Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: analysis of data from a phase II trial of selonsertib
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BACKGROUND & AIMS: Non-invasive tools for monitoring treatment response and disease progression in non-alcoholic steatohepatitis (NASH) are needed. Our objective was to evaluate the utility of magnetic resonance (MR)-based hepatic imaging measures for the assessment of liver histology in patients with NASH. METHODS: We analyzed data from patients with NASH and stage 2 or 3 fibrosis enrolled in a phase II study of selonsertib. Pre- and post-treatment assessments included centrally read MR elastography (MRE)-estimated liver stiffness, MR imaging-estimated proton density fat fraction (MRI-PDFF), and liver biopsies evaluated according to the NASH Clinical Research Network classification and the non-alcoholic fatty liver disease activity score (NAS). RESULTS: Among 54 patients with MRE and biopsies at baseline and week 24, 18 (33%) had fibrosis improvement (≥1-stage reduction) after undergoing 24 weeks of treatment with the study drug. The area under the receiver operating characteristic curve (AUROC) of MRE-stiffness to predict fibrosis improvement was 0.62 (95% CI 0.46-0.78) and the optimal threshold was a ≥0% relative reduction. At this threshold, MRE had 67% sensitivity, 64% specificity, 48% positive predictive value, 79% negative predictive value. Among 65 patients with MRI-PDFF and biopsies at baseline and week 24, a ≥1-grade reduction in steatosis was observed in 18 (28%). The AUROC of MRI-PDFF to predict steatosis response was 0.70 (95% CI 0.57-0.83) and the optimal threshold was a ≥0% relative reduction. At this threshold, MRI-PDFF had 89% sensitivity and 47% specificity, 39% positive predictive value, and 92% negative predictive value. CONCLUSIONS: These preliminary data support the further evaluation of MRE-stiffness and MRI-PDFF for the longitudinal assessment of histologic response in patients with NASH. LAY SUMMARY: Liver biopsy is a potentially painful and risky method to assess damage to the liver due to non-alcoholic steatohepatitis (NASH). We analyzed data from a clinical trial to determine if 2 methods of magnetic resonance imaging - 1 to measure liver fat and 1 to measure liver fibrosis (scarring) - could potentially replace liver biopsy in evaluating NASH-related liver injury. Both imaging methods were correlated with biopsy in showing the effects of NASH on the liver.
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The prediction of fibrosis regression by MRI-PDFF reduction was not unanimously confirmed.
“though this was not unanimously con fi rmed. 269,270”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [269]
In the selonsertib phase II trial, changes in MRE over time were not significantly different between histological responders and non-responders.
“MRE has been proposed as an alternative to VCTE, but despite numerical differences, changes in MRE over time were not signi fi cantly different between histological responders and non-responders in the selonsertib phase II trial. 269”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [269]
Cites
Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791 · see citing works
Younossi, Z. M., Koenig, A. B., Abdelatif, D., Fazel, Y., Henry, L., & Wymer, M. (2016) · Hepatology · doi:10.1002/hep.28431 · Cited by 10,781 · see citing works
Chalasani, N., Younossi, Z., Lavine, J. E., Charlton, M., Cusi, K., Rinella, M., Harrison, S. A., Brunt, E. M., & Sanyal, A. J. (2018) · Hepatology · doi:10.1002/hep.29367 · Cited by 7,239 · see citing works
Self-citationChalasani, N., Younossi, Z. M., Lavine, J. E., Diehl, A. M., Brunt, E. M., Cusi, K. J., Charlton, M., & Sanyal, A. J. (2012) · Hepatology · doi:10.1002/hep.25762 · Cited by 3,805 · see citing works
Self-citationAngulo, P., Kleiner, D. E., Dam-Larsen, S., Adams, L. A., Bjornsson, E. S., Charatcharoenwitthaya, P., Mills, P. R., Keach, J. C., Lafferty, H. D., Stahler, A., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.043 · Cited by 2,987 · see citing works
Ekstedt, M., Hagström, H., Nasr, P., Fredrikson, M., Stål, P., Kechagias, S., & Hultcrantz, R. (2015) · Hepatology · doi:10.1002/hep.27368 · Cited by 2,287 · see citing works
Sampling Variability of Liver Biopsy in Nonalcoholic Fatty Liver Disease
Ratziu, V., Charlotte, F., Heurtier, A., Gombert, S., Giral, P., Bruckert, E., Grimaldi, A., Capron, F., & Poynard, T. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.084 · Cited by 2,106 · see citing works
Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Regev, A., Berho, M. E., Jeffers, L. J., Milikowski, C., Molina, E. G., Pyrsopoulos, N., Feng, Z.-Z., Reddy, K. R., & Schiff, E. R. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.06038.x · Cited by 2,078 · see citing works
Dulai, P. S., Singh, S., Patel, J., Soni, M., Prokop, L. J., Younossi, Z., Sebastiani, G., Ekstedt, M., Hagstrom, H., Nasr, P., et al. (2017) · Hepatology · doi:10.1002/hep.29085 · Cited by 1,965 · see citing works
Self-citationLoomba, R. S., & Sanyal, A. J. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.171 · Cited by 1,696 · see citing works
Self-citationGuha, I. N., Parkes, J., Roderick, P. J., Chattopadhyay, D., Cross, R., Harris, S., Kaye, P., Burt, A. D., Ryder, S. D., Aithal, G. P., et al. (2007) · Hepatology · doi:10.1002/hep.21984 · Cited by 744 · see citing works
Park, C. C., Nguyen, P., Hernandez, C., Bettencourt, R., Ramirez, K., Fortney, L., Hooker, J. C., Sy, E. Z., Savides, M. T., Alquiraish, M. H., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.10.026 · Cited by 715 · see citing works
Self-citationNoureddin, M., Lam, J., Peterson, M. R., Middleton, M., Hamilton, G., Le, T.-A., Bettencourt, R., Changchien, C., Brenner, D. A., Sirlin, C., et al. (2013) · Hepatology · doi:10.1002/hep.26455 · Cited by 550 · see citing works
Self-citationSingh, S., Venkatesh, S. K., Wang, Z., Miller, F. H., Motosugi, U., Low, R. N., Hassanein, T., Asbach, P., Godfrey, E. M., Yin, M., et al. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.09.046 · Cited by 549 · see citing works
Loomba, R., Lawitz, E., Mantry, P. S., Jayakumar, S., Caldwell, S. H., Arnold, H., Diehl, A. M., Djedjos, C. S., Han, L., Myers, R. P., et al. (2018) · Hepatology · doi:10.1002/hep.29514 · Cited by 549 · see citing works
Self-citationLoomba, R. S., Wolfson, T. J., Ang, B., Hooker, J. C., Behling, C. A., Peterson, M. R., Valasek, M. A., Lin, G., Brenner, D. A., Gamst, A. C., et al. (2014) · Hepatology · doi:10.1002/hep.27362 · Cited by 489 · see citing works
Self-citationSeeff, L. B., Everson, G. T., Morgan, T. R. M., Curto, T. M., Lee, W. M., Ghany, M. G., Shiffman, M. L., Fontana, R. J., Bisceglie, A. M. D., Bonkovsky, H. L., et al. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2010.03.025 · Cited by 472 · see citing works
Use of Liver Imaging and Biopsy in Clinical Practice
Tapper, E. B., & Lok, A. S.-F. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1610570 · Cited by 452 · see citing works
Dulai, P. S., Sirlin, C. B., & Loomba, R. S. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.06.005 · Cited by 357 · see citing works
Self-citationPoynard, T., Imbert‐Bismut, F., Munteanu, M., Messous, D., Myers, R. P., Thabut, D., Ratziu, V., Mercadier, A., Benhamou, Y., & Hainque, B. (2004) · Comparative Hepatology · doi:10.1186/1476-5926-3-8 · Cited by 355 · see citing works
Self-citationLoomba, R. S., Sirlin, C. B., Ang, B., Bettencourt, R., Jain, R., Salotti, J., Soaft, L., Hooker, J. C., Kono, Y., Bhatt, A., et al. (2014) · Hepatology · doi:10.1002/hep.27647 · Cited by 346 · see citing works
Self-citationYokoo, T., Serai, S. D., Pirasteh, A., Bashir, M. R., Hamilton, G., Hernando, D., Hu, P., Hetterich, H., Kühn, J., Kukuk, G. M., et al. (2017) · Radiology · doi:10.1148/radiol.2017170550 · Cited by 338 · see citing works
Self-citationMiddleton, M. S., Heba, E. R., Hooker, C. A., Bashir, M. R., Fowler, K. J., Sandrasegaran, K., Brunt, E. M., Kleiner, D. E., Doo, E. C., Natta, M. L. V., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.06.005 · Cited by 278 · see citing works
Self-citationSingh, S., Venkatesh, S. K., Loomba, R. S., Wang, Z., Sirlin, C. B., Chen, J., Yin, M., Miller, F. H., Low, R. N., Hassanein, T., et al. (2015) · European Radiology · doi:10.1007/s00330-015-3949-z · Cited by 252 · see citing works
Self-citationPatel, J. R., Bettencourt, R., Cui, J. Y., Salotti, J., Hooker, J. C., Bhatt, A., Hernandez, C., Nguyen, P., Aryafar, H., Valasek, M. A., et al. (2016) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x16656735 · Cited by 163 · see citing works
Self-citationMiddleton, M. S., Natta, M. L. V., Heba, E. R., Alazraki, A. L., Trout, A. T., Masand, P. M., Brunt, E. M., Kleiner, D. E., Doo, E. C., Tonascia, J. A., et al. (2017) · Hepatology · doi:10.1002/hep.29596 · Cited by 161 · see citing works
Self-citationRepeatability of MR Elastography of Liver: A Meta-Analysis
Serai, S. D., Obuchowski, N. A., Venkatesh, S. K., Sirlin, C. B., Miller, F. H., Ashton, E. A., Cole, P. E., & Ehman, R. L. (2017) · Radiology · doi:10.1148/radiol.2017161398 · Cited by 136 · see citing works
Self-citationPoynard, T., Naour, G. L., Vaillant, J. C., Capron, F., Munteanu, M., Eyraud, D., Ngo, Y., M’Kada, H., Ratziu, V., Hannoun, L., et al. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.01.023 · Cited by 111 · see citing works
Silva, A. M., Grimm, R. C., Glaser, K. J., Wu, T., Wu, T., Ehman, R. L., & Silva, A. C. (2015) · Abdominal Imaging · doi:10.1007/s00261-015-0372-5 · Cited by 67 · see citing works
Heba, E. R., Desai, A. S., Zand, K. A., Hamilton, G., Wolfson, T. J., Schlein, A. N., Gamst, A. C., Loomba, R. S., Sirlin, C. B., & Middleton, M. S. (2015) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25006 · Cited by 60 · see citing works
Self-citationZand, K. A., Shah, A., Heba, E. R., Wolfson, T. J., Hamilton, G., Lam, J., Chen, J., Hooker, J. C., Gamst, A. C., Middleton, M. S., et al. (2015) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24888 · Cited by 28 · see citing works
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Tacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., Zelber-Sagi, S., Valenti, L., Roden, M., Schick, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.04.031 · Cited by 2,210 · see citing works
Berzigotti, A., Tsochatzis, E., Boursier, J., Castera, L., Cazzagon, N., Friedrich-Rust, M., Petta, S., & Thiele, M. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.05.025 · Cited by 1,925 · see citing works
Noninvasive assessment of liver disease in patients with nonalcoholic fatty liver disease
Castera, L., Friedrich-Rust, M., & Loomba, R. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.12.036 · Cited by 1,494 · see citing works
Self-citation(2024) · Obesity Facts · doi:10.1159/000539371 · Cited by 510 · see citing works
Lee, J., Vali, Y., Boursier, J., Spijker, R., Anstee, Q. M., Bossuyt, P. M., & Zafarmand, M. H. (2020) · Liver International · doi:10.1111/liv.14669 · Cited by 385 · see citing works
Advances in non-invasive assessment of hepatic fibrosis
Loomba, R. S., & Adams, L. A. (2020) · Gut · doi:10.1136/gutjnl-2018-317593 · Cited by 351 · see citing works
Self-citationPatel, K., Harrison, S. A., Elkhashab, M., Trotter, J. F., Herring, R., Rojter, S. E., Kayali, Z., Wong, V. W., Greenbloom, S., Jayakumar, S., et al. (2020) · Hepatology · doi:10.1002/hep.31205 · Cited by 347 · see citing works
Self-citationLimitations of non-invasive tests for assessment of liver fibrosis
Patel, K., & Sebastiani, G. (2020) · JHEP Reports · doi:10.1016/j.jhepr.2020.100067 · Cited by 323 · see citing works
Quantification of liver fat content with CT and MRI: state of the art
Starekova, J., Hernando, D., Pickhardt, P. J., & Reeder, S. B. (2021) · Radiology · doi:10.1148/radiol.2021204288 · Cited by 320 · see citing works
Stine, J. G., Munaganuru, N., Barnard, A., Wang, J. L., Kaulback, K., Argo, C. K., Singh, S., Fowler, K. J., Sirlin, C. B., & Loomba, R. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.08.061 · Cited by 283 · see citing works
Self-citationNon-invasive methods for imaging hepatic steatosis and their clinical importance in NAFLD
Tamaki, N., Ajmera, V. H., & Loomba, R. S. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00584-0 · Cited by 254 · see citing works
Self-citationNoninvasive evaluation of nonalcoholic fatty liver disease: Current evidence and practice
Zhou, J., Cai, J., She, Z., & Li, H. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i11.1307 · Cited by 248 · see citing works
Sterling, R. K., Duarte‐Rojo, A., Patel, K., Asrani, S. K., Alsawas, M., Dranoff, J. A., Fiel, M. I., Murad, M. H., Leung, D. H., Levine, D., et al. (2024) · Hepatology · doi:10.1097/hep.0000000000000843 · Cited by 232 · see citing works
Flint, A., Andersen, G., Hockings, P., Johansson, L., Morsing, A., Sundby Palle, M., Vogl, T., Loomba, R., & Plum‐Mörschel, L. (2021) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16608 · Cited by 224 · see citing works
Self-citationLoomba, R., Mohseni, R., Lucas, K. J., Gutierrez, J. A., Perry, R. G., Trotter, J. F., Rahimi, R. S., Harrison, S. A., Ajmera, V., Wayne, J. D., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.07.025 · Cited by 220 · see citing works
Self-citationImaging biomarkers of NAFLD, NASH, and fibrosis
Ajmera, V. H., & Loomba, R. S. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101167 · Cited by 214 · see citing works
Self-citationNakajima, A., Eguchi, Y., Yoneda, M., Imajo, K., Tamaki, N., Suganami, H., Nojima, T., Tanigawa, R., Iizuka, M., Iida, Y., et al. (2021) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16596 · Cited by 213 · see citing works
Self-citationFeng, G., Valenti, L. V. C., Wong, V. W., Fouad, Y. M., Yilmaz, Y. N., Kim, W. K., Sebastiani, G., Younossi, Z. M., Hernández–Gea, V., & Zheng, M. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00846-4 · Cited by 202 · see citing works
Multicenter Validation of Association Between Decline in MRI‐PDFF and Histologic Response in NASH
Loomba, R. S., Neuschwander‐Tetri, B. A., Sanyal, A. J., Chalasani, N., Diehl, A. M., Terrault, N. A., Kowdley, K. V., Dasarathy, S., Kleiner, D. E., Behling, C. A., et al. (2020) · Hepatology · doi:10.1002/hep.31121 · Cited by 151 · see citing works
Self-citationAjmera, V. H., Kim, B. K., Yang, K. Y., Majzoub, A. M., Nayfeh, T., Tamaki, N., Izumi, N., Nakajima, A., Idılman, R., Gümüşsoy, M., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.06.073 · Cited by 139 · see citing works
Self-citationTamaki, N., Munaganuru, N., Jung, J., Yonan, A. Q., Loomba, R. R., Bettencourt, R., Ajmera, V., Valasek, M. A., Behling, C., Sirlin, C. B., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-324264 · Cited by 130 · see citing works
Self-citationEDP-305 in patients with NASH: a phase II double-blind placebo-controlled dose-ranging study
Ratziu, V., Rinella, M. E., Neuschwander-Tetri, B. A., Lawitz, E., Denham, D., Kayali, Z., Sheikh, A., Kowdley, K. V., Desta, T., Elkhashab, M., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2021.10.018 · Cited by 123 · see citing works
Self-citationRecent Epidemiology of Nonalcoholic Fatty Liver Disease
Murag, S., Ahmed, A., & Kim, D. (2020) · Gut and Liver · doi:10.5009/gnl20127 · Cited by 121 · see citing works
MR elastography of liver: current status and future perspectives
İdilman, İ. S., Li, J., Yin, M., & Venkatesh, S. K. (2020) · Abdominal Radiology · doi:10.1007/s00261-020-02656-7 · Cited by 104 · see citing works
Duseja, A. K., Singh, S. P., De, A., Madan, K., Rao, P. N., Shukla, A., Choudhuri, G., Saigal, S., Shalimar, S., Arora, A., et al. (2022) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2022.11.014 · Cited by 105 · see citing works
Roeb, E., Canbay, A. E., Tacke, F., Bantel, H., Bojunga, J., de Laffolie, J., Demir, M., Denzer, U. W., Geier, A., Hofmann, W. P., et al. (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1880-2283 · Cited by 102 · see citing works
Aspirin for Metabolic Dysfunction–Associated Steatotic Liver Disease Without Cirrhosis
Simon, T. G., Wilechansky, R. M., Stoyanova, S., Grossman, A., Dichtel, L. E., Lauer, G. M., Miller, K. K., Hoshida, Y., Corey, K. E., Loomba, R. S., et al. (2024) · JAMA · doi:10.1001/jama.2024.1215 · Cited by 96 · see citing works
Self-citationKazierad, D. J., Chidsey, K., Somayaji, V. R., Bergman, A. J., Birnbaum, M. J., & Calle, R. A. (2021) · Med · doi:10.1016/j.medj.2021.04.007 · Cited by 86 · see citing works
Ajmera, V. H., Liu, A., Singh, S., Yachoa, G., Ramey, M., Bhargava, M., Zamani, A., Lopez, S. J., Mangla, N., Bettencourt, R., et al. (2019) · Hepatology · doi:10.1002/hep.30974 · Cited by 84 · see citing works
Self-citationNASH drug treatment development: challenges and lessons
Tilg, H., Byrne, C. D., & Targher, G. (2023) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(23)00159-0 · Cited by 81 · see citing works
Long, M. T., Gandhi, S., & Loomba, R. S. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154259 · Cited by 79 · see citing works
Self-citationQu, Y., Li, M., Hamilton, G., Zhang, Y. N., & Song, B. (2019) · European Radiology · doi:10.1007/s00330-019-06071-5 · Cited by 77 · see citing works
Han, M. A. T., Vipani, A., Noureddin, N., Ramirez, K., GORNBEIN, J. A., Saouaf, R., Baniesh, N., Cummings-John, O. D., Okubote, T. C., Setiawan, V. W., et al. (2020) · Liver International · doi:10.1111/liv.14593 · Cited by 75 · see citing works
Self-citationTargeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis
Amin, N. B., Carvajal‐Gonzalez, S., Purkal, J. J., Zhu, T., Crowley, C., Perez, S., Chidsey, K., Kim, A. M., & Goodwin, B. J. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav9701 · Cited by 75 · see citing works
Lee, B., Lee, Y., Park, C., Rhee, E., Lee, W., Kim, N. H., Choi, K. M., Park, K., Choi, Y., Soo, B., et al. (2020) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2020.0010 · Cited by 77 · see citing works
Lonardo, A., Mantovani, A., Targher, G., & Baffy, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113320 · Cited by 75 · see citing works
Liver fat quantification: where do we stand?
Starekova, J., & Reeder, S. B. (2020) · Abdominal Radiology · doi:10.1007/s00261-020-02783-1 · Cited by 72 · see citing works
Sumida, Y., Yoneda, M., Tokushige, K., Kawanaka, M., Fujii, H., Yoneda, M., Imajo, K., Takahashi, H., Eguchi, Y., Ono, M., et al. (2021) · Life · doi:10.3390/life11020143 · Cited by 70 · see citing works
Kim, M. N., Han, J. W., An, J., Kim, B. K., Jin, Y., Kim, S., Lee, M., Lee, H. A., Cho, Y., Kim, H. Y., et al. (2024) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0506 · Cited by 62 · see citing works
Bril, F., Barb, D., Lomonaco, R., Lai, J., & Cusi, K. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2019.09.018 · Cited by 55 · see citing works
Jang, W., & Song, J. S. (2023) · Diagnostics · doi:10.3390/diagnostics13111852 · Cited by 55 · see citing works
Drugs for Non-alcoholic Steatohepatitis (NASH): Quest for the Holy Grail
Sharma, M., Premkumar, M., Kulkarni, A. V., Kumar, P., Reddy, D. N., & Rao, N. P. (2020) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2020.00055 · Cited by 55 · see citing works
Kupčová, V., Fedelešová, M., Bulas, J., Kozmonová, P., & Turecký, L. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16193570 · Cited by 55 · see citing works
Imajo, K., Tetlow, L. A., Dennis, A., Shumbayawonda, E., Mouchti, S., Kendall, T. J., Fryer, E., Yamanaka, S., Honda, Y., Kessoku, T., et al. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i7.609 · Cited by 55 · see citing works
Multiparametric ultrasound imaging for the assessment of normal versus steatotic livers
Basavarajappa, L., Baek, J., Reddy, S., Song, J. J., Tai, H., Rijal, G., Parker, K. J., & Hoyt, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-82153-z · Cited by 53 · see citing works
Ye, J., Wu, Y., Li, F., Wu, T., Shao, C., Lin, Y., Wang, W., Feng, S., & Zhong, B. (2019) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284819879047 · Cited by 51 · see citing works
Dennis, A., Mouchti, S., Kelly, M., Fallowfield, J. A., Hirschfield, G. M., Pavlides, M., & Banerjee, R. (2020) · Scientific Reports · doi:10.1038/s41598-020-71995-8 · Cited by 49 · see citing works
Yip, T. C., Lyu, F., Lin, H., Li, G., Yuen, P. C., Wong, V. W., & Wong, G. L. (2022) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0426 · Cited by 46 · see citing works
Non-invasive diagnosis: non-alcoholic fatty liver disease and alcoholic liver disease
Altamirano, J., Qi, Q., Choudhry, S., Abdallah, M., Singal, A. K., Humar, A., Bataller, R. A., Borhani, A. A., & Duarte‐Rojo, A. (2020) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh.2019.11.14 · Cited by 45 · see citing works
Regression of liver fibrosis: evidence and challenges
Sun, Y., Chen, S., & You, H. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000835 · Cited by 46 · see citing works
Histological assessment based on liver biopsy: the value and challenges in NASH drug development
Tong, X., Wang, Q., Zhao, X., Sun, Y., Wu, X., Yang, L., Lu, Z., Ou, X., Jia, J., & You, H. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00874-x · Cited by 44 · see citing works
Efficacy and safety of semaglutide in non-alcoholic fatty liver disease
Zhu, K., Kakkar, R., Chahal, D., Yoshida, E. M., & Hussaini, T. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i37.5327 · Cited by 45 · see citing works
Allen, A. M., Shah, V. H., Therneau, T. M., Venkatesh, S. K., Mounajjed, T., Larson, J. J., Mara, K. C., Kellogg, T. A., Kendrick, M. L., McKenzie, T. J., et al. (2019) · Hepatology Communications · doi:10.1002/hep4.1446 · Cited by 45 · see citing works
CRISPR-mediated BMP9 ablation promotes liver steatosis via the down-regulation of PPARα expression
Yang, Z. H., Li, P., Shang, Q., Wang, Y. A., He, J., Ge, S., Jia, R., & Fan, X. (2020) · Science Advances · doi:10.1126/sciadv.abc5022 · Cited by 45 · see citing works
Lavynenko, O., Abdul‐Ghani, M., Alatrach, M., Puckett, C., Adams, J., Abdelgani, S., Alkhouri, N., Triplitt, C., Clarke, G. D., Vasquez, J. A., et al. (2022) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14650 · Cited by 44 · see citing works
Zhang, Y. N., Fowler, K. J., Boehringer, A. S., Montes, V., Schlein, A. N., Covarrubias, Y., Wolfson, T. J., Hong, C. W., Valasek, M. A., André, M. P., et al. (2021) · European Radiology · doi:10.1007/s00330-021-08369-9 · Cited by 44 · see citing works
Self-citationAssociation between Liver MRI Proton Density Fat Fraction and Liver Disease Risk
Xia, T., Du, M., Li, H., Wang, Y., Zha, J., Wu, T., & Ju, S. (2023) · Radiology · doi:10.1148/radiol.231007 · Cited by 43 · see citing works
Shao, C., Ye, J., Li, F., Feng, S., Wang, W., & Zhong, B. (2019) · Digestive and Liver Disease · doi:10.1016/j.dld.2019.02.019 · Cited by 41 · see citing works
Confounding factors of non-invasive tests for nonalcoholic fatty liver disease
Wai, J. W., Fu, C., & Wong, V. W. (2020) · Journal of Gastroenterology · doi:10.1007/s00535-020-01686-8 · Cited by 41 · see citing works
Shao, C. X., Ye, J., Dong, Z., Li, F., Lin, Y., Liao, B., Feng, S., & Zhong, B. (2021) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223211033119 · Cited by 39 · see citing works
Rosenkranz, S., Feldman, J., McLaughlin, V. V., Rischard, F. P., Lange, T. J., White, R. J., Peacock, A. J., Gerhardt, F., Ebrahimi, R., Brooks, G. C., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00032-1 · Cited by 39 · see citing works
Shao, C., Ye, J., Li, F., Lin, Y., Wu, T., Wang, W., Feng, S., & Zhong, B. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05926-7 · Cited by 38 · see citing works
Emerging synthetic drugs for the treatment of liver cirrhosis
Fallowfield, J. A., Ramos, M. J., & Robertson, A. (2021) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2021.1918099 · Cited by 38 · see citing works
MRI‐Proton Density Fat Fraction Treatment Response Criteria in Nonalcoholic Steatohepatitis
Loomba, R. (2021) · Hepatology · doi:10.1002/hep.31624 · Cited by 36 · see citing works
“In subsequent multicenter studies with diverse therapies such as selonsertib (ASK-1 inhibitor) and obeticholic acid (farnesoid X receptor agonist), these data were then validated.(7,8) The optimal cut-point that was associated with histologic response was noted to be ≥30% relative reduction in MRI-PDFF.”
MethodSelf-citationJinato, T., Chayanupatkul, M., Dissayabutra, T., Chutaputti, A., Tangkijvanich, P., & Chuaypen, N. (2022) · Nutrients · doi:10.3390/nu14142921 · Cited by 36 · see citing works
Endpoints in NASH Clinical Trials: Are We Blind in One Eye?
Lonardo, A., Ballestri, S., Mantovani, A., Targher, G., & Bril, F. (2024) · Metabolites · doi:10.3390/metabo14010040 · Cited by 34 · see citing works
Nogami, A., Yoneda, M., Iwaki, M., Kobayashi, T., Kessoku, T., Honda, Y., Ogawa, Y., Imajo, K., Higurashi, T., Hosono, K., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-25843-6 · Cited by 34 · see citing works
Wang, Y., Song, S. J., Jiang, Y., Lai, J. C., Wong, G. L., Wong, V. W., & Yip, T. C. (2024) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0246 · Cited by 32 · see citing works
Noninvasive Evaluation of Nonalcoholic Fatty Liver Disease
Lee, D. H. (2020) · Endocrinology and Metabolism · doi:10.3803/enm.2020.35.2.243 · Cited by 31 · see citing works
Authors, & Collaborators: (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1880-2388 · Cited by 30 · see citing works
Huang, W., Peng, Y., & Kang, L. (2024) · Open Research (University of Surrey) · doi:10.1002/viw.20240010 · Cited by 30 · see citing works
Mechanism-guided drug development and treatment for liver fibrosis: a clinical perspective
Zeng, X., Huang, D., Zhu, Z., Cai, Q., Yang, Y., Lu, H., & Chen, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1574385 · Cited by 30 · see citing works
Choi, S. J., Kim, S. M., Kim, Y. S., Kwon, O. S., Shin, S. K., Kim, K. K., Lee, K., Park, I. B., Choi, C. S., Chung, D. H., et al. (2020) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2020.0137 · Cited by 29 · see citing works
Quantitative MRI: Rationale and Challenges
Gulani, V., & Seiberlich, N. (2020) · Advances in magnetic resonance technology and applications · doi:10.1016/b978-0-12-817057-1.00001-9 · Cited by 29 · see citing works
Wong, T., Wong, R. J., & Gish, R. G. (2019) · Europe PMC (PubMed Central) · Cited by 29 · see citing works
Hobeika, C., Ronot, M., Guiu, B., Ferraioli, G., Iijima, H., Tada, T., Lee, D. H., Kuroda, H., Lee, Y. H., Lee, J. M., et al. (2024) · Hepatology · doi:10.1097/hep.0000000000000895 · Cited by 28 · see citing works
Ye, J., Hu, X., Wu, T., Wu, Y., Shao, C., Li, F., Lin, Y., Feng, S., Wang, W., & Zhong, B. (2019) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-019-0440-z · Cited by 28 · see citing works
Lee, S. J., & Kim, S. U. (2019) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2019.1608820 · Cited by 27 · see citing works
Cunha, G. M., de Mello, L. L. C., Hasenstab, K. A., Spina, L. D. C., Bussade, I., Mesiano, J. M. P., Coutinho, W. F., Guzmán, G., & Sajoux, I. (2020) · Clinical Radiology · doi:10.1016/j.crad.2020.02.014 · Cited by 26 · see citing works
Caussy, C., & Johansson, L. (2020) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.134 · Cited by 24 · see citing works
Ma, Q., Liao, X., Shao, C., Lin, Y., Wu, T., Sun, Y., Feng, S., Ye, J., & Zhong, B. (2021) · BMC Gastroenterology · doi:10.1186/s12876-021-01790-w · Cited by 24 · see citing works
Kim, B. K., Bergstrom, J., Loomba, R., Tamaki, N., Izumi, N., Nakajima, A., Idılman, R., Gümüşsoy, M., Öz, D. K., Erden, A., et al. (2023) · Hepatology · doi:10.1097/hep.0000000000000470 · Cited by 24 · see citing works
Self-citationMAFLD in adults: non-invasive tests for diagnosis and monitoring of MAFLD
Chan, W., Wong, V. W., Adams, L. A., & Nguyen, M. H. (2024) · Hepatology International · doi:10.1007/s12072-024-10661-x · Cited by 24 · see citing works
Cao, D., Li, M., Liu, Y., Jin, H., Yang, D., Xu, H., Lv, H., Liu, J., Zhang, P., Zhang, Z., et al. (2022) · BMC Medical Imaging · doi:10.1186/s12880-022-00821-6 · Cited by 23 · see citing works
Li, F., Ye, J., Sun, Y., Lin, Y., Wu, T., Shao, C., Ma, Q., Liao, X., Feng, S., & Zhong, B. (2021) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2020.0039 · Cited by 23 · see citing works
Huisman, T. M., Dieterich, D. T., & Friedman, S. L. (2021) · Journal of Experimental Pharmacology · doi:10.2147/jep.s265286 · Cited by 23 · see citing works
Wu, T., Ye, J., Shao, C., Li, F., Lin, Y., Ma, Q., Wang, W., Feng, S., & Zhong, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.691556 · Cited by 22 · see citing works
Ormachea, J., & Parker, K. J. (2022) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2021.12.009 · Cited by 22 · see citing works
Noninvasive Tests in the Assessment of NASH and NAFLD Fibrosis: Now and Into the Future
Adams, L. A., & Chan, W. (2020) · Seminars in Liver Disease · doi:10.1055/s-0040-1713006 · Cited by 22 · see citing works
Tang, A., Dzyubak, B., Yin, M., Schlein, A. N., Henderson, W. C., Hooker, J. C., Delgado, T. I., Middleton, M. S., Zheng, L., Wolfson, T. J., et al. (2021) · European Radiology · doi:10.1007/s00330-021-08381-z · Cited by 21 · see citing works
Self-citationRepurposing drugs to target nonalcoholic steatohepatitis
Sookoian, S., & Pirola, C. J. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i15.1783 · Cited by 20 · see citing works
The Advance of Magnetic Resonance Elastography in Tumor Diagnosis
Yang, J., & Qiu, B. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.722703 · Cited by 21 · see citing works
Jiang, H., Cannella, R., Wu, Z., Bèaufrere, A., Burgio, M. D., Sartoris, R., Wang, Y., Qin, Y., Chen, J., Chen, Y., et al. (2024) · Radiology · doi:10.1148/radiol.233471 · Cited by 19 · see citing works
Noureddin, N., Schattenberg, J. M., Alkhouri, N., & Noureddin, M. (2020) · Hepatology Communications · doi:10.1002/hep4.1473 · Cited by 18 · see citing works
Novel targeted therapies for the management of liver fibrosis
Trivella, J. P., Martin, P. B., & Carrion, A. F. (2020) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2020.1735350 · Cited by 18 · see citing works
Noninvasive Evaluation for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
Kogachi, S., & Noureddin, M. (2021) · Clinical Therapeutics · doi:10.1016/j.clinthera.2021.01.012 · Cited by 18 · see citing works
Chuaypen, N., Siripongsakun, S., Hiranrat, P., Tanpowpong, N., Avihingsanon, A., & Tangkijvanich, P. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269641 · Cited by 17 · see citing works
Noninvasive Tests (NITs) for Hepatic Fibrosis in Fatty Liver Syndrome
Han, M. A. T. (2020) · Life · doi:10.3390/life10090198 · Cited by 17 · see citing works
Jiang, H., Chen, H. C., Lafata, K. J., & Bashir, M. R. (2021) · Radiology · doi:10.1148/radiol.2021204325 · Cited by 17 · see citing works
Anand, A., Elhence, A., Vaishnav, M., Singh, A. A., Rajput, M. S., Banyal, V., Jindal, V., Pathak, P., Kumar, P., Nayak, B., et al. (2020) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15358 · Cited by 17 · see citing works
- Authors
- Jayakumar, S., Middleton, M. S., Lawitz, E. J., Mantry, P. S., Caldwell, S. H., Arnold, H., Mae Diehl, A., Ghalib, R., Elkhashab, M., Abdelmalek, M. F., Kowdley, K. V., Stephen Djedjos, C., Xu, R., Han, L., Mani Subramanian, G., Myers, R. P., Goodman, Z. D., Afdhal, N. H., Charlton, M. R., Sirlin, C. B., & Loomba, R.
- Affiliations
- University of California San Diego (US)
- The University of Texas at San Antonio Health Science Center (US)
- Methodist Dallas Medical Center (US)
- University of Virginia (US)
- Toronto Liver Centre (CA)
- Duke University (US)
- Swedish Medical Center (US)
- Gilead Sciences (United States) (US)
- Inova Fairfax Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- University of Chicago (US)
- Corresponding author
- Loomba, Rohit
- ORCID
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 70
- Issue
- 1
- Pages
- 133-141
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2894776121
- Cited by
- 208
- References
- 31
- Citations by year
- 2026: 16 · 2025: 17 · 2024: 22 · 2023: 19 · 2022: 26 · 2021: 37 · 2020: 46 · 2019: 25
- FWCI
- 21.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Hepatology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Gilead Sciences
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Ultrasound Imaging and Elastography
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- nonalcoholic steatohepatitis, magnetic resonance elastography, liver stiffness, proton density fat fraction, liver fibrosis, hepatic steatosis, liver histopathology, selonsertib, noninvasive fibrosis assessment, treatment response monitoring, liver biopsy, fibrosis regression
- MeSH terms
- Adolescent, Adult, Aged, Benzamides, Biopsy, Dose-Response Relationship, Drug, Female, Humans, Imidazoles, Injections, Subcutaneous, Liver, Magnetic Resonance Imaging, Male, Middle Aged, Pyridines, ROC Curve, Reproducibility of Results, Treatment Outcome, Disease Progression, Elasticity Imaging Techniques, Young Adult, Non-alcoholic Fatty Liver Disease
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