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Cited by 49Sleep and Wakefulness ResearchNeural dynamics and brain functionSleep and related disorders

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Infraslow oscillations in human sleep spindle activity

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Lázár, Zsolt I., Dijk, Derk-Jan, Lázár, Alpár S.·2019·Journal of Neuroscience Methods
DOI 10.1016/j.jneumeth.2018.12.002PMC PMC6390176
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Abstract

BACKGROUND: It has previously been reported that EEG sigma (10-15 Hz) activity during sleep exhibits infraslow oscillations (ISO) with a period of 50 s. However, a detailed analysis of the ISO of individually identified sleep spindles is not available. NEW METHOD: We investigated basic properties of ISO during baseline sleep of 34 healthy young human participants using new and established methods. The analyses focused on fast sleep spindle and sigma activity (13-15 Hz) in NREM stage 2 and slow wave sleep (SWS). To describe ISO in sigma activity we analyzed power of power of the EEG signal. For the study of ISO in sleep spindle activity we applied a new method in which the EEG signal was reduced to a spindle on/off binary square signal. Its spectral properties were contrasted to that of a square signal wherein the same spindles and also the inter spindle intervals were permutated randomly. This approach was validated using surrogate data with imposed ISO modulation. RESULTS: We confirm the existence of ISO in sigma activity albeit with a frequency below the previously reported 0.02 Hz. These ISO are most prominent in the high sigma band and over the centro-parieto-occipital regions. A similar modulation is present in spindle activity. ISO in sleep spindles are most prominent in the centro-parieto-occipital regions, left hemisphere and second half of the night independent of the number of spindles. CONCLUSIONS: The comparison of spectral properties of binary event signals and permutated event signals is effective in detecting slow oscillatory phenomena.

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  • Infraslow oscillatory dynamics in sleep spindle activity are conserved across rodent and human NREM sleep.

    “the infraslow oscillatory dynamics in sleep spindle activity are conserved across rodent and human NREM sleep108,109”

    From Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep (2025) · cites this paper as [109]

    The Results (Spindle event based study; page unavailable) identify infraslow modulation of fast sleep spindles during human NREM stage 2 sleep. The Discussion (Comparison with previous studies; page unavailable) says these features resemble those described by Lecci et al. (2017), but the cited paper does not establish that spindle dynamics are conserved across rodent and human NREM sleep. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 29

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Metadata

Authors
Lázár, Z. I., Dijk, D.-J., & Lázár, A. S.
Affiliations
  • Babeș-Bolyai University (RO)
  • University of Surrey (GB)
  • University of East Anglia (GB)
Corresponding author
  • Lázár, Zsolt I.
  • Lázár, Alpár S.
ORCID
Venue
Journal of Neuroscience Methods
Publisher
Elsevier BV
Published
2019-03
Volume
316
Pages
22-34
ISSN
0165-0270 (ISSN-L)
DOI
10.1016/j.jneumeth.2018.12.002
PMC
PMC6390176
OpenAlex
W2905282471
Cited by
49
References
7
Citations by year
2026: 12 · 2025: 9 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 3 · 2020: 3 · 2019: 3
FWCI
1.19
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroscience Methods (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
  • UEA Digital Repository (University of East Anglia) (submittedVersion)
Funders
  • Biotechnology and Biological Sciences Research Council
  • Romanian National Authority for Scientific Research and Innovation
  • Royal Society-Wolfson Research Merit Award
  • Seed Award in Science from the Wellcome trust
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
infraslow oscillations, sleep spindles, slow-wave sleep, surrogate data, interspike intervals, hemispheric lateralization, sleep EEG
MeSH terms
Sleep, Slow-Wave, Adult, Electroencephalography, Female, Humans, Male, Sleep Stages, Young Adult, Brain Waves

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