Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

Axonal transection in the lesions of multiple sclerosis

Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029

The cell: a molecular approach

(1997) · Choice Reviews Online · doi:10.5860/choice.35-0264 · Cited by 1,465

Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ.

Sternberger, L. A., & Sternberger, N. H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.19.6126 · Cited by 1,158

A Structural Scaffolding of Intermediate Filaments in Health and Disease

Fuchs, E. V., & Cleveland, D. W. (1998) · Science · doi:10.1126/science.279.5350.514 · Cited by 1,013

The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons.

Hoffman, P. N., & Lasek, R. J. (1975) · The Journal of Cell Biology · doi:10.1083/jcb.66.2.351 · Cited by 941

Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells

de Waegh, S. M., Lee, V. M. ‐., & Brady, S. T. (1992) · Cell · doi:10.1016/0092-8674(92)90183-d · Cited by 743

Neurofilament gene expression: a major determinant of axonal caliber.

Hoffman, P. N., Cleveland, D. W., Griffin, J. W., Landes, P. W., Cowan, N. J., & Price, D. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3472 · Cited by 719

A Mechanistic Analysis of Nondisruptive Axonal Injury: A Review

Maxwell, W. L., Povlishock, J. T., & Graham, D. I. (1997) · Journal of Neurotrauma · doi:10.1089/neu.1997.14.419 · Cited by 564

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

Xu, Z. (1993) · Cell · doi:10.1016/0092-8674(93)90157-l · Cited by 543

Minocycline Provides Neuroprotection Against N -Methyl- d -aspartate Neurotoxicity by Inhibiting Microglia

Tikka, T., & Koıstınaho, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7527 · Cited by 539

Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants

Anderton, B. H., Breinburg, D., Downes, M. J., Green, P. J., Tomlinson, B. E., ULRICH, J., Wood, J. N., & Kahn, J. (1982) · Nature · doi:10.1038/298084a0 · Cited by 534

Patients with Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases Have Increased Levels of Neurofilament Protein in CSF

Rosengren, L. E., Karlsson, J., Karlsson, J., Persson, L. I., & Wikkelsø, C. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67052013.x · Cited by 499

Neuronal Intermediate Filaments

Lee, M. K., & Cleveland, D. W. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001155 · Cited by 446

Amyotrophic Lateral Sclerosis

Julien, J. (2001) · Cell · doi:10.1016/s0092-8674(01)00244-6 · Cited by 435

A New Variant of Charcot-Marie-Tooth Disease Type 2 Is Probably the Result of a Mutation in the Neurofilament-Light Gene

Mersiyanova, I., Perepelov, A. V., Polyakov, A. V., Sitnikov, V. F., Леонидовна, Д. Е., Oparin, R. B., Petrin, A. N., & Evgrafov, O. V. (2000) · The American Journal of Human Genetics · doi:10.1086/302962 · Cited by 421

The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy

Bomont, P., Cavalier, L., Blondeau, F., Hamida, C. B., Belal, S., Tazir, M., Demir, E., Topaloğlu, H., Korinthenberg, R., Tüysüz, B., et al. (2000) · Nature Genetics · doi:10.1038/81701 · Cited by 408

Neurofilaments are obligate heteropolymers in vivo

Lee, M. K., Xu, Z., Wong, P., & Cleveland, D. W. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.6.1337 · Cited by 381

A mutant neurofilament subunit causes massive, selective motor neuron death: Implications for the pathogenesis of human motor neuron disease

Lee, M. K., Marszalek, J. R., & Cleveland, D. W. (1994) · Neuron · doi:10.1016/0896-6273(94)90263-1 · Cited by 365

Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex

Hof, P. R., Morrison, J. H., & Cox, K. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.903010105 · Cited by 365 · cited 2×

Neurofilament architecture combines structural principles of intermediate filaments with carboxy‐terminal extensions increasing in size between triplet proteins.

Geisler, N., Kaufmann, E., Fischer, S., Plessmann, U., & Weber, K. (1983) · The EMBO Journal · doi:10.1002/j.1460-2075.1983.tb01584.x · Cited by 359

Elevated neurofilament levels in neurological diseases

Norgren, N., Rosengren, L., & Stigbrand, T. I. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03219-0 · Cited by 351

Deregulation of Cdk5 in a Mouse Model of ALS

Nguyen, M. D., Larivière, R., & Julien, J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00268-9 · Cited by 339

Aberrant neurofilament phosphorylation in Alzheimer disease.

Sternberger, N. H., Sternberger, L. A., & ULRICH, J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4274 · Cited by 338

Functions of intermediate filaments in neuronal development and disease

Larivière, R., & Julien, J. (2003) · Journal of Neurobiology · doi:10.1002/neu.10270 · Cited by 333

Neurofilament light protein and glial fibrillary acidic protein as biological markers in MS

Malmeström, C., Haghighi, S., Rosengren, L., Andersen, O., & Lycke, J. (2003) · Neurology · doi:10.1212/01.wnl.0000098880.19793.b6 · Cited by 318

Neurofilament protein in cerebrospinal fluid: a potential marker of activity in multiple sclerosis

Lycke, J., Karlsson, J.-E., Andersen, O., & Rosengren, L. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.3.402 · Cited by 315

Self-assembly in vitro of the 68,000 molecular weight component of the mammalian neurofilament triplet proteins into intermediate-sized filaments

Geisler, N., & Weber, K. K. (1981) · Journal of Molecular Biology · doi:10.1016/0022-2836(81)90011-5 · Cited by 285

Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation, interneurofilament spacing, and axon caliber.

Nixon, R. A., Paskevich, P. A., Sihag, R. K., & Thayer, C. Y. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.4.1031 · Cited by 277

Intrinsic determinants of neuronal form and function

Letourneau, P. C. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90169-0 · Cited by 266

Neurofilaments Are Transported Rapidly But Intermittently in Axons: Implications for Slow Axonal Transport

Roy, S., Coffee, P., Smith, G. M., Liem, R. K. H., Brady, S. T., & Black, M. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06849.2000 · Cited by 245

SOD1 mutation is assosiated with accumulation of neurofilaments in amyotrophic lateral scelaries

Rouleau, G. A., Clark, A. W., Rooke, K., Pramatarova, A., Krizus, A., Suchowersky, O., Julien, J., & Figlewicz, D. A. (1996) · Annals of Neurology · doi:10.1002/ana.410390119 · Cited by 244

Dephosphorylation of neurofilament proteins enhances their susceptibility to degradation by calpain

Pant, H. C. (1988) · Biochemical Journal · doi:10.1042/bj2560665 · Cited by 238

Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant

Williamson, T. L., Bruijn, L. I., Zhu, Q., Anderson, K. L., Anderson, S., Julien, J., & Cleveland, D. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9631 · Cited by 238

The Axon : structure, function, and pathophysiology

Waxman, S. G. (1995) · Oxford University Press eBooks · Cited by 236

Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.

Lew, J., Winkfein, R. J., Paudel, H. K., & Wang, J. H.-C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35696-5 · Cited by 232

The structure and organization of the human heavy neurofilament subunit (NF‐H) and the gene encoding it.

Lees, J. F., Shneidman, P. S., Skuntz, S., Carden, M. J., & Lazzarini, R. A. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03032.x · Cited by 232

Accumulation of Phosphorylated Neurofilaments in Anterior Horn Motoneurons of Amyotrophic Lateral Sclerosis Patients

Muñoz, D. G., Greene, C., Perl, D. P., & Selkoe, D. J. (1988) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198801000-00002 · Cited by 225

Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase

Couillard‐Després, S., Zhu, Q., Wong, P. C., Price, D. L., Cleveland, D. W., & Julien, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9626 · Cited by 211

Neurofilament functions in health and disease

Julien, J. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00004-5 · Cited by 209

Giant axonal neuropathy ? A unique case with segmental neurofilamentous masses

Asbury, A. K., Gale, M. K., Cox, S. C., Baringer, J. R., & Berg, B. O. (1972) · Acta Neuropathologica · doi:10.1007/bf00686905 · Cited by 209

Phosphorylation protects neurofilaments against proteolysis

Goldstein, M. E., Sternberger, N. H., & Sternberger, L. A. (1987) · Journal of Neuroimmunology · doi:10.1016/0165-5728(87)90049-x · Cited by 206

cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization.

Shetty, K. T., Link, W. T., & Pant, H. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6844 · Cited by 206

Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M

Dong, D. L., Xu, Z. S., Chevrier, M. R., Cotter, R. J., Cleveland, D. W., & Hart, G. W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85471-6 · Cited by 204

Purification of individual components of the neurofilament triplet: filament assembly from the 70000-dalton subunit

Liem, R. K. H., & Hutchison, S. B. (1982) · Biochemistry · doi:10.1021/bi00256a029 · Cited by 201

Phosphorylation of Neurofilaments Is Altered in Amyotrophic Lateral Sclerosis

Manetto, V., Sternberger, N. H., Perry, G. L., Sternberger, L. A., & Gambetti, P. (1988) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198811000-00007 · Cited by 197

Neurofilaments and neurological disease

Al‐Chalabi, A., & Miller, C. C. J. (2003) · BioEssays · doi:10.1002/bies.10251 · Cited by 189

Absence of the Mid-sized Neurofilament Subunit Decreases Axonal Calibers, Levels of Light Neurofilament (NF-L), and Neurofilament Content

Elder, G. A., Friedrich, V. L., Bosco, P., Kang, C., Gourov, A., Tu, P., Lee, V. M. ‐., & Lazzarini, R. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.3.727 · Cited by 180

2-deoxy-d-glucose protects hippocampal neurons against excitotoxic and oxidative injury: Evidence for the involvement of stress proteins

Lee, J., Bruce‐Keller, A. J., Kruman, Y., Chan, S. L., & Mattson, M. P. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990701)57:1 · Cited by 179

Kinesin-mediated transport of neurofilament protein oligomers in growing axons

Yabe, J. T., Pimenta, A., & Shea, T. B. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.21.3799 · Cited by 174

Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy.

Fernyhough, P., Gallagher, A., Averill, S., Priestley, J. V., Hounsom, L., Patel, J. C., & Tomlinson, D. R. (1999) · Diabetes · doi:10.2337/diabetes.48.4.881 · Cited by 174

Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit.

Gill, S. R., Wong, P. C., Monteiro, M. J., & Cleveland, D. W. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.5.2005 · Cited by 172

Glutamate Slows Axonal Transport of Neurofilaments in Transfected Neurons

Ackerley, S., Grierson, A. J., Brownlees, J., Thornhill, P., Anderton, B. H., Leigh, P. N., Shaw, C. E., & Miller, C. C. J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.1.165 · Cited by 170

A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimer's disease

Morrison, J. H., Lewis, D. A., Campbell, M. J., Huntley, G. W., Benson, D. L., & Bouras, C. (1987) · Brain Research · doi:10.1016/0006-8993(87)90914-0 · Cited by 164

The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation.

Heins, S., Wong, P. C., Müller, S., Goldie, K. N., Cleveland, D. W., & Aebi, U. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.6.1517 · Cited by 162

The Regulation of Neurofilament Protein Dynamics by Phosphorylation: Clues to Neurofibrillary Pathobiology

Nixon, R. A. (1993) · Brain Pathology · doi:10.1111/j.1750-3639.1993.tb00723.x · Cited by 161

Neurofilament protein synthesis and phosphorylation

Grant, P. G., & Pant, H. C. (2000) · Journal of Neurocytology · doi:10.1023/a:1010999509251 · Cited by 158

Phosphorylated Neurofilament Antigens in Neurofibrillary Tangles in Alzheimerʼs Disease

Cork, L. C., Sternberger, N. H., Sternberger, L. A., Casanova, M. F., Struble, R. G., & Price, D. L. (1986) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198601000-00005 · Cited by 158

A specific ELISA for measuring neurofilament heavy chain phosphoforms

Petzold, A., Keir, G., Green, A. J. E., Giovannoni, G., & Thompson, E. J. (2003) · Journal of Immunological Methods · doi:10.1016/s0022-1759(03)00189-3 · Cited by 158

Neurofilament-dependent Radial Growth of Motor Axons and Axonal Organization of Neurofilaments Does Not Require the Neurofilament Heavy Subunit (NF-H) or Its Phosphorylation

Rao, M. V., Houseweart, M. K., Williamson, T. L., Crawford, T. O., Folmer, J. S., & Cleveland, D. W. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.1.171 · Cited by 146

Patients with progressive multiple sclerosis have elevated antibodies to neurofilament subunit

Silber, E., Semra, Y. K., Gregson, N. A., & Sharief, M. K. (2002) · Neurology · doi:10.1212/wnl.58.9.1372 · Cited by 143

Disruption of the NF-H Gene Increases Axonal Microtubule Content and Velocity of Neurofilament Transport: Relief of Axonopathy Resulting from the Toxin β,β′-Iminodipropionitrile

Zhu, Q., Lindenbaum, M., Levavasseur, F., Jacomy, H., & Julien, J. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.1.183 · Cited by 142

Disruption of Type IV Intermediate Filament Network in Mice Lacking the Neurofilament Medium and Heavy Subunits

Jacomy, H., Zhu, Q., Couillard‐Després, S., Beaulieu, J., & Julien, J. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730972.x · Cited by 141

Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease

Tikka, T., Vartiainen, N. E., Goldsteins, G., Oja, S. S., Andersen, P. M., Marklund, S. L., & Koıstınaho, J. (2002) · Brain · doi:10.1093/brain/awf068 · Cited by 136

Two novel kinases phosphorylate tau and the KSP site of heavy neurofilament subunits in high stoichiometric ratios

Roder, H. M., & Ingram, V. M. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-11-03325.1991 · Cited by 133

Neurotypy: regional individuality in rat brain detected by immunocytochemistry with monoclonal antibodies.

Sternberger, L. A., Harwell, L. W., & Sternberger, N. H. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.4.1326 · Cited by 132

Heightened intrathecal release of axonal cytoskeletal proteins in multiple sclerosis is associated with progressive disease and clinical disability

Semra, Y. K., Seidi, O., & Sharief, M. K. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00455-6 · Cited by 131

Multiple sclerosis

Eikelenboom, M. J., Petzold, A., Lazeron, R. H. C., Silber, E., Sharief, M. K., Thompson, E. J., Barkhof, F., Giovannoni, G., Polman, C. H., & Uitdehaag, B. M. J. (2003) · Neurology · doi:10.1212/01.wnl.0000041496.58127.e3 · Cited by 127

Differential Cellular Phosphorylation of Neurofilament Heavy Side‐Arms by Glycogen Synthase Kinase‐3 and Cyclin‐Dependent Kinase‐5

Guidato, S., Tsai, L., Woodgett, J., & Miller, C. C. J. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66041698.x · Cited by 126

Axonal damage accumulates in the progressive phase of multiple sclerosis: three year follow up study

Petzold, A. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.043315 · Cited by 126

Phosphorylation of the amino-terminal head domain of the middle molecular mass 145-kDa subunit of neurofilaments. Evidence for regulation by second messenger-dependent protein kinases.

Sihag, R. K., & Nixon, R. A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39718-2 · Cited by 125

An Immunoblot Study of Neurofilament Degradation In Situ and During Calcium‐Activated Proteolysis

Schlaepfer, W. W., Lee, C., LEE, V. M.-Y., & Zimmerman, U.-J. P. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb05442.x · Cited by 125

Identification of Ser-55 as a major protein kinase A phosphorylation site on the 70-kDa subunit of neurofilaments. Early turnover during axonal transport.

Sihag, R. K., & Nixon, R. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55143-7 · Cited by 121

Cytoplasmic O-GlcNAc Modification of the Head Domain and the KSP Repeat Motif of the Neurofilament Protein Neurofilament-H

Dong, D. L.-Y., Xu, Z.-S., Hart, G. W., & Cleveland, D. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20845 · Cited by 112

Effects of phosphorylation of the neurofilament L protein on filamentous structures.

Hisanaga, S., Gonda, Y., Inagaki, M., Ikai, A., & Hirokawa, N. (1990) · Cell Regulation · doi:10.1091/mbc.1.2.237 · Cited by 110

In Vivo Phosphorylation of Distinct Domains of the 70-Kilodalton Neurofilament Subunit Involves Different Protein Kinases

Sihag, R. K., & Nixon, R. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31280-2 · Cited by 109

Interaction of the tail domain of high molecular weight subunits of neurofilaments with the COOH-terminal region of tubulin and its regulation by tau protein kinase II.

Miyasaka, H., Okabe, S., Ishiguro, K., Uchida, T., & Hirokawa, N. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41583-9 · Cited by 109

Axonal transport of neurofilaments in normal and disease states

Miller, C. C. J., Ackerley, S., Brownlees, J., Grierson, A. J., Jacobsen, N. J. O., & Thornhill, P. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8425-7 · Cited by 95

A novel NF-L mutation Pro22Ser is associated with CMT2 in a large Slovenian family

Georgiou, D.-M., Zidar, J., Korošec, M., Middleton, L. T., Kyriakides, T., & Christodoulou, K. (2002) · Neurogenetics · doi:10.1007/s10048-002-0138-4 · Cited by 94

The basic aspects of therapeutics in amyotrophic lateral sclerosis

Strong, M. J. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00040-8 · Cited by 94

The novel neurofilament light (NEFL) mutation Glu397Lys is associated with a clinically and morphologically heterogeneous type of Charcot-Marie-Tooth neuropathy

Zuchner, S. L., Vorgerd, M., Sindern, E., & Schröder, J. M. (2003) · Neuromuscular Disorders · doi:10.1016/j.nmd.2003.10.003 · Cited by 92

Chapter 38 Other inherited neuropathies

Boylan, K., & Chaudhry, V. (2006) · Handbook of clinical neurophysiology · doi:10.1016/s1567-4231(09)70099-1 · Cited by 88

Abnormal processing of multiple proteins in Alzheimer disease.

Zhang, H., Sternberger, N. H., Rubinstein, L. J., Herman, M. M., Binder, L. I., & Sternberger, L. A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.8045 · Cited by 88

Phosphorylation of bovine neurofilament proteins by protein kinase FA (glycogen synthase kinase 3)

Guan, R., Khatra, B. S., & Cohlberg, J. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92971-6 · Cited by 85

Varying degrees of phosphorylation determine microheterogeneity of the heavy neurofilament polypeptide (Nf-H)

Goldstein, M. E., Sternberger, L. A., & Sternberger, N. H. (1987) · Journal of Neuroimmunology · doi:10.1016/0165-5728(87)90048-8 · Cited by 84

Plaque biogenesis in brain aging and Alzheimer's disease

Su, J. H., Cummings, B. J., & Cotman, C. W. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00811-6 · Cited by 83

Age-Related Atrophy of Motor Axons in Mice Deficient in the Mid-Sized Neurofilament Subunit

Elder, G. A., Friedrich, V. L., Margita, A., & Lazzarini, R. A. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.1.181 · Cited by 82

Axonal degeneration and inflammation in acute optic neuritis

Petzold, A. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.017236 · Cited by 79

Phosphorylation‐Dependent Immunoreactivity of Neurofilaments Increases During Axonal Maturation and β,β′‐Iminodipropionitrile Intoxication

Watson, D. F., Griffin, J. W., Fittro, K. P., & Hoffman, P. N. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09248.x · Cited by 77

Phosphorylation state of the native high‐molecular‐weight neurofilament subunit protein from cervical spinal cord in sporadic amyotrophic lateral sclerosis

Strong, M. J., Strong, W., Jaffe, H., Traggert, B., Sopper, M. M., & Pant, H. C. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00094.x · Cited by 75

Alzheimer neurofibrillary tangles contain phosphorylated and hidden neurofilament epitopes.

Haugh, M. C., Probst, A., ULRICH, J., Kahn, J., & Anderton, B. H. (1986) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.49.11.1213 · Cited by 74

Effect of phosphorylation on 68 KDa neurofilament subunit protein assembly by the cyclic AMP dependent protein kinase in vitro

Nakamura, Y., Takeda, M., Angelides, K. J., Tanaka, T., Tada, K., & Nishimura, T. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)90394-3 · Cited by 73

Axonal cytoskeletal pathology in aged and diabetic human sympathetic autonomic ganglia

Schmidt, R. E., Beaudet, L. N., Plurad, S. B., & Dorsey, D. A. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00806-8 · Cited by 73

Neurofilaments and motor neuron disease

Julien, J. (1997) · Trends in Cell Biology · doi:10.1016/s0962-8924(97)01049-0 · Cited by 71

Molecular architecture of the neurofilament

Hisanaga, S., & Hirokawa, N. (1990) · Journal of Molecular Biology · doi:10.1016/0022-2836(90)90080-6 · Cited by 68

Plaque biogenesis in brain aging and Alzheimer's disease. II. Progressive transformation and developmental sequence of dystrophic neurites

Su, J. H., Cummings, B. J., & Cotman, C. W. (1998) · Acta Neuropathologica · doi:10.1007/s004010050920 · Cited by 67

Phosphorylation-related immunoreactivity and the rate of transport of neurofilaments in chronic 2,5-hexanedione intoxication

Watson, D. F., Fittro, K. P., Hoffman, P. N., & Griffin, J. W. (1991) · Brain Research · doi:10.1016/0006-8993(91)90691-n · Cited by 65

The axon reaction in motor and sensory neurones of mice studied by a monoclonal antibody marker of neurofilament protein

Moss, T., & Lewkowicz, S. J. (1983) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(83)90068-0 · Cited by 63

A mutation in the human neurofilament M gene in Parkinson's disease that suggests a role for the cytoskeleton in neuronal degeneration

Lavedan, C. N., Buchholtz, S. A., Nussbaum, R. L., Albin, R. L., & Polymeropoulos, M. H. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02513-7 · Cited by 61

Identification of Phosphorylation Sites on Neurofilament Proteins by Nanoelectrospray Mass Spectrometry

Betts, J. C., Blackstock, W. P., Ward, M. A., & Anderton, B. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.12922 · Cited by 60

Regulation of neurofilament interactionsin vitro by natural and synthetic polypeptides sharing Lys-Ser-Pro sequences with the heavy neurofilament subunit NF-H: Neurofilament crossbridging by antiparallel sidearm overlapping

Gou, J. P., Gotow, T., Janmey, P. A., & Leterrier, J. F. (1998) · Medical & Biological Engineering & Computing · doi:10.1007/bf02522486 · Cited by 60

Phosphorylation of native and reassembled neurofilaments composed of NF-L, NF-M, and NF-H by the catalytic subunit of cAMP-dependent protein kinase.

Hisanaga, S., Matsuoka, Y., Nishizawa, K., Saito, T., Inagaki, M., & Hirokawa, N. (1994) · Molecular Biology of the Cell · doi:10.1091/mbc.5.2.161 · Cited by 59

Increase in Dephosphorylation of the Heavy Neurofilament Subunit in the Monkey Chronic Glaucoma Model

Kashiwagi, K., Ou, B., Nakamura, S., Tanaka, Y., SUZUKI, M. T., & Tsukahara, S. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0398 · Cited by 59

Classification of the hereditary motor and sensory neuropathies

Reilly, M. M. (2000) · Current Opinion in Neurology · doi:10.1097/00019052-200010000-00009 · Cited by 57

Axonal degeneration and disorders of the axonal cytoskeleton

Griffin, J. W., George, E. B., Hsieh, S., & Glass, J. D. (1995) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195082937.003.0020 · Cited by 55

Axonal Pathology in Subarachnoid and Intracerebral Hemorrhage

Petzold, A., Rejdak, K., Belli, A., Sen, J., Keir, G., Kitchen, N. D., Smith, M., & Thompson, E. J. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.407 · Cited by 51

Treatment response in relation to inflammatory and axonal surrogate marker in multiple sclerosis

Petzold, A., Brassat, D., Mas, P., Rejdak, K., Keir, G., Giovannoni, G., Thompson, E. J., & Clanet, M. (2004) · Multiple Sclerosis Journal · doi:10.1191/1352458504ms1021sr · Cited by 48

Quantification of neurodegeneration by measurement of brain-specific proteins

Petzold, A., Baker, D., Pryce, G., Keir, G., Thompson, E. J., & Giovannoni, G. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00092-4 · Cited by 47

Influence of neuronal location on antigenic properties of neurofibrillary tangles

Tabaton, M., Perry, G. L., AUTILIO‐GAMBETTI, L., Manetto, V., & Gambetti, P. L. (1988) · Annals of Neurology · doi:10.1002/ana.410230613 · Cited by 46

Temporal and spatial variations in slow axonal transport velocity along peripheral motoneuron axons

Xu, Z., & Tung, V. W.-Y. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00449-8 · Cited by 42

Cerebrospinal fluid markers in MS patients and their healthy siblings

Haghighi, S., Andersen, O., Odén, A., & Rosengren, L. (2003) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2003.00197.x · Cited by 39

Intragenic sequences are required for cell type-specific and injury- induced expression of the rat peripherin gene

Belecky‐Adams, T. L., Wight, D. A., Kopchick, J., & Parysek, L. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-12-05056.1993 · Cited by 38

Chromatolytic neurons in Werdnig-Hoffmann disease contain phosphorylated neurofilaments

Lippa, C. F., & Smith, T. W. (1988) · Acta Neuropathologica · doi:10.1007/bf00688247 · Cited by 37

Swollen Cortical Neurons in Creutzfeldt-Jakob Disease Contain a Phosphorylated Neurofilament Epitope

Nakazato, Y., Hirato, J., Ishida, Y., HOSHI, S., Hasegawa, M., & FUKUDA, T. (1990) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199005000-00001 · Cited by 36

SPINAL CORD TRAUMA IN MAN: STUDIES OF PHOSPHORYLATED NEUROFILAMENT AND UBIQUITIN EXPRESSION

Martin, J. E., Mather, K., Swash, M., Garofalo, O., Dale, G. E., Leigh, P. N., & Anderton, B. H. (1990) · Brain · doi:10.1093/brain/113.5.1553 · Cited by 31

Dephosphorylation of Microtubule-Binding Sites at the Neurofilament-H Tail Domain by Alkaline, Acid, and Protein Phosphatases1

Hisanaga, S., Yasugawa, S., Yamakawa, T., Miyamoto, E., Ikebe, M., Uchiyama, M., & Kishimoto, T. (1993) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124107 · Cited by 29

Overexpression of neurofilament subunit M accelerates axonal transport of neurofilaments

Xu, Z., & Tung, V. W.-Y. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02390-8 · Cited by 29

Mass spectrometric imaging of immobilized pH gradient gels and creation of “virtual” two-dimensional gels

Walker, A. K., Rymar, G., & Andrews, P. (2001) · Electrophoresis · doi:10.1002/1522-2683()22:5 · Cited by 29

Glutamatergic receptors regulate expression, phosphorylation and accumulation of neurofilaments in spinal cord neurons

Vartiainen, N., Tikka, T., Keinänen, R., Chan, P. H., & Koıstınaho, J. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00200-6 · Cited by 29

Phosphorylated Neurofilaments in Neuronal Perikarya and Dendrites in Human Brain Following Axonal Damage

Hedreen, J. C., & Koliatsos, V. E. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199411000-00013 · Cited by 28

Neurofilament expression in human T lymphocytes.

Murphy, A., Breen, K. C., Long, A., Feighery, C., Casey, E. B., & Kelleher, D. P. (1993) · PubMed Central · Cited by 24

Axonal Charcot-Marie-Tooth Disease and the Neurofilament Light Gene (NF-L)

Lupski, J. R. (2000) · The American Journal of Human Genetics · doi:10.1086/302986 · Cited by 24

Age-related Atrophy of Motor Axons in Mice Deficient in the Mid-sized Neurofilament Subunit

Elder, G. A. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.999.181 · Cited by 24

SMI-32 antibody against non-phosphorylated neurofilaments identifies a subpopulation of cultured cortical neurons hypersensitive to kainate toxicity

Gottron, F. J., Turetskya, D., & Choi, D. W. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11698-v · Cited by 22

Phosphatase Resistance of ERK2 Brain Kinase PK40erk2

Roder, H., Hoffman, F., & Schröder, W. E. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64052203.x · Cited by 22

Proteolysis of filament proteins in glial and neuronal cells afterIn vivo stimulation of hippocampal NMDA receptors

Wang, S., Lees, G. J., Rosengren, L., Karlsson, J.-E., Hamberger, A., & Haglid, K. G. (1992) · Neurochemical Research · doi:10.1007/bf00966828 · Cited by 20

MONOCLONAL ANTIBODIES WHICH RECOGNIZE PHOSPHORYLATED AND NONPHOSPHORYLATED EPITOPES OF NEUROFILAMENT PROTEIN

Nakazato, Y., Sasaki, A., Hirato, J., & Ishida, Y. (1987) · Biomedical Research · doi:10.2220/biomedres.8.369 · Cited by 20

Inherited neuropathies

Chance, P. F., & Reilly, M. M. (1994) · Current Opinion in Neurology · doi:10.1097/00019052-199410000-00002 · Cited by 19

Anti-neurofilament antibodies in neuropathy with monoclonal gammopathy of undetermined significance produce experimental motor nerve conduction block

Stubbs, E. B., Lawlor, M. W., Richards, M. P., Siddiqui, K., Fisher, M. A., Bhoopalam, N., & Siegel, G. J. (2003) · Acta Neuropathologica · doi:10.1007/s00401-002-0615-8 · Cited by 18

Acute and chronic effects of morphine and naloxone on the phosphorylation of neurofilament-H proteins in the rat brain

Jaquet, P. E., Ferrer‐Alcón, M., Ventayol, P., Guimón, J., & Garcı́a-Sevilla, J. A. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01729-3 · Cited by 18

Human monoclonal antineurofilament antibody cross‐reacts with a neuronal surface protein

Sadiq, S. A., van den Berg, L. H., Thomas, F. P., Kilidireas, K., Hays, A. P., & Latov, N. (1991) · Journal of Neuroscience Research · doi:10.1002/jnr.490290307 · Cited by 18

Intermediate filaments

Herrmann, D. N., & Griffin, J. W. (2002) · Neurology · doi:10.1212/wnl.58.8.1141 · Cited by 17

Prevalence of antibodies to neurofilament polypeptides in patients with rheumatoid arthritis complicated by peripheral neuropathy.

Am, S., Nixon, N. B., Pt, D., & Dl, M. (1998) · PubMed · Cited by 16

Quantitative analysis of neurofilament proteins in Alzheimer brain by enzyme linked immunosorbent assay system

Hashimoto, R., Nakamura, Y., Tsujio, I., Tanimukai, H., Kudo, T., & Takeda, M. (1999) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.1999.00610.x · Cited by 15

Role for peroxisome proliferator-activated receptor-gamma in Alzheimer's disease.

van Geel (2001) · Open Repository and Bibliography (University of Luxembourg) · doi:10.1002/1531-8249(20010201)49:2 · Cited by 7

Transcorneal Electrical Stimulation Enhances the Survival of Axotmized Retinal Ganglion Cells In Vivo

Morimoto, T., Miyoshi, T., Fujikado, T., Tano, Y., & Fukuda, Y. (2003) · Investigative Ophthalmology & Visual Science · Cited by 2

Untitled work

(2000) · doi:10.1002/1097-4547(20000801)61:3

Neurofilaments as biomarkers in neurological disorders

Khalil, M., Teunissen, C. E., Otto, M., Piehl, F., Sormani, M. P., Gattringer, T., Barro, C., Kappos, L., Comabella, M., Fazekas, F., et al. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0058-z · Cited by 1,988

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

Dominantly Inherited Alzheimer Network, Preische, O., Schultz, S. A., Apel, A., Kuhle, J., Kaeser, S. A., Barro, C., Gräber, S., Kuder-Buletta, E., LaFougere, C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0304-3 · Cited by 927

Nusinersen initiated in infants during the presymptomatic stage of spinal muscular atrophy: Interim efficacy and safety results from the Phase 2 NURTURE study

Vivo, D. C. D., Bertini, E., Swoboda, K. J., Hwu, W., Crawford, T. O., Finkel, R. S., Kirschner, J., Kuntz, N. L., Parsons, J. A., Ryan, M. M., et al. (2019) · Neuromuscular Disorders · doi:10.1016/j.nmd.2019.09.007 · Cited by 669

Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis

Lu, C.-H., Macdonald-Wallis, C., Gray, E., Pearce, N., Petzold, A., Norgren, N., Giovannoni, G., Fratta, P., Sidle, K., Fish, M., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001642 · Cited by 563

Blood-based NfL: A biomarker for differential diagnosis of parkinsonian disorder

Hansson, O., Janelidze, S., Hall, S., Magdalinou, N., Lees, A. J., Andreasson, U., Norgren, N., Linder, J., Forsgren, L., Constantinescu, R., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000003680 · Cited by 506

Neurofilament a biomarker of neurodegeneration in autoimmune encephalomyelitis

Gnanapavan, S., Grant, D., Pryce, G., Jackson, S., Baker, D., & Giovannoni, G. (2012) · Autoimmunity · doi:10.3109/08916934.2012.654865 · Cited by 13

Neurofilaments as biomarkers in neurological disorders

Khalil, M., Teunissen, C. E., Otto, M., Piehl, F., Sormani, M. P., Gattringer, T., Barro, C., Kappos, L., Comabella, M., Fazekas, F., et al. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0058-z · Cited by 1,988

Neurofilament Proteins as Body Fluid Biomarkers of Neurodegeneration in Multiple Sclerosis

Gresle, M., Butzkueven, H., & Shaw, G. (2011) · Multiple Sclerosis International · doi:10.1155/2011/315406 · Cited by 49

Neurofilament Protein as a Potential Biomarker of Axonal Degeneration in Experimental Autoimmune Encephalomyelitis

Wang, P., Jiang, L., Wang, C., Zhu, Z., & Lai, C. (2020) · Neurology India · doi:10.4103/0028-3886.280651 · Cited by 3

Anti-neurofilament antibodies and neurodegeneration: Markers and generators

Zmira, O., Halpern, A. I., & Drori, T. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577248 · Cited by 13