The DOI matches its Crossref record; 88 of the 90 references it cites were found in a registry or an index.
Endometriosis and Mechanisms of Pelvic Pain
Abstract
Endometriosis remains an enigmatic disorder in that the cause, the natural history, and the precise mechanisms by which it causes pain are not completely understood. The pain symptoms most commonly attributed to endometriosis are dysmenorrhea, dyspareunia, and chronic pelvic pain. Pain may be due to nociceptive, inflammatory, or neuropathic mechanisms, and there is evidence that all 3 of these mechanisms are relevant to endometriosis-associated pelvic pain. It is proposed that the clinically observed inconsistencies of the relationships of endometriosis severity and the presence or severity of pain are likely due to variable roles of different pain mechanisms in endometriosis. A better understanding of the roles of nociceptive, inflammatory, and neuropathic pain in endometriosis is likely to improve the treatment of women with endometriosis-associated pelvic pain.
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In the citing paper
“among women who undergo laparoscopy, endometriosis is found in one-third who undergo surgery for CPP, compared with only 5% of those who do not have infertility or CPP”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Howard, 2009
In the citing paper
“The pathophysiology of pain in RVE is multifactorial and not determined solely by anatomical involvement.”
From Pain and functional outcomes after surgical versus hormonal treatment in rectovaginal endometriosis: a retrospective cohort study (2026) · cites this paper as [8]
In the citing paper
“However, lesion removal does not necessarily eliminate the biological processes that sustain pain [8, 16, 24, 26].”
From Pain and functional outcomes after surgical versus hormonal treatment in rectovaginal endometriosis: a retrospective cohort study (2026) · cites this paper as [8]
In the citing paper
“This discovery suggests that, rather than the growths alone, it is the ectopic growth's own innervation that is a major contributor to the maintenance and modulation of pain in established endometriosis [12].”
From Sprouted Innervation into Uterine Transplants Contributes to the Development of Hyperalgesia in a Rat Model of Endometriosis (2012) · cites this paper as [12]
In the citing paper
“Symptoms include dysmenorrhea, dyspareunia (vaginal hyperalgesia), chronic pelvic/abdominal musculoskeletal and other types of severe pain that are often difficult to alleviate without resorting either to hormonal treatments that produce often-intolerable side effects of hypoestrogenicity or to surgery that frequently fails to help [16,21,27,16,48].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [21]
In the citing paper
“Findings from the rat model and clinical studies strongly support the conclusion that this innervation contributes to endometriosis-associated pain [21,45,48].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [21]
In the citing paper
“Although it is recognized that both inflammatory and neuropathic mechanisms contribute to endometriosis-associated pains, progress in developing new treatment strategies is impeded by a poor understanding of how the growths, which do not correlate with the pains, contribute to them [16,21,27,48].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [21]
In the citing paper
“Although it is recognized that both inflammatory and neuropathic mechanisms contribute to endometriosis-associated pains, progress in developing new treatment strategies is impeded by a poor understanding of how the growths, which do not correlate with the pains, contribute to them [16,21,27,48].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [21]
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Flagged first, then by citations
2 of the 90 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
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Cited by
Sorted by citations
Items 201–218 of 218
Novel triple therapy for hemorrhagic ascites caused by endometriosis: A case report
Han, X., & Zhang, S.-T. (2020) · World Journal of Clinical Cases · doi:10.12998/wjccc.v8.i23.6198
Javdani, M., Shahbandari, F., Soleymanijadian, E., Hashemnia, M., & Barzegar, A. (2022) · Tabari Biomedical Student Research Journal · doi:10.32598/tbsrj.v4i4.10517
Actualization of differential diagnosis of chronic pelvic pain syndrome in women of reproductive age
Solomko, O. B., & Shurpyak, S. О. (2023) · Reproductive health of woman · doi:10.30841/2708-8731.7.2022.272474
CHRONIC PELVIC PAIN SYNDROME ASSOCIATED WITH ENDOMETRIOSIS
Grigoryants, A. A. (2024) · International Scientific Conference «Joint Innovation - Joint Development» · doi:10.37539/231024.2023.23.78.016
Impactos da endometriose na gravidez e suas possíveis complicações
Paiva, A. C. M., Aziz, N. T. A. A., Silva, A. V. E., Duarte, M. L. M., Silva, C. C. A. D., & Ferraz, G. M. (2024) · Brazilian Journal of Health Review · doi:10.34119/bjhrv7n2-107
Endometriosis: Pathogenesis, Diagnosis and Treatment, volume II
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Neuroimmunology of Endometriosis-Associated Pain and Its Psychological Aspects
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Gender, Sexuality and Reproduction
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Evaluation of the Effect of Dietary Habits on the Health Profile in Women with Endometriosis
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Racca, C., Franken, J., Cahen, M., Cicchelero, A., Mormont, M., & Cinotti, R. (2026) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.71087
Metadata
- Authors
- Howard, F. M.
- Affiliations
- University of Rochester Medicine (US)
- Corresponding author
- Howard, Fred M.
- Venue
- Journal of Minimally Invasive Gynecology
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 16
- Issue
- 5
- Pages
- 540-550
- ISSN
- 1553-4650 (ISSN-L)
- OpenAlex
- W2085922363
- Cited by
- 218
- References
- 90
- Citations by year
- 2026: 4 · 2025: 15 · 2024: 14 · 2023: 18 · 2022: 8 · 2021: 12 · 2020: 20 · 2019: 18 · 2018: 11 · 2017: 15 · 2016: 11 · 2015: 15 · 2014: 12 · 2013: 11 · 2012: 12
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Minimally Invasive Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Keywords
- endometriosis, chronic pelvic pain, dysmenorrhea, dyspareunia, nociceptive pain, inflammatory pain, neuropathic pain, pain mechanisms, endometriosis severity, pain management
- MeSH terms
- Animals, Chronic Disease, Disease Models, Animal, Endometriosis, Endometrium, Female, Humans, Interleukins, Mast Cells, Nerve Growth Factors, Pelvic Pain, Chemokine CCL2, Tumor Necrosis Factors, Pain, Referred, Referred Pain
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