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Cited by 18Neuroinflammation and Neurodegeneration MechanismsT-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells

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Priya, Raj, Brutkiewicz, Randy R.·2020·Journal of Neuroimmunology
DOI 10.1016/j.jneuroim.2020.577428PMC PMC7680413
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Abstract

It is unknown whether brain astrocytes and microglia have the capacity to present microbial antigens via the innate immune MR1/MAIT cell axis. We have detected MAIT cells in the normal mouse brain and found that both astrocytes and microglia are MR1+. When we stimulated brain astrocytes and microglia with E. coli, and then co-cultured them with MAIT cells, MR1 surface expression was upregulated and MAIT cells were activated in an antigen-dependent manner. Considering the association of MAIT cells with inflammatory conditions, including those in the CNS, the MR1/MAIT cell axis could be a novel therapeutic target in neuroinflammatory disorders.

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Cited by

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Authors
Priya, R., & Brutkiewicz, R. R.
Affiliations
Indiana University Indianapolis (US)
Corresponding author
Brutkiewicz, Randy R.
ORCID
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2020-12
Volume
349
Pages
577428
ISSN
0165-5728 (ISSN-L)
DOI
10.1016/j.jneuroim.2020.577428
PMC
PMC7680413
OpenAlex
W3093275938
Cited by
18
References
3
Citations by year
2026: 3 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 1
FWCI
0.68
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • IUScholarWorks (Indiana University) (submittedVersion)
Funders
  • National Institutes of Health (R01 CA161178)
  • Indiana Spinal Cord Injury and Brain Injury Grant Program
  • Indiana University School of Medicine's Cooperative Center of Excellence in Hematology (U54 DK106846)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
MR1, mucosal-associated invariant T cells, astrocytes, microglia, antigen presentation, microbial antigens, brain, neuroinflammation, neuroinflammatory disorders, therapeutic target, co-culture, Escherichia coli
MeSH terms
Mucosal-Associated Invariant T Cells, Animals, Astrocytes, Brain, Cell Line, Female, Immunity, Innate, Male, Mice, Inbred C57BL, Histocompatibility Antigens Class I, Minor Histocompatibility Antigens, Microglia, Mice, Knockout, Mice

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