CoChat
Sign Up
Cited by 133Antifungal resistance and susceptibilityInfective Endocarditis Diagnosis and ManagementFungal Infections and Studies

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Attributable mortality of candidemia – Results from the ECMM Candida III multinational European Observational Cohort Study

Open access
Salmanton-García, Jon, Cornely, Oliver A., Stemler, Jannik, Barać, Aleksandra, Steinmann, Jörg, Siváková, Alena, Akalin, Emin Halis, Arikan-Akdagli, Sevtap, Loughlin, Laura, Toscano, Cristina, Narayanan, Manjusha, Rogers, Benedict, Willinger, Birgit, Akyol, Deniz, Roilides, Emmanuel, Lagrou, Katrien, Mikulska, Malgorzata, Denis, Blandine, Ponscarme, Diane, Scharmann, Urlike, Azap, Alpay, Lockhart, Deborah, Bicanic, Tihana, Kron, Florian, Erben, Nurettin, Rautemaa-Richardson, Riina, Goodman, Anna L., Garcia-Vidal, Carolina, Lass-Flörl, Cornelia, Gangneux, Jean-Pierre, Taramasso, Lucia, Ruiz, Maite, Schick, Yael, Van Wijngaerden, Eric, Milacek, Christopher, Giacobbe, Daniele Roberto, Logan, Clare, Rooney, Emily, Gori, Andrea, Akova, Murat, Bassetti, Matteo, Hoenigl, Martin, Koehler, Philipp·2024·Journal of Infection
DOI 10.1016/j.jinf.2024.106229
Open this paper in CoChat — free accountOpen PDF

Abstract

INTRODUCTION: Despite antifungal advancements, candidaemia still has a high mortality rate of up to 40%. The ECMM Candida III study in Europe investigated the changing epidemiology and outcomes of candidaemia for better understanding and management of these infections. METHODS: In this observational cohort study, participating hospitals enrolled the first ten consecutive adults with blood culture-proven candidemia. Collected data included patient demographics, risk factors, hospital stay duration (follow-up of 90 days), diagnostic procedures, causative Candida spp., management details, and outcome. Controls were included in a 1:1 fashion from the same hospitals. The matching process ensured similarity in age (10-year range), primary underlying disease, hospitalization in intensive care versus non-ICU ward, and major surgery within 2 weeks before candidemia between cases and controls. Overall and attributable mortality were described, and a survival probability for cases and controls was performed. RESULTS: One hundred seventy-one pairs consisting of patients with candidemia and matched controls from 28 institutions were included. In those with candidemia, overall mortality was 40.4%. Attributable mortality was 18.1% overall but differed between causative Candida species (7.7% for Candida albicans, 23.7% for Candida glabrata/Nakaseomyces glabratus, 7.7% for Candida parapsilosis and 63.6% for Candida tropicalis). Regarding risk factors, the presence of a central venous catheter, total parenteral nutrition and acute or chronic renal disease were significantly more common in cases versus controls. Duration of hospitalization, and especially that of ICU stay, was significantly longer in candidemia cases (20 (IQR 10-33) vs 15 days (IQR 7-28); p = 0.004). CONCLUSIONS: Although overall and attributable mortality in this subgroup analysis of matched case/control pairs remains high, the attributable mortality appears to have decreased in comparison to historical cohorts. This decrease may be driven by improved prognosis of Candida albicans and Candida parapsilosis candidemia; whereas candidemia due to other Candida spp. exhibits a much higher attributable mortality.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.jinf.2024.106229

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Figures

Image 1
CC-BY · From the PDF
Fig. 1 Participating European countries. Dark blue represents countries that are part of both the ECMM Candida III study and the case-control analysis: the analysis included documented cases and controls from the following countries: United Kingdom (n = 37 case-control pairs), Turkey (n = 34 case-control pairs), Germany (n = 29 case-control pairs), Serbia (n = 13 case-control pairs), Czech Republic (n = 10, case-control pairs), Austria, Italy and Portugal (n = 8 case-control pairs each), Belgium, France, and Greece (n = 7, casecontrol pairs each), and Spain (n = 3 case-control pairs). Light blue represents countries involved in the ECMM Candida III study but not in the case-control analysis: Belarus, Ireland, Netherlands, Russia, Slovakia, Sweden, and Switzerland.
Fig. 1 Participating European countries. Dark blue represents countries that are part of both the ECMM Candida III study and the case-control analysis: the analysis included documented cases and controls from the following countries: United Kingdom (n = 37 case-control pairs), Turkey (n = 34 case-control pairs), Germany (n = 29 case-control pairs), Serbia (n = 13 case-control pairs), Czech Republic (n = 10, case-control pairs), Austria, Italy and Portugal (n = 8 case-control pairs each), Belgium, France, and Greece (n = 7, casecontrol pairs each), and Spain (n = 3 case-control pairs). Light blue represents countries involved in the ECMM Candida III study but not in the case-control analysis: Belarus, Ireland, Netherlands, Russia, Slovakia, Sweden, and Switzerland.CC-BY · From the PDF
Fig. 2 CONSORT diagram on study enrollment.
Fig. 2 CONSORT diagram on study enrollment.CC-BY · From the PDF
Fig. 3 Kaplan Meier survival curves for candidemia patients versus control patients. a) Survival probability in candidemia versus control patients. Sensitivity analysis is provided in Supplementary figure 1a. b) Candidemia survival probability according to species. Sensitivity analysis is provided in Supplementary figure 1b. c) Survival probability in Candida albicans candidemia and matched controls. Sensitivity analysis is provided in Supplementary figure 1c. d) Survival probability in Candida glabrata/ Nakaseomyces glabratus candidemia and matched controls. Sensitivity analysis is provided in Supplementary figure 1d. e) Survival probability in Candida parapsilosis candidemia and matched controls. Sensitivity analysis is provided in Supplementary figure 1e. f) Survival probability in Candida tropicalis candidemia and matched con­ trols. Sensitivity analysis is provided in Supplementary figure 1f.
Fig. 3 Kaplan Meier survival curves for candidemia patients versus control patients. a) Survival probability in candidemia versus control patients. Sensitivity analysis is provided in Supplementary figure 1a. b) Candidemia survival probability according to species. Sensitivity analysis is provided in Supplementary figure 1b. c) Survival probability in Candida albicans candidemia and matched controls. Sensitivity analysis is provided in Supplementary figure 1c. d) Survival probability in Candida glabrata/ Nakaseomyces glabratus candidemia and matched controls. Sensitivity analysis is provided in Supplementary figure 1d. e) Survival probability in Candida parapsilosis candidemia and matched controls. Sensitivity analysis is provided in Supplementary figure 1e. f) Survival probability in Candida tropicalis candidemia and matched con­ trols. Sensitivity analysis is provided in Supplementary figure 1f.CC-BY · From the PDF
Fig. 3 ( continued )
Fig. 3 ( continued )CC-BY · From the PDF
Image 6
CC-BY · From the PDF
Image 7
CC-BY · From the PDF

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 43 references

Research works printed but not linked: 1

  1. Vena, 2024, Laboratory and clinical management capacity for invasive fungal infections: the Italian landscape, Infection, 52, 197, 10.1007/s15010-023-02084-x · DOI

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Salmanton-García, J., Cornely, O. A., Stemler, J., Barać, A., Steinmann, J., Siváková, A., Akalin, E. H., Arikan-Akdagli, S., Loughlin, L., Toscano, C., Narayanan, M., Rogers, B., Willinger, B., Akyol, D., Roilides, E., Lagrou, K., Mikulska, M., Denis, B., Ponscarme, D., Scharmann, U., Azap, A., Lockhart, D., Bicanic, T., Kron, F., Erben, N., Rautemaa-Richardson, R., Goodman, A. L., Garcia-Vidal, C., Lass-Flörl, C., Gangneux, J.-P., Taramasso, L., Ruiz, M., Schick, Y., Van Wijngaerden, E., Milacek, C., Giacobbe, D. R., Logan, C., Rooney, E., Gori, A., Akova, M., Bassetti, M., Hoenigl, M., & Koehler, P.
Affiliations
  • University of Cologne (DE)
  • Paracelsus Medizinische Privatuniversität (DE)
  • Masaryk University (CZ)
  • Belfast Health and Social Care Trust (GB)
  • Hospital de Egas Moniz (PT)
  • Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
  • University Hospitals of Leicester NHS Trust (GB)
  • Medical University of Vienna (AT)
  • Ege University (TR)
  • Aristotle University of Thessaloniki (GR)
  • KU Leuven (BE)
  • Assistance Publique – Hôpitaux de Paris (FR)
  • Hôpital Saint-Louis (FR)
  • Essen University Hospital (DE)
  • Ankara University (TR)
  • University of Aberdeen (GB)
  • National Health Service (GB)
  • Eskişehir Osmangazi University (TR)
  • Inserm (FR)
  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
  • Ospedale Policlinico San Martino (IT)
  • Manchester University NHS Foundation Trust (GB)
  • Hacettepe University (TR)
  • Medical University of Graz (AT)
Corresponding author
  • Cornely, Oliver A.
  • Hoenigl, Martin
ORCID
Venue
Journal of Infection
Publisher
Elsevier BV
Published
2024-09
Volume
89
Issue
3
Pages
106229
ISSN
0163-4453 (ISSN-L)
DOI
10.1016/j.jinf.2024.106229
OpenAlex
W4400673495
Cited by
127
References
43
Citations by year
2026: 61 · 2025: 61 · 2024: 5
FWCI
44.01
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Infection (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Lirias (KU Leuven) (submittedVersion, cc-by)
  • St George's Online Research Archive (St George's University of London) (submittedVersion)
  • Bursa Uludag University - AVESIS (submittedVersion)
  • HAL (submittedVersion, cc-by)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
  • Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, other-oa)
  • CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
  • Newcastle University ePrints (Newcastle Univesity) (cc-by)
Funders
  • National Institute for Health and Care Research (NIHR 203308)
  • Manchester Biomedical Research Centre (NIHR 203308)
  • Medical Research Council (MC_UU_00004/05)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Infective Endocarditis Diagnosis and Management
  • Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords
candidemia, attributable mortality, Candida species, Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, risk factors, central venous catheters, total parenteral nutrition, kidney disease, ICU length of stay, antifungal therapy
MeSH terms
Adult, Aged, Aged, 80 and over, Antifungal Agents, Candida, Europe, Female, Humans, Male, Middle Aged, Risk Factors, Cohort Studies, Case-Control Studies, Candidemia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review