Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1
Open accessAbstract
Mice completely deficient for Dvl1, one of three mouse homologs of the Drosophila segment polarity gene Dishevelled, were created by gene targeting. Dvl1-deficient mice are viable, fertile, and structurally normal. Surprisingly, these mice exhibited reduced social interaction, including differences in whisker trimming, deficits in nest-building, less huddling contact during home cage sleeping, and subordinate responses in a social dominance test. Sensorimotor gating was abnormal, as measured by deficits in prepulse inhibition of acoustic and tactile startle. Thus, Dvl1 mutants may provide a model for aspects of several human psychiatric disorders. These results are consistent with an interpretation that common genetic mechanisms underlie abnormal social behavior and sensorimotor gating deficits and implicate Dvl1 in processes underlying complex behaviors.
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Observational findings in some of these behavioral domains have been reported in some targeted gene mutations, e.g. deficits in social interaction within the home cage have been reported for mice deficient in the dishevelled-1 gene or the NMDA NR1 subunit.
“Observational findings in some of these behavioral domains have been reported in some targeted gene mutations, e.g.deficits in social interaction within the home cage have been reported for mice deficient in the dishevelled-1 gene (Lijam et al. 1997) or the NMDA NR1 subunit (Mohn et al. 1999).”
From Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice (2004) · cites this paper as Lijam et al. 1997
Dishevelled (DVL), which inhibits the destruction complex, was knocked out in the first mouse model of social dysfunction.
“Dishevelled (DVL), which inhibits the destruction complex, was knocked out in the first mouse model of social dysfunction (Lijam et al., 1997), an early predecessor to more recent findings connecting Wnt related signaling molecules to ASD (De Ferrari and Moon, 2006; O'Roak et al., 2012a; Parikshak et al., 2013).”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Lijam et al., 1997
Cites
Antibodies, a laboratory manual
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318 · see citing works
Spatial localization does not require the presence of local cues
Morris, R. G. M. (1981) · Learning and Motivation · doi:10.1016/0023-9690(81)90020-5 · Cited by 2,699 · see citing works
Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Paylor, R. E., Wehner, J. M., & Tonegawa, S. (1992) · Science · doi:10.1126/science.1321493 · Cited by 1,351 · see citing works
Self-citationSensorimotor Gating and Schizophrenia
Braff, D. L. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810140081011 · Cited by 1,312 · see citing works
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T., & Mulligan, R. C. (1991) · Cell · doi:10.1016/0092-8674(91)90011-m · Cited by 1,281 · see citing works
Prestimulus Effects on Human Startle Reflex in Normals and Schizophrenics
BRAFF, D. L., Stone, C., Callaway, E., Geyer, M. A., Glick, I. D., & Bali, L. (1978) · Psychophysiology · doi:10.1111/j.1469-8986.1978.tb01390.x · Cited by 1,171 · see citing works
A Comparison of the Social Postures of Some Common Laboratory Rodents
Grant, E. C., & Mackintosh, J. H. (1963) · Behaviour · doi:10.1163/156853963x00185 · Cited by 1,167 · see citing works
The more or less startling effects of weak prestimulation
Graham, F. K. (1975) · Psychophysiology · doi:10.1111/j.1469-8986.1975.tb01284.x · Cited by 1,119 · see citing works
Fibroblast growth factor receptor 3 is a negative regulator of bone growth.
Deng, C.-X., Wynshaw-Boris, A., Zhou, F., Kuo, A., & Leder, P. (1996) · Cell · doi:10.1016/s0092-8674(00)81069-7 · Cited by 1,095 · see citing works
Self-citationA primary acoustic startle circuit: lesion and stimulation studies
Davis, M., Gendelman, D. S., Tischler, M., & Gendelman, P. M. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-06-00791.1982 · Cited by 967 · see citing works
Assessing the Validity of an Animal Model of Deficient Sensorimotor Gating in Schizophrenic Patients
Swerdlow, N. R. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020063007 · Cited by 708 · see citing works
Dopaminergic stimulation disrupts sensorimotor gating in the rat
Mansbach, R. S., Geyer, M. A., & BRAFF, D. L. (1988) · Psychopharmacology · doi:10.1007/bf00212846 · Cited by 608 · see citing works
WNTs modulate cell fate and behavior during vertebrate development
Moon, R. T. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01093-7 · Cited by 601 · see citing works
Crawley, J. N., & Paylor, R. E. (1997) · Hormones and Behavior · doi:10.1006/hbeh.1997.1382 · Cited by 551 · see citing works
Self-citationSwerdlow, N. R., Paulsen, J. S., BRAFF, D. L., Butters, N., Geyer, M. A., & Swenson, M. R. (1995) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.58.2.192 · Cited by 436 · see citing works
Startle Habituation and Sensorimotor Gating in Schizophrenia and Related Animal Models
Geyer, M. A., & BRAFF, D. L. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.4.643 · Cited by 411 · see citing works
Klingensmith, J., Nusse, R., & Perrimon, N. (1994) · Genes & Development · doi:10.1101/gad.8.1.118 · Cited by 409 · see citing works
Sensorimotor gating in boys with Tourette's syndrome and ADHD: Preliminary results
Castellanos, F. X., Fine, E. J., Kaysen, D. L., Marsh, W., Rapoport, J. L., & Hallett, M. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00101-8 · Cited by 395 · see citing works
The dishevelled protein is modified by wingless signaling in Drosophila.Preprint
Yanagawa, S.-I., van Leeuwen, F. N., Wodarz, A., Klingensmith, J., & Nusse, R. (1995) · Genes & Development · doi:10.1101/gad.9.9.1087 · Cited by 388 · see citing works
Inbred strain differences in prepulse inhibition of the mouse startle response
Paylor, R. E., & Crawley, J. N. (1997) · Psychopharmacology · doi:10.1007/s002130050333 · Cited by 382 · see citing works
Self-citationGeyer, M. A., Wilkinson, L. S., Humby, T., & Robbins, T. W. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90180-l · Cited by 377 · see citing works
A preliminary assessment of sensorimotor gating in patients with obsessive compulsive disorder
Swerdlow, N. R., Benbow, C. H., Zisook, S., Geyer, M. A., & BRAFF, D. L. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90300-3 · Cited by 351 · see citing works
dishevelled is required during wingless signaling to establish both cell polarity and cell identity
Theisen, H., Purcell, J. M., Bennett, M. K., Kansagara, D., Syed, A., & Marsh, J. (1994) · Development · doi:10.1242/dev.120.2.347 · Cited by 339 · see citing works
Startle gating deficits occur across prepulse intensities in schizophrenic patients
Grillon, C., Ameli, R., Charney, D. S., Krystal, J. H., & BRAFF, D. L. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90183-z · Cited by 332 · see citing works
Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response.
Bakshi, V. P., Swerdlow, N. R., & Geyer, M. A. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23831-9 · Cited by 329 · see citing works
Cadenhead, K. S., Geyer, M. A., & BRAFF, D. L. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.12.1862 · Cited by 307 · see citing works
Social Dominance in Inbred Mouse Strains
Lindzey, G. E., Winston, H. D., & Manosevitz, M. (1961) · Nature · doi:10.1038/191474a0 · Cited by 290 · see citing works
Wilkinson, L. S., Killcross, S., Humby, T., Hall, F. S., Geyer, M. A., & Robbins, T. W. (1994) · Neuropsychopharmacology · doi:10.1038/npp.1994.8 · Cited by 267 · see citing works
Differences between inbred strains of mice in Morris water maze performance
Upchurch, M. B., & Wehner, J. M. (1988) · Behavior Genetics · doi:10.1007/bf01067075 · Cited by 238 · see citing works
Jen, Y., Manova, K., & Benezra, R. (1996) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199611)207:3 · Cited by 184 · see citing works
The Neurobiology of Infantile Autism
Ciaranello, A. L., & Ciaranello, R. D. (1995) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.18.030195.000533 · Cited by 184 · see citing works
Sussman, D. J., Klingensmith, J., Salinas, P. C., Adams, P. S., Nusse, R., & Perrimon, N. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1297 · Cited by 183 · see citing works
Self-citationIson, J. R., McAdam, D., & Hammond, G. L. (1973) · Physiology & Behavior · doi:10.1016/0031-9384(73)90185-6 · Cited by 175 · see citing works
DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins
Ponting, C. P., & Phillips, C. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)88973-2 · Cited by 172 · see citing works
Prospects for pharmacotherapy of schizophrenia
Pickar, D. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90469-7 · Cited by 167 · see citing works
Pleckstrin's repeat performance: a novel domain in G-protein signaling?
Ponting, C. P., & Peer Bork, B. (1996) · PubMed · Cited by 152 · see citing works
Johansson, C., Jackson, D. M., Zhang, J., & Svensson, L. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00160-x · Cited by 148 · see citing works
Long-Term Potentiation in Distinct Subtypes of Hippocampal Nonpyramidal Neurons
Maccaferri, G., & McBain, C. J. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05334.1996 · Cited by 133 · see citing works
Self-citationPleckstrin's repeat performance: a novel domain in G-protein signaling?
Ponting, C. P., & Peer Bork, B. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)30027-3 · Cited by 120 · see citing works
Klingensmith, J., Yang, Y., Axelrod, J. D., Beier, D. R., Perrimon, N., & Sussman, D. J. (1996) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00549-7 · Cited by 110 · see citing works
Self-citationHair-nibbling and whisker-trimming as indicators of social hierarchy in mice
Long, S. Y. (1972) · Animal Behaviour · doi:10.1016/s0003-3472(72)80167-2 · Cited by 85 · see citing works
Sensory Gating and Inhibitory Function in Late-life Schizophrenia
McDowd, J. M., Filion, D. L., Harris, M. J., & BRAFF, D. L. (1993) · Schizophrenia Bulletin · doi:10.1093/schbul/19.4.733 · Cited by 81 · see citing works
Strozik, E., & Festing, M. F. W. (1981) · Laboratory Animals · doi:10.1258/002367781780953040 · Cited by 72 · see citing works
Beier, D. R., Dushkin, H., & Sussman, D. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.9102 · Cited by 71 · see citing works
Self-citationPaylor, R. E., Baskall-Baldini, L., Yuva‐Paylor, L. A., & Wehner, J. M. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.6.1415 · Cited by 71 · see citing works
Self-citationDominance behavior: A phylogenetic analysis in the mouse
Messeri, P., Eleftheriou, B. E., & Oliverio, A. (1975) · Physiology & Behavior · doi:10.1016/0031-9384(75)90141-9 · Cited by 54 · see citing works
Issues in the genetics of social behavior
Fuller, J. L., & Hahn, M. E. (1976) · Behavior Genetics · doi:10.1007/bf01065697 · Cited by 51 · see citing works
Pizzuti, A., Novelli, G., Mari, A., et al. (1996) · PubMed · Cited by 47 · see citing works
Hauschka, T. S. (1952) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a106272 · Cited by 36 · see citing works
Issues in the genetics of social behavior: Revisited
Hahn, M. E., & Schanz, N. (1996) · Behavior Genetics · doi:10.1007/bf02359750 · Cited by 31 · see citing works
WNT-mediated relocalization of dishevelled proteins
Steitz, S. A., Tsang, M., & Sussman, D. J. (1996) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/bf02723007 · Cited by 25 · see citing works
Self-citationOrganization and promoter analysis of the mouse dishevelled-1 gene.Preprint
Lijam, N., & Sussman, D. J. (1995) · Genome Research · doi:10.1101/gr.5.2.116 · Cited by 22 · see citing works
Self-citationThe molecular genetics of schizophrenia
Murphy, K. C., Cardno, A. G., & McGuffin, P. (1996) · Journal of Molecular Neuroscience · doi:10.1007/bf02736794 · Cited by 17 · see citing works
Pleckstrin's repeat performance
Ponting, C. P., & Peer Bork, B. (1996) · Trends in Biochemical Sciences · Cited by 8 · see citing works
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Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-1848.2004.00076.x · Cited by 1,545 · see citing works
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de la Torre-Ubieta, L., Won, H., Stein, J. L., & Geschwind, D. H. (2016) · Nature Medicine · doi:10.1038/nm.4071 · Cited by 827 · see citing works
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Mouse Behavioral Assays Relevant to the Symptoms of Autism*
Crawley, J. N. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00096.x · Cited by 541 · see citing works
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Wallingford, J. B., & Habas, R. (2005) · Development · doi:10.1242/dev.02068 · Cited by 509 · see citing works
Nakatani, J., Tamada, K., Hatanaka, F., Ise, S., Ohta, H., Inoue, K., Tomonaga, S., Watanabe, Y., Chung, Y. J., Banerjee, R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.04.024 · Cited by 482 · see citing works
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Self-citationSpencer, C. M., Alekseyenko, O., Serysheva, E., Yuva‐Paylor, L. A., & Paylor, R. (2005) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00123.x · Cited by 349 · see citing works
Self-citationWharton, K. A. (2003) · Developmental Biology · doi:10.1006/dbio.2002.0869 · Cited by 315 · see citing works
Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation
Chen, J., Park, C. S., & Tang, S.-J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511920200 · Cited by 298 · see citing works
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Self-citationDishevelled: at the crossroads of divergent intracellular signaling pathways
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Molecular mechanisms of autism: a possible role for Ca2+ signaling
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Belinson, H., Nakatani, J., Babineau, B. A., Birnbaum, R. Y., Ellegood, J., Bershteyn, M., McEvilly, R. J., Long, J. M., Willert, K., Klein, O. D., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.207 · Cited by 79 · see citing works
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- Authors
- Lijam, N., Paylor, R., McDonald, M. P., Crawley, J. N., Deng, C.-X., Herrup, K., Stevens, K. E., Maccaferri, G., McBain, C. J., Sussman, D. J., & Wynshaw-Boris, A.
- Affiliations
- National Institutes of Health (US)
- National Institute of Mental Health (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Case Western Reserve University (US)
- University of Colorado Health (US)
- University of Maryland, Baltimore (US)
- National Human Genome Research Institute (US)
- Corresponding author
- Wynshaw-Boris, Anthony
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-09
- Volume
- 90
- Issue
- 5
- Pages
- 895-905
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2072392892
- Cited by
- 470
- References
- 54
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 8 · 2023: 10 · 2022: 8 · 2021: 11 · 2020: 14 · 2019: 16 · 2018: 10 · 2017: 13 · 2016: 17 · 2015: 15 · 2014: 18 · 2013: 20 · 2012: 18
- FWCI
- 10.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- National Cancer Institute (CA-63929)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- DVL1, Dishevelled, social interaction, sensorimotor gating, prepulse inhibition, startle response, social dominance, nest building, whisker trimming, social behavior, mental illness, gene targeting, mice
- MeSH terms
- Dishevelled Proteins, Animals, Behavior, Animal, Embryo, Mammalian, Female, Male, Motor Neurons, Nesting Behavior, Neural Inhibition, Neurons, Afferent, Pain Measurement, Phosphoproteins, Psychomotor Performance, Sleep, Social Behavior, Vibrissae, Mice, Knockout, Gene Expression Regulation, Developmental, Drosophila Proteins, Adaptor Proteins, Signal Transducing, Mice
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