Reply to: "Rationale of adding muscle volume to muscle fat infiltration in the definition of an adverse muscle composition is unclear"
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We thank Dr. Leclerq and colleagues for their interest in our paper and for taking the time to express their concerns.1 The discussion of potential sarcopenia biomarkers is important; herein, we reply to authors’ concerns.
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A combined assessment of muscle quantity and muscle fat provides a more complete description of muscle health that has been shown to improve performance in identifying high-risk individuals.
“Therefore, a combined assessment provides a more complete description of muscle health that has been shown to improve the performance in identifying high-risk individuals. [58][59]59][60][61]65,67,69”
From Changes in lean body mass with <scp>glucagon‐like peptide</scp> ‐1‐based therapies and mitigation strategies (2024) · cites this paper as [69]
The reply reports that muscle volume adds predictive value alongside muscle fat: among participants with NAFLD and high muscle fat, those with low muscle volume z-scores had 2.8 times the prevalence of CHD (main text). This supports combining the measures for risk stratification in that population, but the reply does not establish improved identification performance for high-risk individuals generally. (LLM, conf=0.82)
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Cites
Sarcopenia: revised European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., Sayer, A. A., et al. (2019) · Age and Ageing · doi:10.1093/ageing/afy169 · Cited by 13,818 · see citing works
Sarcopenia: revised European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., Sayer, A. A., et al. (2019) · Age and Ageing · doi:10.1093/ageing/afz046 · Cited by 3,803 · see citing works
Cawthon, P. M., Manini, T., Patel, S. M., Newman, A., Travison, T., Kiel, D. P., Santanasto, A. J., Ensrud, K. E., Xue, Q., Shardell, M., et al. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16517 · Cited by 231 · see citing works
Karlsson, A., Rosander, J., Romu, T., Tallberg, J., Grönqvist, A., Borga, M., & Leinhard, O. D. (2014) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24726 · Cited by 215 · see citing works
On the Definition of Sarcopenia in the Presence of Aging and Obesity—Initial Results from UK Biobank
Linge, J., Heymsfield, S. B., & Dahlqvist Leinhard, O. (2020) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glz229 · Cited by 103 · see citing works
Self-citationLinge, J., Ekstedt, M., & Dahlqvist Leinhard, O. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2020.100197 · Cited by 98 · see citing works
Self-citationNachit, M., Horsmans, Y., & Leclercq, I. A. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100235 · Cited by 3 · see citing works
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Neeland, I. J., Linge, J., & Birkenfeld, A. L. (2024) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15728 · Cited by 391 · see citing works
Self-citationLinge, J., Birkenfeld, A. L., & Neeland, I. J. (2024) · Circulation · doi:10.1161/circulationaha.124.067676 · Cited by 180 · see citing works
Self-citationAdverse muscle composition predicts all‐cause mortality in the UK Biobank imaging study
Linge, J., Petersson, M., Forsgren, M. F., Sanyal, A. J., & Dahlqvist Leinhard, O. (2021) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12834 · Cited by 108 · see citing works
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- Authors
- Linge, J., Ekstedt, M., & Dahlqvist Leinhard, O.
- Affiliations
- Linköping University (SE)
- Corresponding author
- Linge, Jennifer
- Venue
- JHEP Reports
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 3
- Issue
- 2
- Pages
- 100257
- ISSN
- 2589-5559 (ISSN-L)
- PMC
- PMC7957143
- OpenAlex
- W3152068251
- Cited by
- 3
- References
- 7
- Citations by year
- 2024: 2 · 2021: 1
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- JHEP Reports (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- sarcopenia, muscle composition, muscle fat infiltration, muscle volume
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