A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases

Stem cells, cancer, and cancer stem cells

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The future of immune checkpoint therapy

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AMPK: a nutrient and energy sensor that maintains energy homeostasis

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A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

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Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

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Cancer regression in patients after transfer of genetically engineered lymphocytes

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Function and regulation of cullin–RING ubiquitin ligases

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Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

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Prader-Willi syndrome

Cassidy, S. B., Schwartz, S., Miller, J. L., & Driscoll, D. J. (2012) · Genetics in Medicine · doi:10.1038/gim.0b013e31822bead0 · Cited by 1,452

Fibroblast growth factors, their receptors and signaling

Powers, C. J., McLeskey, S. W., & Wellstein, A. (2000) · Endocrine-related cancer · doi:10.1677/erc.0.0070165 · Cited by 1,332

PROTAC targeted protein degraders: the past is prologue

Békés, M., Langley, D. R., & Crews, C. M. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00371-6 · Cited by 3,395

Target and tissue selectivity of PROTAC degraders

Guenette, R. G., Yang, S. W., Min, J., Pei, B., & Potts, P. R. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00200k · Cited by 324

Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation

Bond, M. J., & Crews, C. M. (2021) · RSC Chemical Biology · doi:10.1039/d1cb00011j · Cited by 232

Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade

Shukla, S. A., Bachireddy, P., Schilling, B., Galonska, C., Zhan, Q., Bango, C., Langer, R., Lee, P. C., Gusenleitner, D., Keskin, D. B., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.026 · Cited by 179

Tying up loose ends: the N-degron and C-degron pathways of protein degradation

Timms, R. T., & Koren, I. (2020) · Biochemical Society Transactions · doi:10.1042/bst20191094 · Cited by 100

A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex

Yang, S. W., Li, L., Connelly, J. P., Porter, S. N., Kodali, K., Gan, H., Park, J. M., Tacer, K. F., Tillman, H., Peng, J., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2019.12.022 · Cited by 79

MAGE cancer-testis antigens protect the mammalian germline under environmental stress

Tacer, K. F., Montoya, M. C., Oatley, M. J., Lord, T., Oatley, J. M., Klein, J. D., Ravichandran, R., Sheppard, H., Kim, M., Connelly, J. P., et al. (2019) · Science Advances · doi:10.1126/sciadv.aav4832 · Cited by 83

Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs

Lian, Y., Meng, L., Ding, P., & Sang, M. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0550-8 · Cited by 78

Emerging roles of the MAGE protein family in stress response pathways

Gee, R. R. F., Chen, H., Lee, A. K., Daly, C. A., Wilander, B. A., Tacer, K. F., & Potts, P. R. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.008029 · Cited by 76

Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance

Lee, A. K., Klein, J. D., Tacer, K. F., Lord, T., Oatley, M. J., Oatley, J. M., Porter, S. N., Pruett‐Miller, S. M., Tikhonova, E. B., Karamyshev, A. L., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.06.037 · Cited by 66

The X chromosome and male infertility

Vockel, M., Riera‐Escamilla, A., Tüttelmann, F., & Krausz, C. G. (2019) · Human Genetics · doi:10.1007/s00439-019-02101-w · Cited by 66

Prevalence of Novel MAGED2 Mutations in Antenatal Bartter Syndrome

Legrand, A., Tréard, C., Roncelin, I., Dreux, S., Bertholet‐Thomas, A., Broux, F., Bruno, D., Decramer, S., Deschênes, G., Djeddi, D., et al. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05670517 · Cited by 62

The Prader-Willi syndrome proteins MAGEL2 and necdin regulate leptin receptor cell surface abundance through ubiquitination pathways

Wijesuriya, T. M., Ceuninck, L. D., Masschaele, D., Sanderson, M. R., Carias, K. V., Tavernier, J. H., & Wevrick, R. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx311 · Cited by 64

Cytosolic Iron-Sulfur Assembly Is Evolutionarily Tuned by a Cancer-Amplified Ubiquitin Ligase

Weon, J. L., Yang, S. W., & Potts, P. R. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.11.010 · Cited by 49

Prognostic Value of Melanoma-Associated Antigen-A (MAGE-A) Gene Expression in Various Human Cancers: A Systematic Review and Meta-analysis of 7428 Patients and 44 Studies

Poojary, M. S., Jishnu, P. V., & Kabekkodu, S. P. (2020) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-020-00476-5 · Cited by 41

Regulation of MAGE‐A3/6 by the CRL4‐DCAF12 ubiquitin ligase and nutrient availability

Ravichandran, R., Kodali, K., Peng, J., & Potts, P. R. (2019) · EMBO Reports · doi:10.15252/embr.201847352 · Cited by 39

Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer’s Disease

Leung, H.-W., Foo, G., & VanDongen, A. M. J. (2022) · Biomedicines · doi:10.3390/biomedicines10081946 · Cited by 41

PJA1 Coordinates with the SMC5/6 Complex To Restrict DNA Viruses and Episomal Genes in an Interferon-Independent Manner

Xu, W. Q., Ma, C., Zhang, Q., Zhao, R., Hu, D., Zhang, X., Chen, J., Liu, F., Wu, K., Liu, Y., et al. (2018) · Journal of Virology · doi:10.1128/jvi.00825-18 · Cited by 39

Whole-exome sequencing in patients with maturation arrest: a potential additional diagnostic tool for prevention of recurrent negative testicular sperm extraction outcomes

Ghieh, F., Barbotin, A., Swierkowski-Blanchard, N., Leroy, C., Fortemps, J., Gerault, C., Hue, C., Mambueni, H. M., Jaillard, S., Albert, M., et al. (2022) · Human Reproduction · doi:10.1093/humrep/deac057 · Cited by 40

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

Yang, S. W., Huang, X., Lin, W., Min, J., Miller, D. J., Mayasundari, A., Rodrigues, P., Griffith, E. C., Gee, C. T., Li, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18708-x · Cited by 35

Pathophysiology of antenatal Bartterʼs syndrome

Kömhoff, M., & Laghmani, K. (2017) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000346 · Cited by 35

Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity

Stevens, R. V., Esposito, D., & Rittinger, K. (2019) · Life Science Alliance · doi:10.26508/lsa.201900295 · Cited by 34

Heterogeneity in hormone-dependent breast cancer and therapy: Steroid hormones, HER2, melanoma antigens, and cannabinoid receptors

Kunstič, T. T., Debeljak, N., & Tacer, K. F. (2023) · Advances in Cancer Biology - Metastasis · doi:10.1016/j.adcanc.2022.100086 · Cited by 36

A comprehensive analysis of the MAGE family as prognostic and diagnostic markers for hepatocellular carcinoma

Li, R., Gong, J., Xiao, C., Zhu, S., Hu, Z., Liang, J., Li, X., Yan, X., Zhang, X., Li, D., et al. (2020) · Genomics · doi:10.1016/j.ygeno.2020.09.026 · Cited by 31

Comprehensive Atlas of the Myelin Basic Protein Interaction Landscape

Smirnova, E. V., Rakitina, T. V., Ziganshin, R., Arapidi, G. P., Saratov, G. A., Kudriaeva, A. A., & Belogurov, A. A. (2021) · Biomolecules · doi:10.3390/biom11111628 · Cited by 30

Cancer testis antigen subfamilies: Attractive targets for therapeutic vaccine (Review)

Ren, S., Zhang, Z., Li, M., Wang, D., Guo, R., Fang, X., & Chen, F. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5519 · Cited by 30

Re-examination of MAGE-A3 as a T-cell Therapeutic Target

Martin, A. D., Wang, X., Sandberg, M. L., Negri, K. R., Wu, M. L., Warshaviak, D. T., Gabrelow, G. B., McElvain, M. E., Lee, B., Daris, M. E., et al. (2020) · Journal of Immunotherapy · doi:10.1097/cji.0000000000000348 · Cited by 29

MAGE-A expression in oral and laryngeal leukoplakia predicts malignant transformation

Baran, C., Agaimy, A., Wehrhan, F., Weber, M., Hille, V., Brunner, K., Wickenhauser, C., Siebolts, U., Nkenke, E., Kesting, M. R., et al. (2019) · Modern Pathology · doi:10.1038/s41379-019-0253-5 · Cited by 29

Chemical complementarity between tumor resident, T-cell receptor CDR3s and MAGEA3/6 correlates with increased melanoma survival: Potential relevance to MAGE vaccine auto-reactivity

Eakins, R. A., Chobrutskiy, A., Teer, J. K., Patel, D. N., Hsiang, M., Huda, T. I., Zaman, S., Sexton, W. J., Coppola, D., Falasiri, S. S. A., et al. (2022) · Molecular Immunology · doi:10.1016/j.molimm.2022.08.001 · Cited by 28

Epigenetic activation of POTE genes in ovarian cancer

Sharma, A. K., Albahrani, M., Zhang, W., Kufel, C. N., James, S. R., Odunsi, K. O., Klinkebiel, D. L., & Karpf, A. R. (2019) · Epigenetics · doi:10.1080/15592294.2019.1581590 · Cited by 27

Transcriptomic characterization of cancer-testis antigens identifies MAGEA3 as a driver of tumor progression in hepatocellular carcinoma

Craig, A. J., García‐Lezana, T., de Galarreta, M. R., Villacorta-Martín, C., Gonzalez‐Kozlova, E., Martins-Filho, S. N., von Felden, J., Ahsen, M. E., Bresnahan, E. R., Hernandez‐Meza, G., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009589 · Cited by 29

Cullin 4-DCAF Proteins in Tumorigenesis

Zhou, Z., Song, X., Wavelet, C. M., & Wan, Y. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1025-0_15 · Cited by 29

Expression of cancer/testis antigens in cutaneous melanoma: a systematic review

Tio, D., Kasiem, F. R., Willemsen, M., van Doorn, R., van der Werf, N., Hoekzema, R., Luiten, R. M., & Bekkenk, M. W. (2019) · Melanoma Research · doi:10.1097/cmr.0000000000000569 · Cited by 26

Pathogenicity of the MAGE family (Review)

Li, S., Shi, X., Li, J., & Zhou, X. (2021) · Oncology Letters · doi:10.3892/ol.2021.13105 · Cited by 26

Rare X-linked variants carry predominantly male risk in autism, Tourette syndrome, and ADHD

Wang, S., Wang, B., Drury, V., Drake, S., Sun, N., Alkhairo, H., Arbelaez, J., Duhn, C., Genetics), T. I. C. G. (., Bromberg, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43776-0 · Cited by 26

Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation

Videlock, E. J., Mahurkar‐Joshi, S., Hoffman, J. M., Iliopoulos, D., Pothoulakis, C., Mayer, E. A., & Chang, L. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00288.2017 · Cited by 25

Increasing Role of Targeted Immunotherapies in the Treatment of AML

Greiner, J., Götz, M., & Wais, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063304 · Cited by 24

MAGED2

Kömhoff, M., & Laghmani, K. (2018) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000422 · Cited by 24

Inhibition of PPARγ, adipogenesis and insulin sensitivity by MAGED1

Wang, Q., Tang, J. P., Jiang, S., Huang, Z., Song, A., Hou, S., Gao, X., & Ruan, H. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0349 · Cited by 24

Smc5/6, an atypical SMC complex with two RING-type subunits

Solé-Soler, R., & Torres‐Rosell, J. (2020) · Biochemical Society Transactions · doi:10.1042/bst20200389 · Cited by 23

Ligand–Receptor Interactions Elucidate Sex-Specific Pathways in the Trajectory From Primordial Germ Cells to Gonia During Human Development

Overeem, A. W., Chang, Y. W., Spruit, J., Roelse, C. M., & Lopes, S. M. C. D. S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.661243 · Cited by 22

MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21Cip1

Mei, A. H.-C., Tung, K. H.-Y., Han, J., Perumal, D., Laganà, A., Keats, J. J., Auclair, D., Chari, A., Jagannath, S., Parekh, S. S., et al. (2020) · Oncotarget · doi:10.18632/oncotarget.27488 · Cited by 23

Development of novel self‐assembled vaccines based on tumour‐specific antigenic peptide and TLR2 agonist for effective breast cancer immunotherapy via activating CD8+ T cells and enhancing their function

Shi, W., Tong, Z., Chen, S., Qiu, Q., Zhou, J., & Qian, H. (2023) · Immunology · doi:10.1111/imm.13643 · Cited by 21

Oncogenic activity and cellular functionality of melanoma associated antigen A3

Schäfer, P., Paraschiakos, T., & Windhorst, S. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114700 · Cited by 20

Multi-monoubiquitylation controls VASP-mediated actin dynamics

McCormick, L. E., Suarez, C., Herring, L. E., Cannon, K. S., Kovar, D. R., Brown, N. G., & Gupton, S. L. (2024) · Journal of Cell Science · doi:10.1242/jcs.261527 · Cited by 19

Isothermal Microcalorimetry of Tumor Cells: Enhanced Thermogenesis by Metastatic Cells

Lemos, D., Oliveira, T., Martins, L., de Azevedo, V. R., Rodrigues, M. F., Ketzer, L. A., & Rumjanek, F. D. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01430 · Cited by 19

The Arg/N-degron pathway targets transcription factors and regulates specific genes

Vu, T. T. M., Mitchell, D. C., Gygi, S. P., & Varshavsky, A. J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2020124117 · Cited by 19

DNA hypomethylation drives changes in MAGE-A gene expression resulting in alteration of proliferative status of cells

Colemon, A., Harris, T. M., & Ramanathan, S. (2020) · Genes and Environment · doi:10.1186/s41021-020-00162-2 · Cited by 18

Molecular evolution of type II MAGE genes from ancestral MAGED2 gene and their phylogenetic resolution of basal mammalian clades

Donato, M. D., PETERS, S. O., Hussain, T., Rodulfo, H., Thomas, B. N., Babar, M. E., & Imumorin, I. G. (2017) · Mammalian Genome · doi:10.1007/s00335-017-9695-6 · Cited by 20

TMEM176B Regulates AKT/mTOR Signaling and Tumor Growth in Triple-Negative Breast Cancer

Kang, C., Rostoker, R., Ben-Shumel, S., Rashed, R., Duty, J. A., Demircioğlu, D., Antoniou, I. M., Isakov, L., Shen‐Orr, Z., Bravo‐Cordero, J. J., et al. (2021) · Cells · doi:10.3390/cells10123430 · Cited by 17

Discovery and Structural Basis of the Selectivity of Potent Cyclic Peptide Inhibitors of MAGE-A4

Fleming, M. C., Chiou, L. F., Tumbale, P. P., Droby, G. N., Lim, J., Norris-Drouin, J. L., Williams, J. G., Pearce, K. H., Williams, R. S., Vaziri, C., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00185 · Cited by 17

Development of Ligands and Degraders Targeting MAGE-A3

Li, K., Krone, M. W., Butrin, A., Bond, M. J., Linhares, B. M., & Crews, C. M. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c05393 · Cited by 17

The Molecular and Pathophysiological Functions of Members of the LNX/PDZRN E3 Ubiquitin Ligase Family

Hong, J., Won, M., & Ro, H. (2020) · Molecules · doi:10.3390/molecules25245938 · Cited by 17

The CDK4/6 inhibitor PD0332991 stabilizes FBP1 by repressing MAGED1 expression in pancreatic ductal adenocarcinoma

Zhang, B., Li, D., Jin, X., & Zhang, K. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105859 · Cited by 16

Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase

Koirala, S., Klein, J. D., Zheng, Y., Glenn, N. O., Eisemann, T., Tacer, K. F., Miller, D. J., Kulak, O., Lu, M., Finkelstein, D., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107922 · Cited by 17

MAGE-A3 is a prognostic biomarker for poor clinical outcome in cutaneous squamous cell carcinoma with perineural invasion via modulation of cell proliferation

Chen, A., Santana, A. L., Doudican, N. A., Roudiani, N., Laursen, K. B., Therrien, J., Lee, J., Felsen, D., & Carucci, J. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241551 · Cited by 16

The N-terminal domain of the Schaaf–Yang syndrome protein MAGEL2 likely has a role in RNA metabolism

Sanderson, M. R., Fahlman, R. P., & Wevrick, R. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100959 · Cited by 15

VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation

Mangano, K., Guenette, R. G., Hill, S., Li, S., Liu, J. J., Nadel, C. M., Archunan, S., Sadhukhan, A., Kapoor, R., Yang, S. W., et al. (2025) · Cell chemical biology · doi:10.1016/j.chembiol.2025.02.002 · Cited by 14

Antibody response against cancer‑testis antigens MAGEA4 and MAGEA10 in patients with melanoma

unap, K. Ï. ⁄., Kurg, K., sa, L. V. ⁄., li, Ï. ⁄. L. M. ⁄., Teras, M., Planken, A., Ustav, M., & Kurg, R. (2018) · Oncology Letters · doi:10.3892/ol.2018.8684 · Cited by 14

Necdin: A purposive integrator of molecular interaction networks for mammalian neuron vitality

Yoshikawa, K. (2021) · Genes to Cells · doi:10.1111/gtc.12884 · Cited by 15

Downregulation of Brain Enriched Type 2 MAGEs Is Associated With Immune Infiltration and Poor Prognosis in Glioma

Arora, M., Kumari, S., Singh, J., Chopra, A., & Chauhan, S. S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.573378 · Cited by 13

The Implication of X-Linked Genetic Polymorphisms in Susceptibility and Sexual Dimorphism of Cancer

Achilla, C., Papavramidis, T. S., Angelis, L., & Chatzikyriakidou, A. (2022) · Anticancer Research · doi:10.21873/anticanres.15706 · Cited by 13

USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder

Chéron, J., Beccari, L. L., Hagué, P., Icick, R., Despontin, C., Carusone, T. M., Defrance, M., Bhogaraju, S., Martín‐García, E., Capellán, R., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-44120-2 · Cited by 12

Truncated variants of MAGEL2 are involved in the etiologies of the Schaaf-Yang and Prader-Willi syndromes

Heimdörfer, D., Vorleuter, A., Eschlböck, A., Spathopoulou, A., Cubero, M. S., Farhan, H., Reiterer, V., Spanjaard, M., Schaaf, C. P., Huber, L. A., et al. (2024) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.05.023 · Cited by 13

Cancer-testis antigens MAGEA proteins are incorporated into extracellular vesicles released by cells

Kuldkepp, A., Karakai, M., Toomsoo, E., Reinsalu, O., & Kurg, R. (2019) · Oncotarget · doi:10.18632/oncotarget.26979 · Cited by 12

Exploring the role and mechanisms of MAGEA4 in tumorigenesis, regulation, and immunotherapy

Zhu, W., Yi, Q., Chen, Z., Wang, J., Zhong, K., Ouyang, X., Yang, K., Jiang, B., Zhong, J., & Zhong, J. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01079-8 · Cited by 11

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Wang, H., He, K., Huo, R., Li, W., Zhang, S., Jiang, L., Wu, H., Yu, M., Jiang, S., & Xue, J. (2025) · Advanced Science · doi:10.1002/advs.202501119 · Cited by 11

Estimating cis and trans contributions to differences in gene regulation

Hallgrímsdóttir, I. B., Carilli, M., & Pachter, L. S. (2026) · Genetics · doi:10.1093/genetics/iyag228 · Cited by 10

A new tool for early diagnosis of rheumatoid arthritis using a combined biomarkers; synovial MAGE-1 mRNA and serum anti-CCP and R

Al-Qtaitat, A., Nesrin, M., Albtoosh, A., & Nassar, A.-D. (2020) · Pan African Medical Journal · doi:10.11604/pamj.2020.36.270.21827 · Cited by 10

Melanoma antigen-D2 controls cell cycle progression and modulates the DNA damage response

Trussart, C., Pirlot, C., Valentin, E. D., Piette, J. G., & Habraken, Y. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.01.035 · Cited by 10

Cell-specific secretory granule sorting mechanisms: the role of MAGEL2 and retromer in hypothalamic regulated secretion

Štepihar, D., Gee, R. R. F., Sanchez, M. C. H., & Tacer, K. F. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1243038 · Cited by 9

MAGE-A4 induces non–small cell lung cancer and tumor-promoting plasma cell accumulation

Armstrong, D., Chang, C.-Y., Hong, M. J., Green, L., Shen, Y., Hudson, W., Mauk, K. E., Song, L., Jammi, S., Casal, B., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads4227 · Cited by 9

Role and Clinical Utility of Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma

Wu, S. C., & Münger, K. (2021) · Cancers · doi:10.3390/cancers13225690 · Cited by 9

Pulsed electric field induces exocytosis and overexpression of MAGE antigens in melanoma

Szlasa, W., Sauer, N. J., Baczyńska, D., Ziętek, M., Haczkiewicz-Leśniak, K., Karpiński, P., Fleszar, M. G., Fortuna, P., Kulus, M., Piotrowska, A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-63181-x · Cited by 8

Vaccine therapies for glioma: clinical frontiers and potential breakthrough

Xing, Y., Liu, C., Feng, Y., Li, S., & Chen, Y. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1613332 · Cited by 9

Modified Dendritic cell-based T-cell expansion protocol and single-cell multi-omics allow for the selection of the most expanded and in vitro-effective clonotype via profiling of thousands of MAGE-A3-specific T-cells

Sennikov, S. V., Volynets, M., Alrhmoun, S., Perik-Zavodskii, R., Perik-Zavodskaia, O., Fisher, M. S., Lopatnikova, J., Shevchenko, J. A., Вячеславович, Н. К., Philippova, J., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1470130 · Cited by 8

Prognostic and clinicopathological value of melanoma-associated antigen D4 in patients with glioma

Yan, J., Wen, J., Wei, Z., Li, X., Li, P., & Xiao, S. (2018) · Oncology Letters · doi:10.3892/ol.2018.7884 · Cited by 8

The Role of the Meiotic Component in Reproduction of B-RAF-Mutated Melanoma: A Review and “Brainstorming” Session

Pjanova, D., Vainshelbaum, N. M., Salmiņa, K., & Erenpreisa, J. A. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.93641 · Cited by 8

MAGED4B Promotes Glioma Progression via Inactivation of the TNF-α-induced Apoptotic Pathway by Down-regulating TRIM27 Expression

Liu, C., Liu, J., Shao, J., Huang, C., Dai, X., Shen, Y., Hou, W., Shen, Y., & Yu, Y. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00926-6 · Cited by 7

Facts and Hopes in Cancer Antigens Recognized by T Cells

Brochier, W., Bricard, O., & Coulie, P. G. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-3798 · Cited by 7

Immunohistochemical expression and prognostic significance of MAGE-A in canine oral malignant melanoma

Guillén, A., Stiborova, K., Ressel, L., Blackwood, L., Finotello, R., Amores‐Fuster, I., Jama, N., & Killick, D. R. (2021) · Research in Veterinary Science · doi:10.1016/j.rvsc.2021.05.009 · Cited by 6

Anomalies in Human Sex Determination: Usefulness of a Combined Cytogenetic Approach to Characterize an Additional Case with Xp Functional Disomy Associated with 46,XY Gonadal Dysgenesis

Rjiba, K., Slimani, W., Gaddas, M., Hassine, I. H., Jelloul, A., Khelifa, H. B., Amri, F. E., Zaouali, M., McElreavey, K., Saâd, A., et al. (2022) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.galenos.2022.2022-3-15 · Cited by 6

MAGED2 Depletion Promotes Stress-Induced Autophagy by Impairing the cAMP/PKA Pathway

Nasrah, S., Radi, A., Daberkow, J. K., Hummler, H., Weber, S., Seaayfan, E., & Kömhoff, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713433 · Cited by 6

Evolution of Melanoma Antigen-A11 (MAGEA11) During Primate Phylogeny

Willett, C. S., & Wilson, E. M. (2018) · Journal of Molecular Evolution · doi:10.1007/s00239-018-9838-8 · Cited by 6

Identification of MAGE-A family genes in colon cancer patients and their expression mechanism

Almutairi, M. H., Alotaibi, M. M., Alonaizan, R., Alrefaei, A. F., & Almutairi, B. O. (2022) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2022.102251 · Cited by 6

The deubiquitinase OTULIN regulates tau expression and RNA metabolism in neurons

Tangavelou, K., Bondu, V., Li, M., Li, W., Liao, F., & Bhaskar, K. (2025) · Genomic psychiatry : · doi:10.61373/gp025a.0116 · Cited by 5

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice

Li, N., Yu, J., Zhou, M., Qiu, F., Wang, X., & Wang, Z. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.07.013 · Cited by 5

A Single-Step Genome-Wide Association Study for Semen Traits of Egyptian Buffalo Bulls

Nagar, A. G. E., Salem, M. M. I., Amin, A. M. S., Khalil, M. H., Ashour, A. F., Hegazy, M. M., & Abdel-Shafy, H. (2023) · Animals · doi:10.3390/ani13243758 · Cited by 5

Generation of TRIM28 Knockout K562 Cells by CRISPR/Cas9 Genome Editing and Characterization of TRIM28-Regulated Gene Expression in Cell Proliferation and Hemoglobin Beta Subunits

Chang, Y.-J., Kang, Z., Bei, J., Chou, S., Lu, M. J., Su, Y.-L., Lin, S., Wang, H., Lin, S., & Chang, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126839 · Cited by 5

Pathological modulation of genome maintenance by cancer/testes antigens (CTAs)

Vaziri, C., Forker, K., Zhang, X., Wu, D., Zhou, P., & Bowser, J. L. (2025) · DNA repair · doi:10.1016/j.dnarep.2025.103818 · Cited by 4

The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry

Sanderson, M. R., Badior, K. E., Fahlman, R. P., & Wevrick, R. (2020) · Human Genetics · doi:10.1007/s00439-020-02193-9 · Cited by 4

Signatures of conserved and unique molecular features in Afrotheria

Yazhini, A., Srinivasan, N., & Sandhya, S. (2021) · Scientific Reports · doi:10.1038/s41598-020-79559-6 · Cited by 4

Expression of the tumor-expressed protein MageB2 enhances rRNA transcription

Ladelfa, M. F., Peche, L. Y., Amato, G. E., Escalada, M. C., Zampieri, S., Pascucci, F. A., Benevento, A. F., Porto, D. F. D., Dardis, A., Schneider, C., et al. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.119015 · Cited by 4

Caenorhabditis elegans NSE3 homolog (MAGE-1) is involved in genome stability and acts in inter-sister recombination during meiosis

Odiba, A. S., Liao, G., Ezechukwu, C. S., Zhang, L., Hong, Y., Fang, W., Jin, C., Gartner, A., & Wang, B. (2023) · Genetics · doi:10.1093/genetics/iyad149 · Cited by 4

MAGE genes encoding for embryonic development in cattle is mainly regulated by zinc finger transcription factor family and slightly by CpG Islands

Abera, B., & Dinka, H. (2022) · BMC Genomic Data · doi:10.1186/s12863-022-01034-0 · Cited by 4

DUB3 is a MAGEA3 deubiquitinase and a potential therapeutic target in hepatocellular carcinoma

Chen, Y., Gao, F., He, Y., Liu, M., Yuan, Q., & Zhang, P. (2024) · iScience · doi:10.1016/j.isci.2024.109181 · Cited by 3

Melanoma antigens in pediatric medulloblastoma contribute to tumor heterogeneity and species-specificity of group 3 tumors

Collins, R. R. J., Gee, R. R. F., Tozandehjani, S., Bayat, T., Sanchez, M. C. H., Gutierrez, J. S. S., Breznik, B., Lee, A. K., Peters, S., Connelly, J. P., et al. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02055-3 · Cited by 3

A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases

Fu, X., Xu, Y., Huang, J., Huang, Y., Potts, P. R., & Liang, C. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116408 · Cited by 4

Population‐scale genetic control of alternative polyadenylation and its association with human diseases

Li, L., Li, Y., Zou, X., Peng, F., Cui, Y., Wagner, E. J., & Li, W. (2021) · Quantitative Biology · doi:10.15302/j-qb-021-0252 · Cited by 3

MAGE-I proteins and cancer-pathways: A bidirectional relationship

Pascucci, F. A., Escalada, M. C., Suberbordes, M., Vidal, C., Ladelfa, M. F., & Monte, M. (2022) · Biochimie · doi:10.1016/j.biochi.2022.11.005 · Cited by 3

The MAGE protein family and cancer

Weon, J. L., & Potts, P. R. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.08.002 · Cited by 257

When MAGE meets RING: insights into biological functions of MAGE proteins

Feng, Y., Gao, J., & Yang, M. (2011) · Protein & Cell · doi:10.1007/s13238-011-1002-9 · Cited by 56

MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases

Doyle, J., Gao, J., Wang, J., Yang, M., & Potts, P. R. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.029 · Cited by 468

aMAGEing New Players Enter the RING to Promote Ubiquitylation

Espantman, K. C., & O’Shea, C. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.006 · Cited by 12

The MAGE protein family: Protein degradation, genome stability, and cancer

Potts, P. R. (2011) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.10000s12