Listeria monocytogenes meningitis in the Netherlands, 1985–2014: a nationwide surveillance study
Open accessAbstract
OBJECTIVES: Listeria monocytogenes can cause sepsis and meningitis. We report national surveillance data on L. monocytogenes meningitis in the Netherlands, describing incidence changes, genetic epidemiology and fatality rate. METHODS: We analyzed data from the Netherlands Reference Laboratory of Bacterial Meningitis for cases of L. monocytogenes meningitis. Strains were assessed by serotyping and bacterial population structure by multi-locus sequence typing. RESULTS: A total of 375 cases of Listeria meningitis were identified between 1985 and 2014. Peak incidence rates were observed in neonates (0.61 per 100,000 live births) and older adults (peak at 87 year; 0.53 cases per 100,000 population of the same age). Neonatal listerial meningitis decreased 17-fold from 1.95 per 100,000 live births between 1985 and 1989, to 0.11 per 100,000 live births between 2010 and 2014. Overall case fatality rate was 31%, in a multivariate analysis older age and concomitant bacteremia were associated with mortality (both p < 0.01). Clonal complexes (CC) CC1, CC2 and CC3 decreased over time from respectively 32% to 12%, 33% to 9% and 10% to 2% (all p < 0.001), while CC6 increased from 2% to 26% (p < 0.001). CONCLUSIONS: The incidence of neonatal listerial meningitis has declined over the past 25 years. The genotype CC6 has become the predominant genotype in listerial meningitis in the Netherlands. Mortality of listeria meningitis has remained high.
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Enterobacteriaceae such as E. coli and rarely Listeria monocytogenes, Haemophilus influenzae, Streptococcus agalactiae, Staphylococcus aureus are associated with mortality estimates ranging from 30% to 60%.
“These include Enterobacteriaceae such as E. coli and rarely Listeria monocytogenes, Haemophilus influenzae, Streptococcus agalactiae, Staphylococcus aureus, 22 which are associated with mortality estimates ranging from 30% to 60%.7,22,23”
From Community-acquired acute bacterial meningitis in adults: a clinical update (2019) · cites this paper as [23]
The Results report a 31% case-fatality rate for Listeria meningitis, supporting the lower end of the stated mortality range for that pathogen. The cited passages do not establish 30%–60% mortality for the other listed organisms, and the Background’s 61% figure concerns unfavorable outcomes, not mortality. Page numbers were not supplied. (LLM, conf=0.88)
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Cites
Clinical features and prognostic factors in adults with bacterial meningitis
van de Beek, D., de Gans, J., Spanjaard, L., Weisfelt, M., Reitsma, J. B., & Vermeulen, M. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040845 · Cited by 1,639 · see citing works
Self-citationEpidemic Listeriosis — Evidence for Transmission by Food
Schlech, W. F., Lavigne, P. M., Bortolussi, R. A., Allen, A. C., Haldane, E. V., Wort, A. J., Hightower, A. W., Johnson, S. E., King, S. H., Nicholls, E. S., et al. (1983) · New England Journal of Medicine · doi:10.1056/nejm198301273080407 · Cited by 1,503 · see citing works
Acute Bacterial Meningitis in Adults -- A Review of 493 Episodes
Durand, M. L., Calderwood, S. B., Weber, D. J., Miller, S. I., Southwick, F. S., Caviness, V. S., & Swartz, M. N. (1993) · New England Journal of Medicine · doi:10.1056/nejm199301073280104 · Cited by 1,344 · see citing works
Dexamethasone in Adults with Bacterial Meningitis
de Gans, J., & van de Beek, D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021334 · Cited by 1,196 · see citing works
Pasteurized Milk as a Vehicle of Infection in an Outbreak of Listeriosis
Fleming, D. W., Cochi, S. L., MacDonald, K. L., Brondum, J., Hayes, P. S., Plikaytis, B. D., Holmes, M. B., Audurier, A., Broome, C. V., & Reingold, A. L. (1985) · New England Journal of Medicine · doi:10.1056/nejm198502143120704 · Cited by 1,065 · see citing works
Epidemic Listeriosis Associated with Mexican-Style Cheese
Linnan, M. J., Mascola, L., Lou, X. D., Goulet, V., May, S., Salminen, C. A., Hird, D. W., Yonekura, M. L., Hayes, P. S., Weaver, R. E., et al. (1988) · New England Journal of Medicine · doi:10.1056/nejm198809293191303 · Cited by 1,043 · see citing works
Bacterial Meningitis in the United States, 1998–2007
Thigpen, M. C., Whitney, C. G., Messonnier, N. E., Zell, E. R., Lynfield, R., Hadler, J. L., Harrison, L. H., Farley, M. M., Reingold, A. L., Bennett, N. M., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1005384 · Cited by 957 · see citing works
Community-Acquired Bacterial Meningitis in Adults
van de Beek, D., de Gans, J., Tunkel, A. R., & Wijdicks, E. F. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052116 · Cited by 871 · see citing works
Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity
Maury, M. M., Tsai, Y.-H., Charlier, C., Touchon, M., Chenal‐Francisque, V., Leclercq, A., Criscuolo, A., Gaultier, C., Roussel, S., Brisabois, A., et al. (2016) · Nature Genetics · doi:10.1038/ng.3501 · Cited by 699 · see citing works
Global optimal eBURST analysis of multilocus typing data using a graphic matroid approach
Francisco, A. P., Bugalho, M., Ramirez, M., et al. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-152 · Cited by 631 · see citing works
A New Perspective on Listeria monocytogenes Evolution
Ragon, M., Wirth, T., Hollandt, F., Lavenir, R., Lecuit, M., Monnier, A. L., & Brisse, S. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000146 · Cited by 589 · see citing works
Charlier, C., Perrodeau, É., Leclercq, A., Cazenave, B., Pilmis, B., Henry, B., Lopes, A., Maury, M. M., Moura, A., Goffinet, F., et al. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)30521-7 · Cited by 574 · see citing works
Mylonakis, E. E., Hohmann, E. L., & Calderwood, S. B. (1998) · Medicine · doi:10.1097/00005792-199809000-00002 · Cited by 474 · see citing works
Bijlsma, M. W., Brouwer, M. C., Kasanmoentalib, E. S., Kloek, A. T., Lucas, M. J., Tanck, M. W., van der Ende, A., & van de Beek, D. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)00430-2 · Cited by 412 · see citing works
Self-citationGellin, B. G. (1989) · JAMA · doi:10.1001/jama.1989.03420090077035 · Cited by 344 · see citing works
Schuchat, A. (1992) · JAMA · doi:10.1001/jama.267.15.2041 · Cited by 271 · see citing works
Büla, C., Bille, J., & Glauser, M. P. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/20.1.66 · Cited by 251 · see citing works
Community-Acquired Listeria monocytogenes Meningitis in Adults
Brouwer, M. C., van de Beek, D., Heckenberg, S. G. B., Spanjaard, L., & de Gans, J. (2006) · Clinical Infectious Diseases · doi:10.1086/508462 · Cited by 248 · see citing works
Self-citationMethods used for the detection and subtyping of Listeria monocytogenes
Jadhav, S. R., Bhave, M. R., & Palombo, E. A. (2012) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2012.01.002 · Cited by 212 · see citing works
Worldwide Distribution of Major Clones ofListeria monocytogenes
Chenal‐Francisque, V., Lopez, J., Cantinelli, T., et al. (2011) · Emerging infectious diseases · doi:10.3201/eid/1706.101778 · Cited by 188 · see citing works
Role of Foods in Sporadic Listeriosis
Schuchat, A. (1992) · JAMA · doi:10.1001/jama.1992.03480150047035 · Cited by 184 · see citing works
Gellin, B. G., & Broome, C. V. (1989) · PubMed · Cited by 158 · see citing works
Bekker, V., Bijlsma, M. W., van de Beek, D., Kuijpers, T. W., & ENDE, A. V. D. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70919-3 · Cited by 157 · see citing works
Self-citation“Epidemic Clones” of Listeria monocytogenes Are Widespread and Ancient Clonal Groups
Cantinelli, T., Chenal‐Francisque, V., Diancourt, L., Frézal, L., Leclercq, A., Wirth, T., Lecuit, M., & Brisse, S. (2013) · Journal of Clinical Microbiology · doi:10.1128/jcm.01874-13 · Cited by 130 · see citing works
Koopmans, M. M., Brouwer, M. C., Bijlsma, M. W., Man-Bovenkerk, S., Keijzers, W. C., ENDE, A. V. D., & van de Beek, D. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit250 · Cited by 129 · see citing works
Self-citationVoetsch, A. C., Angulo, F. J., Jones, T. F., Moore, M. R., Nadon, C. A., McCarthy, P. V., Shiferaw, B., Megginson, M., Hurd, S., Anderson, B. J., et al. (2007) · Clinical Infectious Diseases · doi:10.1086/511006 · Cited by 119 · see citing works
Benzalkonium tolerance genes and outcome in Listeria monocytogenes meningitis
Kremer, P. H. C., Lees, J. A., Koopmans, M. M., Ferwerda, B., Arends, A., Feller, M., Schipper, K., Serón, M. V., ENDE, A. V. D., Brouwer, M. C., et al. (2016) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2016.12.008 · Cited by 115 · see citing works
Self-citationBijlsma, M. W., Bekker, V., Brouwer, M. C., Spanjaard, L., van de Beek, D., & ENDE, A. V. D. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70806-0 · Cited by 108 · see citing works
Self-citationAmaya‐Villar, R., García-Cabrera, E., Sulleiro, E., et al. (2010) · BMC Infectious Diseases · doi:10.1186/1471-2334-10-324 · Cited by 96 · see citing works
Arslan, F., Meynet, E., Sünbül, M., Sıpahı, O. R., Kurtaran, B., Kaya, S., İnkaya, A. Ç., Pagliano, P., Şengöz, G., Batırel, A. A., et al. (2015) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-015-2346-5 · Cited by 93 · see citing works
Progress and challenges in bacterial meningitis
van de Beek, D. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61808-x · Cited by 92 · see citing works
Listeriosis in the United States: 1980-1982
Ciesielski, C. A. (1988) · Archives of Internal Medicine · doi:10.1001/archinte.1988.00380060180031 · Cited by 82 · see citing works
Pradhan, A. K., Ivanek, R., Grohn, Y. T., et al. (2009) · Journal of Food Protection · doi:10.4315/0362-028x-72.5.978 · Cited by 76 · see citing works
Pregnancy-related listeriosis in France, 1984 to 2011, with a focus on 606 cases from 1999 to 2011
Girard, D., Leclercq, A., Laurent, E., et al. (2014) · Eurosurveillance · doi:10.2807/1560-7917.es2014.19.38.20909 · Cited by 65 · see citing works
Pelegrín, I., Moragas, M., Suárez, C., Ribera, A., Verdaguer, R., Martínez‐Yélamos, S., Borrego, F. R., Ariza, J., Viladrich, P. F., & Cabellos, C. (2014) · Infection · doi:10.1007/s15010-014-0636-y · Cited by 64 · see citing works
Moon, S., Chung, D. R., Kim, S., Chang, H., Lee, H., Jung, D. S., Ys, K., Jung, S., Ryu, S. Y., Heo, S. T., et al. (2010) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-010-0929-8 · Cited by 52 · see citing works
Doorduyn, Y., de Jager, C. M., van der Zwaluw, W. K., et al. (2006) · Weekly releases (1997–2007) · doi:10.2807/esw.11.16.02945-en · Cited by 21 · see citing works
Listeria monocytogenesMeningitis in Adults: The Czech Republic Experience
Džupová, O., Rozsypal, H., Smíšková, D., et al. (2013) · BioMed Research International · doi:10.1155/2013/846186 · Cited by 18 · see citing works
Intensieve surveillance van Listeria monocytogenes in Nederland, 2007
Doorduyn, Y. D., de Jager, C. M., van der Zwaluw, W. K., Wannet, W. J. B., Heuvelink, A., ENDE, A. V. D., Spanjaard, L., & van Pelt, W. (2008) · Data Archiving and Networked Services (DANS) · Cited by 2 · see citing works
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Molecular diagnostics in cerebrospinal fluid for the diagnosis of central nervous system infections
Olie, S. E., Andersen, C. Ø., van de Beek, D., & Brouwer, M. C. (2024) · Clinical Microbiology Reviews · doi:10.1128/cmr.00021-24 · Cited by 38 · see citing works
“It accounts for 5%–10% of bacterial meningitis patients in adults, which makes it the third most common pathogen after S. pneumoniae and N. meningitidis in Western countries (182).”
Self-citationCommunity-acquired acute bacterial meningitis in adults: a clinical update
Ellis, J., Luintel, A., Chandna, A., & Heyderman, R. S. (2019) · British Medical Bulletin · doi:10.1093/bmb/ldz023 · Cited by 12 · see citing works
- Authors
- Koopmans, M. M., Bijlsma, M. W., Brouwer, M. C., van de Beek, D., & van der Ende, A.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Venue
- Journal of Infection
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 75
- Issue
- 1
- Pages
- 12-19
- ISSN
- 0163-4453 (ISSN-L)
- PMC
- PMC5513958
- OpenAlex
- W2606594309
- Cited by
- 79
- References
- 39
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 15 · 2023: 4 · 2022: 9 · 2021: 11 · 2020: 8 · 2019: 10 · 2018: 12 · 2017: 1
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Infection (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- European Commission (279185)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Listeria monocytogenes in Food Safety
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Keywords
- Listeria monocytogenes, incidence trends, neonatal listeriosis, case fatality rate, clonal complexes, genetic epidemiology, multilocus sequence typing, serotyping, bacteremia, mortality risk factors, Netherlands
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Genotype, Humans, Infant, Infant, Newborn, Listeria monocytogenes, Male, Meningitis, Listeria, Middle Aged, Mortality, Netherlands, Serotyping, Incidence, Bacteremia, Young Adult, Multilocus Sequence Typing, Epidemiological Monitoring
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