Eliminating mother-to-child transmission of the human immunodeficiency virus in sub-Saharan Africa: The journey so far and what remains to be done

Adetokunboh, Olatunji O.; Oluwasanu, Mojisola

doi:10.1016/j.jiph.2015.06.010

Cited by 59HIV/AIDS Research and InterventionsGlobal Maternal and Child HealthHIV/AIDS drug development and treatment

Eliminating mother-to-child transmission of the human immunodeficiency virus in sub-Saharan Africa: The journey so far and what remains to be done

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Adetokunboh, Olatunji O., Oluwasanu, Mojisola·2016·Journal of Infection and Public Health

DOI 10.1016/j.jiph.2015.06.010

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Abstract

This review was carried out to provide a comprehensive overview of efforts toward elimination of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) with respect to progress, challenges, and recommendations in 21 sub-Saharan African priority countries. We reviewed literature published from 2011 to April 2015 using 3 databases; PubMed, Scopus, and Web of Science, as well as the 2014 Global Plan Progress Report. A total of 39 studies were included. Between 2009 and 2013, there was a 43% reduction in new HIV infections, the final MTCT rate was reduced from 28% to 18%, and antiretroviral therapy (ART) coverage increased from 11% to 24%. Challenges included poor adherence to antiretroviral therapy, poor linkage between mother-child pairs and post-natal healthcare services low early infant diagnosis coverage, low pediatric ART coverage, and high unmet needs for contraceptive services. Future recommendations include identification of key barriers, health system strengthening, strengthening community involvement, and international collaboration. There has been significant progress toward eliminating MTCT of HIV, but more effort is still needed.

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Barriers to PMTCT service uptake and retention include lack of coordinated and continuous care for HIV-positive mother-baby pairs.
“Barriers to PMTCT service uptake and retention include lack of coordinated and continuous care for HIV-positive mother-baby pairs [10-12]”
From Development and Implementation of a Mobile Phone–Based Prevention of Mother-To-Child Transmission of HIV Cascade Analysis Tool: Usability and Feasibility Testing in Kenya and Mozambique (2019) · cites this paper as [12]

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Development and Implementation of a Mobile Phone–Based Prevention of Mother-To-Child Transmission of HIV Cascade Analysis Tool: Usability and Feasibility Testing in Kenya and Mozambique
Kawakyu, N., Nduati, R., Munguambe, K., Coutinho, J., Mburu, N., DeCastro, G., Inguane, C., Zunt, A., Abburi, N., Sherr, K., et al. (2019) · JMIR mHealth and uHealth · doi:10.2196/13963 · Cited by 19 · see citing works

Authors: Adetokunboh, O. O., & Oluwasanu, M.
Affiliations: Stellenbosch University (ZA)
University of Ibadan (NG)
Corresponding author: Adetokunboh, Olatunji O.
ORCID: Adetokunboh, Olatunji O.
Oluwasanu, Mojisola
Venue: Journal of Infection and Public Health
Publisher: Elsevier BV
Published: 2016-07
Volume: 9
Issue: 4
Pages: 396-407
ISSN: 1876-0341 (ISSN-L)
DOI: 10.1016/j.jiph.2015.06.010
OpenAlex: W870269380
Cited by: 59
References: 45
Citations by year: 2026: 2 · 2025: 7 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 9 · 2017: 3 · 2016: 2 · 2015: 1
FWCI: 0.74
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 182 d)
Locations: Journal of Infection and Public Health (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Bill and Melinda Gates Foundation
Topics: Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Global Maternal and Child Health
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Keywords: mother-to-child transmission, HIV, sub-Saharan Africa, antiretroviral therapy, antiretroviral therapy adherence, early infant HIV diagnosis, pediatric antiretroviral therapy, contraceptive services, health system strengthening, community participation, international cooperation
MeSH terms: Health Services Accessibility, Humans, Infant, Mothers, HIV Infections, Africa South of the Sahara, Infectious Disease Transmission, Vertical, Anti-Retroviral Agents

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Eliminating mother-to-child transmission of the human immunodeficiency virus in sub-Saharan Africa: The journey so far and what remains to be done

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