MIF -173G/C polymorphism is associated with NMO disease severity

A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis

Lennon, V. A., Wingerchuk, D. M., Kryzer, T. J., Pittock, S. J., Lucchinetti, C. F., Fujihara, K., Nakashima, I., & Weinshenker, B. G. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17551-x · Cited by 3,239 · see citing works

MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

Bernhagen, J., Krohn, R. M., Lue, H., Gregory, J. L., Zernecke, A., Koenen, R. R., Dewor, M., Georgiev, I., Schober, A., Leng, L., et al. (2007) · Nature Medicine · doi:10.1038/nm1567 · Cited by 1,256 · see citing works

MIF Signal Transduction Initiated by Binding to CD74

Leng, L., Metz, C. N., Fang, Y., Xu, J., Donnelly, S., Baugh, J., Delohery, T., Chen, Y., Mitchell, R. A., & Bucala, R. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030286 · Cited by 1,154 · see citing works

MIF as a glucocorticoid-induced modulator of cytokine production

Calandra, T., Bernhagen, J., Metz, C. N., Spiegel, L. A., Bacher, M., Donnelly, T. M., Cerami, A., & Bucala, R. (1995) · Nature · doi:10.1038/377068a0 · Cited by 1,148 · see citing works

MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia

Bernhagen, J., Calandra, T., Mitchell, R. A., Martin, S. B., Tracey, K. J., Voelter, W., Manogue, K. R., Cerami, A., & Bucala, R. (1993) · Nature · doi:10.1038/365756a0 · Cited by 1,001 · see citing works

Update on the diagnosis and treatment of neuromyelitis optica: Recommendations of the Neuromyelitis Optica Study Group (NEMOS)

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Purification, Bioactivity, and Secondary Structure Analysis of Mouse and Human Macrophage Migration Inhibitory Factor (MIF)

Bernhagen, J., Mitchell, R. A., Calandra, T., Voelter, W., Cerami, A., & Bucala, R. (1994) · Biochemistry · doi:10.1021/bi00251a025 · Cited by 409 · see citing works

A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis

Baugh, J. A., Chitnis, S., Donnelly, S. C., Monteiro, J., Lin, X., Plant, B. J., Wolfe, F., Gregersen, P. K., & Bucala, R. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363867 · Cited by 360 · see citing works

Neuromyelitis optica: clinical features, immunopathogenesis and treatment

Jarius, S., Wildemann, B., & Paul, F. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12271 · Cited by 343 · see citing works

Demographic and clinical features of neuromyelitis optica: A review

Pandit, L., Asgari, N., Apiwattanakul, M., Palace, J., Paul, F., Leite, M., Kleiter, I., Chitnis, T., & the GJCF International Clinical Consortium & Biorepository for Neuromyelitis Optica (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458515572406 · Cited by 341 · see citing works

Neuromyelitis optica and the evolving spectrum of autoimmune aquaporin‐4 channelopathies: a decade later

Pittock, S. J., & Lucchinetti, C. F. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12794 · Cited by 227 · see citing works

Role for macrophage migration inhibitory factor in asthma

Mizue, Y., Ghani, S., Leng, L., McDonald, C., Kong, P. L., Baugh, J. A., Lane, S. J., Craft, J., Nishihira, J., Donnelly, S. C., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507189102 · Cited by 203 · see citing works

An epidemiological study of neuromyelitis optica in Cuba

Cabrera-Gómez, J. A., Kurtzke, J. F., González‐Quevedo, A., & Lara-Rodríguez, R. (2009) · Journal of Neurology · doi:10.1007/s00415-009-0009-0 · Cited by 185 · see citing works

Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus

Bilsborrow, J. B., Doherty, E. H., Tilstam, P. V., & Bucala, R. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1656718 · Cited by 169 · see citing works

MS and neuromyelitis optica in Martinique (French West Indies)

Cabre, P., Heinzlef, O., Merle, H., Buisson, G.-G., Béra, O., Bellance, R., Vernant, J. C., & Smadja, D. (2001) · Neurology · doi:10.1212/wnl.56.4.507 · Cited by 158 · see citing works

A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica

Estrada, K., Whelan, C. W., Zhao, F., Bronson, P. G., Handsaker, R. E., Sun, C., Carulli, J. P., Harris, T., Ransohoff, R. M., McCarroll, S. A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04332-3 · Cited by 140 · see citing works

Prevalence of neuromyelitis optica spectrum disorder and phenotype distribution

Bizzoco, E., Lolli, F., Repice, A. M., Hakiki, B., Falcini, M., Barilaro, A., Taiuti, R., Siracusa, G., Amato, M. P., Biagioli, T., et al. (2009) · Journal of Neurology · doi:10.1007/s00415-009-5171-x · Cited by 130 · see citing works

Macrophage Migration Inhibitory Factor: Gene Polymorphisms and Susceptibility to Inflammatory Diseases

Renner, P., Roger, T., & Calandra, T. (2005) · Clinical Infectious Diseases · doi:10.1086/432009 · Cited by 124 · see citing works

Macrophage migration inhibitory factor in rheumatoid arthritis: clinical correlations

Morand, E. F. (2002) · British journal of rheumatology · doi:10.1093/rheumatology/41.5.558 · Cited by 122 · see citing works

Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus

Sreih, A. G., Ezzeddine, R., Leng, L., LaChance, A., Yu, G., Mizue, Y., Subrahmanyan, L., Pons‐Estel, B. A., Abelson, A.-K., Gunnarsson, I., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30624 · Cited by 112 · see citing works

Incidence of acquired demyelinating syndromes of the CNS in Dutch children: a nationwide study

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Overlapping CNS inflammatory diseases: differentiating features of NMO and MS

Juryńczyk, M., Craner, M. J., & Palace, J. A. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-308984 · Cited by 106 · see citing works

Epidemiology of Neuromyelitis Optica in the World: A Systematic Review and Meta-Analysis

Etemadifar, M., Nasr, Z., Khalili, B., Taherioun, M., & Vosoughi, R. (2015) · Multiple Sclerosis International · doi:10.1155/2015/174720 · Cited by 104 · see citing works

MIF and D-DT are potential disease severity modifiers in male MS subjects

Benedek, G., Meza‐Romero, R., Jordan, K. R., Zhang, Y., Nguyen, H., Kent, G., Li, J., Siu, E., Frazer, J., Piecychna, M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1712288114 · Cited by 99 · see citing works

Macrophage migration inhibitory factor promoter polymorphisms and the clinical expression of scleroderma

Wu, S., Leng, L., Feng, Z. Z., Liu, N., Zhao, H., McDonald, C., Lee, A., Arnett, F. C., Gregersen, P. K., Mayes, M. D., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22179 · Cited by 98 · see citing works

The epidemiology of neuromyelitis optica amongst adults in the Merseyside county of United Kingdom

Jacob, A., Panicker, J., Lythgoe, D. T., Elsone, L., Mutch, K., Wilson, M., Das, K., & Boggild, M. (2013) · Journal of Neurology · doi:10.1007/s00415-013-6926-y · Cited by 97 · see citing works

MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis

Yoo, S., Leng, L., Kim, B., Du, X., Tilstam, P. V., Kim, K. H., Kong, J., Yoon, H.-J., Liu, A., Wang, T., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612717113 · Cited by 86 · see citing works

Neuromyelitis Optica: An Antibody-Mediated Disorder of the Central Nervous System

Oh, J., & Levy, M. (2012) · Neurology Research International · doi:10.1155/2012/460825 · Cited by 82 · see citing works

Functional Polymorphisms in the Promoter Region of Macrophage Migration Inhibitory Factor and Atopy

Hizawa, N., Yamaguchi, E., Takahashi, D., Nishihira, J., & Nishimura, M. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200307-933oc · Cited by 75 · see citing works

MIF, MIF Alleles, and Prospects for Therapeutic Intervention in Autoimmunity

Bucala, R. (2012) · Journal of Clinical Immunology · doi:10.1007/s10875-012-9781-1 · Cited by 72 · see citing works

Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus

Yao, J., Leng, L., Sauler, M., Fu, W., Junsong, Z., Zhang, Y., Du, X., Yu, X., Lee, P. J., & Bucala, R. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81937 · Cited by 69 · see citing works

Aquaporin-4-autoimmunity in patients with systemic lupus erythematosus: A predominantly population-based study

Asgari, N., Jarius, S., Laustrup, H., Skejø, H. P. B., Lillevang, S. T., Weinshenker, B. G., & Voss, A. (2017) · Multiple Sclerosis Journal · doi:10.1177/1352458517699791 · Cited by 66 · see citing works

Cutting Edge: Macrophage Migration Inhibitory Factor Is Necessary for Progression of Experimental Autoimmune Encephalomyelitis

Powell, N. D., Papenfuss, T. L., McClain, M. A., Gienapp, I. E., Shawler, T. M., Satoskar, A. R., & Whitacre, C. C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.5611 · Cited by 64 · see citing works

Neuromyelitis optica — Devic's syndrome, update

Mandler, R. N. (2006) · Autoimmunity Reviews · doi:10.1016/j.autrev.2006.02.008 · Cited by 61 · see citing works

HLA-DRα1 Constructs Block CD74 Expression and MIF Effects in Experimental Autoimmune Encephalomyelitis

Meza‐Romero, R., Benedek, G., Yu, X., Mooney, J. L., Dahan, R., Duvshani, N., Bucala, R., Offner, H., Reiter, Y., Burrows, G. G., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303118 · Cited by 54 · see citing works

Partial MHC class II constructs inhibit MIF / CD 74 binding and downstream effects

Benedek, G., Meza‐Romero, R., Andrew, S. F., Leng, L., Burrows, G. G., BOURDETTE, D. N., Offner, H., Bucala, R., & Vandenbark, A. A. (2013) · European Journal of Immunology · doi:10.1002/eji.201243162 · Cited by 53 · see citing works

The emerging role of MIF in septic shock and infection

Bernhagen, J., Calandra, T., & Bucala, R. (1994) · Biotherapy · doi:10.1007/bf01878495 · Cited by 47 · see citing works

Anti-aquaporin-4 autoantibodies in systemic lupus erythematosus persist for years and induce astrocytic cytotoxicity but not CNS disease

Alexopoulos, H., Kampylafka, E. I., Fouka, P., Tatouli, I. P., Akrivou, S., Politis, P. K., Moutsopoulos, H. Μ., Tzioufas, A. G., & Dalakas, M. C. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.10.007 · Cited by 42 · see citing works

A novel regulatory pathway for autoimmune disease: Binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance

Vandenbark, A. A., Meza‐Romero, R., Benedek, G., Andrew, S. F., Huan, J., Chou, Y. K., Buenafe, A. C., Dahan, R., Reiter, Y., Mooney, J. L., et al. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.08.004 · Cited by 39 · see citing works

Serum antinuclear antibody may be associated with less severe disease activity in neuromyelitis optica

Masuda, H., Mori, M., Uzawa, A., Muto, M., Uchida, T., & Kuwabara, S. (2015) · European Journal of Neurology · doi:10.1111/ene.12714 · Cited by 39 · see citing works

Macrophage Migration Inhibitory Factor -173 G/C Polymorphism: A Global Meta-Analysis across the Disease Spectrum

Illescas, O., Gómez-Verján, J. C., García‐Velázquez, L., Govezensky, T., & Rodríguez‐Sosa, M. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00055 · Cited by 38 · see citing works

The role of AQP4 in neuromyelitis optica: More answers, more questions

Yang, X., Ransom, B. R., & Ma, J. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.06.002 · Cited by 35 · see citing works

Increased occurrence of anti-AQP4 seropositivity and unique HLA Class II associations with neuromyelitis optica (NMO), among Muslim Arabs in Israel.

Brill, L., Mandel, M., Karussis, D., Petrou, P., Miller, K., Ben-Hur, T., Karni, A., Paltiel, O., Israel, S., & Vaknin-Dembinsky, A. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.02.006 · Cited by 30 · see citing works

Neuromyelitis optica

Barnett, M. H., & Sutton, I. (2012) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3283533a3f · Cited by 26 · see citing works

MIF functional polymorphisms (-794 CATT5-8 and -173 G>C) are associated with MIF serum levels, severity and progression in male multiple sclerosis from western Mexican population

Castañeda-Moreno, V. A., la Cruz-Mosso, U. D., Torres‐Carrillo, N., Macías-Islas, M. Á., la Torre, O. P.-D., Mireles-Ramírez, M. A., González-Pérez, Ó., Ruíz‐Sandoval, J. L., Huerta, M., Trujillo, X., et al. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.04.006 · Cited by 25 · see citing works

Association between high expression macrophage migration inhibitory factor (MIF) alleles and West Nile virus encephalitis

Das, R., Loughran, K. A., Murchison, C., Qian, F., Leng, L., Song, Y., Montgomery, R. R., Loeb, M. B., & Bucala, R. (2015) · Cytokine · doi:10.1016/j.cyto.2015.11.021 · Cited by 17 · see citing works

Neuroprotective Effects of Recombinant T-cell Receptor Ligand in Autoimmune Optic Neuritis in HLA-DR2 Mice

Adamus, G., Brown, L., Andrew, S. F., Meza‐Romero, R., Burrows, G. G., & Vandenbark, A. A. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8419 · Cited by 15 · see citing works

Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases

Saggau, C., Bacher, P., Esser, D., Rasa, M., Meise, S., Mohr, N., Kohlstedt, N., Hutloff, A., Schacht, S.-S., Dargvainiene, J., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.08.005 · Cited by 79 · see citing works

A Comprehensive Review on the Role of Genetic Factors in Neuromyelitis Optica Spectrum Disorder

Ghafouri‐Fard, S., Azimi, T., & Taheri, M. N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.737673 · Cited by 29 · see citing works

The roles of macrophage migration inhibitory factor in retinal diseases

Zhang, H., Zhang, X., Li, H., Wang, B., Chen, P., & Meng, J. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.379020 · Cited by 15 · see citing works

Estudo da atividade de células citotóxicas em portadores de esclerose múltipla em uso de diferentes tratamentos

Boldrini, V. D. O. (2020) · doi:10.47749/t/unicamp.2020.1238365

MIF Promoter Variant rs755622 (−173G/C) in Younger and Older Turkish Adults: An Exploratory Cross-Sectional Genetic and in Silico Analysis

Özdilli, K., Öztan, G., Öğret, Y., Oguz, R., Çiftçi, H. Ş., Aydın, F., & Oguz, P. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177818

Significant Association Between Fc Receptor-Like 3 Polymorphisms (-1901A>G and -658C>T) and Neuromyelitis Optica (NMO) Susceptibility in the Chinese Population

Wang, X., Yu, T., Yan, Q., Wang, W., Meng, N., Li, X., & Luo, Y. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-9036-7 · Cited by 17 · see citing works

High Prevalence of MMP9 −1562C/T Gene Polymorphism in an Iranian Population of Neuromyelitis Optica, A Pilot Study

Dehghani, L., Sabbagh, S., Esmaeilian-Afyouni, N., Shaygannejad, V., Saboori, M., Rezvani, M., Nadeali, Z., Moayednia, M., Nouri, H., Mortazavi, Z., et al. (2021) · Gene Reports · doi:10.1016/j.genrep.2021.101061

CD58 polymorphisms associated with the risk of neuromyelitis optica in a Korean population

Kim, Y., Bae, J. S., Kim, H. J., & Shin, H. D. (2014) · BMC Neurology · doi:10.1186/1471-2377-14-57 · Cited by 31 · see citing works

Neuromyelitis Optica (NMO IgG+) and Genetic Susceptibility, Potential Ethnic Influences

Rivas‐Alonso, V., Flores-Rivera, J. D. J., Garci, Y. R., Granados, J., Sánchez-Correa, T. E., Mena‐Hernández, L., & Corona, T. (2018) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524916666160229115047 · Cited by 43 · see citing works

Association of Macrophage Migration Inhibitory Factor Gene Promoter Polymorphisms with Multiple Sclerosis in Turkish Patients

Akçalı, A., Pehlıvan, S., Pehlıvan, M., Sever, T., & Neyal, M. A. (2010) · Journal of International Medical Research · doi:10.1177/147323001003800108 · Cited by 33 · see citing works