Cited by 405Barrier Structure and Function StudiesMultiple Sclerosis Research StudiesCell Adhesion Molecules Research

How do immune cells overcome the blood-brain barrier in multiple sclerosis?

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Larochelle, Catherine, Alvarez, Jorge Ivan, Prat, Alexandre·2011·FEBS Letters

Abstract

The presence of the blood-brain barrier (BBB) restricts the movement of soluble mediators and leukocytes from the periphery to the central nervous system (CNS). Leukocyte entry into the CNS is nonetheless an early event in multiple sclerosis (MS), an inflammatory disorder of the CNS. Whether BBB dysfunction precedes immune cell infiltration or is the consequence of perivascular leukocyte accumulation remains enigmatic, but leukocyte migration modifies BBB permeability. Immune cells of MS subjects express inflammatory cytokines, reactive oxygen species (ROS) and enzymes that can facilitate their migration to the CNS by influencing BBB function, either directly or indirectly. In this review, we describe how immune cells from the peripheral blood overcome the BBB and promote CNS inflammation in MS through BBB disruption.

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Crossref · 10.1016/j.febslet.2011.04.066

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  • Systemic inflammation contributes to MS disease progression and activation of immune cells allows infiltration of T and B cells into the CNS, promoting release of chemokines that stimulate migration of more immune cells, leading to BBB disruption.

    “Previous studies showed that systemic inflammation contributes to the disease progression and the activation of immune cells allows the infiltration of T and B cells into the CNS, promoting the release of chemokines that in turn stimulate the migration of more immune cells, leading to BBB disruption (Holman et al., 2011; Kooij et al., 2011; Larochelle et al., 2011; Willis, 2011).”

    From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Larochelle et al., 2011

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Authors
Larochelle, C., Alvarez, J. I., & Prat, A.
Affiliations
Hôpital Notre-Dame (CA)
Corresponding author
Prat, Alexandre
Venue
FEBS Letters
Publisher
Wiley
Published
2011-05-04
Volume
585
Issue
23
Pages
3770-3780
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2007217012
Cited by
405
References
222
Citations by year
2026: 15 · 2025: 26 · 2024: 36 · 2023: 32 · 2022: 26 · 2021: 39 · 2020: 31 · 2019: 26 · 2018: 27 · 2017: 25 · 2016: 38 · 2015: 25 · 2014: 23 · 2013: 18 · 2012: 16
FWCI
1.66
Type
journal article
Language
en
Open access
Locations
  • FEBS Letters (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Multiple Sclerosis Society of Canada
  • Multiple Sclerosis Society
  • Canadian Institutes of Health Research (MOP89885, MOP14828)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
multiple sclerosis, blood-brain barrier, leukocyte migration, immune cell infiltration, blood-brain barrier permeability, reactive oxygen species, inflammatory cytokines, neuroinflammation, BBB dysfunction
MeSH terms
Animals, Blood-Brain Barrier, Cell Movement, Humans, Lymphocytes, Multiple Sclerosis, Reactive Oxygen Species, Matrix Metalloproteinases

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