The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss
Open accessAbstract
This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising anti-neurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the present symposium on multiple sclerosis, the current literature on body fluid levels of neurofilaments in demyelinating disease is summarised.
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“NfL is a component of the axonal cytoskeleton and is primarily expressed in large-caliber myelinated axons11,12.”
From Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease (2019) · cites this paper as [11]
In the citing paper
“Changes of NfL in bodily fluids have been linked to brain damage and brain atrophy in mouse models and multiple neurological disorders including proteopathic neurodegenerative diseases11,13–16.”
From Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease (2019) · cites this paper as [11]
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Cites
Axonal transection in the lesions of multiple sclerosis
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A Structural Scaffolding of Intermediate Filaments in Health and Disease
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de Waegh, S. M., Lee, V. M. ‐., & Brady, S. T. (1992) · Cell · doi:10.1016/0092-8674(92)90183-d · Cited by 743
Neurofilament gene expression: a major determinant of axonal caliber.
Hoffman, P. N., Cleveland, D. W., Griffin, J. W., Landes, P. W., Cowan, N. J., & Price, D. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3472 · Cited by 719
A Mechanistic Analysis of Nondisruptive Axonal Injury: A Review
Maxwell, W. L., Povlishock, J. T., & Graham, D. I. (1997) · Journal of Neurotrauma · doi:10.1089/neu.1997.14.419 · Cited by 564
Tikka, T., & Koıstınaho, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7527 · Cited by 539
Research works printed but not linked: 2
- Bö L, Grey matter pathology in early MS. In: Miller, DH, Filipi M, A.J. Thompson, editors. MAGNIMS Clinically Isolated Syndrome Workshop, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, 22.–23. Jan. MS NMR Research, Unit, Department of Neuroinflammation; 2004.
- Julien, 1999, Neurofilament functions in health and disease, Curr Opin Neurobiol, 9, 554, 10.1016/S0959-4388(99)00004-5 · DOI
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Neurofilaments as biomarkers in neurological disorders
Khalil, M., Teunissen, C. E., Otto, M., Piehl, F., Sormani, M. P., Gattringer, T., Barro, C., Kappos, L., Comabella, M., Fazekas, F., et al. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0058-z · Cited by 1,988
Self-citationDominantly Inherited Alzheimer Network, Preische, O., Schultz, S. A., Apel, A., Kuhle, J., Kaeser, S. A., Barro, C., Gräber, S., Kuder-Buletta, E., LaFougere, C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0304-3 · Cited by 927
Vivo, D. C. D., Bertini, E., Swoboda, K. J., Hwu, W., Crawford, T. O., Finkel, R. S., Kirschner, J., Kuntz, N. L., Parsons, J. A., Ryan, M. M., et al. (2019) · Neuromuscular Disorders · doi:10.1016/j.nmd.2019.09.007 · Cited by 669
Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis
Lu, C.-H., Macdonald-Wallis, C., Gray, E., Pearce, N., Petzold, A., Norgren, N., Giovannoni, G., Fratta, P., Sidle, K., Fish, M., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001642 · Cited by 563
Self-citationBlood-based NfL: A biomarker for differential diagnosis of parkinsonian disorder
Hansson, O., Janelidze, S., Hall, S., Magdalinou, N., Lees, A. J., Andreasson, U., Norgren, N., Linder, J., Forsgren, L., Constantinescu, R., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000003680 · Cited by 506
Metadata
- Authors
- Petzold, A.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- Corresponding author
- Petzold, Axel
- ORCID
- Petzold, Axel
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 233
- Issue
- 1-2
- Pages
- 183-198
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2133652987
- Cited by
- 688
- References
- 135
- Citations by year
- 2026: 26 · 2025: 44 · 2024: 40 · 2023: 49 · 2022: 46 · 2021: 65 · 2020: 42 · 2019: 54 · 2018: 38 · 2017: 27 · 2016: 24 · 2015: 23 · 2014: 38 · 2013: 27 · 2012: 24
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
- discovery.ucl.ac.uk
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- neurofilaments, axonal injury, axonal degeneration, surrogate markers, neurofilament assembly, multiple sclerosis, demyelinating disease, neurodegeneration
- MeSH terms
- Animals, Axons, Enzyme-Linked Immunosorbent Assay, Glycosylation, Humans, Immunohistochemistry, Models, Biological, Nerve Degeneration, Phosphorylation, Blotting, Western, Biomarkers, Neurofilament Proteins, Protein Isoforms
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