The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
Connective Tissue and Fibroblast Senescence in Skin Aging
Open accessAbstract
There is increasing evidence that skin aging is significantly enforced by the accumulation of senescent dermal fibroblasts. Various stressors damaging macromolecules inside and outside fibroblasts are responsible. In addition, NK cells fail to adequately remove senescent (SEN) fibroblasts from tissues. SEN fibroblasts by the release of the proinflammatory, tissue degrading senescent-associated secretory phenotype factors and vesicles with distinct cargo impact on their endogenous niche and spread senescence and skin aging. In this review, we will further discuss less noticed facets, including the plasticity of distinct dermal fibroblast phenotypes, the underestimated impact of the extracellular matrix itself, and the depletion of fibroblast subsets on skin homeostasis and aging.
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“In contrast, the dermal region is more susceptible to photodamage, which results in loss of skin resilience [34].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [34]
Citations
Cites
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Cited by
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Fibroblasts in cancer: Unity in heterogeneity
Chhabra, Y., & Weeraratna, A. T. (2023) · Cell · doi:10.1016/j.cell.2023.03.016 · Cited by 505
Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging
Ansary, T. M., Hossain, M. R., Kamiya, K., Komine, M., & Ohtsuki, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083974 · Cited by 393
Skin aging from mechanisms to interventions: focusing on dermal aging
Shin, S. H., Lee, Y. H., Rho, N., & Park, K. Y. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1195272 · Cited by 355
Environmentally-Induced (Extrinsic) Skin Aging: Exposomal Factors and Underlying Mechanisms
Krutmann, J., Schikowski, T., Morita, A., & Berneburg, M. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.12.011 · Cited by 253
Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin
Lee, H. J., Hong, Y., & Kim, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212489 · Cited by 276
Metadata
- Authors
- Wlaschek, M., Maity, P., Makrantonaki, E., & Scharffetter-Kochanek, K.
- Affiliations
- Universität Ulm (DE)
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 141
- Issue
- 4
- Pages
- 985-992
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W3126843737
- Semantic Scholar
- 4870ccd091834d4e0584823f87394b1665d80d2c
- Cited by
- 245
- References
- 128
- Citations by year
- 2026: 29 · 2025: 55 · 2024: 57 · 2023: 49 · 2022: 36 · 2021: 19
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- skin aging, dermal fibroblasts, fibroblast senescence, senescence-associated secretory phenotype, extracellular vesicles, extracellular matrix, natural killer cells, senescence-associated inflammation, skin homeostasis, connective tissue
- MeSH terms
- Animals, Cell Communication, Connective Tissue, Extracellular Matrix, Fibroblasts, Humans, Killer Cells, Natural, Skin, Skin Aging, Cellular Senescence, Models, Animal, Mice
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