Bronchoalveolar lavage Aspergillus Galactomannan lateral flow assay versus Aspergillus-specific lateral flow device test for diagnosis of invasive pulmonary Aspergillosis in patients with hematological malignancies
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Recent studies showed that BAL fluid GM has improved sensitivity compared to serum GM in high-risk patients with IPA, including nonneutropenic patients.
“Recent studies showed that BAL fluid GM has improved sensitivity compared to serum GM in high-risk patients with IPA, including nonneutropenic patients (88, 114–119).”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [116]
Cites
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Self-citationClinical evaluation of the newly formatted lateral‐flow device for invasive pulmonary aspergillosis
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Aspergillus fumigatus and Aspergillosis in 2019
Latgé, J.-P., & Chamilos, G. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00140-18 · Cited by 1,400 · see citing works
Aspergillus fumigatus and aspergillosis: From basics to clinics
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Self-citationIntensive care management of influenza-associated pulmonary aspergillosis
Koehler, P., Bassetti, M., Kochanek, M., Shimabukuro-Vornhagen, A., & Cornely, O. A. (2019) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2019.04.031 · Cited by 82 · see citing works
Jenks, J. D., Mehta, S. R., Taplitz, R., Aslam, S., Reed, S. L., & Hoenigl, M. (2018) · Mycoses · doi:10.1111/myc.12881 · Cited by 81 · see citing works
Self-citationJenks, J. D., Prattes, J., Frank, J., Spieß, B., Mehta, S. R., Boch, T., Buchheidt, D., & Hoenigl, M. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1281 · Cited by 78 · see citing works
“Test strips were than inserted into the sample running buffer aliquot and results read after 30 minutes based on the manufacturers recommendations, as described before [24, 25, 27, 32].”
MethodSelf-citationMercier, T., Dunbar, A., de Kort, E., Schauwvlieghe, A. F. A. D., Reynders, M., Guldentops, E., Blijlevens, N. M. A., Vonk, A. G., Rijnders, B. J. A., Verweij, P. E., et al. (2019) · Medical Mycology · doi:10.1093/mmy/myz079 · Cited by 75 · see citing works
An update on current and novel molecular diagnostics for the diagnosis of invasive fungal infections
Jenks, J. D., White, P. L., Kidd, S. E., Goshia, T., Fraley, S. I., Hoenigl, M., & Thompson, G. R. (2023) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2023.2267977 · Cited by 61 · see citing works
“Early diagnosis and prompt initiation of appropriate anti-fungal therapy is an important predictor of survival in individuals with IFD [24], yet diagnosis and subsequent targeted treatment remains challenging, particularly during early stages of infection [15,25].”
BackgroundSelf-citationThornton, C. R. (2019) · Advances in applied microbiology · doi:10.1016/bs.aambs.2019.10.003 · Cited by 59 · see citing works
The Evolving Landscape of Fungal Diagnostics, Current and Emerging Microbiological Approaches
Weiss, Z., Leon, A., & Koo, S. (2021) · Journal of Fungi · doi:10.3390/jof7020127 · Cited by 52 · see citing works
“In patients with hematological malignancies, sensitivity and specificity of the LFD and LFA from BAL were 78%–89% and 88%–100%, respectively [106].”
BackgroundBlood Aspergillus PCR: The Good, the Bad, and the Ugly
Egger, M., Jenks, J. D., Hoenigl, M., & Prattes, J. (2020) · Journal of Fungi · doi:10.3390/jof6010018 · Cited by 53 · see citing works
Self-citationJenks, J. D., Gangneux, J.-P., Schwartz, I. S., Alastruey-Izquierdo, A., Lagrou, K., Thompson III, G. R., Lass-Flörl, C., Hoenigl, M., & Investigators, E. C. O. M. M. (. C. (2020) · Journal of Fungi · doi:10.3390/jof6040216 · Cited by 44 · see citing works
“For the LFA, so far limited data has shown no significant impact of mold-active antifungals on efficacy (51, 64-66).”
BackgroundResultSelf-citationPoint of care aspergillus testing in intensive care patients
Mercier, T., Dunbar, A., Veldhuizen, V., Holtappels, M., Schauwvlieghe, A. F. A. D., Maertens, J. A., Rijnders, B. J. A., & Wauters, J. (2020) · Critical Care · doi:10.1186/s13054-020-03367-7 · Cited by 43 · see citing works
The Aspergillus Lateral Flow Assay for the Diagnosis of Invasive Aspergillosis: an Update
Jenks, J. D., Miceli, M. H., Prattes, J., Mercier, T., & Hoenigl, M. (2020) · Current Fungal Infection Reports · doi:10.1007/s12281-020-00409-z · Cited by 41 · see citing works
Self-citationOutbreaks of Fungal Infections in Hospitals: Epidemiology, Detection, and Management
Douglas, A. P., Stewart, A. G., Halliday, C. L., & Chen, S. C. ‐. (2023) · Journal of Fungi · doi:10.3390/jof9111059 · Cited by 44 · see citing works
“Both LFA formats are sensitive and specific for haematology patients with pulmonary aspergillosis [45,46].”
BackgroundMercier, T., Guldentops, E., Lagrou, K., & Maertens, J. A. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa295 · Cited by 39 · see citing works
Lass‐Flörl, C., Cascio, G. L., Nucci, M., dos Santos, M. C., Colombo, A. L., Vossen, M. G., & Willinger, B. (2019) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2019.08.009 · Cited by 35 · see citing works
Takazono, T., Ito, Y., Tashiro, M., Nishimura, K., Saijo, T., Yamamoto, K., Imamura, Y., Miyazaki, T., Yanagihara, K., Mukae, H., et al. (2019) · Journal of Clinical Microbiology · doi:10.1128/jcm.00095-19 · Cited by 33 · see citing works
“The sensitivity and specificity of the AspLFD for serum samples were similar to those from a recent study in nonneutropenic invasive pulmonary aspergillosis (IPA) patients (15).”
ResultInfluentialThe SSS revolution in fungal diagnostics: speed, simplicity and sensitivity
Baker, J., & Denning, D. W. (2023) · British Medical Bulletin · doi:10.1093/bmb/ldad011 · Cited by 31 · see citing works
Improving the rates ofAspergillusdetection: an update on current diagnostic strategies
Jenks, J. D., Salzer, H. J. F., & Hoenigl, M. (2018) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2018.1558054 · Cited by 33 · see citing works
“Combining both POC tests was associated with a further increase of sensitivity [75,87].”
BackgroundSelf-citationMercier, T., Schauwvlieghe, A. F. A. D., de Kort, E., Dunbar, A., Reynders, M., Guldentops, E., Rijnders, B. J. A., Verweij, P. E., Lagrou, K., & Maertens, J. A. (2019) · Journal of Clinical Microbiology · doi:10.1128/jcm.01913-18 · Cited by 30 · see citing works
“However, except for a study mentioned in one recent letter (8), all previously published studies with the LFD have used a prototype device.”
BackgroundResult(New) Methods for Detection of Aspergillus fumigatus Resistance in Clinical Samples
Jenks, J. D., Spieß, B., Buchheidt, D., & Hoenigl, M. (2019) · Current Fungal Infection Reports · doi:10.1007/s12281-019-00342-w · Cited by 28 · see citing works
Self-citationPoint-of-care diagnostics for invasive aspergillosis: nearing the finish line
Jenks, J. D., & Hoenigl, M. (2020) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2020.1820864 · Cited by 28 · see citing works
Self-citationRawlings, S. A., Heldt, S., Prattes, J., Eigl, S., Jenks, J. D., Flick, H., Rabensteiner, J., Prüller, F., Wölfler, A., Neumeister, P., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01798 · Cited by 27 · see citing works
Self-citationBuil, J. B., Huygens, S., Dunbar, A., Schauwvlieghe, A. F. A. D., Reynders, M., Langerak, D., van Dijk, K., Bruns, A. H. W., Haas, P., Postma, D. F., et al. (2023) · Journal of Clinical Microbiology · doi:10.1128/jcm.00044-23 · Cited by 27 · see citing works
Monoclonal Antibodies and Invasive Aspergillosis: Diagnostic and Therapeutic Perspectives
Lian, X., Scott-Thomas, A., Lewis, J. G., Bhatia, M., MacPherson, S. A., Zeng, Y., & Chambers, S. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105563 · Cited by 23 · see citing works
Mould‐reactive T cells for the diagnosis of invasive mould infection—A prospective study
Steinbach, A., Cornely, O. A., Wisplinghoff, H., Schauss, A. C., Vehreschild, J. J., Rybniker, J., Hamprecht, A. G., Richter, A., Bächer, P., Scheffold, A., et al. (2019) · Mycoses · doi:10.1111/myc.12919 · Cited by 22 · see citing works
Hoenigl, M., Egger, M., Boyer, J., Schulz, E., Prattes, J., & Jenks, J. D. (2021) · Mycoses · doi:10.1111/myc.13352 · Cited by 22 · see citing works
Self-citationPoint-of-care testing for viral-associated pulmonary aspergillosis
Aerts, R., Autier, B., Gornicec, M., Prattes, J., Lagrou, K., Gangneux, J., & Hoenigl, M. (2023) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2023.2257597 · Cited by 21 · see citing works
“[32,36,56,68,90] compared to the OLM LFD (69– 80”
MethodResultSelf-citationGuo, J., Xiao, C., Tian, W., Lv, L., Hu, L., Ni, L., Wang, D., Li, W., Qiao, D., & Wu, W. (2023) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-023-04724-4 · Cited by 21 · see citing works
“Some studies have reported on the practicality of the IMMY Aspergillus LFA in serum or BALF [10, 17, 18].”
BackgroundOsaigbovo, I. I., & Bongomin, F. (2021) · Therapeutic Advances in Infectious Disease · doi:10.1177/20499361211034266 · Cited by 16 · see citing works
Linder, K. A., Kauffman, C. A., & Miceli, M. H. (2020) · Journal of Fungi · doi:10.3390/jof6040297 · Cited by 15 · see citing works
“In one clinical study, the Aspergillus GM-LFA showed sensitivity and specificity as high as 89% and 100% when BALF from a small number of patients (n = 9) who had a hematological malignancy and proven or probable IPA were studied [9].”
MethodResultAerts, R., Cuypers, L., Mercier, T., Maertens, J. A., & Lagrou, K. (2023) · Mycopathologia · doi:10.1007/s11046-023-00739-9 · Cited by 15 · see citing works
“The first paper describing the IMMY LFA dates from 2019 [14, 22].”
BackgroundMethodImmune Parameters for Diagnosis and Treatment Monitoring in Invasive Mold Infection
Jenks, J. D., Rawlings, S. A., García‐Vidal, C., Koehler, P. A., Mercier, T., Prattes, J., Lass‐Flörl, C., Martín-Gómez, M. T., Buchheidt, D., Pagano, L., et al. (2019) · Journal of Fungi · doi:10.3390/jof5040116 · Cited by 15 · see citing works
“Early diagnosis and appropriate treatment remain the most important predictors of survival [5], although early diagnosis remains difficult to establish, particularly at the initial stages of infection [6,7], and treatment is becoming increasingly complicated due to antifungal resistance [8,9].”
BackgroundSelf-citationNo-cost ballpoint pen dispenser for lateral flow assays
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Performance of the sōna Aspergillus Galactomannan Lateral Flow Assay in a Cancer Patient Population
Jani, K., McMillen, T. A., Morjaria, S. M., & Babady, N. E. (2021) · Journal of Clinical Microbiology · doi:10.1128/jcm.00598-21 · Cited by 14 · see citing works
“, aplastic anemia) 2 (10) 11 (3) Unknown (e.”
ResultCurrent and emerging technologies to develop Point-of-Care Diagnostics in medical mycology
Matsuo, T., Wurster, S., Hoenigl, M., & Kontoyiannis, D. P. (2024) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2024.2397515 · Cited by 11 · see citing works
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Zhang, X., Shang, X., Zhang, Y., Li, X., Yang, K., Wang, Y., & Guo, K. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34569 · Cited by 9 · see citing works
Invasive Aspergillosis in the Intensive Care Unit
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Editorial: Diagnostic Approaches for Aspergillus Infections
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“…brought by the introduction of noncultural diagnostic tests for aspergillosis in blood and bronchoalveolar lavage fluid, including, galactomannan antigen testing, PCR, and 1,3-ß-D-glucan testing in patients at risk (Eigl et al., 2017; Heldt et al., 2018; Prattes et al., 2018; Jenks et al., 2019b).”
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“27,28 The samples used by LFD technology in the diagnosis of pulmonary aspergillosis are mainly blood and BALF, but recently some researchers have found that urine can also be a potential sample for the diagnosis of IPA.”
BackgroundFungal Diseases and Their Treatment: A Holistic Approach
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Nanosensors for Detection of Human Fungal Pathogens
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Recent approaches in point-of-care-tests (POCTs) for fungal pathogens
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- Authors
- Jenks, J. D., Mehta, S. R., Taplitz, R., Law, N., Reed, S. L., & Hoenigl, M.
- Affiliations
- University of California San Diego (US)
- Medical University of Graz (AT)
- Corresponding author
- Jenks, Jeffrey D.
- Hoenigl, Martin
- Venue
- Journal of Infection
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 78
- Issue
- 3
- Pages
- 249-259
- ISSN
- 0163-4453 (ISSN-L)
- OpenAlex
- W2899169728
- Cited by
- 54
- References
- 10
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 10 · 2022: 3 · 2021: 6 · 2020: 10 · 2019: 14 · 2018: 3
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Infection (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- invasive pulmonary aspergillosis, Aspergillus galactomannan, lateral flow devices, bronchoalveolar lavage, hematologic malignancies, diagnostic biomarkers
- MeSH terms
- Aspergillosis, Aspergillus, Galactose, Humans, Mannans, Polymerase Chain Reaction, Cytokines, Bronchoalveolar Lavage, Hematologic Neoplasms, Invasive Pulmonary Aspergillosis
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