & Sonnenday, C. J. (2010) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2010.03.039 · Cited by 778
Fujiwara, N., Nakagawa, H., Kudo, Y., Tateishi, R., Taguri, M., Watadani, T., Nakagomi, R., Kondo, M., Nakatsuka, T., Minami, T., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.02.031 · Cited by 713
ESPEN Guidelines on Enteral Nutrition: Liver disease
Plauth, M., Cabré, E., Riggio, O., Assis-Camilo, M., Pirlich, M., Kondrup, J., Ferenci, P., Holm, E., Dahl, S. V., Müller, M. J., et al. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.01.018 · Cited by 679
Cited by
Sorted by citations
Items 101–200 of 606
Engelmann, C., Schob, S., Nonnenmacher, I., Werlich, L., Aehling, N., Ullrich, S., Kaiser, T., Krohn, S., Herber, A., Sucher, R., et al. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15026 · Cited by 41
Alexopoulos, T., Vasilieva, L., Kontogianni, M. D., Tenta, R., Georgiou, A., Stroumpouli, E., Mani, I., & Alexopoulou, A. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00184.2021 · Cited by 40
Vidot, H., Kline, K., Cheng, R., Finegan, L., Lin, A., Kempler, E., Strasser, S. I., Bowen, D. G., McCaughan, G. W., Carey, S., et al. (2019) · Nutrients · doi:10.3390/nu11092097 · Cited by 40
N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease
Ábrigo, J., Marín, T., Aguirre, F. S., Tacchi, F., Vilos, C., Simón, F., Arrese, M. A., Cabrera, D., & Cabello‐Verrugio, C. (2019) · Current Molecular Medicine · doi:10.2174/1566524019666190917124636 · Cited by 40
Zhang, Y., Chen, X., Hou, L., Lin, X., Qin, D., Wang, H., Hai, S., Cao, L., & Dong, B. (2020) · The journal of nutrition health & aging · doi:10.1007/s12603-020-1361-0 · Cited by 40
Saeki, C., & Tsubota, A. (2021) · Life · doi:10.3390/life11090899 · Cited by 42
Evaluation and Management of Nutritional Consequences of Chronic Liver Diseases
Espina, S., Deza, D. C., Monterde, V. B., Domper-Arnal, M. J., García, S. G., & Luè, A. (2023) · Nutrients · doi:10.3390/nu15153487 · Cited by 43
Automated low-flow ascites pump for the treatment of cirrhotic patients with refractory ascites
Stirnimann, G., Banz, V. M., Storni, F., & Gottardi, A. D. (2017) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x16684688 · Cited by 39
Effect of loop diuretics on skeletal muscle depletion in patients with liver cirrhosis
Hanai, T., Shiraki, M., Miwa, T., Watanabe, S., Imai, K., Suetsugu, A., Takai, K., Moriwaki, H., & Shimizu, M. (2018) · Hepatology Research · doi:10.1111/hepr.13244 · Cited by 39
Managing diabetes and liver disease association
Hamed, A. E., Elsahhar, M., Elwan, N. M., El-Nakeep, S. A. K., Naguib, M., Soliman, H. H., Aboubakr, A. A., Sholkamy, A. A., Sedrak, H. K., Assaad, S. N., et al. (2018) · Arab Journal of Gastroenterology · doi:10.1016/j.ajg.2018.08.003 · Cited by 39
Jeong, J. Y., Lim, S., Sohn, J. H., Lee, J. G., Jun, D. W., & Kim, Y. (2018) · Journal of Korean Medical Science · doi:10.3346/jkms.2018.33.e299 · Cited by 38
Lattanzi, B., Bruni, A., Cola, S. D., Molfino, A., Santis, A. D., Muscaritoli, M., & Merli, M. (2021) · Nutrients · doi:10.3390/nu13072296 · Cited by 38
Self-citationMohta, S., Anand, A., Sharma, S., Qamar, S., Agarwal, S., Gunjan, D., Singh, N., Madhusudhan, K. S., Pandey, R. M., & Saraya, A. (2022) · Hepatology International · doi:10.1007/s12072-022-10334-7 · Cited by 38
Yamamoto, K., Ishizu, Y., Honda, T., Ito, T., Imai, N., Nakamura, M., Kawashima, H., Kitaura, Y., Ishigami, M., & Fujishiro, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-07810-3 · Cited by 37
Frailty as Tested by Gait Speed Is a Risk Factor for Liver Transplant Respiratory Complications
Salim, T. I., Nestlerode, L. C., Lucatorto, E., Wasserman‐Wincko, T., Din, H. A., Landsittel, D. P., Tevar, A. D., Johnson, J. T., Duarte‐Rojo, A., & Dunn, M. A. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000609 · Cited by 36
Wu, C., Liang, P., Hsu, C., Chang, F.-T., Shao, Y., & Shih, T. T. (2020) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2020.07.005 · Cited by 36
Endo, K., Sato, T., Kakisaka, K., & Takikawa, Y. (2020) · Hepatology Research · doi:10.1111/hepr.13589 · Cited by 40
Nutritional assessment in patients with liver cirrhosis
Ali, S. H., Sneineh, A. T. A., & Hasweh, R. (2022) · World Journal of Hepatology · doi:10.4254/wjh.v14.i9.1694 · Cited by 42
Marrone, G., Serra, A., Miele, L., Biolato, M., Liguori, A., Grieco, A., & Gasbarrini, A. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i19.2905 · Cited by 35
Kim, Y. R., Park, S., Han, S., Ahn, J., Kim, S., Sinn, D. H., Jeong, W. K., Ko, J. S., Gwak, M. S., & Kim, G. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-25628-w · Cited by 35
Yoshida, Y., Kosaki, K., Sugasawa, T., Matsui, M., Yoshioka, M., Aoki, K., Kuji, T., Mizuno, R., Kuro‐o, M., Yamagata, K., et al. (2020) · Nutrients · doi:10.3390/nu12113474 · Cited by 35
Bloom, A., Bloom, S., Silva, H., Nicoll, A., & Sawhney, R. (2021) · Annals of Hepatology · doi:10.1016/j.aohep.2021.100549 · Cited by 35
Ismaiel, A., Bucșa, C., Farcas, A. M., Leucuta, D., Popa, S., & Dumitrascu, D. L. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.749969 · Cited by 38
Lin, Y., Zhang, Q., Yang, Y., & Zhou, J. (2022) · International Journal of Endocrinology · doi:10.1155/2022/4026940 · Cited by 36
A prognostic model of acute-on-chronic liver failure based on sarcopenia
Peng, X., Zhang, Q., Luo, L., Lei, S., Xiong, T., Li, L., Xiong, Y., Zhang, L., Zheng, J., & Luo, X. (2022) · Hepatology International · doi:10.1007/s12072-022-10363-2 · Cited by 35
Nardelli, S., Gioia, S., Faccioli, J., Riggio, O., & Ridola, L. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i35.5257 · Cited by 34
Yukawa‐Muto, Y., Kamiya, T., Fujii, H., Mori, H., Toyoda, A., Sato, I., Konishi, Y., Hirayama, A., Hara, E., Fukuda, S., et al. (2022) · Hepatology Communications · doi:10.1002/hep4.1954 · Cited by 39
Burra, P., Giannini, E. G., Caraceni, P., Corradini, S. G., Rendina, M. G., Volpes, R., & Toniutto, P. (2018) · Liver International · doi:10.1111/liv.13755 · Cited by 33
Excess Weight Gain After Cure of Hepatitis C Infection with Direct-Acting Antivirals
Do, A., Esserman, D. A., Krishnan, S., Lim, J. K., Taddei, T. H., Hauser, R. G., Tate, J. P., Re, V. L., & Justice, A. C. (2020) · Journal of General Internal Medicine · doi:10.1007/s11606-020-05782-6 · Cited by 33
Alqahtani, S. A., Chan, W., & Yu, M. (2023) · Clinics in Liver Disease · doi:10.1016/j.cld.2023.01.019 · Cited by 32
Benavides-Rodriguez, L. E., García‐Hermoso, A., Rodrigues-Bezerra, D., Izquierdo, M., Correa‐Bautista, J. E., & Ramírez‐Vélez, R. (2017) · Nutrients · doi:10.3390/nu9070695 · Cited by 32
Arase, Y., Shiraishi, K., Anzai, K., Sato, H., Teramura, E., Tsuruya, K., Hirose, S., Deguchi, R., Toyoda, M., Mine, T., et al. (2019) · Clinical Drug Investigation · doi:10.1007/s40261-019-00785-6 · Cited by 32
Clinical utility of bioimpedance analysis in liver cirrhosis
Nishikawa, H., Enomoto, H., Iwata, Y., Nishimura, T., Iijima, H., & Nishiguchi, S. (2017) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.455 · Cited by 32
Sugimoto, R., Iwasa, M., Hara, N., Tamai, Y., Yoshikawa, K., Ogura, S., Tanaka, H., Eguchi, A., Yamamoto, N., Kobayashi, Y., et al. (2017) · Hepatology Research · doi:10.1111/hepr.12999 · Cited by 31
Nagamatsu, A., Kawaguchi, T., Hirota, K., Koya, S., Tomita, M., Hashida, R., Kida, Y., Narao, H., Manako, Y., Tanaka, D., et al. (2019) · Hepatology Research · doi:10.1111/hepr.13405 · Cited by 31
Protective Effect of Angiotensin 1–7 on Sarcopenia Induced by Chronic Liver Disease in Mice
Aguirre, F. S., Ábrigo, J., González, F., González, A., Simón, F., & Cabello‐Verrugio, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113891 · Cited by 32
Definition of Sarcopenia in Chronic Liver Disease
Son, S. W., Song, D. S., Chang, U. I., & Yang, J. M. (2021) · Life · doi:10.3390/life11040349 · Cited by 32
Skladaný, Ľ., Molčan, P., Vnenčáková, J., Vrbová, P., Kukla, M., Lafférs, L., & Koller, T. (2021) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2021/5576531 · Cited by 31
Benedek, Z., Todor-Boér, S., Kocsis, L., Bauer, O., Suciu, N., & Coroș, M. F. (2021) · Medicina · doi:10.3390/medicina57050472 · Cited by 31
Sarcopenia, healthy living, and mortality in patients with chronic liver diseases
Dongen, C. V., Paik, J. M., Harring, M., Younossi, Y., Price, J. K., Kabbara, K. W., Golabi, P., & Younossi, Z. M. (2022) · Hepatology Communications · doi:10.1002/hep4.2061 · Cited by 31
Behiry, M. E., Mogawer, S., Ali, A. Y., Rakha, M., Awad, R., Emad, N., & Abdelfatah, Y. (2019) · International Journal of Hepatology · doi:10.1155/2019/8092865 · Cited by 31
Fan, X., Peng, Y., Li, B., Wang, X., Liu, Y., Shen, Y., Liu, G., Zheng, Y., Deng, Q., Liu, J., et al. (2025) · Advanced Science · doi:10.1002/advs.202410439 · Cited by 30
Exercise and physical activity in cirrhosis: opportunities or perils
Bellar, A., Welch, N., & Dasarathy, S. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00798.2019 · Cited by 33
Self-citationKappus, M. R., Wegermann, K., Bozdoĝan, E., Patel, Y. A., Janas, G., Shropshire, E., Parish, A., Niedzwiecki, D., Muir, A. J., & Bashir, M. R. (2020) · Liver Transplantation · doi:10.1002/lt.25802 · Cited by 30
Attaway, A. H., Welch, N., Dasarathy, D., Amaya‐Hughley, J., Bellar, A., Biehl, M., Dugar, S. P., ENGELEN, M. P. K. J., Zein, J., & Dasarathy, S. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13052 · Cited by 32
Self-citationArresting frailty and sarcopenia in cirrhosis: Future prospects
Chen, H., & Dunn, M. A. (2018) · Clinical Liver Disease · doi:10.1002/cld.691 · Cited by 30
Nutritional deficiencies in alcohol use disorder/alcohol-associated liver disease
Jophlin, L., Liu, T.-Y., & McClain, C. J. (2024) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000999 · Cited by 29
Wells, C. I., McCall, J. L., & Plank, L. D. (2018) · Liver Transplantation · doi:10.1002/lt.25314 · Cited by 30
Impact of Decorin on the Physical Function and Prognosis of Patients with Hepatocellular Carcinoma
Kawaguchi, T., Yoshio, S., Sakamoto, Y., Hashida, R., Koya, S., Hirota, K., Nakano, D., Yamamura, S., Niizeki, T., Matsuse, H., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9040936 · Cited by 29
Badran, H. M., Elsabaawy, M., Ragab, A., Aly, R. A., Alsebaey, A., & Sabry, A. (2020) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2020.21.11.3285 · Cited by 29
Yoshio, S., Shimagaki, T., Hashida, R., Kawaguchi, T., Tsutsui, Y., Sakamoto, Y., Yoshida, Y., Kawai, H., Yoshikawa, S., Yamazoe, T., et al. (2021) · Hepatology Research · doi:10.1111/hepr.13667 · Cited by 29
Guo, M., Zhang, J., Ma, Y., Zhu, Z., Zuo, H., Yao, J., Wu, X., Wang, D., Yu, J., Meng, M., et al. (2023) · Aging Cell · doi:10.1111/acel.13961 · Cited by 28
Cognitive Impairment and Physical Frailty in Patients With Cirrhosis
Berry, K., Duarte‐Rojo, A., Grab, J. D., Dunn, M. A., Boyarsky, B. J., Verna, E. C., Kappus, M. R., Volk, M. L., McAdams‐DeMarco, M., Segev, D. L., et al. (2021) · Hepatology Communications · doi:10.1002/hep4.1796 · Cited by 28
Sarcopenia in Hepatocellular Carcinoma: Pathogenesis and Management
Gallo, P., Silletta, M., Vincentis, A. D., Prinzi, F. L., Terracciani, F., Fazio, G. R. D., Flagiello, V., Gentilucci, U. V., Incalzi, R. A., & Picardi, A. (2021) · Chemotherapy · doi:10.1159/000521741 · Cited by 28
Yang, C., Zhu, X., Liu, J., Shi, Q., Du, H., Yang, C. G., Huang, S., Zhou, C., Wang, Y., Li, T., et al. (2022) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000461 · Cited by 31
High Intensity Interval Training: A Potential Method for Treating Sarcopenia
Liu, Q., Xie, W., Luo, Y., Li, Y., Huang, W., Wu, Y., & Li, Y. (2022) · Clinical Interventions in Aging · doi:10.2147/cia.s366245 · Cited by 34
Controversies in Diagnosing Sarcopenia in Cirrhosis—Moving from Research to Clinical Practice
Sinclair, M. J. (2019) · Nutrients · doi:10.3390/nu11102454 · Cited by 28
Nutritional Challenges in Patients with Advanced Liver Cirrhosis
Stirnimann, J., & Stirnimann, G. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111926 · Cited by 28
Zhou, D., Zhang, D., Zeng, C., Zhang, L., Gao, X., & Wang, X. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13334 · Cited by 27
Liver Cirrhosis: The Immunocompromised State
Rodríguez-Negrete, E. V., Gálvez-Martínez, M., Sánchez-Reyes, K., Fajardo-Felix, C. F., Pérez-Reséndiz, K. E., Madrigal‐Santillán, E., Morales‐González, Á., & Morales‐González, J. A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13185582 · Cited by 30
Hou, Y., Xie, Z., Zhao, X., Yuan, Y., Dou, P., & Wang, Z. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219628 · Cited by 27
Liver fibrosis-induced muscle atrophy is mediated by elevated levels of circulating TNFα
Kurosawa, T., Goto, M., Kaji, N., Aikiyo, S., Mihara, T., Ikemoto‐Uezumi, M., Toyoda, M., Kanazawa, N., Nakazawa, T., Hori, M., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-020-03353-5 · Cited by 31
Jung, C., Kim, H. W., Ahn, S. H., Kim, S. U., & Kim, B. S. (2022) · Liver International · doi:10.1111/liv.15208 · Cited by 27
The association of testosterone with sarcopenia and frailty in chronic liver disease
Chrysavgis, L., Adamantou, M., Angelousi, A. G., & Cholongitas, Ε. (2023) · European Journal of Clinical Investigation · doi:10.1111/eci.14108 · Cited by 28
Nutrition in Patients With Cirrhosis.
Calmet, F. H., Martin, P. B., & Pearlman, M. Y. (2019) · PubMed Central · Cited by 26
Lai, Q., Magistri, P., Lionetti, R., Avolio, A. W., Lenci, I., Giannelli, V., Pecchi, A., Ferri, F., Marrone, G., Angelico, M., et al. (2021) · Liver International · doi:10.1111/liv.14889 · Cited by 26
Sano, A., Kakazu, E., Morosawa, T., Inoue, J., Kogure, T., Ninomiya, M., Iwata, T., Umetsu, T., Nakamura, T., Takai, S., et al. (2018) · Journal of Gastroenterology · doi:10.1007/s00535-018-1435-5 · Cited by 26
Zambrano, D. N., Xiao, J., Prado, C. M. M., & González, M. C. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.06.018 · Cited by 26
Stadlbauer, V., Komarova, I., Klymiuk, I., Durdević, M., Reisinger, A. C., Blesl, A., Rainer, F., & Horvath, A. (2020) · Liver International · doi:10.1111/liv.14382 · Cited by 27
Molecular Mechanisms and Treatment of Sarcopenia in Liver Disease: A Review of Current Knowledge
Kamimura, H., Sato, T., Natsui, K., Kobayashi, T., Yoshida, T., Kamimura, K., Tsuchiya, A., Murayama, T., Yokoyama, J., Kawai, H., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031425 · Cited by 24
Bhandari, K., & Kapoor, D. (2021) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2021.08.028 · Cited by 25
Jo, I. H., Song, D. S., Chang, U. I., & Yang, J. M. (2023) · Scientific Reports · doi:10.1038/s41598-023-34263-z · Cited by 25
Intensive Care of Pulmonary Complications Following Liver Transplantation
Lui, J. K., Spaho, L., Holzwanger, E. A., Bui, R., Daly, J. S., Bozorgzadeh, A., & Kopec, S. E. (2018) · Journal of Intensive Care Medicine · doi:10.1177/0885066618757410 · Cited by 26
Feng, Z., Zhao, H., Jiang, Y., He, Z., Sun, X., Rong, P., & Wang, W. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.01.021 · Cited by 26
An Approach to the Management of Diabetes Mellitus in Cirrhosis: A Primer for the Hepatologist
Puri, P., & Kotwal, N. (2021) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2021.09.010 · Cited by 29
Clinical Overview of Sarcopenia, Frailty, and Malnutrition in Patients With Liver Cirrhosis
Kusnik, A. T., Penmetsa, A., Chaudhary, F., Renjith, K., Ramaraju, G. A., Laryea, M. A., & Allard, J. P. (2024) · Gastroenterology Research · doi:10.14740/gr1707 · Cited by 27
Calf Circumference as a Useful Predictor of Sarcopenia in Patients With Liver Diseases
Nishikawa, H., Yoh, K., Enomoto, H., Iwata, Y., Sakai, Y., Kishino, K., Shimono, Y., Ikeda, N., Takashima, T., Aizawa, N., et al. (2020) · In Vivo · doi:10.21873/invivo.12073 · Cited by 26
Hénin, G., Lanthier, N., & Dahlqvist, G. (2022) · Acta gastro-enterologica belgica · doi:10.51821/85.4.10899 · Cited by 26
Khoja, S., Nitzahn, M., Hermann, K. J., Truong, B., Borzone, R., Willis, B., Rudd, M., Palmer, D. J., Ng, P., Brunetti‐Pierri, N., et al. (2018) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2018.04.001 · Cited by 24
Lee, D. U., Fan, G. H., Ahern, R. R., & Karagozian, R. (2020) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001991 · Cited by 23
Tamai, Y., Chen, Z., Wu, Y., Okabe, J., Kobayashi, Y., Chiba, H., Hui, S., Eguchi, A., Iwasa, M., Ito, M., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111181 · Cited by 23
Attaway, A. H., Welch, N., Yadav, R., Bellar, A., Hatipoglu, U. S., Meli, Y. M., ENGELEN, M. P. K. J., Zein, J., & Dasarathy, S. (2021) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1080/15412555.2021.1897560 · Cited by 25
Self-citationBibliometric Analysis of the Knowledge Base and Future Trends on Sarcopenia from 1999–2021
Xiao, Y., Deng, Z., Tan, H.-J., Jiang, T., & Chen, Z. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19148866 · Cited by 25
Main factors influencing long-term outcomes of liver transplantation in 2022
Fuochi, E., Anastasio, L., Lynch, E. N., Campani, C., Dragoni, G., Milani, S., Galli, A., & Innocenti, T. (2023) · World Journal of Hepatology · doi:10.4254/wjh.v15.i3.321 · Cited by 24
Holeček, M., & Vodeničarovová, M. (2018) · International Journal of Experimental Pathology · doi:10.1111/iep.12299 · Cited by 25
Espina, S., Sanz‐París, A., Gonzalez-Irazabal, Y., Pérez‐Matute, P., Andrade, F., Garcia-Rodriguez, B., Carpéné, C., Zakaroff, A., Monterde, V. B., Fuentes, J., et al. (2022) · Nutrients · doi:10.3390/nu14112344 · Cited by 23
Namba, M., Hiramatsu, A., Aikata, H., Kodama, K., Uchikawa, S., Ohya, K., Morio, K., Fujino, H., Nakahara, T., Murakami, E., et al. (2019) · Journal of Gastroenterology · doi:10.1007/s00535-019-01623-4 · Cited by 22
Lee, P., Lee, K., Yang, T., Lu, H., Cheng, T.-Y., Chen, Y.-J., Chiou, J.-J., Huang, C.-W., Yang, U., Tan, E. C., et al. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100619 · Cited by 22
Pichon, C., Nachit, M., Gillard, J., Velde, G. V., Lanthier, N., & Leclercq, I. A. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1051157 · Cited by 26
Yin, L., Chu, S.-L., Lv, W., Zhou, C., Liu, K., Zhu, Y.-J., Zhang, W., Wang, C.-X., Zhang, Y.-H., Lu, D., et al. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i18.2875 · Cited by 22
Lin, X., Teng, S., Wang, L., Zhang, J., Shang, Y., Liu, H., & Zang, Y. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-011840 · Cited by 23
Stam, S. P., Osté, M. C. J., Eisenga, M. F., Blokzijl, H., van den Berg, A. P., Bakker, S. J. L., & de Meijer, V. E. (2018) · American Journal of Transplantation · doi:10.1111/ajt.14926 · Cited by 22
Emerging Treatment Options for Sarcopenia in Chronic Liver Disease
Kim, Y. (2021) · Life · doi:10.3390/life11030250 · Cited by 26
Sidhu, S. S., Saggar, K., Goyal, O., Varshney, T., Kishore, H., Bansal, N., & Sidhu, S. S. (2020) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001761 · Cited by 21
Murata, K., Kaji, K., Nishimura, N., Enomoto, M., Fujimoto, Y., Takeda, S., Tsuji, Y., Fujinaga, Y., Takaya, H., Kawaratani, H., et al. (2022) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2022.5157 · Cited by 21
Zhang, Y., & Fang, X.-M. (2023) · The Chinese Journal of Physiology · doi:10.4103/cjop.cjop-d-22-00131 · Cited by 22
Nutritional support in cirrhotic patients with sarcopenia
Vasques, J., Guerreiro, C. S., Sousa, J., Pinto, M., & Cortez‐Pinto, H. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.07.011 · Cited by 21
Georgiou, A. (2019) · Annals of Gastroenterology · doi:10.20524/aog.2019.0432 · Cited by 21
Sarcopenia in cirrhosis: From pathophysiology to interventional therapy
Chen, H., Yang, C., Yan, S., Liu, X., Zhou, L., & Yuan, X. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112571 · Cited by 24
Jo, M. H., Lim, T. S., Jeon, M. Y., Lee, H. W., Kim, B. K., Park, J. Y., Kim, D. Y., Ahn, S. H., Han, K., & Kim, S. U. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8030322 · Cited by 20
Metadata
- Authors
- Dasarathy, S., & Merli, M.
- Affiliations
- Cleveland Clinic (US)
- Sapienza University of Rome (IT)
- Corresponding author
- Dasarathy, Srinivasan
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 65
- Issue
- 6
- Pages
- 1232-1244
- ISSN
- 0168-8278 (ISSN-L)
- PMC
- PMC5116259
- OpenAlex
- W2507464717
- Cited by
- 608
- References
- 147
- Citations by year
- 2026: 48 · 2025: 56 · 2024: 60 · 2023: 86 · 2022: 64 · 2021: 73 · 2020: 63 · 2019: 66 · 2018: 50 · 2017: 38 · 2016: 3
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (5r01dk083414-05, 4u01aa021893-05, DK83414, AA021893, UO1 AA021893)
- National Institute on Alcohol Abuse and Alcoholism (R21AA022742, U01-AA021893, P50AA024333)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK-083414, U01DK061732)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- sarcopenia, liver cirrhosis, hyperammonemia, myostatin, eIF2α phosphorylation, leucine, glutamine, mitochondrial dysfunction, reactive oxygen species, autophagy, endotoxemia, gut microbiota, muscle fatigue, exercise training, protein supplementation, malnutrition, anabolic resistance
- MeSH terms
- Ketoglutaric Acids, Liver Diseases, Quality of Life, Muscle, Skeletal, Sarcopenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
