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Cited by 23Epigenetics and DNA MethylationChromosomal and Genetic VariationsPlant Molecular Biology Research

Epigenetic variation as a new plant breeding tool: A review

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Alfalahi, Ayoob Obaid, Hussein, Zeyad Tariq, Khalofah, Ahlam, Sadder, Monther Taha, Qasem, Jamal Ragheb, Al-Khayri, Jameel Mohammed, Jain, Shri Mohan, Almehemdi, Ali Fadaam·2022·Journal of King Saud University - Science
DOI 10.1016/j.jksus.2022.102302
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Abstract

Epigenetic variations are inherited or uninherited effects that occur beyond the DNA sequence of an individual. However, DNA sequence has a critical role in shaping epigenetic variation. The great diversity of epigenetic markers confers an advantage of various uses without interrupting its highly environmental independence. The epigenetic effects are highlighted by many vital events, especially the regulation of gene expression in hybrid vigor and inbreeding depression, even in the absence of genetic diversity. However, various stress genes can include many repeats that undergo alternately methylation and demethylation states to regulate gene expression positively or negatively. After all the arguments raised on the genetic basis of hybrid vigor in its both traditional and molecular aspects, the term “epigenome” strongly emerged as one of the main causes of performance deviation among offspring. These include both histone and DNA biochemical modifications, which play a key role during successive stages of development and differentiation in addition to the regulation of gene expression in response to biotic and abiotic stresses. Evidence has shown a correlation between unique DNA methylation and heterosis in many plant species as well as between inbreeding and the sharp decline in fitness of most naturally cross-pollinated species. Although detailed molecular mechanisms laying behind many of these plant breeding aspects remain little understood, epigenetics has provided some explanations.

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  • Epigenetic variability observed at the phenotype level reflects adaptations of cellular processes to constraints of in vitro cultivation, which usually implies sequential dedifferentiation and re-differentiation.

    “This epigenetic variability, which frequently is observed at phenotype level, reflects, in reality, the adaptations of the cellular processes to the various constraints of the in vitro cultivation technology, that usually implies sequential dedifferentiation (formation of callus) and re-differentiation (regeneration of plants) [91,95,96,97,98,99,100].”

    From Somaclonal Variation—Advantage or Disadvantage in Micropropagation of the Medicinal Plants (2023) · cites this paper as [100]

    Sections 10 and 12 (page unavailable) link in-vitro culture stresses to epigenetic instability and describe phenotypic differences in regenerated plants. The copy does not say that cultivation usually proceeds through sequential callus-forming dedifferentiation and plant-regenerating re-differentiation, so that part of the claim is unsupported. (LLM, conf=0.85)

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Cited by

Sorted by citations

Authors
Alfalahi, A. O., Hussein, Z. T., Khalofah, A., Sadder, M. T., Qasem, J. R., Al-Khayri, J. M., Jain, S. M., & Almehemdi, A. F.
Affiliations
  • University of Anbar (IQ)
  • King Khalid University (SA)
  • University of Jordan (JO)
  • King Faisal University (SA)
  • University of Helsinki (FI)
Corresponding author
Khalofah, Ahlam
ORCID
Venue
Journal of King Saud University - Science
Publisher
Scientific Scholar
Published
2022-11
Volume
34
Issue
8
Pages
102302
ISSN
1018-3647 (ISSN-L)
DOI
10.1016/j.jksus.2022.102302
OpenAlex
W4294647412
Cited by
23
References
5
Citations by year
2026: 4 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 1
FWCI
1.55
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of King Saud University - Science (publishedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Työväentutkimus Vuosikirja (submittedVersion)
Funders
University of Anbar
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords
epigenetic variation, plant breeding, DNA methylation, histone modifications, epigenetic modifications, heterosis, inbreeding depression, gene expression regulation, stress response, epigenome, epigenetic inheritance

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