Connective Tissue and Fibroblast Senescence in Skin Aging

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

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The senescence-associated secretory phenotype: the dark side of tumor suppression

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Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

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Cellular senescence: when bad things happen to good cells

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A framework for advancing our understanding of cancer-associated fibroblasts

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

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Cellular Senescence: Defining a Path Forward

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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

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Cellular senescence: from physiology to pathology

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The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

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Cellular senescence in aging and age-related disease: from mechanisms to therapy

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A complex secretory program orchestrated by the inflammasome controls paracrine senescence

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DNA damage, aging, and Cancer

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

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An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

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Ink4a/Arf expression is a biomarker of aging

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Programmed cell senescence during mammalian embryonic development

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From discoveries in ageing research to therapeutics for healthy ageing

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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

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A proteomic atlas of senescence-associated secretomes for aging biomarker development

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Distinct fibroblast lineages determine dermal architecture in skin development and repair

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Senescent cells: an emerging target for diseases of ageing

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Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

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Mechanisms and functions of cellular senescence

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Living on a break: cellular senescence as a DNA-damage response

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An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

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Oxidative Stress in Aging Human Skin

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Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

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The Endocrinology of Aging

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Unmasking senescence: context-dependent effects of SASP in cancer

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Biomarkers, oxidative stress and autophagy in skin aging

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A senescent cell bystander effect: senescence‐induced senescence

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Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

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Identification of HSP90 inhibitors as a novel class of senolytics

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In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs

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Interventions to slow aging in humans: are we ready?

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The dynamic nature of senescence in cancer

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Impaired immune surveillance accelerates accumulation of senescent cells and aging

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Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming

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p16 INK4A is a robust in vivo biomarker of cellular aging in human skin

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Niche stiffness underlies the ageing of central nervous system progenitor cells

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Fibroblast heterogeneity: implications for human disease

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Senescent cell clearance by the immune system: Emerging therapeutic opportunities

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Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin

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The Association of Plasma IL-6 Levels With Functional Disability in Community-Dwelling Elderly

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Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

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Circuit Design Features of a Stable Two-Cell System

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Understanding fibroblast heterogeneity in the skin

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Stem cell competition orchestrates skin homeostasis and ageing

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Biomarkers of cellular senescence and skin aging

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Chronic low-grade inflammation and age-related sarcopenia

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Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning

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DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

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The senescent bystander effect is caused by ROS-activated NF-κB signalling

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UVA‐INDUCED AUTOCRINE STIMULATION OF FIBROBLAST‐DERIVED COLLAGENASE/MMP‐1 BY INTERRELATED LOOPS OFINTERLEUKIN–1 andINTERLEUKIN–6

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Enhancing Structural Support of the Dermal Microenvironment Activates Fibroblasts, Endothelial Cells, and Keratinocytes in Aged Human Skin In Vivo

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Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype

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Keeping the senescence secretome under control: molecular reins on the senescence-associated secretory phenotype.

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The bystander effect contributes to the accumulation of senescent cells in vivo

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Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging

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In the Elderly, Interleukin-6 Plasma Levels and the −174G>C Polymorphism Are Associated With the Development of Cardiovascular Disease

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Origin and functional heterogeneity of fibroblasts

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Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs

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Characterization of Skin Aging–Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin

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Ultraviolet Light Induces Increased Circulating Interleukin-6 in Humans

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Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial

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Rescuing replication and osteogenesis of aged mesenchymal stem cells by exposure to a young extracellular matrix

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Cellular senescence and chronological age in various human tissues: A systematic review and meta‐analysis

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Hematopoietic Hierarchy – An Updated Roadmap

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Role of Mitochondria in Photoaging of Human Skin: The Defective Powerhouse Model

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The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer

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Therapeutic interventions for aging: the case of cellular senescence

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DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age

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Nanotubes mediate niche–stem-cell signalling in the Drosophila testis

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Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring

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Paracrine roles of cellular senescence in promoting tumourigenesis

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Regulation of ATP utilization during metastatic cell migration by collagen architecture

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Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease

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Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome

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The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging

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Lineage Identity and Location within the Dermis Determine the Function of Papillary and Reticular Fibroblasts in Human Skin

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Chronically Ultraviolet‐exposed Human Skin Shows a Higher Mutation Frequency of Mitochondrial DNA as Compared to Unexposed Skin and the Hematopoietic System

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Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis

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Deciphering the functional heterogeneity of skin fibroblasts using single‐cell RNA sequencing

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