The DOI matches its Crossref record; 219 of the 229 references it cites were found in a registry or an index.
A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases
Open accessAbstract
Melanoma antigen (MAGE) genes are conserved in all eukaryotes and encode for proteins sharing a common MAGE homology domain. Although only a single MAGE gene exists in lower eukaryotes, the MAGE family rapidly expanded in eutherians and consists of more than 50 highly conserved genes in humans. A subset of MAGEs initially garnered interest as cancer biomarkers and immunotherapeutic targets due to their antigenic properties and unique expression pattern that is primary restricted to germ cells and aberrantly reactivated in various cancers. However, further investigation revealed that MAGEs not only drive tumorigenesis but also regulate pathways essential for diverse cellular and developmental processes. Therefore, MAGEs are implicated in a broad range of diseases including neurodevelopmental, renal, and lung disorders, and cancer. Recent biochemical and biophysical studies indicate that MAGEs assemble with E3 RING ubiquitin ligases to form MAGE-RING ligases (MRLs) and act as regulators of ubiquitination by modulating ligase activity, substrate specification, and subcellular localization. Here, we present a comprehensive guide to MAGEs highlighting the molecular mechanisms of MRLs and their physiological roles in germ cell and neural development, oncogenic functions in cancer, and potential as therapeutic targets in disease.
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“An example of such a family of ligases are the MAGE (melanoma antigen genes) family of ubiquitin E3 ligases, often referred to as the MAGE-RING ligases (MRLs), which comprise proteins that serve as substrate-recruitment modules for other RING E3 ligases156,157, adding to and/or altering the substrate specificity of their co-E3 ligases (reviewed elsewhere155,158).”
From PROTAC targeted protein degraders: the past is prologue (2022) · cites this paper as [158]
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Items 201–219 of 219
MAGE proteins regulate KRAB zinc finger transcription factors and KAP1 E3 ligase activity
Xiao, T. Z., Suh, Y. K., & Longley, B. J. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.07.026 · Cited by 21
Bhatia, N., Yang, B., Xiao, T. Z., Peters, N. R., Hoffmann, M. F., & Longley, B. J. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.01.007 · Cited by 21
Teuber, J., Mueller, B., Fukabori, R., Lang, D. G., Albrecht, A., & Stork, O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063067 · Cited by 20
Hagiwara, Y., Sieverling, L., Hanif, F., Anton, J., Dickinson, E. R., Bui, T. T. T., Andreeva, A. E., Barran, P. E., Cota, E., & Nikolova, P. V. (2016) · Scientific Reports · doi:10.1038/srep25182 · Cited by 20
Nishimura, I., Shimizu, S., Sakoda, J.-Y., & Yoshikawa, K. (2006) · Gene Expression Patterns · doi:10.1016/j.modgep.2006.09.008 · Cited by 18
Prognostic value of MAGE-A9 expression in patients with colorectal cancer
Zhan, W., Zhang, Z., Zhang, Y., Ma, J., Wu, T., Gu, Y., Li, Y., & Yang, J. (2015) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2015.08.005 · Cited by 17
Noh, S. T., Lee, H. S., Lim, S. J., Kim, S. W., Chang, H. K., Oh, J., Jeon, C., Park, J. W., & Lee, K. D. (2016) · International Journal of Clinical Oncology · doi:10.1007/s10147-016-0989-6 · Cited by 17
MAGEL2 and Oxytocin—Implications in Prader-Willi Syndrome and Beyond
Fountain, M. D., & Schaaf, C. P. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.006 · Cited by 16
McCurdy, D., Tai, L.-Q., Nguyen, J., Wang, Z., Yang, H., Udar, N., Naiem, F., CONCANNON, P. J., & Gatti, R. A. (1998) · Molecular Genetics and Metabolism · doi:10.1006/mgme.1997.2639 · Cited by 16
Suyama, T., Ohashi, H., Nagai, H., Hatano, S., Asano, H., Murate, T., Saito, H., & Kinoshita, T. (2002) · Leukemia Research · doi:10.1016/s0145-2126(02)00048-6 · Cited by 16
The Use of MAGE C1 and Flow Cytometry to Determine the Malignant Cell Type in Multiple Myeloma
Wienand, K., & Shires, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120734 · Cited by 15
Melanoma antigen-A11 regulates substrate-specificity of Skp2-mediated protein degradation
Su, S., Chen, X., Geng, J., Minges, J. T., Grossman, G., & Wilson, E. M. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.10.006 · Cited by 15
Identification of MAGEA12 as a prognostic outlier gene in gastric cancers
Wu, J., Wang, J., & Shen, W. (2017) · Neoplasma · doi:10.4149/neo_2017_210 · Cited by 15
MAGE-B2 Autoantibody: A New Biomarker for Pediatric Systemic Lupus Erythematosus
Hoftman, A., Tai, L., Tze, S., Seligson, D. B., Gatti, R. A., & McCurdy, D. (2008) · The Journal of Rheumatology · doi:10.3899/jrheum.080333 · Cited by 12
Jäger, E., & Knuth, A. K. (2012) · Europe PMC (PubMed Central) · doi:10.5167/uzh-75664 · Cited by 10
Hartmann, S., Brisam, M., Rauthe, S., Driemel, O., Brands, R. C., Rosenwald, A., Kübler, A. C., & Müller-Richter, U. D. A. (2016) · Oncology Letters · doi:10.3892/ol.2016.4945 · Cited by 8
Zarour, H. M., DeLeo, A. B., Finn, O. J., & Storkus, W. J. (2003) · Cited by 3
Expression of melanoma antigen gene by cells from inflamed joints in juvenile rheumatoid arthritis.
McCurdy, D., Tai, L., Imfeld, K. L., Schwartz, M., Zaldivar, F. P., & Berman, M. A. (2002) · PubMed · Cited by 3
Melanoma antigen protein MAGEC1 mutation identified in familial non-obstructive azoospermia
Pastuszak, A. W., cengiz, C., Bekheirnia, M. R., & Lamb, D. J. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.07.246 · Cited by 1
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10 of the 229 references couldn’t be matched to a known paper.
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- Gilbert, 2000, Developmental Biology. 6th edition. Sunderland (MA): Sinauer Associates, Spermatogenesis
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PROTAC targeted protein degraders: the past is prologue
Békés, M., Langley, D. R., & Crews, C. M. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00371-6 · Cited by 3,395
Target and tissue selectivity of PROTAC degraders
Guenette, R. G., Yang, S. W., Min, J., Pei, B., & Potts, P. R. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00200k · Cited by 324
Self-citationBond, M. J., & Crews, C. M. (2021) · RSC Chemical Biology · doi:10.1039/d1cb00011j · Cited by 232
Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade
Shukla, S. A., Bachireddy, P., Schilling, B., Galonska, C., Zhan, Q., Bango, C., Langer, R., Lee, P. C., Gusenleitner, D., Keskin, D. B., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.026 · Cited by 179
Self-citationTying up loose ends: the N-degron and C-degron pathways of protein degradation
Timms, R. T., & Koren, I. (2020) · Biochemical Society Transactions · doi:10.1042/bst20191094 · Cited by 100
Metadata
- Authors
- Lee, A. K., & Potts, P. R.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Potts, Patrick Ryan
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 429
- Issue
- 8
- Pages
- 1114-1142
- ISSN
- 0022-2836 (ISSN-L)
- PMC
- PMC5421567
- OpenAlex
- W2592245646
- Cited by
- 136
- References
- 229
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 10 · 2023: 11 · 2022: 18 · 2021: 16 · 2020: 24 · 2019: 11 · 2018: 12 · 2017: 5
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM111332)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Keywords
- E3 ubiquitin ligase, ubiquitination, germ cell development, neural development, carcinogenesis, tumor markers, immunotherapy targets, therapeutic target
- MeSH terms
- Antigens, Neoplasm, Bartter Syndrome, Chromosome Mapping, Multigene Family, Humans, Immunotherapy, Neoplasms, Prader-Willi Syndrome, Gene Expression Regulation, Developmental, Evolution, Molecular, Ubiquitin-Protein Ligases, Ubiquitination, Melanoma-Specific Antigens
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