A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases

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Vaccination with Mage-3a1 Peptide–Pulsed Mature, Monocyte-Derived Dendritic Cells Expands Specific Cytotoxic T Cells and Induces Regression of Some Metastases in Advanced Stage IV Melanoma

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RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

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The DNA sequence of the human X chromosome

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Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster

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The Arp2/3 Activator WASH Controls the Fission of Endosomes through a Large Multiprotein Complex

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Structure, chromosomal localization, and expression of 12 genes of the MAGE family

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Cancer/testis (CT) antigens: Potential targets for immunotherapy

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The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

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A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting

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Efficacy of the MAGE-A3 cancer immunotherapeutic as adjuvant therapy in patients with resected MAGE-A3-positive non-small-cell lung cancer (MAGRIT): a randomised, double-blind, placebo-controlled, phase 3 trial

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An overview of the MAGE gene family with the identification of all human members of the family.

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MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases

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RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis

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RING domains: master builders of molecular scaffolds?

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The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins

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Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase

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Genomic imprinting effects on brain development and function

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Cancer-Testis Genes Are Coordinately Expressed and Are Markers of Poor Outcome in Non–Small Cell Lung Cancer

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A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism

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Genome-wide analysis of cancer/testis gene expression

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Mass Spectrometric Analysis of the Anaphase-Promoting Complex from Yeast: Identification of a Subunit Related to Cullins

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Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome

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Paternally inherited microdeletion at 15q11.2 confirms a significant role for the SNORD116 C/D box snoRNA cluster in Prader–Willi syndrome

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The MAGE proteins: Emerging roles in cell cycle progression, apoptosis, and neurogenetic disease

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Adjuvant MAGE-A3 Immunotherapy in Resected Non–Small-Cell Lung Cancer: Phase II Randomized Study Results

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Sequence-Dependent Sorting of Recycling Proteins by Actin-Stabilized Endosomal Microdomains

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Truncating mutations of MAGEL2 cause Prader-Willi phenotypes and autism

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Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine.

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Inverted Repeat Structure of the Human Genome: The X-Chromosome Contains a Preponderance of Large, Highly Homologous Inverted Repeats That Contain Testes GenesPreprint

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Expression of MAGE genes in primary and metastatic cutaneous melanoma

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Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double‐strand breaks

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MAGE-A, mMage-b, and MAGE-C Proteins Form Complexes with KAP1 and Suppress p53-Dependent Apoptosis in MAGE-Positive Cell Lines

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MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents

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Monogenic causes of X-linked mental retardation

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Regulation of WASH-Dependent Actin Polymerization and Protein Trafficking by Ubiquitination

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Identification of a Cullin Homology Region in a Subunit of the Anaphase-Promoting Complex

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Rexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2?-deoxycytidine treatment

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Tumor Antigen Expression in Melanoma Varies According to Antigen and Stage

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A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene

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The imprinted gene Magel2 regulates normal circadian output

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[Monogenic causes of X-linked mental retardation].

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Selection of Immunostimulant AS15 for Active Immunization With MAGE-A3 Protein: Results of a Randomized Phase II Study of the European Organisation for Research and Treatment of Cancer Melanoma Group in Metastatic Melanoma

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Identification of MAGE-1 and MAGE-4 proteins in spermatogonia and primary spermatocytes of testis.

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Retromer-mediated endosomal protein sorting: all WASHed up!

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Disruption of the mouse necdin gene results in early post-natal lethality

Gérard, M., Hernandez, L. F., Wevrick, R., & Stewart, C. L. (1999) · Nature Genetics · doi:10.1038/13828 · Cited by 208

USP7 acts as a molecular rheostat to promote WASH-dependent endosomal protein recycling and is mutated in a human neurodevelopmental disorder.

Hao, Y.-H., Fountain, M. D., Fon Tacer, K., Xia, F., Bi, W., Kang, S.-H. L., Patel, A., Rosenfeld, J. A., Le Caignec, C., Isidor, B., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.033 · Cited by 206

Inactivation of the mouse Magel2 gene results in growth abnormalities similar to Prader-Willi syndrome

Bischof, J. M., Stewart, C. L., & Wevrick, R. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm225 · Cited by 200

Polyhydramnios, Transient Antenatal Bartter’s Syndrome, andMAGED2Mutations

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Promoter Demethylation and Histone Acetylation Mediate Gene Expression of MAGE-A1, -A2, -A3, and -A12 in Human Cancer Cells

Wischnewski, F., Pantel, K., & Schwarzenbach, H. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0229 · Cited by 185

Vaccine-Induced CD4+ T Cell Responses to MAGE-3 Protein in Lung Cancer Patients

Atanackovic, D., Altorki, N. K., Stockert, E., Williamson, B., Jungbluth, A. A., Ritter, E., Santiago, D., Ferrara, C. A., Matsuo, M., Selvakumar, A., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.3289 · Cited by 184

Identification of a new MAGE gene with tumor-specific expression by representational difference analysis.

Lucas, S., Smet, C. D., Arden, K. C., Viars, C. S., Lethé, B., Lurquin, C., & Boon, T. (1998) · PubMed · Cited by 184

An oncological view on the blood–testis barrier

Bart, J., Groen, H. J. M., van der Graaf, W. T. A., Hollema, H., Hendrikse, N. H., Vaalburg, W., Sleijfer, D. T., & de Vries, E. G. E. (2002) · The Lancet Oncology · doi:10.1016/s1470-2045(02)00776-3 · Cited by 183

Mutations in the KIAA0196 Gene at the SPG8 Locus Cause Hereditary Spastic Paraplegia

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A phase I trial combining decitabine/dendritic cell vaccine targeting MAGE-A1, MAGE-A3 and NY-ESO-1 for children with relapsed or therapy-refractory neuroblastoma and sarcoma

Krishnadas, D. K., Shusterman, S., Bai, F., Diller, L., Sullivan, J. E., Cheerva, A. C., George, R. E., & Lucas, K. G. (2015) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-015-1731-3 · Cited by 176

MAGRIT: The Largest-Ever Phase III Lung Cancer Trial Aims to Establish a Novel Tumor-Specific Approach to Therapy

Tyagi, P., & Mirakhur, B. (2009) · Clinical Lung Cancer · doi:10.3816/clc.2009.n.052 · Cited by 175

A Review of Idiopathic Hydramnios and Pregnancy Outcomes

Magann, E. F., Chauhan, S. P., Doherty, D. A., Lutgendorf, M. A., Magann, M. I., & Morrison, J. C. (2007) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000290349.58707.e0 · Cited by 173

Immunisation of metastatic cancer patients with MAGE-3 protein combined with adjuvant SBAS-2: a clinical report

Marchand, M.-C., Punt, C. J. A., Aamdal, S., Escudier, B. J., Kruit, W. H. J., Keilholz, U., Håkansson, L., van Baren, N., Humblet, Y., Mulders, P., et al. (2002) · European Journal of Cancer · doi:10.1016/s0959-8049(02)00479-3 · Cited by 169

Congenital hypokalemia with hypercalciuria in preterm infants: A hyperprostaglandinuric tubular syndrome different from Bartter syndrome

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Mage-A Cancer/Testis Antigens Inhibit p53 Function by Blocking Its Interaction with Chromatin

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GSK's antigen-specific cancer immunotherapy programme: Pilot results leading to Phase III clinical development

Brichard, V. G., & Lejeune, D. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.06.038 · Cited by 159

Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis.

Jang, S. J., Soria, J., Wang, L., Hassan, K. A., Morice, R. C., Walsh, G. L., Hong, W. K., & Mao, L. (2001) · PubMed · Cited by 158

Expression and imprinting of MAGEL2 suggest a role in Prader-Willi syndrome and the homologous murine imprinting phenotype

Lee, S. F. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.12.1813 · Cited by 156

A novel brain-specific mRNA encoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells

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Limited Gene Activation in Tumor and Normal Epithelial Cells Treated with the DNA Methyltransferase Inhibitor 5-Aza-2′-deoxycytidine

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Identification of Alzheimer disease-associated variants in genes that regulate retromer function

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Prader–Willi syndrome and autism spectrum disorders: an evolving story

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Two Members of the HumanMAGEBGene Family Located in Xp21.3 Are Expressed in Tumors of Various Histological Origins

Lurquin, C., Smet, C. D., Brasseur, F., Muscatelli, F., Martelange, V., Plaen, E. D., Brasseur, R., Monaco, A. P., & Boon, T. (1997) · Genomics · doi:10.1006/geno.1997.5052 · Cited by 139

The Melanoma-Associated Antigen A3 Mediates Fibronectin-Controlled Cancer Progression and Metastasis

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A paternal deletion of MKRN3, MAGEL2 and NDN does not result in Prader–Willi syndrome

Kanber, D., Giltay, J. C., Wieczorek, D., Zogel, C., Hochstenbach, R., Caliebe, A., Kuechler, A., Horsthemke, B., & Buiting, K. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.232 · Cited by 134

Melanoma Antigen Gene Protein MAGE-11 Regulates Androgen Receptor Function by Modulating the Interdomain Interaction

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Pure adult-onset spastic paraplegia caused by a novel mutation in the KIAA0196 (SPG8) gene

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MAGE-A3 is highly expressed in a cancer stem cell-like side population of bladder cancer cells.

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Necdin acts as a transcriptional repressor that interacts with multiple guanosine clusters

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Proto-oncogene Activity of Melanoma Antigen-A11 (MAGE-A11) Regulates Retinoblastoma-related p107 and E2F1 Proteins

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Singlemagegene in the chicken genome encodes CMage, a protein with functional similarities to mammalian type II Mage proteins

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Overexpression of MAGE-A9 predicts unfavorable outcome in breast cancer

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Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding

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Epigenetic Control of MAGE Gene Expression by the KIT Tyrosine Kinase

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Comparative expression analysis of the MAGED genes during embryogenesis and brain development

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Expression and prognostic value of MAGE-A9 in laryngeal squamous cell carcinoma.

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Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells

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A necdin/MAGE-like gene in the chromosome 15 autism susceptibility region: expression, imprinting, and mapping of the human and mouse orthologues

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Analysis of the Nse3/MAGE-Binding Domain of the Nse4/EID Family Proteins

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High expression of MAGE-A9 in tumor and stromal cells of non-small cell lung cancer was correlated with patient poor survival.

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The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice

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The SMAGE gene family is expressed in post-meiotic spermatids during mouse germ cell differentiation

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A Comprehensive Expression Analysis of Cancer Testis Antigens in Head and Neck Squamous Cell Carcinoma Revels MAGEA3/6 as a Marker for Recurrence

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Quantitative expression and immunogenicity of MAGE‐3 and ‐6 in upper aerodigestive tract cancer

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Neonatal Bartter syndrome: spontaneous resolution of all signs and symptoms

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HCA587 Antigen Expression in Normal Tissues and Cancers: Correlation with Tumor Differentiation in Hepatocellular Carcinoma

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Human MageB2 Protein Expression Enhances E2F Transcriptional Activity, Cell Proliferation, and Resistance to Ribotoxic Stress

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Differential Evolution of MAGE Genes Based on Expression Pattern and Selection Pressure

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Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E

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The cancer/testis antigen MAGEC2 promotes amoeboid invasion of tumor cells by enhancing STAT3 signaling

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Cell- and stage-specific expression of Mage genes during mouse spermatogenesis

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Prognostic Significance of MAGE-A11 in Esophageal Squamous Cell Carcinoma and Identification of Related Genes Based on DNA Microarray

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Deficiency of Trim27 protects dopaminergic neurons from apoptosis in the neurotoxin model of Parkinson׳s disease

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Prospective assessment of a gene signature potentially predictive of clinical benefit in metastatic melanoma patients following MAGE-A3 immunotherapeutic (PREDICT)

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The expression of MAGE-C1 and MAGE-C2 in breast cancer and their clinical significance

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FGF-2 isoforms of 18 and 22.5 kDa differentially modulate t-PA and PAI-1 expressions on the pancreatic carcinoma cells AR4-2J: Consequences on cell spreading and invasion

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PROTAC targeted protein degraders: the past is prologue

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Target and tissue selectivity of PROTAC degraders

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Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation

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Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade

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Tying up loose ends: the N-degron and C-degron pathways of protein degradation

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The MAGE protein family and cancer

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When MAGE meets RING: insights into biological functions of MAGE proteins

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MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases

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aMAGEing New Players Enter the RING to Promote Ubiquitylation

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The MAGE protein family: Protein degradation, genome stability, and cancer

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