Cited by 688Skin and Cellular Biology ResearchHereditary Neurological DisordersMultiple Sclerosis Research Studies

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Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

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Petzold, Axel·2005·Journal of the Neurological Sciences

DOI 10.1016/j.jns.2005.03.015

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Abstract

This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising anti-neurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the present symposium on multiple sclerosis, the current literature on body fluid levels of neurofilaments in demyelinating disease is summarised.

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Authors: Petzold, A.
Affiliations: UCL Queen Square Institute of Neurology (GB)
Corresponding author: Petzold, Axel
ORCID: Petzold, Axel
Venue: Journal of the Neurological Sciences
Publisher: Elsevier BV
Published: 2005-06
Volume: 233
Issue: 1-2
Pages: 183-198
ISSN: 0022-510X (ISSN-L)
DOI: 10.1016/j.jns.2005.03.015
OpenAlex: W2133652987
Cited by: 688
References: 135
Citations by year: 2026: 26 · 2025: 44 · 2024: 40 · 2023: 49 · 2022: 46 · 2021: 65 · 2020: 42 · 2019: 54 · 2018: 38 · 2017: 27 · 2016: 24 · 2015: 23 · 2014: 38 · 2013: 27 · 2012: 24
FWCI: 1.17
Type: journal article
Language: en
Open access: green
discovery.ucl.ac.uk
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the Neurological Sciences (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: neurofilaments, axonal injury, axonal degeneration, surrogate markers, neurofilament assembly, multiple sclerosis, demyelinating disease, neurodegeneration
MeSH terms: Animals, Axons, Enzyme-Linked Immunosorbent Assay, Glycosylation, Humans, Immunohistochemistry, Models, Biological, Nerve Degeneration, Phosphorylation, Blotting, Western, Biomarkers, Neurofilament Proteins, Protein Isoforms

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Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

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