Cited by 85Endometriosis Research and TreatmentGastrointestinal motility and disordersPlant and fungal interactions

Hyperinnervation in Intestinal Deep Infiltrating Endometriosis

Wang, Guoyun, Tokushige, Natsuko, Russell, Peter, Dubinovsky, Sylvia, Markham, Robert, Fraser, Ian S.·2009·Journal of Minimally Invasive Gynecology

Abstract

Study objective To investigate the extent and types of innervation of endometriotic lesions in various regions of the bowel.Design Retrospective nonrandomized immunohistochemical study (Canadian Task Force classification II-3.Setting University-based laboratory.Patients Thirty-six women undergoing laparoscopy or laparotomy because of deep infiltrating endometriosis in various regions of the bowel, including the sigmoid colon, appendix, and rectum.Interventions Immunohistochemical staining of endometriotic specimens with antibodies against protein gene product 9.5, neurofilament, nerve growth factor, nerve growth factor receptors tyrosine kinase receptor A and p75, growth-associated protein 43, substance P, neuropeptide Y, and vasoactive intestinal peptide to demonstrate myelinated, unmyelinated, sensory, and autonomic nerve fibers.Measurements and main results There were significantly more nerve fibers in intestinal deep infiltrating endometriosis (mean [SD] 172.6 [94.2]/mm(2)) than in other deep infiltrating endometriotic lesions (e.g., cul-de-sac and uterosacral ligament) (67.6 [65.1]/mm(2); p<.01). Intestinal deep infiltrating endometriosis was innervated abundantly by sensory Adelta,sensory C, cholinergic, and adrenergic nerve fibers. Nerve growth factor, tyrosine kinase receptor A, and p75 were strongly expressed in endometriotic lesions, and growth-associated protein-43 was also strongly expressed in the endometriosis-associated nerve fibers.Conclusion The hyperinnervation in intestinal deep infiltrating endometriosis may help to explain why patients with this type of lesion have more severe pain.

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Crossref · 10.1016/j.jmig.2009.07.012

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Authors
Wang, G., Tokushige, N., Russell, P., Dubinovsky, S., Markham, R., & Fraser, I. S.
Affiliations
  • Shandong University (CN)
  • The University of Sydney (AU)
Corresponding author
Wang, Guoyun
Venue
Journal of Minimally Invasive Gynecology
Publisher
Elsevier BV
Published
2009-11
Volume
16
Issue
6
Pages
713-719
ISSN
1553-4650 (ISSN-L)
OpenAlex
W2015421305
Cited by
85
References
47
Citations by year
2026: 3 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 9 · 2014: 7 · 2013: 3 · 2012: 9
FWCI
5.47
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Minimally Invasive Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of Sydney
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Plant and fungal interactions
Keywords
deep infiltrating endometriosis, intestinal endometriosis, hyperinnervation, nerve fibers, sensory nerve fibers, cholinergic fibers, adrenergic nerve fibers, nerve growth factor, p75 neurotrophin receptor, growth-associated protein 43, substance P, neuropeptide Y, vasoactive intestinal peptide, endometriosis-associated pain, sigmoid colon, appendix, rectum
MeSH terms
Adult, Endometriosis, Female, Humans, Immunohistochemistry, Intestine, Large, Middle Aged, Retrospective Studies, GAP-43 Protein, Receptor, Nerve Growth Factor, Receptor, trkA, Nerve Growth Factor, Young Adult

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