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Comparison of six Aspergillus-specific IgG assays for the diagnosis of chronic pulmonary aspergillosis (CPA)
Open accessAbstract
Objectives Chronic pulmonary aspergillosis (CPA) is estimated to affect 3 million persons worldwide. Aspergillus-specific IgG is a key component in CPA diagnosis. We aimed to establish the optimal diagnostic cut offs for CPA and the comparative performance of six assays in this context. Methods Sera from 241 patients with CPA and 100 healthy blood donors were tested using five Aspergillus-specific IgG assays plus precipitin testing using Microgen Aspergillus antigens. Results Receiver operating characteristic (ROC) curve area under the curve (AUC) results were as follows: ThermoFisher Scientific ImmunoCAP 0.996 (95% confidence interval 0.992-1), Siemens Immulite 0.991 (0.982-1), Serion 0.973 (0.960-0.987), Dynamiker 0.918 (0.89-0.946) and Genesis 0.902 (0.871-0.933). Optimal CPA diagnostic cut-offs were; ImmunoCAP 20 mg/L (96% sensitivity, 98% specificity), Immulite 10 mg/L (96% sensitivity, 98% specificity), Serion 35 U/ml (90% sensitivity, 98% specificity), Dynamiker 65 AU/ml (77% sensitivity, 97% specificity) and Genesis 20 U/ml (75% sensitivity, 99% specificity). The precipitin test was 59% sensitive and 100% specific. Conclusions ImmunoCAP and Immulite were statistically significantly superior to the other assays. Precipitins testing performed poorly. The currently accepted ImmunoCAP cut-off of 40 mg/L appears sub-optimal for CPA diagnosis and may require revision in this context.
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Citations
Cites
The meaning and use of the area under a receiver operating characteristic (ROC) curve.
Hanley, J. A., & McNeil, B. J. (1982) · Radiology · doi:10.1148/radiology.143.1.7063747 · Cited by 21,856
Basic principles of ROC analysis
Metz, C. E. (1978) · Seminars in Nuclear Medicine · doi:10.1016/s0001-2998(78)80014-2 · Cited by 6,122
Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management
Denning, D. W., Cadranel, J., Beigelman-Aubry, C., Ader, F., Chakrabarti, A., Blot, S., Ullmann, A. J., Dimopoulos, G., & Lange, C. (2016) · European Respiratory Journal · doi:10.1183/13993003.00583-2015 · Cited by 1,030
Self-citationAgarwal, R., Chakrabarti, A., Shah, A., Gupta, D., Meis, J. F., Guleria, R., Moss, R., Denning, D. W., & ABPA complicating asthma ISHAM working group (2013) · Clinical & Experimental Allergy · doi:10.1111/cea.12141 · Cited by 896
Self-citationDenning, D. W., Riniotis, K., Dobrashian, R., & Sambatakou, H. (2003) · Clinical Infectious Diseases · doi:10.1086/376526 · Cited by 551
Self-citationDenning, D. W., Pleuvry, A., & Cole, D. C. (2013) · Medical Mycology · doi:10.3109/13693786.2012.738312 · Cited by 495
Self-citationChakrabarti, A., Denning, D. W., Ferguson, B. J., Ponikau, J. U., Buzina, W., Kita, H., Marple, B. F., Panda, N. K., Vlaminck, S., Kauffmann‐Lacroix, C., et al. (2009) · The Laryngoscope · doi:10.1002/lary.20520 · Cited by 482
Self-citationUnderlying conditions in chronic pulmonary aspergillosis including simple aspergilloma
Smith, N. L., & Denning, D. W. (2011) · European Respiratory Journal · doi:10.1183/09031936.00054810 · Cited by 449
Self-citationGlobal burden of chronic pulmonary aspergillosis as a sequel to pulmonary tuberculosis
Denning, D., Pleuvry, A., & Cole, D. (2011) · Bulletin of the World Health Organization · doi:10.2471/blt.11.089441 · Cited by 420
Self-citationNovel immunologic classification of aspergillosis in adult cystic fibrosis
Baxter, C. G., Dunn, G., Jones, A. M., Webb, A. K., Gore, R. B., Richardson, M. D., & Denning, D. W. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.007 · Cited by 213
Self-citation
Research works printed but not linked: 1
- MacKenzie DW. Serological tests. In: Evans E, Richardson MD, editors. Medical mycology: a practical approach. 1st ed. Oxford: IRL Press; 1989. p. 201–234
Cited by
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Aspergillus fumigatus and Aspergillosis in 2019
Latgé, J.-P., & Chamilos, G. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00140-18 · Cited by 1,400
Agarwal, R., Sehgal, I. S., Muthu, V., Denning, D. W., Chakrabarti, A., Kathirvel, S., Garg, M. K., Rudramurthy, S. M., Dhooria, S., Armstrong-James, D. P. H., et al. (2024) · European Respiratory Journal · doi:10.1183/13993003.00061-2024 · Cited by 291
“The cut-off of A. fumigatus -IgG for automated immunoassays differs from the manufacturer ’ s recommendation and between assays and different populations [65, 66].”
Self-citationPredictors of mortality in chronic pulmonary aspergillosis
Lowes, D., Al-Shair, K., Newton, P. J., Morris, J., Harris, C., Rautemaa-Richardson, R., & Denning, D. W. (2017) · European Respiratory Journal · doi:10.1183/13993003.01062-2016 · Cited by 194
Self-citationPage, I. D., Byanyima, R. K., Hosmane, S. R., Onyachi, N., Opira, C., Richardson, M. D., Sawyer, R., Sharman, A., & Denning, D. W. (2019) · European Respiratory Journal · doi:10.1183/13993003.01184-2018 · Cited by 170
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Agarwal, R., Sehgal, I. S., Dhooria, S., Muthu, V., Prasad, K., Bal, A., Aggarwal, A., & Chakrabarti, A. (2020) · The Indian Journal of Medical Research · doi:10.4103/ijmr.ijmr_1187_19 · Cited by 157
Case Definition of Chronic Pulmonary Aspergillosis in Resource-Constrained Settings
Denning, D. W., Page, I. D., Chakaya, J., Jabeen, K., Jude, C. M., Cornet, M., Alastruey-Izquierdo, A., Bongomin, F., Bowyer, P., Chakrabarti, A., et al. (2018) · Emerging Infectious Diseases · doi:10.3201/eid2408.171312 · Cited by 144
“Elevated circulating levels of Aspergillus antibodies are present in >95% but 100% of patients ( 49–51 Serologic testing for Aspergillus relies mainly on the detection of IgG and of precipitating antibodies (known as precipitins), which may be IgG or IgM.”
BackgroundSelf-citationPulmonary and sinus fungal diseases in non-immunocompromised patients
Denning, D. W., & Chakrabarti, A. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30309-2 · Cited by 150
Self-citationJenks, J. D., & Hoenigl, M. (2018) · Journal of Fungi · doi:10.3390/jof4030098 · Cited by 146
Denning, D. W. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0468 · Cited by 117
Self-citationDenning, D. W., Perlin, D. S., Muldoon, E. G., Colombo, A. L., Chakrabarti, A., Richardson, M. D., & Sorrell, T. C. (2016) · Emerging infectious diseases · doi:10.3201/eid2302.152042 · Cited by 95
Self-citationTwelve-month clinical outcomes of 206 patients with chronic pulmonary aspergillosis
Bongomin, F., Harris, C., Hayes, G., Kosmidis, C., & Denning, D. W. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193732 · Cited by 91
“The currently available tests for Aspergillus -specific IgG have wide variability with coefficient of variation (CV) between 3.4–43.7% [24].”
BackgroundInfluentialSelf-citationRole of Serological Tests in the Diagnosis of Mold Infections
Richardson, M. D., & Page, I. D. (2018) · Current Fungal Infection Reports · doi:10.1007/s12281-018-0321-1 · Cited by 90
Self-citationAllergic Bronchopulmonary Aspergillosis
Tracy, M. C., Okorie, C. U. A., Foley, E., & Moss, R. B. (2016) · Journal of Fungi · doi:10.3390/jof2020017 · Cited by 94
“Other serologic markers, such as precipitins and IgG antibodies to Aspergillus, are currently not standardized and a variety of methods of differing sensitivity, specificity, and cutoffs are employed [37,38].”
BackgroundAgarwal, R., Dua, D., Choudhary, H., Aggarwal, A. N., Sehgal, I. S., Dhooria, S., Garg, M. K., Behera, D., & Chakrabarti, A. (2016) · Mycoses · doi:10.1111/myc.12541 · Cited by 89
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Maghrabi, F., & Denning, D. W. (2017) · Current Fungal Infection Reports · doi:10.1007/s12281-017-0304-7 · Cited by 83
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Hayes, G., & Novak-Frazer, L. (2016) · Journal of Fungi · doi:10.3390/jof2020018 · Cited by 77
“Standardisation of techniques, re-evaluation of controls and, perhaps, reassignment of normal levels, is needed to ensure that antibody testing remains relevant and appropriate to the target population [80].”
MethodRecent Advances in Diagnosing Chronic Pulmonary Aspergillosis
Takazono, T., & Izumikawa, K. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01810 · Cited by 71
Sehgal, I. S., Choudhary, H., Dhooria, S., Aggarwal, A. N., Garg, M. K., Chakrabarti, A., & Agarwal, R. (2018) · Mycoses · doi:10.1111/myc.12815 · Cited by 75
Chronic pulmonary aspergillosis update: A year in review
Barac, A. M., Kosmidis, C., Alastruey‐Izquierdo, A., Salzer, H. J. F., & CPAnet (2018) · Medical Mycology · doi:10.1093/mmy/myy070 · Cited by 72
Post tuberculosis treatment infectious complications
Hsu, D., Irfan, M., Jabeen, K., Iqbal, N., Hasan, R., Migliori, G. B., Zumla, A. I., Visca, D., Centis, R., & Tiberi, S. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.02.032 · Cited by 68
Bongomin, F., Asio, L. G., Baluku, J. B., Kwizera, R., & Denning, D. W. (2020) · Journal of Fungi · doi:10.3390/jof6020075 · Cited by 71
“However, similar studies have shown that using the ImmunoCAP system, a cut-off of 40 mg/L appears sub-optimal for CPA diagnosis and may require revision in this context [55].”
BackgroundSelf-citationSehgal, I. S., Dhooria, S., Choudhary, H., Aggarwal, A. N., Garg, M. K., Chakrabarti, A., & Agarwal, R. (2019) · Journal of Clinical Microbiology · doi:10.1128/jcm.01821-18 · Cited by 64
Non-surgical treatment options for pulmonary aspergilloma
Lang, M., Lang, A. L., Chauhan, N. R., & Gill, A. (2020) · Respiratory Medicine · doi:10.1016/j.rmed.2020.105903 · Cited by 60
Thornton, C. R. (2019) · Advances in applied microbiology · doi:10.1016/bs.aambs.2019.10.003 · Cited by 60
“In a study 667 comparing six of these assays (Page et al., 2016), the automated ImmunoCAP fluoroenzyme 668 immunoassay and Immunolite ELISA variant (Page et al., 2015) were significantly superior to 669 the other assays (Dynamiker, Genesis, and Serion) in diagnosing CPA, with identical 670…”
BackgroundMethodAspergillusserology: Have we arrived yet?
Richardson, M. D., & Page, I. D. (2016) · Medical Mycology · doi:10.1093/mmy/myw116 · Cited by 58
Self-citationHunter, E. S., Richardson, M. D., & Denning, D. W. (2019) · Journal of Clinical Microbiology · doi:10.1128/jcm.00538-19 · Cited by 55
“Using other suggested cutoff values of 20 mgA/liter (6) and 50 mgA/liter (22), the ImmunoCAP sensitivities for this data set were calculated as 93.”
MethodSelf-citationMulticenter Evaluation of a Novel Immunochromatographic Test for Anti-aspergillus IgG Detection
Piarroux, R., Romain, T., Martin, A., Vainqueur, D., Vitte, J., Lachaud, L., Gangneux, J., Gabriel, F., Fillaux, J., & Ranque, S. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00012 · Cited by 51
Bronchiectasis andAspergillus: How are they linked?
Soyza, A. D., & Aliberti, S. (2016) · Medical Mycology · doi:10.1093/mmy/myw109 · Cited by 50
Page, I. D., Baxter, C. G., Hennequin, C., Richardson, M. D., Hoeyveld, E. V., van Toorenenbergen, A. W., & Denning, D. W. (2018) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2018.01.001 · Cited by 50
Self-citationSalzer, H. J. F., Heyckendorf, J., Kalsdorf, B., Rolling, T., & Lange, C. G. (2016) · Mycoses · doi:10.1111/myc.12589 · Cited by 49
An overview of the available treatments for chronic cavitary pulmonary aspergillosis
Sehgal, I. S., Dhooria, S., Muthu, V., Prasad, K. T., & Agarwal, R. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2020.1750956 · Cited by 48
“fumigatus-specific IgG, ImmunoCap and Immulite were found to be the most reliable [9].”
BackgroundValtonen, V. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00951 · Cited by 48
The Burden of Fungal Infections in Ethiopia
Tufa, T. B., & Denning, D. W. (2019) · Journal of Fungi · doi:10.3390/jof5040109 · Cited by 45
Self-citationCurrent Infections of the Orofacial Region: Treatment, Diagnosis, and Epidemiology
Tahmasebi, E., Keshvad, A., Alam, M. M. R., Abbasi, K., Rahimi, S., Nouri, F., Yazdanıan, M., Tebyanian, H., Heboyan, A. G., & Fernandes, G. V. O. (2023) · Life · doi:10.3390/life13020269 · Cited by 49
Sehgal, I. S., Dhooria, S., Choudhary, H., Aggarwal, A. N., Garg, M. K., Chakrabarti, A., & Agarwal, R. (2019) · Mycoses · doi:10.1111/myc.12987 · Cited by 44
Carsin, A., Romain, T., Ranque, S., Reynaud‐Gaubert, M., Dubus, J. ‐., Mège, J., & Vitte, J. (2017) · Allergy · doi:10.1111/all.13204 · Cited by 44
Li, H., Rui, Y., Zhou, W., Liu, L., He, B., Shi, Y. P., & Su, X. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01438 · Cited by 43
“6%) was slightly lower compared to the previously published results obtained using Dynamiker assay (97%), Immuno CAP assay (98%), Immulite (98%), Serion (98%), Genesis (99%) and Precipitins (100%) assays (Page et al., 2016).”
BackgroundResultInfluentialNguyen, N. T. B., Ngoc, H. L., Nhung, N. V., Dinh, L. V., Nhung, N. V., Nguyen, H. T., & Denning, D. W. (2021) · Journal of Fungi · doi:10.3390/jof7070532 · Cited by 40
Self-citationAllergic and Noninvasive Infectious Pulmonary Aspergillosis Syndromes
Muldoon, E. G., Strek, M. E., & Patterson, K. C. (2017) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2017.04.012 · Cited by 40
Severe interstitial pulmonary fibrosis in a patient with chronic ulcerative colitis.
McKee, A. L., Rajapaksa, A., Kalish, P. E., & Pitchumoni, C. S. (1983) · PubMed · Cited by 39
Godet, C., Alastruey‐Izquierdo, A., Flick, H., Hennequin, C., Mikilps-Mikgelbs, R., Munteanu, O., Page, I. D., Seidel, D., Salzer, H. J. F., & CPAnet (2017) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx390 · Cited by 37
Self-citationInnate and Adaptive Immune Defects in Chronic Pulmonary Aspergillosis
Bongomin, F., Harris, C., Foden, P., Kosmidis, C., & Denning, D. W. (2017) · Journal of Fungi · doi:10.3390/jof3020026 · Cited by 36
“(2016) reported two cases without any Aspergillus IgG in multiple assays and referred to them as “seronegative CPA”, since they had overt CPA but negative titres for Aspergillus antibody; ineffective antibody response to Aspergillus due to underlying immune deficit was a suggested explanation [42].”
BackgroundSelf-citationTashiro, M., Takazono, T., & Izumikawa, K. (2024) · Therapeutic Advances in Infectious Disease · doi:10.1177/20499361241253751 · Cited by 39
“165 ,166 Various cutoff values have been proposed, but no definitive conclusion has been reached.”
BackgroundHarada, K., Oguma, T., Saito, A., Fukutomi, Y., Tanaka, J., Tomomatsu, K., Taniguchi, M., & Asano, K. (2018) · Allergology International · doi:10.1016/j.alit.2018.04.009 · Cited by 34
Lee, M., Huang, H.-L., Chen, L.-C., Yang, H., Ko, J., Cheng, M., Chong, I., Lee, L., Wang, J., & Dimopoulos, G. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2019.12.009 · Cited by 34
Ray, A., Chowdhury, M., Sachdev, J., Sethi, P., Meena, V. P., Singh, G., Xess, I., Vyas, S., Khan, M. A., Sinha, S., et al. (2022) · Journal of Fungi · doi:10.3390/jof8040400 · Cited by 33
Self-citationImproving the rates ofAspergillusdetection: an update on current diagnostic strategies
Jenks, J. D., Salzer, H. J. F., & Hoenigl, M. (2018) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2018.1558054 · Cited by 33
“To date the most promising diagnostic test for CPA is the Aspergillus-specific IgG antibody assay from blood with a reported sensitivity and specificity of up to 96%and 99%, respectively [120,121].”
BackgroundChronic pulmonary aspergillosis is common among patients with presumed tuberculosis relapse in Ghana
Ocansey, B. K., Otoo, B., Adjei, A., Gbadamosi, H., Kotey, F. C. N., Kosmidis, C., Afriyie-Mensah, J. S., Denning, D. W., & Opintan, J. A. (2022) · Medical Mycology · doi:10.1093/mmy/myac063 · Cited by 30
Self-citationNon-invasive and invasive diagnoses of aspergillosis in a rat model by mass spectrometry
Luptáková, D., Pluháček, T., Petřík, M., Novák, J., Palyzová, A., Sokolová, L., Škríba, A., Šedivá, B., Lemr, K., & Havlı́ček, V. (2017) · Scientific Reports · doi:10.1038/s41598-017-16648-z · Cited by 29
Volpe‐Chaves, C. E., de Oliveira, S. M. D. V. L., Venturini, J., Grande, A. J., Sylvestre, T. F., Mendes, R. P., & Paniago, A. M. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0222738 · Cited by 29
“Two studies used commercials tests [23, 26] using the fluorescent enzyme immunoassay method with the ImmunoCAP system, and the best cut-off value for this test in our study (sensitivity: 100%, specificity: 96%) was 27 mgA/L [26].”
BackgroundMethodInfluentialYu, Q., He, J., Xing, B., Li, X., Qian, H., Zhang, H., Xu, M., & Peng, H. (2020) · BMC Pulmonary Medicine · doi:10.1186/s12890-020-1125-y · Cited by 28
Hunter, E. S., Wilopo, B. A. P., Richardson, M. D., Kosmidis, C., & Denning, D. W. (2021) · Respiratory Medicine · doi:10.1016/j.rmed.2020.106290 · Cited by 28
“In rare cases (estimated 3.7% [8] - 7%), patients presented with clear clinical and radiological evidence of CPA as well as repeatedly positive sputum Aspergillus culture or PCR (ELITech, Puteaux, France), despite the absence of an antibody response (negative Aspergillus serology).”
BackgroundResultInfluentialSelf-citationImmunoproteomics of Aspergillus for the development of biomarkers and immunotherapies
Kniemeyer, O., Ebel, F., Krüger, T., Bächer, P., Scheffold, A., Luo, T., Straßburger, M., & Brakhage, A. A. (2016) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201600053 · Cited by 26
Aspergillus-specific antibodies – Targets and applications
Schubert, M., Spiegel, H., Schillberg, S., & Nölke, G. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.03.016 · Cited by 26
Ma, X., Wang, K., Zhao, X., Liu, Y., Li, Y., Yu, X., Li, C., Denning, D. W., & Xie, L. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-4303-x · Cited by 26
Self-citationSiemens Immulite Aspergillus-specific IgG assay for chronic pulmonary aspergillosis diagnosis
Page, I. D., Richardson, M. D., & Denning, D. W. (2018) · Medical Mycology · doi:10.1093/mmy/myy024 · Cited by 25
Self-citationZhong, H., Wang, Y., Gu, Y., Ni, Y., Wang, Y., Shen, K., Shi, Y. P., & Su, X. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.811807 · Cited by 25
Lu, Y., Liu, L., Li, H., Chen, B., Gu, Y., Wang, L., Feng, C., Chen, C., Chen, Y., Sun, W., et al. (2023) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2023.02.002 · Cited by 25
Martín-Gómez, M. T., Goterris, L., Martínez‐Martí, A., Sampol, J., Roldán, E., Almirante, B., & Ruíz-Camps, I. (2019) · Mycoses · doi:10.1111/myc.12950 · Cited by 24
Jaca, A., Ndze, V. N., & Wiysonge, C. S. (2019) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2019.1631567 · Cited by 24
Diagnostic Aspects of Chronic Pulmonary Aspergillosis: Present and New Directions
Wilopo, B. A. P., Richardson, M. D., & Denning, D. W. (2019) · Current Fungal Infection Reports · doi:10.1007/s12281-019-00361-7 · Cited by 23
Self-citationChronic Pulmonary Aspergillosis: A Brief Review.
Zarif, A., Thomas, A., & Vayro, A. (2021) · PubMed Central · doi:10.17863/cam.80907 · Cited by 23
Salzer, H. J. F., Wassilew, N., Köhler, N., Olaru, I. D., Günther, G., Herzmann, C., Kalsdorf, B., Carballo, P. M. S., Terhalle, E., Rolling, T., et al. (2016) · Respiration · doi:10.1159/000449037 · Cited by 22
Shinfuku, K., Suzuki, J., Takeda, K., Kawashima, M., Morio, Y., Sasaki, Y., Nagai, H., Watanabe, A., Matsui, H., & Kamei, K. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.03435-22 · Cited by 22
Clinical Characteristics and Treatment Outcomes of Pathologically Confirmed Aspergillus Nodules
Kang, N., Park, J., & Jhun, B. W. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072185 · Cited by 20
Aspergillus-Associated Endophenotypes in Bronchiectasis
Jaggi, T. K., Ter, S. K., Aogáin, M. M., & Chotirmall, S. H. (2021) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0041-1730947 · Cited by 19
Serological evidence of chronic pulmonary Aspergillosis in tuberculosis patients in Kenya
Mohamed, A., Obanda, B. A., Njeri, H. K., Loroyokie, S. N., Mashedi, O., Ouko, T. T., Gatumwa, E. M., Korir, R. K., Yaguchi, T., & Bii, C. C. (2022) · BMC Infectious Diseases · doi:10.1186/s12879-022-07782-9 · Cited by 19
“fumigatus IgG tests and only comparable to automated fluorescent ELISA assays [21, 31].”
MethodLarkin, P. M. K., Multani, A., Beaird, O. E., Dayo, A. J., Fishbein, G. A., & Yang, S. (2020) · Journal of Fungi · doi:10.3390/jof6030106 · Cited by 20
“Antibody testing for Aspergillus precipitins appears to have lower sensitivity than conventional Aspergillus-specific IgG assays [14].”
BackgroundAnan, K., Kataoka, Y., Okabayashi, S., Yamamoto, R., Namkoong, H., & Yamamoto, Y. (2021) · Mycoses · doi:10.1111/myc.13253 · Cited by 18
Setianingrum, F., Rozaliyani, A., Sjam, R., Adawıyah, R., Tugiran, M., Sari, C. Y. I., Burhan, E., Wahyuningsih, R., Rautemaa‐Richardson, R., & Denning, D. W. (2020) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2020.115124 · Cited by 18
Self-citationSehgal, I. S., Kathirvel, S., Agarwal, R., Muthu, V., Dhooria, S., Prasad, K. T., Salzer, H. J. F., Cornely, O. A., Aggarwal, A. N., & Chakrabarti, A. (2025) · Mycoses · doi:10.1111/myc.70060 · Cited by 17
“[60–62].”
Rodríguez, N. B., Juan-Galán, J. L. S., Andreu, C. M. F., Yera, D. M., Pita, M. B., Lancha, M. R. P., Martínez, R. E. V., Zaragozí, M. T. I., & Machín, G. F. M. (2019) · Journal of Fungi · doi:10.3390/jof5010018 · Cited by 17
Takeda, K., Suzuki, J., Watanabe, A., Narumoto, O., Kawashima, M., Sasaki, Y., Nagai, H., Kamei, K., & Matsui, H. (2021) · Journal of Clinical Microbiology · doi:10.1128/jcm.02018-21 · Cited by 16
Developments in Fungal Serology
White, P. L. (2023) · Current Fungal Infection Reports · doi:10.1007/s12281-023-00462-4 · Cited by 17
Niu, Y., Li, J., Shui, W., Li, D., Yu, C., Fu, X., & Zhang, C. (2020) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2020.101041 · Cited by 16
Lee, M., Huang, H., Keng, L., Chang, H., Sheu, C., Fu, P., Wang, J., Chong, I., Shih, J., & Yu, C. (2021) · Journal of Fungi · doi:10.3390/jof7060480 · Cited by 16
“, none of control group (from Uganda) had Asp-IgG level above 40 mgA/L [14].”
BackgroundMethodInfluentialAwareness of predictors of mortality may help improve outcome in chronic pulmonary aspergillosis
Salzer, H. J. F., & Cornely, O. A. (2017) · European Respiratory Journal · doi:10.1183/13993003.02520-2016 · Cited by 15
ELISA Test for the Serological Detection of Scedosporium/Lomentospora in Cystic Fibrosis Patients
Martin–Souto, L., Buldain, I., Areitio, M., Aparicio-Fernandez, L., Antoran, A., Bouchara, J., Martín-Gómez, M. T., Rementerı́a, A., Hernando, F. L., & Ramirez‐Garcia, A. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.602089 · Cited by 15
“Hence, further experiments were carried out using Total WCP. Crude antigenic extracts have been widely used in immunodiagnostic systems, some of them being currently commercially available for the detection of Aspergillus (Page et al., 2016; Richardson and Page, 2017).”
MethodComparison of Aspergillus-specific antibody cut-offs for the diagnosis of aspergillosis
Hsiao, C.-W., Yen, T., Wu, Y.-C., Chen, J., Chen, Y., Huang, W., Chen, Y., & Chen, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1060727 · Cited by 15
“…A. fumigatus Healthy control 122 50 98/84 Japan Fujiuchi et al., 2016 Disease control 51 CPA 96 8 A. fumigatus CPA (UK) 241 20 96/98 United Kingdom Page et al., 2016 Healthy controls (Uganda) 100 9 A. fumigatus CPA (United Kingdom) 241 50 83.8/95.6 United Kingdom Page et al., 2018 Healthy…”
BackgroundMethodResultInfluentialSingh, S., Choudhary, H., Agnihotri, S., Sehgal, I. S., Agarwal, R., Kaur, H., Ghosh, A. K., Chakrabarti, A., & Rudramurthy, S. M. (2022) · Indian Journal of Medical Microbiology · doi:10.1016/j.ijmmb.2022.03.002 · Cited by 15
Jabeen, K., Farooqi, J. Q., Iqbal, N., Wahab, K., & Irfan, M. (2020) · Journal of Fungi · doi:10.3390/jof6040249 · Cited by 14
“fumigatus-specific IgG, reported in our study, is lower than that reported in previous studies evaluating similar assay [6,7,13,14].”
ResultZhu, R., Zhou, L., Cheng, J.-H., Luo, Y., Qiu, W., Huang, J.-T., Jiang, Y., Zhao, H., Wang, X., Chen, Z., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.00264-23 · Cited by 14
Aspergillus-Nachweis im Atemwegsmaterial
Salzer, H. J. F., Lange, C. G., & Hönigl, M. (2017) · Der Internist · doi:10.1007/s00108-017-0334-9 · Cited by 14
Chronic Cavitary Infections Other than Tuberculosis
Holt, M. R., & Chan, E. D. (2018) · Journal of Thoracic Imaging · doi:10.1097/rti.0000000000000345 · Cited by 13
Yao, Y., Zhou, H., Shen, Y., Yang, Q., Ye, J., Fu, Y., Lu, G., Lou, H., Yu, Y., & Zhou, J. (2018) · The Clinical Respiratory Journal · doi:10.1111/crj.12957 · Cited by 12
Ndze, V. N., Jaca, A., & Wiysonge, C. S. (2019) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2019.1623998 · Cited by 11
Seroprevalence of Aspergillus-Specific IgG Antibody among Mozambican Tuberculosis Patients
Salzer, H. J. F., Massango, I., Bhatt, N., Machonisse, E., Reimann, M., Heldt, S., Lange, C. G., Höelscher, M., Khosa, C., & Rachow, A. (2021) · Journal of Fungi · doi:10.3390/jof7080595 · Cited by 11
“There are several commercially available Aspergillus-specific IgG antibody tests showing high sensitivity and specificity of up to 93% and 99%, respectively [12,13].”
BackgroundPersat, F., Hennequin, C., Gangneux, J., & for the Société Française de Mycologie Médicale – SFMM Study group (2016) · Medical Mycology · doi:10.1093/mmy/myw078 · Cited by 11
Huang, S., Li, S., Chan, Y., Huang, Y., Yang, Y., & Wang, F. (2020) · Mycoses · doi:10.1111/myc.13143 · Cited by 11
Sehgal, I. S., Dhooria, S., Sachdeva, N. K., Rudramurthy, S. M., Prasad, K. T., Muthu, V., Aggarwal, A. N., Garg, M. K., Chakrabarti, A., & Agarwal, R. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15356 · Cited by 9
Mei, Z., Han, J.-F., Yu, H., Zhang, Y., Ji, P., Xie, Y., & Hsueh, P. (2023) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-023-04637-2 · Cited by 9
Yao, Y., Zhou, H., Yang, Q., Lu, G., Yu, Y., Shen, Y., & Zhou, J. (2017) · The Clinical Respiratory Journal · doi:10.1111/crj.12702 · Cited by 8
Wilopo, B. A. P., Hunter, E. S., Richardson, M. D., & Denning, D. W. (2020) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2020.106021 · Cited by 8
Self-citationLiu, A., Chen, W., Wei, Y., Liang, J., Liao, S.-H., Chen, Y., Li, Y., Wang, X., Chen, W., Qiu, Y., et al. (2023) · BMC Pulmonary Medicine · doi:10.1186/s12890-023-02620-3 · Cited by 8
“A. fumigatus -specific IgG detected using double gel diffusion technique has a sensitivity of only 27% in the diagnosis of ABPA while the commercial enzyme immunoassay methods for measuring A. fumigatus -specific IgG have a sensitivity exceeding 90% [31, 32].”
MethodImproving Diagnostic Sensitivity of Chronic Pulmonary Aspergillosis Using Species‐Specific IgG
Sehgal, I. S., Agarwal, R., Muthu, V., Dhooria, S., Prasad, K. T., Rudramurthy, S. M., Aggarwal, A. N., Garg, M. K., & Chakrabarti, A. (2025) · Mycoses · doi:10.1111/myc.70107 · Cited by 7
“The sensitivity of serum A. fumigatus - IgG ranges from 85% to 92%, potentially missing 8%– 15% of the CPA cases [6–11].”
Dewi, I. M. W., Fauziah, N., Ekawardhani, S., Andriyoko, B., Adawıyah, R., Hartantri, Y., Soeroto, A. Y., Alisjahbana, B., Denning, D. W., & Wahyuningsih, R. (2023) · Medical Mycology · doi:10.1093/mmy/myad036 · Cited by 7
Self-citationStandardization of Aspergillus IgG diagnostic cutoff in Nigerians
Oladele, R. O., Otu, A. A., Balogun, O. J., Babalola, M. O., Nwosu, A. O., Osaigbovo, I. I., Gbaja-Biamila, T. A., Irurhe, N., Fayemiwo, S. A., Shettima, S. A., et al. (2021) · Therapeutic Advances in Infectious Disease · doi:10.1177/20499361211050158 · Cited by 7
Self-citationSennekamp, J., Lehmann, E., & Joest, M. (2022) · Allergo Journal International · doi:10.1007/s40629-022-00208-7 · Cited by 7
Maruguchi, N., Tanaka, E., Okagaki, N., Tanaka, Y., Sakamoto, H., Takeda, A., Yamamoto, R., Nakamura, S., Matsumura, K., Ueyama, M., et al. (2023) · Internal Medicine · doi:10.2169/internalmedicine.0836-22 · Cited by 7
“Considering the reported high sensitivity and specificity of anti-Aspergillus antibodies, their detection plays a vital role in this process (20).”
BackgroundKeng, L., Lin, C.-C., Wu, C. W., Liu, C.-J., Chang, L., Lee, M., Chen, J., & Wang, J. (2024) · Pathogens and Global Health · doi:10.1080/20477724.2024.2424489 · Cited by 5
“Aspergillus IgG was measured using an automated ImmunoCAP system (Phadia 100; Thermo Fisher Scientific, Uppsala, Sweden) [11].”
Metadata
- Authors
- Page, I. D., Richardson, M. D., & Denning, D. W.
- Affiliations
- Manchester Academic Health Science Centre (GB)
- Corresponding author
- Page, Iain D.
- Richardson, Malcolm D.
- Denning, David W.
- Venue
- Journal of Infection
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 72
- Issue
- 2
- Pages
- 240-249
- ISSN
- 0163-4453 (ISSN-L)
- OpenAlex
- W2239408616
- Cited by
- 161
- References
- 32
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 12 · 2023: 18 · 2022: 12 · 2021: 13 · 2020: 16 · 2019: 15 · 2018: 18 · 2017: 15 · 2016: 12
- FWCI
- 11.68
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Journal of Infection (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- Funders
- National Institute for Health Research Respiratory and Allergy Clinical Research Facility
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- chronic pulmonary aspergillosis, Aspergillus-specific IgG, serological diagnosis, diagnostic thresholds, ImmunoCAP, Immulite, Genesis, precipitin test, sensitivity and specificity, Aspergillus antigen
- MeSH terms
- Adult, Aged, Aged, 80 and over, Antibodies, Fungal, Aspergillus, Chronic Disease, Female, Humans, Immunoglobulin G, Male, Middle Aged, Sensitivity and Specificity, Serologic Tests, Pulmonary Aspergillosis, Young Adult
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