Inhibition of DNA methylation in the COL1A2 promoter by anacardic acid prevents UV-Induced decrease of type i procollagen expression

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Nan, X., Ng, H.-H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N., & Bird, A. (1998) · Nature · doi:10.1038/30764 · Cited by 3,440 · see citing works

Epigenetic modifications and human disease

Portela, A., & Esteller, M. (2010) · Nature Biotechnology · doi:10.1038/nbt.1685 · Cited by 2,843 · see citing works

Collagens—structure, function, and biosynthesis

Gelse, K. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.08.002 · Cited by 2,663 · see citing works

The Collagen Family

Ricard-Blum, S. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004978 · Cited by 2,305 · see citing works

Linking DNA methylation and histone modification: patterns and paradigms

Cedar, H., & Bergman, Y. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2540 · Cited by 2,267 · see citing works

Kcnq1ot1 Antisense Noncoding RNA Mediates Lineage-Specific Transcriptional Silencing through Chromatin-Level Regulation

Pandey, R. R., Mondal, T., Mohammad, F., Enroth, S., Redrup, L., Komorowski, J., Nagano, T., Mancini‐DiNardo, D., & Kanduri, C. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.022 · Cited by 1,192 · see citing works

Photoaging: mechanisms and repair

Rabe, J. H., Mamelak, A. J., McElgunn, P. J. S., Morison, W. L., & Sauder, D. N. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.05.010 · Cited by 610 · see citing works

CpG methylation is maintained in human cancer cells lacking DNMT1

Rhee, I. P., Jair, K., Yen, R.-W. C., Christoph Lengauer, C., Herman, J. G., Kinzler, K. W., Vogelstein, B., Baylin, S. B., & Schuebel, K. E. (2000) · Nature · doi:10.1038/35010000 · Cited by 453 · see citing works

DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns

Lokk, K., Modhukur, V., Rajashekar, B., Märtens, K., Mägi, R., Kolde, R., Koltšina, M., Nilsson, T. K., Vilo, J., Salumets, A., et al. (2014) · Genome Biology · doi:10.1186/gb-2014-15-4-r54 · Cited by 444 · see citing works

Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

Chen, S.-J., Yuan, W., Mori, Y., Levenson, A. S., Varga, J., & Trojanowska, M. E. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00477.x · Cited by 411 · see citing works

Modulation of Skin Collagen Metabolism in Aged and Photoaged Human Skin In Vivo

Chung, J. H., Seo, J. Y., Choi, H. R., Lee, M. K., Youn, C. S., Rhie, G., Cho, K. H., Kim, K. H., Park, K. C., & Eun, H. C. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01544.x · Cited by 410 · see citing works

Epigallocatechin-3-Gallate, a Histone Acetyltransferase Inhibitor, Inhibits EBV-Induced B Lymphocyte Transformation via Suppression of RelA Acetylation

Choi, K., Jung, M. G., Lee, Y., Yoon, J. C., Kwon, S. H., Kang, H., Kim, M., Cha, J., Kim, Y. J., Jun, W. J., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2442 · Cited by 354 · see citing works

Dependence of Transcriptional Repression on CpG Methylation Density

Hsieh, C. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5487 · Cited by 300 · see citing works

DNA methylation models histone acetylation

Eden, S., Hashimshony, T., Keshet, I., Cedar, H., & Thorne, A. W. (1998) · Nature · doi:10.1038/29680 · Cited by 277 · see citing works

Aging and Chronic Sun Exposure Cause Distinct Epigenetic Changes in Human Skin

Grönniger, E., Weber, B., Heil, O., Peters, N., Stäb, F., Wenck, H., Korn, B., Winnefeld, M., & Lyko, F. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000971 · Cited by 275 · see citing works

Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases.

Tommasi, S., Denissenko, M. F., & Pfeifer, G. P. (1997) · PubMed · Cited by 237 · see citing works

Antagonistic Regulation of Type I Collagen Gene Expression by Interferon-γ and Transforming Growth Factor-β

Ghosh, A. K., Yuan, W., Mori, Y., Chen, S.-J., & Varga, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004709200 · Cited by 225 · see citing works

Epigenetic Modifications in Double-Strand Break DNA Damage Signaling and Repair

Rossetto, D., Truman, A. W., Kron, S. J., & Côté, J. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0513 · Cited by 174 · see citing works

Transforming Growth Factor β1 Induces the Expression of Collagen Type I by DNA Methylation in Cardiac Fibroblasts

Pan, X., Chen, Z., Huang, R., Yao, Y., & Ma, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060335 · Cited by 164 · see citing works

UV irradiation stimulates histone acetylation and chromatin remodeling at a repressed yeast locus

Yu, Y., Teng, Y., Liu, H., Reed, S. H., & Waters, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501458102 · Cited by 156 · see citing works

Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin

Vandiver, A. R., Irizarry, R. A., Hansen, K. D., Garza, L. A., Rúnarsson, Á. R., Li, X., Chien, A. L.-L., Wang, T. S., Leung, S. G., Kang, S., et al. (2015) · Genome biology · doi:10.1186/s13059-015-0644-y · Cited by 154 · see citing works

DNA Methylation Has a Local Effect on Transcription and Histone Acetylation

Irvine, R. A., Lin, I. G., & Hsieh, C. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.19.6689-6696.2002 · Cited by 148 · see citing works

A Novel Prodrug of Epigallocatechin-3-gallate: Differential Epigenetic hTERT Repression in Human Breast Cancer Cells

Meeran, S. M., Patel, S. N., Chan, T. H., & Tollefsbol, T. O. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0009 · Cited by 146 · see citing works

Specific Age-Associated DNA Methylation Changes in Human Dermal Fibroblasts

Koch, C., Suschek, C., Lin, Q., Bork, S., Goergens, M., Joussen, S., Pallua, N., Ho, A., Zenke, M., & Wagner, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016679 · Cited by 139 · see citing works

Identification of Epigenetically Silenced Genes in Tumor Endothelial Cells

Hellebrekers, D. M. E. I., Melotte, V., Viré, E. A., Langenkamp, E., Molema, G., Fuks, F., Herman, J. G., Criekinge, W. V., Griffioen, A. W., & van Engeland, M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3032 · Cited by 136 · see citing works

Elevated Cysteine-Rich 61 Mediates Aberrant Collagen Homeostasis in Chronologically Aged and Photoaged Human Skin

Quan, T., He, T., Shao, Y., Lin, L., Kang, S., Voorhees, J. J., & Fisher, G. J. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060128 · Cited by 130 · see citing works

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway

Nakada, D., Hirano, Y., & Sugimoto, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.10016-10025.2004 · Cited by 113 · see citing works

Estrogen-mediated epigenetic repression of large chromosomal regions through DNA loopingPreprint

Hsu, P.-Y., Hsu, H.-K., Singer, G. A. C., Yan, P. S., Rodriguez, B. A. T., Liu, J. C., Weng, Y.-I., Deatherage, D. E., Chen, Z., Pereira, J. S., et al. (2010) · Genome Research · doi:10.1101/gr.101923.109 · Cited by 99 · see citing works

IL-1α Is a DNA Damage Sensor Linking Genotoxic Stress Signaling to Sterile Inflammation and Innate Immunity

Cohen, I., Rider, P., Vornov, E., Tomas, M., Tudor, C., Wegner, M., Brondani, L., Freudenberg, M., Mittler, G., Ferrando-May, E., et al. (2015) · Scientific Reports · doi:10.1038/srep14756 · Cited by 98 · see citing works

Aging is associated with highly defined epigenetic changes in the human epidermis

Raddatz, G., Hagemann, S., Aran, D., Söhle, J., Kulkarni, P. P., Kaderali, L., Hellman, A., Winnefeld, M., & Lyko, F. (2013) · Epigenetics & Chromatin · doi:10.1186/1756-8935-6-36 · Cited by 93 · see citing works

The Role of p300 Histone Acetyltransferase in UV-Induced Histone Modifications and MMP-1 Gene Transcription

Kim, M.-K., Shin, J., Eun, H. C., & Chung, J. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004864 · Cited by 86 · see citing works

Interaction between GC Box Binding Factors and Smad Proteins Modulates Cell Lineage-specific α2(I) Collagen Gene Transcription

Inagaki, Y., Nemoto, T., Nakao, A., ten Dijke, P., KOBAYASHI, K. P., Takehara, K., & Greenwel, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010485200 · Cited by 78 · see citing works

CpG hypermethylation of collagen type I α 2 contributes to proliferation and migration activity of human bladder cancer

Enokida (2009) · International Journal of Oncology · doi:10.3892/ijo_00000289 · Cited by 53 · see citing works

MDM2 Overexpression Deregulates the Transcriptional Control of RB/E2F Leading to DNA Methyltransferase 3A Overexpression in Lung Cancer

Tang, Y.-A., Lin, R.-K., Tsai, Y.-T., Hsu, H., Yang, Y., Chen, C., & Wang, Y. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2617 · Cited by 49 · see citing works

Reduction in DNA methyltransferases and alteration of DNA methylation pattern associate with mouse skin ageing

Qian, H., & Xu, X. Z. S. (2014) · Experimental Dermatology · doi:10.1111/exd.12375 · Cited by 37 · see citing works

Prostaglandin E2 Promotes UV Radiation-Induced Immune Suppression through DNA Hypermethylation

Prasad, R., & Katiyar, S. K. (2013) · Neoplasia · doi:10.1593/neo.13424 · Cited by 36 · see citing works

Epigenetic Modifications in Fibrotic Diseases: Implications for Pathogenesis and Pharmacological Targets

Yao, H., & Li, J. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.219816 · Cited by 34 · see citing works

DNA methylation inhibits transcription of procollagen α2(I) promoters

Guenette, D. K., Ritzenthaler, J. D., Foley, J., Jackson, J. D., & Smith, B. D. (1992) · Biochemical Journal · doi:10.1042/bj2830699 · Cited by 29 · see citing works

UVB irradiation does not directly induce detectable changes of DNA methylation in human keratinocytes

Lahtz, C., Kim, S., Bates, S., Li, A. X., Wu, X., & Pfeifer, G. P. (2013) · F1000Research · doi:10.12688/f1000research.2-45.v1 · Cited by 25 · see citing works

UV-induced DNA damage and histone modification may involve MMP-1 gene transcription in human skin in vivo

Kim, M., Lee, D. H., Lee, S., Kim, E. J., & Chung, J. H. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.10.004 · Cited by 17 · see citing works

Topical application of anacardic acid (6-nonadecyl salicylic acid) reduces UV-induced histone modification, MMP-13, MMP-9, COX-2 and TNF-α expressions in hairless mice skin

Kim, M. K., Lee, S., Kim, E. J., Kong, K. H., Lee, D. H., & Chung, J. H. (2012) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2012.11.008 · Cited by 15 · see citing works

The influence of sun exposure on the DNA methylation status of MMP9, miR-137, KRT14 and KRT19 genes in human skin

Melo, A. R. D. S., Barroso, H., Araújo, D. U. D., Pereira, F. R., & de Oliveira, N. F. P. (2015) · European Journal of Dermatology · doi:10.1684/ejd.2015.2598 · Cited by 15 · see citing works

Human SP1 But not human AP1 binding to the TGF-β element in the 5′ flanking region of the rat PROα1(I) collagen gene

Cutroneo, K. R. (2000) · Molecular Biology Reports · doi:10.1023/a:1007206014638 · Cited by 11 · see citing works

Molecular and tissue alterations of collagens in fibrosis

Ricard‐Blum, S., Baffet, G., & Théret, N. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.02.004 · Cited by 170 · see citing works

Boosting the Photoaged Skin: The Potential Role of Dietary Components

Geng, R., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13051691 · Cited by 116 · see citing works

Protective Effects of Sesamin against UVB-Induced Skin Inflammation and Photodamage In Vitro and In Vivo

Lin, T.-Y., Wu, P., Hou, C.-W., Chien, T.-Y., Chang, Q.-X., Wen, K., Lin, C., & Chiang, H. (2019) · Biomolecules · doi:10.3390/biom9090479 · Cited by 63 · see citing works

Increased Histone Acetylation and Decreased Expression of Specific Histone Deacetylases in Ultraviolet-Irradiated and Intrinsically Aged Human Skin In Vivo

Lee, Y., Shin, M. H., Kim, M. K., Kim, Y. K., Shin, H. S., Lee, D. H., & Chung, J. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042032 · Cited by 34 · see citing works

Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets

Wang, J., & Chao, J. (2025) · Pharmaceuticals · doi:10.3390/ph18060812 · Cited by 29 · see citing works

UV-induced DNA methyltransferase 1 promotes hypermethylation of tissue inhibitor of metalloproteinase 2 in the human skin

Kim, H.-Y., Lee, D. H., Shin, M. H., Shin, H. S., Kim, M. K., & Chung, J. H. (2018) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2018.03.009 · Cited by 23 · see citing works

Protective Effect of Potentilla glabra in UVB-Induced Photoaging Process

You, L., Kim, M., & Cho, J. Y. (2021) · Molecules · doi:10.3390/molecules26175408 · Cited by 20 · see citing works

TWIST1-EP300 Expedites Gastric Cancer Cell Resistance to Apatinib by Activating the Expression of COL1A2

Yu, G., Chen, W., Li, X., Yu, L., Xu, Y., Ruan, Q., He, Y., & Wang, Y. (2022) · Analytical Cellular Pathology · doi:10.1155/2022/5374262 · Cited by 18 · see citing works

Dual role of enhancer of zeste homolog 2 in the regulation of ultraviolet radiation-induced matrix metalloproteinase-1 and type I procollagen expression in human dermal fibroblasts

Kim, M.-K., Shin, H. S., Shin, M. H., Kim, H., Lee, D. H., & Chung, J. H. (2023) · Matrix Biology · doi:10.1016/j.matbio.2023.04.001 · Cited by 12 · see citing works

Purified anacardic acids exert multiple neuroprotective effects in pesticide model of Parkinson's disease: in vivo and in silico analysis

Augusto, R. L., Mendonça, I. P., Rego, G. N. A., Pereira, D. D., Gonçalves, L. V. D. P., dos Santos, M. L., de Souza, R. F., Moreno, G. M. M., Cardoso, P. R. G., Andrade, D. D. S., et al. (2020) · IUBMB Life · doi:10.1002/iub.2304 · Cited by 10 · see citing works

Comparative Efficacy of Botryocladia leptopoda Extracts in Scar Inhibition and Skin Regeneration: A Study on UV Protection, Collagen Synthesis, and Fibroblast Proliferation

Hsieh, C., Yi, T.-K., Kao, Y.-F., Lin, S., Tu, M.-C., Chou, Y.-C., Lu, J.-J., Chai, H., & Cheng, K. (2024) · Molecules · doi:10.3390/molecules29235688 · Cited by 5 · see citing works

Identification of potential immune-related ceRNA Regulatory Network in UVB-irradiated human skin

Qiang, M., & Zhang, R. (2023) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2023.2175501 · Cited by 4 · see citing works

Photodamage attenuation effect by angelic acid in UVA irradiation-induced damages in normal human dermal fibroblast

Ku, J.-E. (2018) · Biomedical Dermatology · doi:10.1186/s41702-017-0013-4 · Cited by 4 · see citing works

Uncoupling TGFβ1 signalling from collagen protein synthesis in Dupuytren's disease

Cooper, G., Gumbs, J. A., Alkharabsheh, S., Lee, K. J., Carter, A., Coleman, H., O'Heneghan-Yates, N., Ijaz, R., Beamish, E. L., Menezes, L. A., et al. (2026) · The Journal of Pathology · doi:10.1002/path.70020 · Cited by 2 · see citing works

Palmitoyl-KVK-L-ascorbic acid conjugate improves matrix abnormality associated with skin aging via epigenetic regulation

Kim, M. K., Shin, M. H., Lim, J. H., Bae, J., Lee, Y. R., Shin, H. S., Cho, S. I., Chung, J. H., & Lee, D. H. (2021) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2020.12.006 · Cited by 2 · see citing works

Histone Modulation Blocks Treg-Induced Foxp3 Binding to the IL-2 Promoter of Virus-Specific CD8+ T Cells from Feline Immunodeficiency Virus-Infected Cats

Nag, M., Wang, Y., Paris, K. D., & Fogle, J. E. (2018) · Viruses · doi:10.3390/v10060287 · Cited by 1 · see citing works

Intense pulsed light rejuvenates UVB-induced photoaging in human keratinocytes and guinea pig skin by inhibition of ERK-AP-1-MMP pathway

Liu, C., Hu, W., Zhang, X., Lu, M., Xiang, J., Tan, L., Tao, Y., Ma, K., Zhang, L., Yang, Z., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-50438-w

The protective effect of hydrolyzed collagen gel from mackerel scad ( Decapterus macarellus ) to attenuate chronic UVB-induced photodamage

Herawati, E., Titisari, R. S., Kristin, H., Prasasti, F. F. T. A., Agnesia, P., Astirin, O. P., Listyawati, S., Susanti, E., Herdyastuti, N., Laily, N., et al. (2025) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2025-0093

Impact de la programmation fœtale sur le remodelage matriciel et le vieillissement vasculaire.

Vanalderwiert, L. (2024) · doi:10.70675/9ffb242ezbd0ez4bd1zb076z7301e237867c

ac4C modification of PDK4 by NAT10 promotes pulmonary fibrosis by reprogramming mitochondrial dynamics in fibroblasts

Liu, D., Li, Y., Liu, T., Du, Y., Zhuo, J., Du, J., Yu, Q., Huang, L., Huang, L., Chen, Y., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.06.020

Nanotechnology and nanocosmetics

Kaul, S., Jain, N., Singh, S., Saifi, I., Triveni, & Nagaich, U. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-41499-2.00013-6

Ultraviolet irradiation-induced inhibition of histone deacetylase 4 increases the expression of matrix metalloproteinase-1 but decreases that of type I procollagen via activating JNK in human dermal fibroblasts

Lee, Y., Shin, M. H., Kim, M. K., Park, C., Shin, H. S., Lee, D. H., & Chung, J. H. (2020) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2020.11.008 · Cited by 16 · see citing works

LB813 Palmitoyl-KVK-L-ascorbic acid increases type I procollagen expression by inhibition of DNA methyltrasferase activity

Lim, J. H., An, H., Kim, J., Moon, S. H., & Chang, S.-J. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.05.068

Anacardic acid ameliorates ultraviolet irradiation-induced damage to human skin

Kim, M. K., Shin, M. H., Kim, Y. K., Kim, H.-Y., Lee, Y. R., Lee, D. H., & Chung, J. H. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.03.019 · Cited by 9 · see citing works

The role of p300 histone acetyltransferase in UV-induced histone modifications and MMP-1 gene transcription. PLoS One 2009

Kim, M.-K., Shin, J.-M., Eun, H. C., & Chung, J. H. (2016)

231 H3K27 acetylation modulation to prevent UVA-induced photoaging

Pelletier, N., Reymermier, C., & Frei, V. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.09.242