The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.
Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma
Abstract
Immune checkpoint inhibitor (ICI) therapy targeting anti-programmed cell death-1 (anti-PD-1) or its ligand (anti-PD-L1) is the backbone of numerous combination regimens aimed at improving the objective response and survival of patients with hepatocellular carcinoma (HCC). Clinical trials of immuno-oncology regimens in other cancer types have shed light on issues of study design, including how to choose candidate regimens based on early-phase trial results, statistical considerations in trials with multiple primary endpoints, and the importance of predictive biomarkers. In this review, the updated data from early-phase trials of combination immunotherapy for HCC are summarised. Since the most extensively tested combination regimens for advanced HCC comprise anti-PD-1/anti-PD-L1 agents plus antiangiogenic agents, the relative benefit and antitumor mechanism of antiangiogenic multikinase inhibitors versus specific VEGF/VEGFR inhibitors are discussed. Other critical issues in the development of combination immunotherapy, including optimal management of immune-related adverse events and the value of ICI therapy in combination with locoregional treatment for HCC, are also explored.
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Epigenetics in hepatocellular carcinoma development and therapy: The tip of the iceberg
Fernández-Barrena, M. G., Arechederra, M., Colyn, L., Berasain, C., & Avila, M. A. (2020) · JHEP Reports · doi:10.1016/j.jhepr.2020.100167 · Cited by 126
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Metadata
- Authors
- Cheng, A.-L., Hsu, C., Chan, S. L., Choo, S.-P., & Kudo, M.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 72
- Issue
- 2
- Pages
- 307-319
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2999298357
- Cited by
- 528
- References
- 152
- FWCI
- 42.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cheng, A.-L., Hsu, C., Chan, S. L., Choo, S.-P., & Kudo, M. (2020). Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2019.09.025
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
