The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The effects of collagen concentration and crosslink density on the biological, structural and mechanical properties of collagen-GAG scaffolds for bone tissue engineering
Open accessAbstract
In this study, we examined the effects of varying collagen concentration and crosslink density on the biological, structural and mechanical properties of collagen-GAG scaffolds for bone tissue engineering. Three different collagen contents (0.25%, 0.5% and 1% collagen) and two different dehydrothermal (DHT) crosslinking processes [1] 105 degrees C for 24 h and [2] 150 degrees C for 48 h were investigated. These scaffolds were assessed for (1) pore size, (2) permeability (3) compressive strength and (4) cell viability. The largest pore size, permeability rate, compressive modulus, cell number and cell metabolic activity was all found to occur on the 1% collagen scaffold due to its increased collagen composition and the DHT treatment at 150 degrees C was found to significantly improve the mechanical properties and not to affect cellular number or metabolic activity. These results indicate that doubling the collagen content to 1% and dehydrothermally crosslinking the scaffold at 150 degrees C for 48 h has enhanced mechanical and biological properties of the scaffold making it highly attractive for use in bone tissue engineering.
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Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
O'Brien, J., Wilson, I., Orton, T., & Pognan, F. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01606.x · Cited by 3,446
Cited by
Biomaterials & scaffolds for tissue engineering
O'Brien, F. J. (2011) · Materials Today · doi:10.1016/s1369-7021(11)70058-x · Cited by 3,437
Self-citationTreatment of critical-sized bone defects: clinical and tissue engineering perspectives
Roddy, E., DeBaun, M. R., Daoud-Gray, A., Yang, Y. P., & Gardner, M. J. (2018) · European Journal of Orthopaedic Surgery & Traumatology · doi:10.1007/s00590-017-2063-0 · Cited by 459
Lyons, F. G., Al-Munajjed, A. A., Kieran, S. M., Toner, M. E., Murphy, C. M., Duffy, G. P., & O’Brien, F. J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.056 · Cited by 222
Self-citationThompson, E. M., Matsiko, A., Farrell, E., Kelly, D. J., & O'Brien, F. J. (2015) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1918 · Cited by 147
Self-citationCosta, A., Naranjo, J. D., Londono, R., & Badylak, S. F. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025676 · Cited by 135
Metadata
- Authors
- Tierney, C. M., Haugh, M. G., Liedl, J., Mulcahy, F., Hayes, B., & O’Brien, F. J.
- Venue
- Journal of the Mechanical Behavior of Biomedical Materials
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 2
- Issue
- 2
- Pages
- 202-209
- ISSN
- 1751-6161 (ISSN-L)
- OpenAlex
- W2059779956
- Cited by
- 223
- References
- 2
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Tierney, C. M., Haugh, M. G., Liedl, J., Mulcahy, F., Hayes, B., & O’Brien, F. J. (2009). The effects of collagen concentration and crosslink density on the biological, structural and mechanical properties of collagen-GAG scaffolds for bone tissue engineering. Journal of the Mechanical Behavior of Biomedical Materials. https://doi.org/10.1016/j.jmbbm.2008.08.007
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