Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine
Open accessAbstract
Patients who develop chronic fibrotic liver disease, caused by viral or metabolic aetiologies, are at a high risk of developing hepatocellular carcinoma (HCC). Even after complete HCC tumour resection or ablation, the carcinogenic tissue microenvironment in the remnant liver can give rise to recurrent de novo HCC tumours, which progress into incurable, advanced-stage disease in most patients. Thus, early detection and prevention of HCC development is, in principle, the most impactful strategy to improve patient prognosis. However, a "one-size-fits-all" approach to HCC screening for early tumour detection, as recommended by clinical practice guidelines, is utilised in less than 20% of the target population, and the performance of screening modalities, including ultrasound and alpha-fetoprotein, is suboptimal. Furthermore, optimal screening strategies for emerging at-risk patient populations, such as those with chronic hepatitis C after viral cure, or those with non-cirrhotic, non-alcoholic fatty liver disease remain controversial. New HCC biomarkers and imaging modalities may improve the sensitivity and specificity of HCC detection. Clinical and molecular HCC risk scores will enable precise HCC risk prediction followed by tailoured HCC screening of individual patients, maximising cost-effectiveness and optimising allocation of limited medical resources. Several aetiology-specific and generic HCC chemoprevention strategies are evolving. Epidemiological and experimental studies have identified candidate chemoprevention targets and therapies, including statins, anti-diabetic drugs, and selective molecular targeted agents, although their clinical testing has been limited by the lengthy process of cancer development that requires long-term, costly studies. Individual HCC risk prediction is expected to overcome the challenge by enabling personalised chemoprevention, targeting high-risk patients for precision HCC prevention and substantially improving the dismal prognosis of HCC.
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Observational and case-control studies indicate that, in people with T2D and MASLD-related advanced fibrosis or cirrhosis, metformin may improve transplant-free survival (but not the risk of hepatic decompensation), and reduce the risk of primary liver and extrahepatic cancer.
“As far as clinical outcomes, there is some indication from observational and case-control studies that, in people with T2D and MASLD-related advanced fi brosis or cirrhosis, metformin may improve transplant-free survival (but not the risk of hepatic decompensation), and reduce the risk of primary liver and extrahepatic cancer.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [431]
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Cites
Global cancer statistics, 2012
Torre, L. A., Bray, F., Siegel, R. L., Ferlay, J., Lortet‐Tieulent, J., & Jemal, A. (2015) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21262 · Cited by 26,858 · see citing works
Younossi, Z. M., Koenig, A. B., Abdelatif, D., Fazel, Y., Henry, L., & Wymer, M. (2016) · Hepatology · doi:10.1002/hep.28431 · Cited by 10,781 · see citing works
AASLD guidelines for the treatment of hepatocellular carcinoma
Heimbach, J. K., Kulik, L., Finn, R. S., Sirlin, C. B., Abecassis, M. M., Roberts, L. R., Zhu, A. X., Murad, M. H., & Marrero, J. A. (2017) · Hepatology · doi:10.1002/hep.29086 · Cited by 4,072 · see citing works
Risk of Hepatocellular Carcinoma Across a Biological Gradient of Serum Hepatitis B Virus DNA Level
Chen, C.-J. (2006) · JAMA · doi:10.1001/jama.295.1.65 · Cited by 3,140 · see citing works
Levin, B., Lieberman, D. A., McFarland, B. G., Andrews, K. S., Brooks, D. D., Bond, J. H., Dash, C., Giardiello, F. M., Glick, S. N., Johnson, D., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.02.002 · Cited by 2,987 · see citing works
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
Ally, A., Balasundaram, M., Carlsen, R., Chuah, E., Clarke, A., Dhalla, N., Holt, R. A., Jones, S. J. M., Lee, D., Ma, Y., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.046 · Cited by 2,490 · see citing works
Lamivudine for Patients with Chronic Hepatitis B and Advanced Liver Disease
Liaw, Y., Sung, J. J. �., Chow, W. C., Farrell, G. C., Lee, C., Yuen, H., Tanwandee, T., Tao, Q.-M., Shue, K., Keene, O. N., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033364 · Cited by 2,259 · see citing works
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., et al. (2013) · Nature · doi:10.1038/nature12347 · Cited by 2,219 · see citing works
Blach, S., Zeuzem, S., Manns, M. P., et al. (2016) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(16)30181-9 · Cited by 2,005 · see citing works
The Essential Medicinal Chemistry of Curcumin
Nelson, K. M., Dahlin, J. L., Bisson, J., Graham, J., Pauli, G. F., & Walters, M. A. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00975 · Cited by 1,956 · see citing works
Levin, B., Lieberman, D. A., McFarland, B., Smith, R. A., Brooks, D. D., Andrews, K. S., Dash, C., Giardiello, F. M., Glick, S. N., Levin, T. R., et al. (2008) · CA A Cancer Journal for Clinicians · doi:10.3322/ca.2007.0018 · Cited by 1,800 · see citing works
Park, E. J., Lee, J. H., Yu, G.-Y., He, G., Ali, S. R., Holzer, R. G., Österreicher, C. H., Takahashi, H., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2009.12.052 · Cited by 1,764 · see citing works
Bhaskaran, K., Douglas, I., Forbes, H., dos-Santos-Silva, I., Leon, D. A., & Smeeth, L. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60892-8 · Cited by 1,707 · see citing works
Adipose-derived circulating miRNAs regulate gene expression in other tissues
Thomou, T., Mori, M. A., Dreyfuss, J. M., Konishi, M., Sakaguchi, M., Wolfrum, C., Rao, T. N., Winnay, J. N., Garcia-Martin, R., Grinspoon, S. K., et al. (2017) · Nature · doi:10.1038/nature21365 · Cited by 1,539 · see citing works
Hepatic stellate cells as key target in liver fibrosis
Higashi, T., Friedman, S. L., & Hoshida, Y. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.05.007 · Cited by 1,485 · see citing works
Self-citationPromotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
Dapito, D. H., Mencin, A., Gwak, G.-Y., Pradere, J.-P., Jang, M.-K., Mederacke, I., Caviglia, J. M., Khiabanian, H., Adeyemi, A., Bataller, R., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.007 · Cited by 1,346 · see citing works
Gene expression in fixed tissues and outcome in hepatocellular carcinoma
Hoshida, Y., Villanueva, A., Kobayashi, M., Peix, J., Chiang, D. Y., Camargo, A., Gupta, S., Moore, J., Wrobel, M. J., Lerner, J., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0804525 · Cited by 1,286 · see citing works
Self-citationBruix, J., Takayama, T., Mazzaferro, V., Chau, G.-Y., Yang, J., Kudo, M., Cai, J., Poon, R. T., Han, K.-H., Tak, W. Y., et al. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(15)00198-9 · Cited by 1,120 · see citing works
Use of Archived Specimens in Evaluation of Prognostic and Predictive Biomarkers
Simon, R. M., Paik, S., & Hayes, D. F. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp335 · Cited by 1,040 · see citing works
Ratziu, V., Harrison, S. A., Francque, S., Bedossa, P., Lehert, P., Serfaty, L., Romero-Gomez, M., Boursier, J., Abdelmalek, M., Caldwell, S., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.01.038 · Cited by 1,035 · see citing works
Mechanisms of HBV-induced hepatocellular carcinoma.
Levrero, M., & Zucman-Rossi, J. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.02.021 · Cited by 1,008 · see citing works
Ryerson, A. B., Eheman, C. R., Altekruse, S. F., Ward, J. W., Jemal, A., Sherman, R., Henley, S. J., Holtzman, D. J., Lake, A., Noone, A., et al. (2016) · Cancer · doi:10.1002/cncr.29936 · Cited by 944 · see citing works
Risk of Hepatocellular Cancer in HCV Patients Treated With Direct-Acting Antiviral Agents
Kanwal, F., Kramer, J. R., Asch, S. M., Chayanupatkul, M., Cao, Y., & El‐Serag, H. B. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.06.012 · Cited by 931 · see citing works
Buzzai, M., Jones, R. G., Amaravadi, R. K., Lum, J. J., DeBerardinis, R. J., Zhao, F., Viollet, B., & Thompson, C. B. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4447 · Cited by 923 · see citing works
El‐Serag, H. B., Hampel, H., & Javadi, F. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2005.12.007 · Cited by 821 · see citing works
Singal, A. G., Pillai, A., & Tiro, J. (2014) · PLoS Medicine · doi:10.1371/journal.pmed.1001624 · Cited by 817 · see citing works
Singal, A. G., Volk, M. L., Waljee, A. K., Salgia, R. J., HIGGINS, P., Rogers, M. A. M., & Marrero, J. A. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04014.x · Cited by 816 · see citing works
Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
Totoki, Y., Tatsuno, K., Covington, K. R., Ueda, H., Creighton, C. J., Kato, M., Tsuji, S., Donehower, L. A., Slagle, B. L., Nakamura, H., et al. (2014) · Nature Genetics · doi:10.1038/ng.3126 · Cited by 781 · see citing works
NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis
Ma, C., Kesarwala, A. H., Eggert, T., Medina-Echeverz, J., Kleiner, D. E., Jin, P., Stroncek, D. F., Terabe, M., Kapoor, V., ElGindi, M., et al. (2016) · Nature · doi:10.1038/nature16969 · Cited by 766 · see citing works
PEPE, M. S., Feng, Z., Janes, H., Bossuyt, P. M., & Potter, J. D. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn326 · Cited by 723 · see citing works
Yang, H., Yuen, M., Chan, H. L., Han, K., Chen, P., Kim, D. Y., Ahn, S. H., Chen, C., Wong, V. W., & Seto, W. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70077-8 · Cited by 671 · see citing works
Friedman, S. L., Ratziu, V., Harrison, S. A., Abdelmalek, M. F., Aithal, G. P., Caballeria, J., Francque, S., Farrell, G., Kowdley, K. V., Craxi, A., et al. (2018) · Hepatology · doi:10.1002/hep.29477 · Cited by 671 · see citing works
Self-citationLok, A. S.-F., Seeff, L. B., Morgan, T. R. M., Bisceglie, A. M. D., Sterling, R. K., Curto, T. M., Everson, G. T., Lindsay, K. L., Lee, W. M., Bonkovsky, H. L., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.09.014 · Cited by 651 · see citing works
Mittal, S., El-Serag, H. B., Sada, Y. H., Kanwal, F., Duan, Z., Temple, S., May, S. B., Kramer, J. R., Richardson, P. A., & Davila, J. A. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.07.019 · Cited by 648 · see citing works
Plasma MicroRNA Panel to Diagnose Hepatitis B Virus–Related Hepatocellular Carcinoma
Zhou, J., Yu, L., Gao, X. J., Hu, J., Wang, J., Dai, Z., Wang, J.-F., Zhang, Z., Lu, S., Huang, X., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.38.2697 · Cited by 636 · see citing works
Global trends and predictions in hepatocellular carcinoma mortality
Bertuccio, P., Turati, F., Carioli, G., Rodriguez, T., Vecchia, C. L., Malvezzi, M., & Negri, E. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.03.011 · Cited by 635 · see citing works
Decreased Incidence of Hepatocellular Carcinoma in Hepatitis B Vaccinees: A 20-Year Follow-up Study
Chang, M., You, S., Chen, C., Liu, C., Lee, C., Lin, S., Chu, H.-C., Wu, T., Yang, S., Kuo, H., et al. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp288 · Cited by 633 · see citing works
Yuen, M., Tanaka, Y., Fong, D., Fung, J., Wong, D. K.-H., Yuen, J. C., But, D. Y.-K., Chan, A. O., Wong, B. C., Mizokami, M., et al. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.07.023 · Cited by 584 · see citing works
Associations Between Hepatitis B Virus Genotype and Mutants and the Risk of Hepatocellular Carcinoma
Yang, H., Yeh, S.-H., Chen, P., Iloeje, U. H., Jen, C.-L., Su, J., Wang, L., Lu, S., You, S., Chen, D., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn243 · Cited by 579 · see citing works
Papatheodoridis, G., Dalekos, G. Ν., Sypsa, V., Yurdaydın, C., Buti, M., Goulis, J., Calleja, J. L., Chi, H., Manolakopoulos, S., Mangia, G., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.11.035 · Cited by 561 · see citing works
A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer
Asgharpour, A., Cazanave, S. C., Pacana, T., Seneshaw, M., Vincent, R., Banini, B. A., Kumar, D. P., Daita, K., Min, H.-K., Mirshahi, F., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.05.005 · Cited by 538 · see citing works
Self-citationNahon, P., Bourcier, V., Layese, R., Audureau, É., Cagnot, C., Marcellin, P., Guyader, D., Fontaine, H., Larrey, D. G., Lédinghen, V. D., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.09.009 · Cited by 532 · see citing works
Hepatocellular Carcinoma From Epidemiology to Prevention: Translating Knowledge into Practice
Singal, A. G., & El-Serag, H. B. (2015) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.08.014 · Cited by 530 · see citing works
Tice, J. A., Cummings, S. R., Smith‐Bindman, R., Ichikawa, L., Barlow, W. E., & Kerlikowske, K. M. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-5-200803040-00004 · Cited by 527 · see citing works
ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development
Nakagawa, H., Umemura, A., Taniguchi, K., Font-Burgada, J., Dhar, D., Ogata, H., Zhong, Z., Valasek, M. A., Seki, E., Hidalgo, J., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.07.001 · Cited by 525 · see citing works
Cancer biomarker discovery and validation.
Goossens, N., Nakagawa, S., Sun, X., & Hoshida, Y. (2015) · PubMed · doi:10.3978/j.issn.2218-676x.2015.06.04 · Cited by 520 · see citing works
Self-citationPapatheodoridis, G., Chan, H. L., Hansen, B. E., Janssen, H. L. A., & Lampertico, P. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.01.002 · Cited by 511 · see citing works
Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis
Kettner, N. M., Voicu, H., Finegold, M. J., Coarfa, C., Sreekumar, A., Putluri, N., Katchy, C. A., Lee, C., Moore, D. D., & Fu, L. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.007 · Cited by 508 · see citing works
Clinical Scoring System to Predict Hepatocellular Carcinoma in Chronic Hepatitis B Carriers
Wong, V. W., Chan, S. L., Mo, F. K. F., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.2675 · Cited by 505 · see citing works
Adjuvant Immunotherapy With Autologous Cytokine-Induced Killer Cells for Hepatocellular Carcinoma
Lee, J. H., Lee, J.-H., Lim, Y.-S., Yeon, J. E., Song, T.-J., Yu, S. J., Gwak, G.-Y., Kim, K. M., Kim, Y. J., Lee, J. W., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.02.055 · Cited by 503 · see citing works
Loo, T. M., Kamachi, F., Watanabe, Y., Yoshimoto, S., Kanda, H., Arai, Y., Nakajima-Takagi, Y., Iwama, A., Koga, T., Sugimoto, Y., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0932 · Cited by 478 · see citing works
Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis
Velázquez, R. F., Rodríguez, M., Navascués, C., Linares, A., Pérez, R., Sotorríos, N. G., Martínez, I., & Rodrigo, L. (2003) · Hepatology · doi:10.1053/jhep.2003.50093 · Cited by 457 · see citing works
Singh, S., Singh, P. P., Singh, A. G., Murad, M. H., & Sánchez, W. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.10.005 · Cited by 452 · see citing works
Non-alcoholic fatty liver disease
Neuschwander‐Tetri, B. A. (2017) · BMC Medicine · doi:10.1186/s12916-017-0806-8 · Cited by 452 · see citing works
Wang, C., Wang, X., Gong, G., Ben, Q., Qiu, W., Chen, Y., Guo-ping, L., & Wang, L. (2011) · International Journal of Cancer · doi:10.1002/ijc.26165 · Cited by 450 · see citing works
Future of Hepatocellular Carcinoma Incidence in the United States Forecast Through 2030
Petrick, J. L., Kelly, S. P., Altekruse, S. F., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.64.7412 · Cited by 443 · see citing works
Geissler, E. K., Schnitzbauer, A. A., Zülke, C., Lamby, P. E., Proneth, A., Duvoux, C., Burra, P., Jauch, K.-W., Rentsch, M., Ganten, T. M., et al. (2016) · Transplantation · doi:10.1097/tp.0000000000000965 · Cited by 433 · see citing works
Incidence of Hepatocellular Carcinoma in All 50 United States, From 2000 Through 2012
White, D. L., Thrift, A. P., Kanwal, F., Davila, J. A., & El‐Serag, H. B. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.11.020 · Cited by 418 · see citing works
Cheung, M. C. M., Walker, A. J., Hudson, B., Verma, S., McLauchlan, J., Mutimer, D., Brown, A. S., Gelson, W., MacDonald, D. C., Agarwal, K., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.06.019 · Cited by 408 · see citing works
Gomes, A. L., Teijeiro, A., Burén, S., Tummala, K. S., Yilmaz, M., Waisman, A., Theurillat, J.-P., Perna, C., & Djouder, N. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.020 · Cited by 401 · see citing works
Trinchet, J., Chaffaut, C., Bourcier, V., Degos, F., Henrion, J., Fontaine, H., Roulot, D. M., Mallat, A., Hillaire, S., Calès, P., et al. (2010) · Hepatology · doi:10.1002/hep.24545 · Cited by 399 · see citing works
Trends and Patterns of Disparities in Cancer Mortality Among US Counties, 1980-2014
Mokdad, A. H., Dwyer‐Lindgren, L., Fitzmaurice, C., Stubbs, R. W., Bertozzi-Villa, A., Morozoff, C., Charara, R. N., Allen, C., Naghavi, M., & Murray, C. J. L. (2017) · JAMA · doi:10.1001/jama.2016.20324 · Cited by 399 · see citing works
Shen, Q., Fan, J., Yang, X., Tan, Y., Zhao, W., Xu, Y., Wang, N., Niu, Y., Wu, Z., Zhou, J., et al. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70233-4 · Cited by 394 · see citing works
Chen, H.-P., Shieh, J., Chang, C., Chen, T.-T., Lin, J., Wu, M., Lin, J.-H., & Wu, C. (2012) · Gut · doi:10.1136/gutjnl-2011-301708 · Cited by 392 · see citing works
Nonalcoholic Fatty Liver Disease: Cytokine-Adipokine Interplay and Regulation of Insulin Resistance
Tilg, H., & Hotamışlıgil, G. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.054 · Cited by 385 · see citing works
Kumar, V., Kato, N., Urabe, Y., Takahashi, A., Muroyama, R., Hosono, N., Otsuka, M., Tateishi, R., Omata, M., Nakagawa, H., et al. (2011) · Nature Genetics · doi:10.1038/ng.809 · Cited by 377 · see citing works
GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma
Marrero, J. A., Romano, P. R., Nikolaeva, O., et al. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.05.028 · Cited by 366 · see citing works
Johnson, P. J., Pirrie, S. J., Cox, T. F., Berhane, S., Teng, M. J., Palmer, D. H., Morse, J., Hull, D., Patman, G., Kagebayashi, C., et al. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-0870 · Cited by 360 · see citing works
Kim, S. Y., An, J., Lim, Y.-S., Han, S., Lee, J.-Y., Byun, J. H., Won, H. J., Lee, S. J., Lee, H. C., & Lee, Y. S. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2016.3147 · Cited by 356 · see citing works
Singh, S., Fujii, L. L., Murad, M. H., Wang, Z., Asrani, S. K., Ehman, R. L., Kamath, P. S., & Talwalkar, J. A. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.07.034 · Cited by 353 · see citing works
Fuchs, B. C., Hoshida, Y., Fujii, T., Wei, L., Yamada, S., Lauwers, G. Y., McGinn, C. M., DePeralta, D. K., Chen, X., Kuroda, T., et al. (2013) · Hepatology · doi:10.1002/hep.26898 · Cited by 352 · see citing works
Self-citationCholesterol Treatment Trialists' (CTT) Collaboration (2012) · PLoS ONE · doi:10.1371/journal.pone.0029849 · Cited by 351 · see citing works
FGF21 mediates endocrine control of simple sugar intake and sweet taste preference by the liver
von Holstein-Rathlou, S., BonDurant, L. D., Peltekian, L., Naber, M. C., Yin, T. C., Claflin, K. E., Urizar, A. I., Madsen, A. N., Ratner, C., Holst, B., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.003 · Cited by 347 · see citing works
Zhang, H., Zhai, Y., Hu, Z., Wu, C. H., Qian, J., Jia, W., Ma, F., Huang, W., Yu, L., Yue, W., et al. (2010) · Nature Genetics · doi:10.1038/ng.638 · Cited by 346 · see citing works
International trends in liver cancer incidence, overall and by histologic subtype, 1978–2007
Petrick, J. L., Braunlin, M., Laversanne, M., Valery, P. C., Bray, F., & McGlynn, K. A. (2016) · International Journal of Cancer · doi:10.1002/ijc.30211 · Cited by 343 · see citing works
Population attributable fractions of risk factors for hepatocellular carcinoma in the United States
Makarova‐Rusher, O. V., Altekruse, S. F., McNeel, T. S., Ulahannan, S. V., Duffy, A. G., Graubard, B. I., Greten, T. F., & McGlynn, K. A. (2016) · Cancer · doi:10.1002/cncr.29971 · Cited by 332 · see citing works
Simmons, O. L., Fetzer, D. T., Yokoo, T., Marrero, J. A., Yopp, A. C., Kono, Y., Parikh, N. D., Browning, T. G., & Singal, A. G. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13841 · Cited by 328 · see citing works
Identification of Osteopontin as a Novel Marker for Early Hepatocellular Carcinoma
Shang, S., Plymoth, A., Ge, S., Feng, Z., Rosen, H. R., Sangrajrang, S., Hainaut, P. L., Marrero, J. A., & Beretta, L. (2011) · Hepatology · doi:10.1002/hep.24703 · Cited by 321 · see citing works
Jiang, D., Sun, J., Cao, G., Liu, Y., Lin, D., Gao, Y.-Z., Ren, W.-H., Long, X., Zhang, H., Ma, X.-P., et al. (2012) · Nature Genetics · doi:10.1038/ng.2483 · Cited by 309 · see citing works
Singal, A. G., Mukherjee, A., Elmunzer, J. B., Higgins, P., Lok, A. S.-F., Zhu, J., Marrero, J. A., & Waljee, A. K. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.332 · Cited by 306 · see citing works
Santi, V., Trevisani, F., Gramenzi, A., Grignaschi, A., Cappa, F. M., Poggio, P. D., Nolfo, M. A. D., Benvegnù, L., Farinati, F., Zoli, M., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.03.010 · Cited by 304 · see citing works
Statins and the Risk of Hepatocellular Carcinoma in Patients With Hepatitis B Virus Infection
Tsan, Y., Lee, C., Wang, J., & Chen, P. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.36.0917 · Cited by 294 · see citing works
Trépo, E., Romeo, S., Zucman‐Rossi, J., & Nahon, P. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.03.011 · Cited by 293 · see citing works
Wong, G. L., Chan, H. L., Wong, C. K., Leung, C. K.-L., Chan, C. Y., Ho, P. P., Chung, V. C., Chan, Z. C., Tse, Y., Chim, A. M., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.09.029 · Cited by 281 · see citing works
Nomograms for Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B Virus Infection
Yang, H., Sherman, M., Su, J., Chen, P., Liaw, Y., Iloeje, U. H., & Chen, C. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.4456 · Cited by 281 · see citing works
Yang, J. D., Mohamed, E. A., Aziz, A. O. A., Shousha, H. I., Hashem, M. B., Nabil, M. M., Abdelmaksoud, A., Elbaz, T. M., Afihene, M., Duduyemi, B. M., et al. (2016) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(16)30161-3 · Cited by 280 · see citing works
Yuan, J., Govindarajan, S., Arakawa, K., & Yu, M. C. (2004) · Cancer · doi:10.1002/cncr.20427 · Cited by 275 · see citing works
Chemopreventive strategies in hepatocellular carcinoma
Singh, S., Singh, P. P., Roberts, L. R., & Sánchez, W. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.143 · Cited by 272 · see citing works
Atiq, O., Tiro, J., Yopp, A. C., Muffler, A., Marrero, J. A., Parikh, N. D., Murphy, C., McCallister, K., & Singal, A. G. (2017) · Hepatology · doi:10.1002/hep.28895 · Cited by 266 · see citing works
Yu, N. C., Chaudhari, V. V., Raman, S. S., Lassman, C., Tong, M. J., Busuttil, R. W., & Lu, D. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2010.09.017 · Cited by 265 · see citing works
MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals
Donati, B., Dongiovanni, P., Romeo, S., Meroni, M., McCain, M. V., Miele, L., Petta, S., Maier, S., Rosso, C., Luca, L. D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04991-0 · Cited by 262 · see citing works
Yuen, M., Seto, W., Chow, D. H.-F., Tsui, K., Wong, D. K.-H., Ngai, V. W.-S., Wong, B. C., Fung, J., Yuen, J. C., & Lai, C. (2007) · Antiviral Therapy · doi:10.1177/135965350701200816 · Cited by 256 · see citing works
Meta-analysis of epidemiologic studies on cigarette smoking and liver cancer
Lee, Y.-C. A., Cohet, C., Yang, Y.-C., Stayner, L. T., Hashibe, M., & Straíf, K. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp280 · Cited by 255 · see citing works
Effectiveness of Hepatocellular Carcinoma Surveillance in Patients with Cirrhosis
Singal, A. G., Conjeevaram, H. S., Volk, M. L., Fu, S., Fontana, R. J., Askari, F. K., Su, G. L., Lok, A. S.-F., & Marrero, J. A. (2012) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-1005 · Cited by 249 · see citing works
Marrone, G., Russo, L., Rosado, E., Hide, D., García‐Cardeña, G., García‐Pagán, J. C., Bosch, J., & Gracia‐Sancho, J. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.08.026 · Cited by 244 · see citing works
EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation
Lanaya, H., Natarajan, A., Komposch, K., Li, L., Amberg, N., Chen, L., Wculek, S. K., Hammer, M., Zenz, R., Peck‐Radosavljevic, M., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3031 · Cited by 243 · see citing works
Livingston, S., Simonetti, J., McMahon, B. J., BULKOW, L. R., Hurlburt, K. J., Homan, C., Snowball, M. M., Cagle, H. H., Williams, J. L., & Chulanov, V. (2006) · The Journal of Infectious Diseases · doi:10.1086/509894 · Cited by 240 · see citing works
Durán, Á., Hernandez, E. D., Reina‐Campos, M., Castilla, E. A., Subramaniam, S., Raghunandan, S., Roberts, L. R., Kisseleva, T., Karin, M., Díaz-Meco, M. T., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.09.004 · Cited by 240 · see citing works
Giles, D. A., Moreno‐Fernandez, M. E., Stankiewicz, T. E., Graspeuntner, S., Cappelletti, M., Wu, D. X.-Y., Mukherjee, R., Chan, C. C., Lawson, M. J., Klarquist, J. S., et al. (2017) · Nature Medicine · doi:10.1038/nm.4346 · Cited by 238 · see citing works
Oliveri, F., De Salvo, G. L., Bruno, S., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)07236-5 · Cited by 230 · see citing works
Pathogenesis and prevention of hepatitis C virus-induced hepatocellular carcinoma
Hoshida, Y., Fuchs, B. C., Bardeesy, N. M., Baumert, T. F., & Chung, R. T. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.07.010 · Cited by 229 · see citing works
Self-citationAlcohol and liver cancer: a systematic review and meta-analysis of prospective studies
Turati, F., Galeone, C., Rota, M., Pelucchi, C., Negri, E., Bagnardi, V., Corrao, G., Boffetta, P., & Vecchia, C. L. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu020 · Cited by 229 · see citing works
Teufel, A., Itzel, T., Erhart, W., Brosch, M., Wang, X. Y., Kim, Y. O., von Schönfels, W., Herrmann, A., Brückner, S., Stickel, F., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.05.051 · Cited by 229 · see citing works
Prognostic Gene Expression Signature for Patients With Hepatitis C–Related Early-Stage Cirrhosis
Hoshida, Y., Villanueva, A., Sangiovanni, A., Solé, M., Hur, C., Andersson, K. L., Chung, R. T., Gould, J., Kojima, K., Gupta, S. K., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.021 · Cited by 228 · see citing works
Self-citationAntiviral Therapy Improves Postoperative Survival in Patients With Hepatocellular Carcinoma
Huang, G., Lau, W. Y., Wang, Z., et al. (2014) · Annals of Surgery · doi:10.1097/sla.0000000000000858 · Cited by 227 · see citing works
Su, T., Hu, T., Chen, C.-Y., et al. (2016) · Liver International · doi:10.1111/liv.13253 · Cited by 225 · see citing works
Hepatic RIG-I Predicts Survival and Interferon-α Therapeutic Response in Hepatocellular Carcinoma
Hou, J., Zhou, Y., Zheng, Y., Fan, J., Zhou, W., Ng, I. O., Sun, H., Qin, L., Qiu, S., Lee, J. M. F., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.11.011 · Cited by 221 · see citing works
EGFR Signaling in Liver Diseases
Komposch, K., & Sibilia, M. C. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms17010030 · Cited by 221 · see citing works
Benvegnù, L. (1998) · Padua Research Archive (University of Padova) · Cited by 221 · see citing works
Zheng, L., Yang, W. K., Wu, F., Wang, C., Yu, L., Tang, L., Qiu, B., Li, Y., Guo, L., Wu, M.-C., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0203 · Cited by 218 · see citing works
FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans
Søberg, S., Sandholt, C. H., Jespersen, N. Z., Toft, U., Madsen, A. L., von Holstein-Rathlou, S., Grevengoed, T. J., Christensen, K. B., Bredie, W. L. P., Potthoff, M. J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.009 · Cited by 216 · see citing works
Kim, W. R., Loomba, R. S., Berg, T., Schall, R. A., Yee, L. J., Dinh, P. V., Flaherty, J. F., Martins, E. B., Therneau, T. M., Jacobson, I. M., et al. (2015) · Cancer · doi:10.1002/cncr.29537 · Cited by 212 · see citing works
Kim, J. H., Sinn, D. H., Kang, W., et al. (2016) · Hepatology · doi:10.1002/hep.28916 · Cited by 212 · see citing works
Statins and the Risk of Hepatocellular Carcinoma in Patients With Hepatitis C Virus Infection
Tsan, Y., Lee, C., Ho, W., Lin, M., Wang, J., & Chen, P. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.44.6831 · Cited by 210 · see citing works
Nakagawa, S., Wei, L., Song, W. M., Higashi, T., Ghoshal, S., Kim, R. S., Bian, C. B., Yamada, S., Sun, X., Venkatesh, A., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.11.004 · Cited by 205 · see citing works
Self-citationMinimization of hepatitis B infection by a 25-year universal vaccination program
Ni, Y., Chang, M., Wu, J., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.05.021 · Cited by 203 · see citing works
Consumption of n-3 Fatty Acids and Fish Reduces Risk of Hepatocellular Carcinoma
Sawada, N., Inoue, M., Iwasaki, M., Sasazuki, S., Shimazu, T., Yamaji, T., Takachi, R., Tanaka, Y., Mizokami, M., & Tsugane, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.02.018 · Cited by 196 · see citing works
Diagnostic accuracy of tumor markers for hepatocellular carcinoma: a systematic review
Tateishi, R., Yoshida, H., Matsuyama, Y., Mine, N., Kondo, Y., & Omata, M. (2007) · Hepatology International · doi:10.1007/s12072-007-9038-x · Cited by 195 · see citing works
Matsumoto, A., Tanaka, E., Rokuhara, A., et al. (2005) · Hepatology Research · doi:10.1016/j.hepres.2005.02.006 · Cited by 194 · see citing works
Hepatocyte autotaxin expression promotes liver fibrosis and cancer
Kaffe, E., Katsifa, A., Xylourgidis, N., Ninou, I., Ζαννίκου, Μ., Harokopos, V., Foka, P., Dimitriadis, A., Evangelou, K., Moulas, A. N., et al. (2016) · Hepatology · doi:10.1002/hep.28973 · Cited by 192 · see citing works
Kennedy, O. J., Roderick, P. J., Buchanan, R. M., Fallowfield, J. A., Hayes, P. C., & Parkes, J. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-013739 · Cited by 190 · see citing works
Lok, A. S.-F., Everhart, J. E., Wright, E. C., Bisceglie, A. M. D., Kim, H., Sterling, R. K., Everson, G. T., Lindsay, K. L., Lee, W. M., Bonkovsky, H. L., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.11.050 · Cited by 189 · see citing works
Cancer prevention research — then and now
Bode, A. M., & Dong, Z. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2646 · Cited by 188 · see citing works
Liver Damage, Inflammation, and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition
Umemura, A., Park, E. J., Taniguchi, K., Lee, J. H., Shalapour, S., Valasek, M. A., Aghajan, M., Nakagawa, H., Seki, E., Hall, M. N., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.001 · Cited by 183 · see citing works
Lim, K., Han, C. L., Dai, Y., Shen, M., & Wu, T. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0551 · Cited by 182 · see citing works
El‐Serag, H. B., Kanwal, F., Davila, J. A., Kramer, J. R., & Richardson, P. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.045 · Cited by 181 · see citing works
Goossens, N., Singal, A. G., King, L. Y., Andersson, K. L., Fuchs, B. C., Besa, C., Taouli, B. A., Chung, R. T., & Hoshida, Y. (2017) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2017.26 · Cited by 180 · see citing works
Self-citationCao, Z., Fan-Minogue, H., Bellovin, D. I., Yevtodiyenko, A., Arzeno, J., Yang, Q., Gambhir, S. S., & Felsher, D. W. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3367 · Cited by 179 · see citing works
Simon, T. G., Bonilla, H. F., Yan, P., Chung, R. T., & Butt, A. A. (2016) · Hepatology · doi:10.1002/hep.28506 · Cited by 179 · see citing works
Risk prediction of hepatocellular carcinoma in patients with cirrhosis: The ADRESS‐HCC risk model
Flemming, J. A., Yang, J. D., Vittinghoff, E., Kim, W. R., & Terrault, N. A. (2014) · Cancer · doi:10.1002/cncr.28832 · Cited by 178 · see citing works
Miki, D., Ochi, H., Hayes, C. N., Abe, H., Yoshima, T., Aikata, H., Ikeda, K., Kumada, H., Toyota, J., Morizono, T., et al. (2011) · Nature Genetics · doi:10.1038/ng.876 · Cited by 176 · see citing works
Yu, M., Lin, C., Liu, C., Yang, S.-H., Tseng, Y.-L., & Wu, C. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.07.001 · Cited by 176 · see citing works
Liu, X., Desmyter, L., Gao, C., Laroy, W., Dewaele, S., Vanhooren, V., Wang, L., Zhuang, H., Callewaert, N., Libert, C., et al. (2007) · Hepatology · doi:10.1002/hep.21855 · Cited by 174 · see citing works
Kato, J., Miyanishi, K., Kobune, M., Nakamura, T., Takada, K., Takimoto, R., Kawano, Y., Takahashi, S., Takahashi, M., Sato, Y., et al. (2007) · Journal of Gastroenterology · doi:10.1007/s00535-007-2095-z · Cited by 172 · see citing works
Gong, Q., Hu, Z., Zhang, F., Cui, A., Chen, X., Jiang, H., Gao, J., Chen, X., Han, Y., Liang, Q., et al. (2016) · Hepatology · doi:10.1002/hep.28523 · Cited by 172 · see citing works
Pocha, C., Dieperink, E. W., McMaken, K., Knott, A., THURAS, P. D., & Ho, S. B. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12370 · Cited by 171 · see citing works
Cho, J., Paik, Y., Sohn, W., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-306409 · Cited by 171 · see citing works
Freedman, N. D., Cross, A. J., McGlynn, K. A., Abnet, C. C., Park, Y., Hollenbeck, A. R., Schatzkin, A. G., Everhart, J., & Sinha, R. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djq301 · Cited by 169 · see citing works
Inhibition of Autophagy Enhances Anticancer Effects of Atorvastatin in Digestive Malignancies
Yang, P., Liu, Y.-L., Lin, Y.-C., Shun, C., Wu, M., & Chen, C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1626 · Cited by 155 · see citing works
Matsuura, K., Sawai, H., Ikeo, K., Ogawa, S., Iio, E., Isogawa, M., Shimada, N., Komori, A., Toyoda, H., Kumada, T., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.041 · Cited by 154 · see citing works
Ji, J., Eggert, T., Budhu, A., Forgues, M., Takai, A., Dang, H. T., Ye, Q., Lee, J., Kim, J. H., Greten, T. F., et al. (2015) · Hepatology · doi:10.1002/hep.27822 · Cited by 151 · see citing works
Hepatitis C Disease Burden in the United States in the era of oral direct‐acting antivirals
Chhatwal, J., Wang, X., Ayer, T., Kabiri, M., Chung, R. T., Hur, C., Donohue, J. M., Roberts, M. S., & Kanwal, F. (2016) · Hepatology · doi:10.1002/hep.28571 · Cited by 149 · see citing works
Zheng, C., Zeng, H., Lin, H., Wang, J., Feng, X., Qiu, Z., Chen, J., Luo, J., Luo, Y., Huang, Y., et al. (2017) · Hepatology · doi:10.1002/hep.29310 · Cited by 149 · see citing works
Hepatitis C-related hepatocellular carcinoma in the era of new generation antivirals
Baumert, T. F., Jühling, F., Ono, A., & Hoshida, Y. (2017) · BMC Medicine · doi:10.1186/s12916-017-0815-7 · Cited by 146 · see citing works
Self-citationWeylandt, K. H., Krause, L. F., Gomolka, B., et al. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr049 · Cited by 145 · see citing works
Mittal, S., Kanwal, F., Ying, J., Chung, R., Sada, Y. H., Temple, S., Davila, J. A., & El‐Serag, H. B. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.07.025 · Cited by 145 · see citing works
Besa, C., Lewis, S. C., Pandharipande, P. V., Chhatwal, J., Kamath, A., Cooper, N., Knight‐Greenfield, A., Babb, J. S., Boffetta, P., Padrón, N. A., et al. (2016) · Abdominal Radiology · doi:10.1007/s00261-016-0841-5 · Cited by 144 · see citing works
Yang, Y., Zhao, W., Zhong, Y. ‐., Xia, H., Shen, L., & Zhang, N. (2009) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2009.01070.x · Cited by 141 · see citing works
Kim, M. N., Kim, S. U., Kim, B. K., et al. (2015) · Hepatology · doi:10.1002/hep.27735 · Cited by 140 · see citing works
Tsochatzis, E. A., Bruno, S., Isgrò, G., Hall, A. R., Theocharidou, E., Manousou, P., Dhillon, A. P., Burroughs, A. K., & Luong, T. V. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.12.023 · Cited by 140 · see citing works
Dayyeh, B. K. A., YANG, M. H., Fuchs, B. C., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.03.045 · Cited by 140 · see citing works
Hassan, M. M., Botrus, G., Abdel‐Wahab, R., Wolff, R. A., Li, D., Tweardy, D. J., Phan, A. T., Hawk, E. T., Javle, M. M., Lee, J., et al. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.05.036 · Cited by 140 · see citing works
Evaluation of Midkine as a Diagnostic Serum Biomarker in Hepatocellular Carcinoma
Zhu, W., Guo, J., Guo, L., Jia, H., Zhu, M., Zhang, J., Loffredo, C. A., Forgues, M., Huang, H., Xing, X.-J., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3363 · Cited by 137 · see citing works
Poggio, P. D., Olmi, S., Ciccarese, F., Marco, M. D., Rapaccini, G. L., Benvegnù, L., Borzio, F., Farinati, F., Zoli, M., Giannini, E. G., et al. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.02.025 · Cited by 133 · see citing works
Liver Iron, HFE Gene Mutations, and Hepatocellular Carcinoma Occurrence in Patients With Cirrhosis
Nahon, P., Sutton, A., Rufat, P., Ziol, M., Thabut, G., Schischmanoff, P. O., Vidaud, D., Charnaux, N., Couvert, P., Ganne‐Carrié, N., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.10.038 · Cited by 133 · see citing works
Mouse models of acute and chronic hepacivirus infection
Billerbeck, E., Wolfisberg, R., Fahnøe, U., et al. (2017) · Science · doi:10.1126/science.aal1962 · Cited by 133 · see citing works
Singal, A. G., Mittal, S., Yerokun, O. A., Ahn, C. W., Marrero, J. A., Yopp, A. C., Parikh, N. D., & Scaglione, S. (2017) · The American Journal of Medicine · doi:10.1016/j.amjmed.2017.01.021 · Cited by 132 · see citing works
Moreno, M., Gonzalo, T., Kok, R. J., Sancho‐Bru, P., van Beuge, M. M., Swart, J., Prakash, J., Temming, K., Fondevila, C., Beljaars, L., et al. (2009) · Hepatology · doi:10.1002/hep.23419 · Cited by 131 · see citing works
Ikeda, M., Fujiyama, S., Tanaka, M., et al. (2005) · Journal of Gastroenterology · doi:10.1007/s00535-004-1519-2 · Cited by 131 · see citing works
Chang, F., Wang, Y., Lang, H., et al. (2017) · Hepatology · doi:10.1002/hep.29172 · Cited by 130 · see citing works
Precancer Atlas to Drive Precision Prevention Trials
Spira, A. E., Yurgelun, M. B., Alexandrov, L. B., Rao, A., Bejar, R., Polyák, K., Giannakis, M., Shilatifard, A., Finn, O. J., Dhodapkar, M., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2346 · Cited by 130 · see citing works
Zhang, D. Y., Goossens, N., Guo, J., Tsai, M., Chou, H.-I., Altunkaynak, C., Sangiovanni, A., Iavarone, M. A., Colombo, M., Kobayashi, M., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-309655 · Cited by 129 · see citing works
Self-citationYang, Y., Zhang, D., Feng, N., Chen, G., Liu, J., Chen, G., & Zhu, Y. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.08.005 · Cited by 129 · see citing works
Oakley, F., Teoh, V. W. Y., Ching-A-Sue, G., Bataller, R. A., Colmenero, J., Jonsson, J. R., Eliopoulos, A. G., Watson, M. R., Manas, D., & Mann, D. A. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.081 · Cited by 127 · see citing works
Guyot, E., Sutton, A., Rufat, P., Laguillier, C., Mansouri, A., Moreau, R., Ganne‐Carrié, N., Beaugrand, M., Charnaux, N., Trinchet, J., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.09.036 · Cited by 126 · see citing works
Song, P. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i1.262 · Cited by 126 · see citing works
Cadier, B., Bulsei, J., Nahon, P., Séror, O., Laurent, A., Rosa, I., Layese, R., Costentin, C. E., Cagnot, C., Durand‐Zaleski, I., et al. (2017) · Hepatology · doi:10.1002/hep.28961 · Cited by 125 · see citing works
Suh, B., Park, S., Shin, D. W., Yun, J. M., Yang, H., Yu, S. J., Shin, C., Kim, J., Ahn, E., Lee, H., et al. (2014) · Hepatology · doi:10.1002/hep.27654 · Cited by 121 · see citing works
Wen, C.-P., Lin, J. M., Yang, Y. C., Tsai, M. K., Tsao, C. K., Etzel, C. J., Huang, M., Hsu, C. Y., Ye, Y., Mishra, L., et al. (2012) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djs372 · Cited by 120 · see citing works
Wang, W., Zhao, C., Zhou, J., Zhen, Z., Wang, Y., & Shen, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076538 · Cited by 117 · see citing works
Chen, H., Cai, W., Chu, E. S., Tang, J. T., Wong, C.-C., Wong, S. H., Sun, W., Liang, Q., Fang, J., Sun, Z., et al. (2017) · Oncogene · doi:10.1038/onc.2017.73 · Cited by 115 · see citing works
Statin use is associated with a reduced risk of fibrosis progression in chronic hepatitis C
Simon, T. G., King, L. Y., Zheng, H. W., & Chung, R. T. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.08.013 · Cited by 114 · see citing works
Kim, J. H., Sohn, B. H., Lee, H., Kim, S.-B., Yoo, J. E., Park, Y., Jeong, W., Lee, S. S., Park, E. S., Kaseb, A. O., et al. (2014) · PLoS Medicine · doi:10.1371/journal.pmed.1001770 · Cited by 112 · see citing works
Zhou, X., Chen, J., Gao, Y., Deng, M., Liu, H., Liang, M., Shi, B., Fu, X., Chen, Y., Chen, L., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6418 · Cited by 109 · see citing works
Fedirko, V., Duarte‐Salles, T., Bamia, C., Trichopoulou, A., Aleksandrova, K., Trichopoulos, D., Trépo, E., Tjønneland, A. M., Olsen, A., Overvad, K., et al. (2014) · Hepatology · doi:10.1002/hep.27079 · Cited by 108 · see citing works
Gender disparity in hepatocellular carcinoma (HCC): multiple underlying mechanisms
Zheng, B. J., Zhu, Y., Wang, H., et al. (2017) · Science China Life Sciences · doi:10.1007/s11427-016-9043-9 · Cited by 108 · see citing works
Vitamin D3 Upregulated Protein 1 Suppresses TNF-α–Induced NF-κB Activation in Hepatocarcinogenesis
Kwon, H., Won, Y., Suh, H., Jeon, J.-H., Shao, Y. X., Yoon, S. R., Chung, J.-W., Kim, T., Kim, H., Nam, K., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000990 · Cited by 106 · see citing works
Chu, Y., Yang, H., Wu, H., et al. (2017) · International Journal of Cancer · doi:10.1002/ijc.30782 · Cited by 106 · see citing works
Bruix, J., Poynard, T., Colombo, M., Schiff, E. R., Burak, K. W., Heathcote, E. J., Berg, T., Poo, J., Mello, C., Guenther, R. K., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.03.010 · Cited by 105 · see citing works
Kawaguchi, T., Shiraishi, K., Ito, T., et al. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.08.050 · Cited by 104 · see citing works
Molecular classification of hepatocellular carcinoma: potential therapeutic implications
Goossens, N., Sun, X., & Hoshida, Y. (2015) · Hepatic Oncology · doi:10.2217/hep.15.26 · Cited by 104 · see citing works
Self-citationThe oncologic burden of hepatitis C virus infection: A clinical perspective
Torres, H. A., Shigle, T. L., Hammoudi, N., Link, J. T., Samaniego, F., Kaseb, A. O., & Mallet, V. O. (2017) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21403 · Cited by 104 · see citing works
Assessment of Fibrosis and Cirrhosis in Liver Biopsies: An Update
Germani, G., Hytiroglou, P., Fotiadu, A., Burroughs, A. K., & Dhillon, A. P. (2011) · Seminars in Liver Disease · doi:10.1055/s-0031-1272836 · Cited by 103 · see citing works
Marcolongo, M., Young, B. A., Pero, F. D., Fattovich, G., Peraro, L., Guido, M., Sebastiani, G., Palù, G., & Alberti, A. (2009) · Hepatology · doi:10.1002/hep.23111 · Cited by 102 · see citing works
Lee, J. H., Kang, Y. E., Chang, J. Y., Park, K. C., Kim, H.-W., Kim, J. T., Kim, H. J., Yi, H., Shong, M., Chung, H. K., et al. (2016) · PubMed Central · Cited by 101 · see citing works
Heckley, G., Jarl, J., Asamoah, B. O., & Gerdtham, U. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-446 · Cited by 100 · see citing works
Singal, A. G., Tiro, J. A., Marrero, J. A., McCallister, K., Mejias, C. A., Adamson, B., Bishop, W. P., Santini, N. O., & Halm, E. A. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.10.042 · Cited by 100 · see citing works
Mazziotti, G., Sorvillo, F., Morisco, F., Carbone, A., Rotondi, M., Stornaiuolo, G., Precone, D. F., Cioffi, M., Gaeta, G. B., Caporaso, N., et al. (2002) · Cancer · doi:10.1002/cncr.11002 · Cited by 99 · see citing works
Chong, L., Hsu, Y., Lee, T., et al. (2015) · BMC Gastroenterology · doi:10.1186/s12876-015-0248-8 · Cited by 99 · see citing works
Zheng, F., Liao, Y.-J., Cai, M.-Y., Liu, T.-H., Chen, S.-P., Wu, P., Wu, L., Bian, X., Guan, X., Zeng, Y.-X., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1004873 · Cited by 98 · see citing works
Chang, K.-C., Hung, C., Lu, S.-N., et al. (2012) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dks269 · Cited by 97 · see citing works
Bamia, C., Λάγιου, Π., Jenab, M., Trichopoulou, A., Fedirko, V., Aleksandrova, K., Pischon, T., Overvad, K., Olsen, A., Tjønneland, A. M., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.29214 · Cited by 95 · see citing works
Aleksandrova, K., Bamia, C., Drogan, D., Λάγιου, Π., Trichopoulou, A., Jenab, M., Fedirko, V., Romieu, I., Bueno-de-Mesquita, H. B., Pischon, T., et al. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.116095 · Cited by 93 · see citing works
Petrick, J. L., Sahasrabuddhe, V. V., Chan, A. T., Alavanja, M. C. R., Freeman, L. E. B., Buring, J. E., Chen, J., Chong, D. Q., Freedman, N. D., Fuchs, C. S., et al. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-15-0126 · Cited by 93 · see citing works
Ganne‐Carrié, N., Layese, R., Bourcier, V., Cagnot, C., Marcellin, P., Guyader, D., Pol, S., Larrey, D. G., de Lédinghen, V., Ouzan, D., et al. (2016) · Hepatology · doi:10.1002/hep.28702 · Cited by 93 · see citing works
Molecular cancer prevention: Current status and future directions
Maresso, K. C., Tsai, K. Y., Brown, P. H., Szabo, E. M., Lippman, S. M., & Hawk, E. T. (2015) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21287 · Cited by 92 · see citing works
Roudier, E. A., Mistafa, O., & Stenius, U. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0352 · Cited by 92 · see citing works
Lee, T., Wu, J., Yu, S., Lin, J., Wu, M., & Wu, C. (2017) · International Journal of Cancer · doi:10.1002/ijc.30784 · Cited by 92 · see citing works
Yoshiji, H., Noguchi, R., Toyohara, M., Ikenaka, Y., Kitade, M., Kaji, K., Yamazaki, M., Yamao, J., Mitoro, A., Sawai, M., et al. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.04.011 · Cited by 91 · see citing works
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- [237]Burra P Rodriguez-Castro KI Neoplastic disease after liver transplantation: Focus on de novo neoplasms World J Gastroenterol 2015 21 8753 68 26269665 PMC4528018
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Tacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., Zelber-Sagi, S., Valenti, L., Roden, M., Schick, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.04.031 · Cited by 2,210 · see citing works
Hepatocellular carcinoma in the setting of alcohol-related liver disease
Ganne-Carrié, N., & Nahon, P. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.10.008 · Cited by 360 · see citing works
Epigenetics in hepatocellular carcinoma development and therapy: The tip of the iceberg
Fernández-Barrena, M. G., Arechederra, M., Colyn, L., Berasain, C., & Avila, M. A. (2020) · JHEP Reports · doi:10.1016/j.jhepr.2020.100167 · Cited by 126 · see citing works
Moeini, A., Torrecilla, S., Tovar, V., Montironi, C., Andreu-Oller, C., Peix, J., Higuera, M., Pfister, D., Ramadori, P., Pinyol, R., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.07.028 · Cited by 92 · see citing works
Self-citationLuu, H. N., Behari, J., Goh, G. B.-B., Wang, R., Jin, A., Thomas, C. E., Clemente, J. C., Odegaard, A. O., Koh, W.-P., & Yuan, J.-M. (2021) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-20-1201 · Cited by 33 · see citing works
Authors, & Collaborators: (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1880-2388 · Cited by 30 · see citing works
- Authors
- Fujiwara, N., Friedman, S. L., Goossens, N., & Hoshida, Y.
- Affiliations
- Tisch Cancer Institute (US)
- University Hospital of Geneva (CH)
- Corresponding author
- Hoshida, Yujin
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 68
- Issue
- 3
- Pages
- 526-549
- ISSN
- 0168-8278 (ISSN-L)
- PMC
- PMC5818315
- OpenAlex
- W2763700772
- Cited by
- 659
- References
- 311
- Citations by year
- 2026: 20 · 2025: 44 · 2024: 70 · 2023: 97 · 2022: 133 · 2021: 125 · 2020: 91 · 2019: 51 · 2018: 28
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Hepatology (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK56621)
- Irma T. Hirschl Trust
- U.S. Department of Defense (W81XWH-16-1-0363, R01 DK099558, W81XWH-16-1-0455)
- European Commission
- Uehara Memorial Foundation
- Topics
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- hepatocellular carcinoma, HCC risk factors, HCC screening, precision medicine, HCC risk scores, chronic liver disease, chronic hepatitis C, HCC recurrence, alpha-fetoprotein, statins, antidiabetic drugs, targeted therapy
- MeSH terms
- Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Prognosis, Risk Factors, Precision Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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