The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Burrowing and nest building behavior as indicators of well-being in mice
Open accessAbstract
The assessment of pain, distress and suffering, as well as evaluation of the efficacy of stress-reduction strategies, is crucial in animal experimentation but can be challenging in laboratory mice. Nest building and burrowing performance, observed in the home cage, have proved to be valuable and easy-to-use tools to assess brain damage or malfunction as well as neurodegenerative diseases. Both behaviors are used as parameters in models of psychiatric disorders or to monitor sickness behavior following infection. Their use has been proposed in more realistic and clinically relevant preclinical models of disease, and reduction of these behaviors seems to be especially useful as an early sign of dysfunction and to monitor disease progression. Finally, both behaviors are reduced by pain and stress. Therefore, in combination with specific disease markers, changes in nest building and burrowing performance may help provide a global picture of a mouse's state, and thus aid monitoring to ensure well-being in animal experimentation.
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Cites
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Cited by
Seo, D.-O., O’Donnell, D., Jain, N., Ulrich, J. D., Herz, J., Li, Y., Lemieux, M., Cheng, J., Hu, H., Serrano, J. R., et al. (2023) · Science · doi:10.1126/science.add1236 · Cited by 254
Hohlbaum, K., Bert, B., Dietze, S., Palme, R., Fink, H., & Thöne-Reineke, C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179588 · Cited by 156
APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction
Soto, I., Graham, L. C., Richter, H. J., Simeone, S. N., Radell, J. E., Grabowska, W., Funkhouser, W. K., Howell, M. C., & Howell, G. R. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002279 · Cited by 140
Sun, Y., Guo, Y., Feng, X., Jia, M., Ai, N., Dong, Y., Zheng, Y., Fu, L., Yu, B., Zhang, H., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01749-w · Cited by 122
Tau Reduction Prevents Key Features of Autism in Mouse Models
Tai, C., Chang, C.-W., Yu, G.-Q., Lopez, I., Yu, X., Wang, X., Guo, W., & Mucke, L. (2020) · Neuron · doi:10.1016/j.neuron.2020.01.038 · Cited by 96
Metadata
- Authors
- Jirkof, P.
- Venue
- Journal of Neuroscience Methods
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 234
- Pages
- 139-146
- ISSN
- 0165-0270 (ISSN-L)
- OpenAlex
- W2080093346
- Cited by
- 438
- References
- 107
- FWCI
- 20.30
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
