The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
Molecular targeted therapies: Ready for “prime time” in biliary tract cancer
Open accessAbstract
Patients with biliary tract cancers (cholangiocarcinoma (CCA) and gallbladder cancer (GBC)) have a poor prognoses and incidence is increasing. Most patients are diagnosed with advanced disease when options of treatment are limited to palliative approaches, mainly focused on chemotherapy. In recent years, novel treatment targets of relevance to biliary tract cancers, mainly present in patients with intrahepatic cholangiocarcinoma (iCCA), have been identified and are rapidly changing the field. These include fibroblast growth factor receptor (FGFR) fusions and isocitrate dehydrogenase (IDH)-1 and -2 mutations which are each present in around 10-20% of patients with iCCA patients. In addition, inhibition of other pathways is currently being explored, such as human epidermal growth factor receptor (HER) family, the Wnt pathway, neurotropic tyrosine kinase receptor (NTRK) fusions and BRAF mutations. The IDH1 inhibitor ivosidenib has already been tested in a phase III clinical trials in pre-treated CCA and showed benefit in terms of progression-free survival (the primary end-point). Multiple FGFR inhibitors are currently in development in phase II and III trials. There has been a consistently high response rate reported for these compounds (ranging between 20.7% and 35.5%), especially for patients harbouring FGFR2 fusions. This review provides an overview of the status of targeted therapies in biliary tract cancers. Detailed discussion regarding current clinical development of IDH and FGFR inhibitors is provided, with an overview of current caveats and future steps.
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Cites
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Cited by
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Metadata
- Authors
- Lamarca, A., Barriuso, J., McNamara, M. G., & Valle, J. W.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 73
- Issue
- 1
- Pages
- 170-185
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W3010157383
- Cited by
- 367
- References
- 145
- FWCI
- 47.44
- Type
- journal article
- Language
- en
- Open access
- green
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